DrC_00467
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00467 (2590 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Con... 90 4e-17 sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Con... 84 2e-15 sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-... 84 3e-15 sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Con... 82 8e-15 sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1)... 81 1e-14 sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protei... 54 3e-06 sp|P15285|PSPB_RABIT Pulmonary surfactant-associated protei... 51 1e-05 sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein ... 49 6e-05 sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucos... 49 6e-05 sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor 47 2e-04
>sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)] Length = 524 Score = 89.7 bits (221), Expect = 4e-17 Identities = 100/456 (21%), Positives = 181/456 (39%), Gaps = 21/456 (4%) Frame = +3 Query: 1134 VVDRYGDILMTFIINHMDAKS-ICKLIHACTSVNVQLKPIRKMKGIECDAC-----RLVV 1295 +VD Y +++ I M +C ++ C S+ L + K +E + VV Sbjct: 109 IVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVV 168 Query: 1296 KKFKEYI-------SDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAE 1454 F I P ++ + K+ D C D IQ + F+ A Sbjct: 169 APFMANIPLLLYPQDGPRSKPQPKD--NGDVC----QDCIQMVTDIQTAVRTNSTFVQAL 222 Query: 1455 VDVDKICKFFGLCNAKLSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLK---ICPRL 1625 V+ K EC+ M ++ K S +SE + + ++ IC + Sbjct: 223 VEHVKE--------------ECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALV 268 Query: 1626 SVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSGNETLKC 1805 + + T +P + + SK + L+L + K ++ + C Sbjct: 269 GFCDEVKEMPMQTLVP-------AKVASKNVIPALELVEPIKKHEVP------AKSDVYC 315 Query: 1806 EICRFAILEVRTLLTDPGFQK-IFENFLINEICPHF-KTKQQQCTNDINQYYSLVVNIIV 1979 E+C F + EV L+ + +K I + F +++C K+ ++C ++ Y S +++I++ Sbjct: 316 EVCEFLVKEVTKLIDNNKTEKEILDAF--DKMCSKLPKSLSEECQEVVDTYGSSILSILL 373 Query: 1980 EFLNPSL-CSELGLCNSTIKQVIMRQPLVQINRSKKTSNCRLCCKFYNYL-QTISSKSSH 2153 E ++P L CS L LC+ T + V + + K C +C K YL + + S+ Sbjct: 374 EEVSPELVCSMLHLCSGTRLPALT----VHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTK 429 Query: 2154 SNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNP 2330 +L L C+ + + +C + + V+ F C C K Sbjct: 430 QEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPL 489 Query: 2331 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438 LG C WGP +WC + + A C AV+HC+ +VW Sbjct: 490 LGTEKCIWGPSYWCQNTETAAQC--NAVEHCKRHVW 523
Score = 77.4 bits (189), Expect = 2e-13
Identities = 96/477 (20%), Positives = 156/477 (32%), Gaps = 77/477 (16%)
Frame = +3
Query: 42 DCLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCIQFVRVVES 221
+C +G WC K A CG + C N LP C+ C V
Sbjct: 24 ECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLP--------CDICKDVVTAAGD 75
Query: 222 KIPKLTEKEFINLINTFICDRI-QVNTHWKCRDFVAEFGPLIYEEIKTEAT-PEKICGLI 395
+ +E I + CD + + N C++ V + P+I + IK E + P ++C +
Sbjct: 76 MLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSAL 135
Query: 396 QACEN----------QKEMSXXXXXXXXXXXX---------------------------- 461
CE+ QK++
Sbjct: 136 NLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNG 195
Query: 462 ELCAKCKEIFDFLDAMFSKVTPDEFKYLLETLV---CSQLPSEFRDTCKALLDGYVTQLY 632
++C C ++ D + T F L V C +L D CK + Y +++
Sbjct: 196 DVCQDCIQMVT--DIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQY-SEIA 252
Query: 633 YLIKSLLDGDRICPLIHFC------PSNTTVTLN--SWNCQTCLDVVVMLKKDMVNVPAS 788
+ + IC L+ FC P T V S N L++V +KK V +
Sbjct: 253 IQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSD 312
Query: 789 -----------EVEALIKNN------------ICAKLNFVAKPICNDYVDNYVPKFMSEI 899
EV LI NN +C+KL C + VD Y +S +
Sbjct: 313 VYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSIL 372
Query: 900 QSTMTPQQICNTNHFCMAPSIPKPNVDMKGPVT---CNLCEIAVSEMKSFISNTENXXXX 1070
++P+ +C+ H C +P V + P C +C+ V + +
Sbjct: 373 LEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEI 432
Query: 1071 XXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQL 1241
V Y +L+ ++ MD +C I AC S + L
Sbjct: 433 LAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPL 489
Score = 47.0 bits (110), Expect = 3e-04
Identities = 75/381 (19%), Positives = 146/381 (38%), Gaps = 26/381 (6%)
Frame = +3
Query: 1257 MKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSD-KIQCQQIVDEYFNLI 1433
+K + CD C+ VV + + D ATE EI +L+ ++ + C++IVD Y +I
Sbjct: 58 VKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVI 117
Query: 1434 LNFILAEVD-VDKICKFFGLCNAKLSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLK 1610
L+ I E+ ++C LC + L +H+ + NH +++ SN I
Sbjct: 118 LDIIKGEMSRPGEVCSALNLCES--------LQKHLAE-------LNHQKQLESNKI--- 159
Query: 1611 ICPRLSVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSGN 1790
P L + + P + +I LL + + +
Sbjct: 160 --PELD--------MTEVVAPFMANIP----------------LLLYPQDGPRSKPQPKD 193
Query: 1791 ETLKCEICRFAILEVRTLL-TDPGF-QKIFENFLINEICPHFKTKQQQ-CTNDINQYYSL 1961
C+ C + +++T + T+ F Q + E+ + E C C N I+QY +
Sbjct: 194 NGDVCQDCIQMVTDIQTAVRTNSTFVQALVEH--VKEECDRLGPGMADICKNYISQYSEI 251
Query: 1962 VVNIIVEFLNPSLCSELGLCNS--------------TIKQVIMRQPLVQ-INRSKKTSNC 2096
+ +++ +C+ +G C+ K VI LV+ I + + +
Sbjct: 252 AIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKS 311
Query: 2097 RLCCKFYNYL-----QTISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAF 2261
+ C+ +L + I + + +L C+++ EC + + + I +
Sbjct: 312 DVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSI 371
Query: 2262 NKSKTINEF-CEMTKMCSHQR 2321
+ E C M +CS R
Sbjct: 372 LLEEVSPELVCSMLHLCSGTR 392
Score = 37.7 bits (86), Expect = 0.17
Identities = 18/38 (47%), Positives = 20/38 (52%)
Frame = +3
Query: 2331 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVWRQ 2444
LG CT G WC + K A C GAVKHC VW +
Sbjct: 20 LGLKECTRGSAVWCQNVKTASDC--GAVKHCLQTVWNK 55
>sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Contains: Saposin A; Saposin B; Saposin C; Saposin D] Length = 518 Score = 84.0 bits (206), Expect = 2e-15 Identities = 102/493 (20%), Positives = 185/493 (37%), Gaps = 78/493 (15%) Frame = +3 Query: 1194 SICKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCY 1373 S C + C NV KP + I CD C+ +V + + D TE EI+++L+ C Sbjct: 41 SQCGAVKHCQQ-NVWSKPA--VNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKR-CE 96 Query: 1374 IFGSDKI--QCQQIVDEYFNLILNFILAEVD-VDKICKFFGLCNAKLSGI---------- 1514 + +C++IVD Y +I++ I E D + +C LC + + Sbjct: 97 FLPDQGLASECKEIVDSYLPVIMDMIKEEFDKPEVVCSALSLCQSLQKHLAAMKLQKQLQ 156 Query: 1515 --------------------------------ECELCEHVMDEVIKVVTS-NHSEEVVSN 1595 + + E V + I++VT + + Sbjct: 157 SNKIPELDFSELTSPFMANVPLLLYPQDKPKQKSKATEDVCQDCIRLVTDVQEAVRTNAT 216 Query: 1596 FIKLKI------CPRLSV-IKNECVIIVDTY--LPVIFSIARSTLNSKVICTELKLCTLL 1748 F+K + C RL + + C + Y L + + K IC + C + Sbjct: 217 FVKSLVAHAKEECDRLGPGMSDMCKSYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSV 276 Query: 1749 SKKKISFLMNRSGNETLK----------------CEICRFAILEVRTLLTDPGFQK--IF 1874 + L+ +K CEIC + EV LL ++ + Sbjct: 277 KSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVH 336 Query: 1875 ENFLINEICPHFKTKQQQCTNDINQYYSLVVNIIVEFLNP-SLCSELGLC--NSTIKQVI 2045 E ++ + P + + QC + I Y ++++++E NP ++C L C N +Q + Sbjct: 337 EMEVVCYLLP--ASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPV 394 Query: 2046 MRQPLVQINRSKKTSNCRLCCKFYNYLQTISSKSSHSNLLFGLV-SFCNQISAHERLECL 2222 + +P C +C Y K++ + + L+ C+ + +C+ Sbjct: 395 VVKP--------AGGFCDICKMIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCV 446 Query: 2223 KQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGFWCVSRKHAVAC 2399 + + V+ F C +C +K LG++ C WGPG+WC + + A C Sbjct: 447 QFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAKKPLLGEDACVWGPGYWCKNMETAAQC 506 Query: 2400 GPGAVKHCEMNVW 2438 AV HC +VW Sbjct: 507 --NAVDHCRRHVW 517
Score = 72.0 bits (175), Expect = 8e-12
Identities = 79/417 (18%), Positives = 149/417 (35%), Gaps = 73/417 (17%)
Frame = +3
Query: 468 CAKCKEIFDFLDAMFS-KVTPDEFKYLLETLVCSQLPSE-FRDTCKALLDGYVTQLYYLI 641
C CKE+ + + T DE + LE C LP + CK ++D Y+ + +I
Sbjct: 64 CDLCKELVTVVGKVLKDNGTEDEIRSYLEKR-CEFLPDQGLASECKEIVDSYLPVIMDMI 122
Query: 642 KSLLDGDRI-CPLIHFCPS---------------------------------NTTVTLNS 719
K D + C + C S N + L
Sbjct: 123 KEEFDKPEVVCSALSLCQSLQKHLAAMKLQKQLQSNKIPELDFSELTSPFMANVPLLLYP 182
Query: 720 WN------------CQTCLDVVVMLKKDMVNVPASEVEALIKN--NICAKLNFVAKPICN 857
+ CQ C+ +V ++ + V A+ V++L+ + C +L +C
Sbjct: 183 QDKPKQKSKATEDVCQDCIRLVTDVQ-EAVRTNATFVKSLVAHAKEECDRLGPGMSDMCK 241
Query: 858 DYVDNYVPKFMSEIQ--STMTPQQICNTNHFCMA--------------------PSIPKP 971
Y+ Y + + P+ IC FC + ++ K
Sbjct: 242 SYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVVHEVKMETVEKA 301
Query: 972 NVDMKGPVTCNLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYG 1151
V K C +CE V E+ + + + ++ YG
Sbjct: 302 TVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYG 361
Query: 1152 DILMTFIINHMDAKSICKLIHACTSVNVQLKPIR-KMKGIECDACRLVVKKFKEYISDPA 1328
L+ ++ + +++C ++ C + +P+ K G CD C+++V + + A
Sbjct: 362 QALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGFCDICKMIVAYADKELEKNA 421
Query: 1329 TETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA 1499
T TEI+ L+ ++ S QC Q V++Y +++ + +D +C G+C A
Sbjct: 422 TTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGA 478
Score = 70.9 bits (172), Expect = 2e-11
Identities = 85/463 (18%), Positives = 160/463 (34%), Gaps = 70/463 (15%)
Frame = +3
Query: 42 DCLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCIQFVRVVES 221
DC KGP WC + + A +CG + C + + N +P C+ C + V VV
Sbjct: 25 DCAKGPEVWCQSLRTASQCGAVKHCQQNVWSKPAVNSIP--------CDLCKELVTVVGK 76
Query: 222 KI-PKLTEKEFINLIN---TFICDRIQVNTHWKCRDFVAEFGPLIYEEIKTE-ATPEKIC 386
+ TE E + + F+ D+ + +C++ V + P+I + IK E PE +C
Sbjct: 77 VLKDNGTEDEIRSYLEKRCEFLPDQGLAS---ECKEIVDSYLPVIMDMIKEEFDKPEVVC 133
Query: 387 GLIQACEN----------QKEMS--------------------------XXXXXXXXXXX 458
+ C++ QK++
Sbjct: 134 SALSLCQSLQKHLAAMKLQKQLQSNKIPELDFSELTSPFMANVPLLLYPQDKPKQKSKAT 193
Query: 459 XELCAKC-KEIFDFLDAMFSKVTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQLYY 635
++C C + + D +A+ + T + C +L D CK+ + Y
Sbjct: 194 EDVCQDCIRLVTDVQEAVRTNATFVKSLVAHAKEECDRLGPGMSDMCKSYISEYSDLAIQ 253
Query: 636 LIKSLLDGD--RICPLIHFCPSNTTVTLNSW---------NCQTCLDVVVMLKK----DM 770
++ + D IC ++ FCPS +V L + +T V K ++
Sbjct: 254 MMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSVCEI 313
Query: 771 VNVPASEVEALIKNN------------ICAKLNFVAKPICNDYVDNYVPKFMSEIQSTMT 914
EV L+++N +C L K C D+++ Y + +
Sbjct: 314 CETMVKEVTGLLESNKTEEEIVHEMEVVCYLLPASVKDQCKDFIEVYGQALIDMLLEATN 373
Query: 915 PQQICNTNHFCMAPSIPKPNVDMK-GPVTCNLCEIAVSEMKSFISNTENXXXXXXXXXXX 1091
P+ +C C A P+ V +K C++C++ V+ +
Sbjct: 374 PEAVCVMLKCCAANKPPQQPVVVKPAGGFCDICKMIVAYADKELEKNATTTEIEALLEKV 433
Query: 1092 XXXXXXXXXXXXXXVVDRYGDILMTFIINHMDAKSICKLIHAC 1220
V++Y +++ + MD +C + C
Sbjct: 434 CHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVC 476
Score = 67.0 bits (162), Expect = 3e-10
Identities = 62/295 (21%), Positives = 114/295 (38%), Gaps = 32/295 (10%)
Frame = +3
Query: 177 ETCNTCIQFVRVVESKIPKLTEKEFINLINTFI---CDRIQVNTHWKCRDFVAEFGPLIY 347
+ C CI+ V V+ + T F+ + CDR+ C+ +++E+ L
Sbjct: 195 DVCQDCIRLVTDVQEAVR--TNATFVKSLVAHAKEECDRLGPGMSDMCKSYISEYSDLAI 252
Query: 348 EEIK--TEATPEKICGLIQACENQK----------------EMSXXXXXXXXXXXXELCA 473
+ + + P+ IC ++ C + K +M +C
Sbjct: 253 QMMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSVCE 312
Query: 474 KC----KEIFDFLDAMFSKVTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQLYYLI 641
C KE+ L+ S T +E + +E +VC LP+ +D CK ++ Y L ++
Sbjct: 313 ICETMVKEVTGLLE---SNKTEEEIVHEME-VVCYLLPASVKDQCKDFIEVYGQALIDML 368
Query: 642 KSLLDGDRICPLIHFCPSN------TTVTLNSWNCQTCLDVVVMLKKDM-VNVPASEVEA 800
+ + +C ++ C +N V C C +V K++ N +E+EA
Sbjct: 369 LEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGFCDICKMIVAYADKELEKNATTTEIEA 428
Query: 801 LIKNNICAKLNFVAKPICNDYVDNYVPKFMSEIQSTMTPQQICNTNHFCMAPSIP 965
L++ +C L C +V+ Y P + + M P +C C A P
Sbjct: 429 LLE-KVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAKKP 482
Score = 40.8 bits (94), Expect = 0.020
Identities = 18/36 (50%), Positives = 21/36 (58%)
Frame = +3
Query: 2331 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438
L + C GP WC S + A CG AVKHC+ NVW
Sbjct: 21 LWQKDCAKGPEVWCQSLRTASQCG--AVKHCQQNVW 54
>sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin) Length = 557 Score = 83.6 bits (205), Expect = 3e-15 Identities = 98/504 (19%), Positives = 178/504 (35%), Gaps = 111/504 (22%) Frame = +3 Query: 1260 KGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSD-KIQCQQIVDEYFNLIL 1436 K + CD C+ VV + + D AT+ EI ++L+ +I S C+++VD Y +IL Sbjct: 59 KSLPCDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSYLPVIL 118 Query: 1437 NFILAEV-DVDKICKFFGLCNA-------------------------------------- 1499 + I E+ + ++C LC + Sbjct: 119 DMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQKQLESNKIPEVDMARVVAPFMSNIPLLL 178 Query: 1500 ------------KLSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIK--LKICPRLSV-I 1634 K + C+ C ++ +V V +N S + F+ + C RL + Sbjct: 179 YPQDHPRSQPQPKANEDVCQDCMKLVSDVQTAVKTNSS--FIQGFVDHVKEDCDRLGPGV 236 Query: 1635 KNECVIIVDTYLPVIFSIARSTLNS--KVICTELKLCTLLSKKKISFLMNRSGNETLK-- 1802 + C VD Y V + + K IC C + + + L+ ET+K Sbjct: 237 SDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVKRVPMKTLV--PATETIKNI 294 Query: 1803 ----------------------CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKT 1916 C+ C+F + + L+ + +++ L N Sbjct: 295 LPALEMMDPYEQNLVQAHNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDP 354 Query: 1917 KQQQCTNDINQYYSLVVNIIVEFLNPS-LCSELGLCNS-------------TIKQVIMRQ 2054 + +C + + +++I + +NPS LC +GLC + I ++++ Sbjct: 355 ARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKE 414 Query: 2055 PL--------------VQINRSKKTSNCRLCCKFYNYLQ-TISSKSSHSNLLFGLVSFCN 2189 P + K C +C K YL+ + S+ +L L C+ Sbjct: 415 PTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCS 474 Query: 2190 QISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGF 2366 + + +C + ++ F C +C K LG C WGP + Sbjct: 475 FLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPSAYKLLLGTEKCVWGPSY 534 Query: 2367 WCVSRKHAVACGPGAVKHCEMNVW 2438 WC + + A C AV HC+ +VW Sbjct: 535 WCQNMETAARC--NAVDHCKRHVW 556
Score = 59.3 bits (142), Expect = 5e-08
Identities = 103/488 (21%), Positives = 186/488 (38%), Gaps = 45/488 (9%)
Frame = +3
Query: 717 SWNCQTCLD-----VVVMLKKDMVNVPASEVEALIKNNICAKLN-FVAKPICNDYVDNYV 878
S +C+ +D ++ M+K +M N P AL N+C L ++A+ N +
Sbjct: 103 SASCKEVVDSYLPVILDMIKGEMSN-PGEVCSAL---NLCQSLQEYLAEQNQKQLESNKI 158
Query: 879 PK---------FMSEIQSTMTPQQICNTNHFCMAPSIPKPNVDMKGPVTCNLCEIAVSEM 1031
P+ FMS I + PQ +H P PK N D+ C C VS++
Sbjct: 159 PEVDMARVVAPFMSNIPLLLYPQ-----DHPRSQPQ-PKANEDV-----CQDCMKLVSDV 207
Query: 1032 KSFI-SNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFIINHMDA--KSIC 1202
++ + +N+ VD+Y ++ + +++ D K IC
Sbjct: 208 QTAVKTNSSFIQGFVDHVKEDCDRLGPGVSDICKNYVDQYSEVCVQMLMHMQDQQPKEIC 267
Query: 1203 KLIHACTSVN-VQLKP-------------------------IRKMKGIECDACRLVVKKF 1304
L C V V +K ++ I C C+ V+ KF
Sbjct: 268 VLAGFCNEVKRVPMKTLVPATETIKNILPALEMMDPYEQNLVQAHNVILCQTCQFVMNKF 327
Query: 1305 KEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFF 1484
E I + ATE + L N + + +CQ++V + +L+ + EV+ +C
Sbjct: 328 SELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVI 387
Query: 1485 GLCNAKLSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNECVIIVDT 1664
GLC A+ +E + +VS +K P+ + +
Sbjct: 388 GLCAARPELVE--------------ALEQPAPAIVSALLKEPTPPKQPAQPKQSAL--PA 431
Query: 1665 YLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSGNETLKCEICRFAILEVRTL 1844
++P + C ++C KK + +L + + K EI A+ + +
Sbjct: 432 HVP--------PQKNGGFC---EVC----KKLVLYLEHNLEKNSTKEEILA-ALEKGCSF 475
Query: 1845 LTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVNIIVEFLNPS-LCSELGLC 2021
L DP +QK QC + + +Y L++ I+VE ++P +CS++G+C
Sbjct: 476 LPDP-YQK-------------------QCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVC 515
Query: 2022 NSTIKQVI 2045
S K ++
Sbjct: 516 PSAYKLLL 523
Score = 48.5 bits (114), Expect = 9e-05
Identities = 48/215 (22%), Positives = 78/215 (36%), Gaps = 33/215 (15%)
Frame = +3
Query: 183 CNTCIQFV--RVVESKIPKLTEKEFINLINTFICDRIQVNTHWKCRDFVAEFGPLIYEEI 356
C TC QFV + E + TE+ + ++ C + KC++ V FGP + +
Sbjct: 317 CQTC-QFVMNKFSELIVNNATEELLVKGLSN-ACALLPDPARTKCQEVVGTFGPSLLDIF 374
Query: 357 KTEATPEKICGLIQACENQKEM------------------------------SXXXXXXX 446
E P +CG+I C + E+ S
Sbjct: 375 IHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVP 434
Query: 447 XXXXXELCAKCKEIFDFLDAMFSK-VTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVT 623
C CK++ +L+ K T +E LE CS LP ++ C + Y
Sbjct: 435 PQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEK-GCSFLPDPYQKQCDDFVAEYEP 493
Query: 624 QLYYLIKSLLDGDRICPLIHFCPSNTTVTLNSWNC 728
L ++ ++D +C I CPS + L + C
Sbjct: 494 LLLEILVEVMDPGFVCSKIGVCPSAYKLLLGTEKC 528
Score = 40.4 bits (93), Expect = 0.026
Identities = 32/131 (24%), Positives = 62/131 (47%), Gaps = 6/131 (4%)
Frame = +3
Query: 1707 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 1880
S V+C ++K K + ++ ++L C+IC+ + E LL D Q+ +
Sbjct: 29 SAVLCRDVKTAVDCGAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATQEEILH 88
Query: 1881 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVIM 2048
+L + C H + C ++ Y +++++I E NP +CS L LC S +++ +
Sbjct: 89 YL-EKTCEWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS-LQEYLA 146
Query: 2049 RQPLVQINRSK 2081
Q Q+ +K
Sbjct: 147 EQNQKQLESNK 157
>sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)] Length = 525 Score = 82.0 bits (201), Expect = 8e-15 Identities = 56/216 (25%), Positives = 96/216 (44%), Gaps = 4/216 (1%) Frame = +3 Query: 1803 CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 1979 CE+C F + EV L+ + ++ + L +++C T +QC ++ Y +++I++ Sbjct: 316 CEVCEFVVKEVAKLIDNNRTEEEILHAL-DKVCSKLPTSLAEQCQEVVDTYGRSILSILL 374 Query: 1980 EFLNPSL-CSELGLCNSTIKQVIMRQPLVQINRSKKTSNCRLCCKFYNYL-QTISSKSSH 2153 + +P L CS L LC+S + V++ K C +C K YL + + S+ Sbjct: 375 DEASPELVCSMLHLCSSRG----LPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTK 430 Query: 2154 SNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNP 2330 +L L C+ + R +C + + V+ F C C K Sbjct: 431 EQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPL 490 Query: 2331 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438 LG C WGP +WC + + A C AV+HC +VW Sbjct: 491 LGAEKCVWGPSYWCQNMESAALC--NAVEHCRRHVW 524
Score = 78.2 bits (191), Expect = 1e-13
Identities = 58/289 (20%), Positives = 112/289 (38%), Gaps = 31/289 (10%)
Frame = +3
Query: 726 CQTCLDVVVMLKKDMVNVPASEVEALIKN--NICAKLNFVAKPICNDYVDNYVPKFMSEI 899
CQ C+ +V ++ + + ++ VEAL+ + C +L +C +Y++ Y + +
Sbjct: 199 CQDCIQLVTDVQ-EALRTNSTFVEALVDHAKEECDRLGPGMSDMCKNYINQYSEVAIQMV 257
Query: 900 QSTMTPQQICNTNHFC--------------------------MAPSIPKPNVDMKGPVTC 1001
M P++IC FC + I K K + C
Sbjct: 258 MH-MQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIPALGLVEPIKKDPAPAKADIYC 316
Query: 1002 NLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFIINH 1181
+CE V E+ I N VVD YG +++ +++
Sbjct: 317 EVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGRSILSILLDE 376
Query: 1182 MDAKSICKLIHACTSVNVQLKPIRKMK---GIECDACRLVVKKFKEYISDPATETEIKNF 1352
+ +C ++H C+S + +R M G C+ C+ +V + +T+ +I
Sbjct: 377 ASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTKEQILAA 436
Query: 1353 LKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA 1499
L+ ++ + QC Q V EY +++ ++ +D +C G C A
Sbjct: 437 LEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPA 485
Score = 73.2 bits (178), Expect = 4e-12
Identities = 98/477 (20%), Positives = 159/477 (33%), Gaps = 77/477 (16%)
Frame = +3
Query: 42 DCLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCIQFVRVVES 221
+C +G WC K A CG + C + LP C+ C + +
Sbjct: 24 ECTRGSAVWCQNVKTAADCGAVQHCLQTVWSKPTVKSLP--------CDICKDVITAAGN 75
Query: 222 KIP-KLTEKEFINLINTFICDRI-QVNTHWKCRDFVAEFGPLIYEEIKTEAT-PEKICGL 392
+ TE+E + + CD + + N C++ V + P+I + IK + + P ++C
Sbjct: 76 LLKDNATEQEILMYLER-TCDWLPKPNMSASCKEIVDSYLPVILDMIKGQMSHPGEVCSA 134
Query: 393 IQACEN-QKEMSXXXXXXXXXXXX-------ELCAKCKEIFDFL----DAMFSKVTPDEF 536
+ CE+ QK ++ E+ A FL D SK P +
Sbjct: 135 LNLCESLQKHLAELNHQKQLESNQIPELDMAEVVAPFMANIPFLLYPQDGSHSKPQPKKA 194
Query: 537 K----------------------YLLETLV------CSQLPSEFRDTCKALLDGYVTQLY 632
+E LV C +L D CK ++ Y
Sbjct: 195 NGNVCQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLGPGMSDMCKNYINQYSEVAI 254
Query: 633 YLIKSLLDGDRICPLIHFC------PSNTTVTLN--SWNCQTCLDVVVMLKKDMVNVPAS 788
++ + + IC L FC P T V S N L +V +KKD A
Sbjct: 255 QMVMHMQPKE-ICVLAGFCDEVKEMPMKTLVPAEVVSENVIPALGLVEPIKKDPAPAKAD 313
Query: 789 -----------EVEALIKNN------------ICAKLNFVAKPICNDYVDNYVPKFMSEI 899
EV LI NN +C+KL C + VD Y +S +
Sbjct: 314 IYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGRSILSIL 373
Query: 900 QSTMTPQQICNTNHFCMAPSIPKPNVDM---KGPVTCNLCEIAVSEMKSFISNTENXXXX 1070
+P+ +C+ H C + +P V + K C +C+ V + +
Sbjct: 374 LDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTKEQI 433
Query: 1071 XXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQL 1241
V Y +L+ ++ MD +C I AC + + L
Sbjct: 434 LAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPL 490
Score = 68.9 bits (167), Expect = 7e-11
Identities = 48/184 (26%), Positives = 98/184 (53%), Gaps = 6/184 (3%)
Frame = +3
Query: 1512 IECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSI 1688
I CE+CE V+ EV K++ +N +EE + + + K+C +L + + +C +VDTY I SI
Sbjct: 314 IYCEVCEFVVKEVAKLIDNNRTEEEILHALD-KVCSKLPTSLAEQCQEVVDTYGRSILSI 372
Query: 1689 ARSTLNSKVICTELKLCTL--LSKKKISFLMNRSGNETLKCEICRFAILEV-RTLLTDPG 1859
+ +++C+ L LC+ L + + + G CE+C+ + + R L +
Sbjct: 373 LLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGG---FCEVCKKLVGYLDRNLEKNST 429
Query: 1860 FQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIVEFLNPS-LCSELGLCNSTI 2033
++I + + C + ++QC + +Y +++ I+VE ++PS +C ++G C +
Sbjct: 430 KEQILA--ALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAH 487
Query: 2034 KQVI 2045
K ++
Sbjct: 488 KPLL 491
Score = 68.6 bits (166), Expect = 9e-11
Identities = 88/437 (20%), Positives = 162/437 (37%), Gaps = 88/437 (20%)
Frame = +3
Query: 708 TLNSWNCQTCLDVVVMLKKDMVNVPASEVEALIKNNICAKLNFVAKP----ICNDYVDNY 875
T+ S C C DV+ +++ A+E E L+ + +++ KP C + VD+Y
Sbjct: 57 TVKSLPCDICKDVITAAG-NLLKDNATEQEILMY--LERTCDWLPKPNMSASCKEIVDSY 113
Query: 876 VPKFMSEIQSTMT-PQQICNT--------------NHFCMAPSIPKPNVDMKGPVT---- 998
+P + I+ M+ P ++C+ NH S P +DM V
Sbjct: 114 LPVILDMIKGQMSHPGEVCSALNLCESLQKHLAELNHQKQLESNQIPELDMAEVVAPFMA 173
Query: 999 -------------------------CNLCEIAVSEMKSFI-SNTENXXXXXXXXXXXXXX 1100
C C V++++ + +N+
Sbjct: 174 NIPFLLYPQDGSHSKPQPKKANGNVCQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDR 233
Query: 1101 XXXXXXXXXXXVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQ-------------- 1238
+++Y ++ + ++ HM K IC L C V
Sbjct: 234 LGPGMSDMCKNYINQYSEVAIQMVM-HMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSEN 292
Query: 1239 -------LKPIRK-----MKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFG 1382
++PI+K I C+ C VVK+ + I + TE EI + L +
Sbjct: 293 VIPALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPT 352
Query: 1383 SDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA------------KLSGIECEL 1526
S QCQ++VD Y IL+ +L E + +C LC++ + G CE+
Sbjct: 353 SLAEQCQEVVDTYGRSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEV 412
Query: 1527 CEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSIARSTL 1703
C+ ++ + + + N ++E + ++ K C L + +C V Y PV+ I +
Sbjct: 413 CKKLVGYLDRNLEKNSTKEQILAALE-KGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVM 471
Query: 1704 NSKVICTELKLCTLLSK 1754
+ +C ++ C K
Sbjct: 472 DPSFVCLKIGACPAAHK 488
Score = 62.8 bits (151), Expect = 5e-09
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 1/194 (0%)
Frame = +3
Query: 150 KLPYVASKSETCNTCIQFVRVVESKIPK-LTEKEFINLINTFICDRIQVNTHWKCRDFVA 326
K P A C C V+ V I TE+E ++ ++ +C ++ + +C++ V
Sbjct: 305 KDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDK-VCSKLPTSLAEQCQEVVD 363
Query: 327 EFGPLIYEEIKTEATPEKICGLIQACENQKEMSXXXXXXXXXXXXELCAKCKEIFDFLDA 506
+G I + EA+PE +C ++ C + + + C CK++ +LD
Sbjct: 364 TYGRSILSILLDEASPELVCSMLHLC-SSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDR 422
Query: 507 MFSKVTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQLYYLIKSLLDGDRICPLIHF 686
K + E CS LP ++R C + Y L ++ ++D +C I
Sbjct: 423 NLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGA 482
Query: 687 CPSNTTVTLNSWNC 728
CP+ L + C
Sbjct: 483 CPAAHKPLLGAEKC 496
Score = 44.3 bits (103), Expect = 0.002
Identities = 79/395 (20%), Positives = 146/395 (36%), Gaps = 24/395 (6%)
Frame = +3
Query: 1200 CKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF 1379
C + C V KP +K + CD C+ V+ + D ATE EI +L+ ++
Sbjct: 42 CGAVQHCLQT-VWSKPT--VKSLPCDICKDVITAAGNLLKDNATEQEILMYLERTCDWLP 98
Query: 1380 GSD-KIQCQQIVDEYFNLILNFILAEVD-VDKICKFFGLCNAKLSGIECELCEHVMDEVI 1553
+ C++IVD Y +IL+ I ++ ++C LC + L +H+ +
Sbjct: 99 KPNMSASCKEIVDSYLPVILDMIKGQMSHPGEVCSALNLCES--------LQKHLAE--- 147
Query: 1554 KVVTSNHSEEVVSNFIKLKICPRLSVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELK 1733
NH +++ SN I P L + E V +P + + +SK
Sbjct: 148 ----LNHQKQLESNQI-----PELDMA--EVVAPFMANIPFLL-YPQDGSHSKP------ 189
Query: 1734 LCTLLSKKKISFLMNRSGNETLKCEICRFAILEVR-TLLTDPGFQKIFENFLINEICPHF 1910
KK +GN C+ C + +V+ L T+ F + + E
Sbjct: 190 -----QPKK------ANGN---VCQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLG 235
Query: 1911 KTKQQQCTNDINQYYSLVVNIIVEFLNPSLCSELGLCNS--------------TIKQVIM 2048
C N INQY + + +++ +C G C+ + VI
Sbjct: 236 PGMSDMCKNYINQYSEVAIQMVMHMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIP 295
Query: 2049 RQPLVQ-INRSKKTSNCRLCCKFYNYL-----QTISSKSSHSNLLFGLVSFCNQISAHER 2210
LV+ I + + + C+ ++ + I + + +L L C+++
Sbjct: 296 ALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLA 355
Query: 2211 LECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCS 2312
+C + + I + + E C M +CS
Sbjct: 356 EQCQEVVDTYGRSILSILLDEASPELVCSMLHLCS 390
Score = 36.6 bits (83), Expect = 0.37
Identities = 17/36 (47%), Positives = 19/36 (52%)
Frame = +3
Query: 2331 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438
LG CT G WC + K A C GAV+HC VW
Sbjct: 20 LGLRECTRGSAVWCQNVKTAADC--GAVQHCLQTVW 53
>sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin) Length = 554 Score = 81.3 bits (199), Expect = 1e-14 Identities = 98/519 (18%), Positives = 188/519 (36%), Gaps = 106/519 (20%) Frame = +3 Query: 1200 CKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF 1379 C+ + C + V KP K + CD C+ VV + + D ATE EI ++L+ +I Sbjct: 42 CRAVKHCQQM-VWSKPTAK--SLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIH 98 Query: 1380 GSD-KIQCQQIVDEYFNLILNFILAEV-DVDKICKFFGLCNA------------------ 1499 S C+++VD Y +IL+ I E+ + ++C LC + Sbjct: 99 DSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKI 158 Query: 1500 --------------------------------KLSGIECELCEHVMDEVIKVVTSNHS-E 1580 K + C+ C ++ ++ V +N S Sbjct: 159 PEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFV 218 Query: 1581 EVVSNFIKLKICPRLSV-IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKK 1757 + + + +K + C RL + + C VD Y V + + K IC + C + + Sbjct: 219 QGLVDHVK-EDCDRLGPGVSDICKNYVDQYSEVAVQMMMH-MQPKEICVMVGFCDEVKRV 276 Query: 1758 KISFLMNRS----------------------GNETLKCEICRFAILEVRTLLTDPGFQKI 1871 + L+ + + C++C+ + ++ L+ + +++ Sbjct: 277 PMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEEL 336 Query: 1872 FENFLINEICPHFKTKQQQCTNDINQYYSLVVNIIVEFLNPS-LCSELGLCNSTIKQV-I 2045 L +C + + ++++++ +NP+ LC + LC++ V Sbjct: 337 LIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGT 396 Query: 2046 MRQPLVQINRS--------------------------KKTSNCRLCCKFYNYLQ-TISSK 2144 + QP I + K C +C K YL+ + Sbjct: 397 LEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKN 456 Query: 2145 SSHSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQR 2321 S+ +L L C+ + + +C + + ++ F C +C Sbjct: 457 STKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAY 516 Query: 2322 KNPLGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438 K LG C WGPG+WC + + A C AV HC+ +VW Sbjct: 517 KLLLGTEKCVWGPGYWCQNSETAARC--NAVDHCKRHVW 553
Score = 50.8 bits (120), Expect = 2e-05
Identities = 60/320 (18%), Positives = 115/320 (35%), Gaps = 64/320 (20%)
Frame = +3
Query: 726 CQTCLDVVVMLKKDMVNVPASEVEALIKN--NICAKLNFVAKPICNDYVDNYVPKFMSEI 899
CQ C+ +V ++ V +S V+ L+ + C +L IC +YVD Y + ++
Sbjct: 197 CQDCMKLVTDIQT-AVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQY-SEVAVQM 254
Query: 900 QSTMTPQQICNTNHFC-------MAPSIPK--------PNVDMKGP-----------VTC 1001
M P++IC FC M +P P +++ P + C
Sbjct: 255 MMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFC 314
Query: 1002 NLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFIINH 1181
+C++ + ++ I N V+ +G L+ +++
Sbjct: 315 QVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHE 374
Query: 1182 MDAKSICKLIHACTSVNVQL------------------------------------KPIR 1253
++ +C +I C S N L P +
Sbjct: 375 VNPNFLCGVISLC-SANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQ 433
Query: 1254 KMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLI 1433
K G C+ C+ +V + + +T+ EI L+ ++ + QC + V EY L+
Sbjct: 434 KNGGF-CEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLL 492
Query: 1434 LNFILAEVDVDKICKFFGLC 1493
L ++ +D +C G+C
Sbjct: 493 LEILVEVMDPSFVCSKIGVC 512
Score = 49.3 bits (116), Expect = 6e-05
Identities = 42/213 (19%), Positives = 73/213 (34%), Gaps = 31/213 (14%)
Frame = +3
Query: 183 CNTCIQFVRVVESKIPKLTEKEFINLINTFICDRIQVNTHWKCRDFVAEFGPLIYEEIKT 362
C C +R + I +E + + C + KC++ + FGP + + +
Sbjct: 314 CQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMH 373
Query: 363 EATPEKICGLIQACE------------------------------NQKEMSXXXXXXXXX 452
E P +CG+I C + + S
Sbjct: 374 EVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQ 433
Query: 453 XXXELCAKCKEIFDFLDAMFSK-VTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQL 629
C CK++ +L+ K T +E LE CS LP ++ C + Y L
Sbjct: 434 KNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEK-GCSFLPDPYQKQCDEFVAEYEPLL 492
Query: 630 YYLIKSLLDGDRICPLIHFCPSNTTVTLNSWNC 728
++ ++D +C I CPS + L + C
Sbjct: 493 LEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKC 525
Score = 38.9 bits (89), Expect = 0.075
Identities = 31/131 (23%), Positives = 62/131 (47%), Gaps = 6/131 (4%)
Frame = +3
Query: 1707 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 1880
S V+C ++K K + ++ ++L C+IC+ + E LL D ++ +
Sbjct: 29 SAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILH 88
Query: 1881 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVIM 2048
+L + C H + C ++ Y +++++I E NP +CS L LC S +++ +
Sbjct: 89 YL-EKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS-LQEYLA 146
Query: 2049 RQPLVQINRSK 2081
Q Q+ +K
Sbjct: 147 EQNQRQLESNK 157
>sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein B precursor (SP-B) (Pulmonary surfactant-associated proteolipid SPL(Phe)) Length = 377 Score = 53.5 bits (127), Expect = 3e-06 Identities = 60/320 (18%), Positives = 112/320 (35%), Gaps = 49/320 (15%) Frame = +3 Query: 726 CQTCLDVVVMLKKDMVNVPASEVEALIKNNICAKLNF-VAKPICNDYVDNYVPKFMSEIQ 902 CQ C D+V +L K E C L + P C +D Y+P + Q Sbjct: 68 CQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQ 127 Query: 903 STMTPQQICNTNHFC------------MAPSIPKPNVDM-------------KGPVT--- 998 S + P+ ICN C M ++P P +D GP T Sbjct: 128 SQINPKAICNHVGLCPRGQAKPEQNPGMPDAVPNPLLDKLVLPVLPGALLARPGPHTQDF 187 Query: 999 -----------CNLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDR 1145 C LC + +++ I + +R Sbjct: 188 SEQQLPIPLPFCWLCRTLIKRVQAVIPK----GVLAVAVSQVCHVVPLVVGGICQCLAER 243 Query: 1146 YGDILMTFIINHMDAKSICKLIHACTSVNVQ------LKPIRK---MKGIECDACRLVVK 1298 Y +L+ ++ + + +C L+ C++ + ++P+ + ++ EC C+ V+ Sbjct: 244 YTVLLLDALLGRVVPQLVCGLVLRCSTEDAMGPALPAVEPLIEEWPLQDTECHFCKSVIN 303 Query: 1299 KFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICK 1478 + T + + C F D+ +C+Q V+++ +L + D C+ Sbjct: 304 QAWN------TSEQAMPQAMHQACLRFWLDRQKCEQFVEQHMPQLLALVPRSQDAHITCQ 357 Query: 1479 FFGLCNAKLSGIECELCEHV 1538 G+C A S ++C H+ Sbjct: 358 ALGVCEAPASPLQCFQTPHL 377
Score = 48.5 bits (114), Expect = 9e-05
Identities = 64/365 (17%), Positives = 125/365 (34%), Gaps = 49/365 (13%)
Frame = +3
Query: 18 SVCYAFDFDCLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCI 197
++ A +C +GP FWC + ++A +C + C + A ++ C C
Sbjct: 22 AITSASSLECAQGPQFWCQSLEHAVQCRALGHCLQEVWGH---------AGANDLCQECE 72
Query: 198 QFVRVVESKIPKLTEKEFINLINTFI---CDRIQVNTHW-KCRDFVAEFGPLIYEEIKTE 365
V ++ +K+ K E F I F+ CD + + +CR + + PL+ + +++
Sbjct: 73 DIVHLL-TKMTK--EDAFQEAIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQSQ 129
Query: 366 ATPEKICGLIQACENQKEMSXXXXXXXXXXXXELCAKC--------------KEIFDFLD 503
P+ IC + C + L K DF +
Sbjct: 130 INPKAICNHVGLCPRGQAKPEQNPGMPDAVPNPLLDKLVLPVLPGALLARPGPHTQDFSE 189
Query: 504 AMFSKVTPDEFKYLLETL-------------------VCSQLPSEFRDTCKALLDGYVTQ 626
P F +L TL VC +P C+ L + Y
Sbjct: 190 QQLP--IPLPFCWLCRTLIKRVQAVIPKGVLAVAVSQVCHVVPLVVGGICQCLAERYTVL 247
Query: 627 LYYLIKSLLDGDRICPLIHFCPSNTTV---------TLNSWNCQTCLDVVVMLKKDMVNV 779
L + + +C L+ C + + + W Q D K ++N
Sbjct: 248 LLDALLGRVVPQLVCGLVLRCSTEDAMGPALPAVEPLIEEWPLQ---DTECHFCKSVINQ 304
Query: 780 PASEVEALI---KNNICAKLNFVAKPICNDYVDNYVPKFMSEIQSTMTPQQICNTNHFCM 950
+ E + + C + ++ + C +V+ ++P+ ++ + + C C
Sbjct: 305 AWNTSEQAMPQAMHQACLRF-WLDRQKCEQFVEQHMPQLLALVPRSQDAHITCQALGVCE 363
Query: 951 APSIP 965
AP+ P
Sbjct: 364 APASP 368
Score = 44.3 bits (103), Expect = 0.002
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)
Frame = +3
Query: 1473 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 1631
C+ G C ++ G C+ CE ++ + K+ + +E + F++ + I P L +
Sbjct: 48 CRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDILP-LKL 106
Query: 1632 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 1739
+ C ++D YLP++ +S +N K IC + LC
Sbjct: 107 LVPRCRQVLDVYLPLVIDYFQSQINPKAICNHVGLC 142
Score = 37.7 bits (86), Expect = 0.17
Identities = 16/31 (51%), Positives = 18/31 (58%)
Frame = +3
Query: 2346 CTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 2438
C GP FWC S +HAV C A+ HC VW
Sbjct: 31 CAQGPQFWCQSLEHAVQC--RALGHCLQEVW 59
>sp|P15285|PSPB_RABIT Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe)) Length = 370 Score = 51.2 bits (121), Expect = 1e-05 Identities = 65/311 (20%), Positives = 111/311 (35%), Gaps = 41/311 (13%) Frame = +3 Query: 726 CQTCLDVVVMLKKDMVNVPASEVEALIKNNICAKLNF-VAKPICNDYVDNYVPKFMSEIQ 902 CQ C D+V +L K + + C L + P C+ +D Y P ++ Q Sbjct: 70 CQECQDIVNILTKMTKEAIFQDTIRKFLEHECDVLPLKLLVPQCHHVLDVYFPLTITYFQ 129 Query: 903 STMTPQQICNTNHFCMAPSIPKPNVD-----------------MKGPVT----------- 998 S + + IC C P P+P +D GP T Sbjct: 130 SQINAKAICQHLGLCQ-PGSPEPPLDPLPDKLVLPTLLGALPAKPGPHTQDLSAQRFPIP 188 Query: 999 ---CNLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTF 1169 C LC + +++ I + +RY IL+ Sbjct: 189 LPLCWLCRTLLKRIQAMIPK----GVLAMAVAQVCHVVPLVVGGICQCLAERYTVILLEV 244 Query: 1170 IINHMDAKSICKLIHACTSVNV--QLKPIRKM-------KGIECDACRLVVKKFKEYISD 1322 ++ H+ + +C L+ C+SV+ Q+ P + + EC C V + + IS+ Sbjct: 245 LLGHVLPQLVCGLVLRCSSVDSIGQVPPTLEALPGEWLPQDPECRLCMSVTTQARN-ISE 303 Query: 1323 PATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNAK 1502 + + C DK +C+Q V+ + +L+ + D IC+ G C A Sbjct: 304 QTRPQAVYHA-----CLSSQLDKQECEQFVELHTPQLLSLLSRGWDARAICQALGACVAT 358 Query: 1503 LSGIECELCEH 1535 LS ++C H Sbjct: 359 LSPLQCIQSPH 369
Score = 40.8 bits (94), Expect = 0.020
Identities = 23/96 (23%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Frame = +3
Query: 1473 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 1631
CK G C ++ G C+ C+ +++ + K+ ++ + F++ + + P L +
Sbjct: 50 CKALGHCLQEVWGHVGADDLCQECQDIVNILTKMTKEAIFQDTIRKFLEHECDVLP-LKL 108
Query: 1632 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 1739
+ +C ++D Y P+ + +S +N+K IC L LC
Sbjct: 109 LVPQCHHVLDVYFPLTITYFQSQINAKAICQHLGLC 144
Score = 40.4 bits (93), Expect = 0.026
Identities = 56/349 (16%), Positives = 110/349 (31%), Gaps = 42/349 (12%)
Frame = +3
Query: 45 CLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCIQFVRVVESK 224
C +GP FWC + + A +C + C + + C C V ++
Sbjct: 33 CAQGPEFWCQSLEQALQCKALGHCLQEVWGH---------VGADDLCQECQDIVNILTKM 83
Query: 225 IPKLTEKEFINLINTFICDRIQVNTHW-KCRDFVAEFGPLIYEEIKTEATPEKICGLIQA 401
+ ++ I CD + + +C + + PL +++ + IC +
Sbjct: 84 TKEAIFQDTIRKFLEHECDVLPLKLLVPQCHHVLDVYFPLTITYFQSQINAKAICQHLGL 143
Query: 402 CE--------------------------NQKEMSXXXXXXXXXXXXELCAKCKEIFDFLD 503
C+ + LC C+ + +
Sbjct: 144 CQPGSPEPPLDPLPDKLVLPTLLGALPAKPGPHTQDLSAQRFPIPLPLCWLCRTLLKRIQ 203
Query: 504 AMFSKVTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQLYYLIKSLLDGDRICPLIH 683
AM P + VC +P C+ L + Y L ++ + +C L+
Sbjct: 204 AMI----PKGVLAMAVAQVCHVVPLVVGGICQCLAERYTVILLEVLLGHVLPQLVCGLVL 259
Query: 684 FCPSNTTV-----TLNS----W-----NCQTCLDVVVMLKKDMVNV-PASEVEALIKNNI 818
C S ++ TL + W C+ C+ V + P + A + + +
Sbjct: 260 RCSSVDSIGQVPPTLEALPGEWLPQDPECRLCMSVTTQARNISEQTRPQAVYHACLSSQL 319
Query: 819 CAKLNFVAKPICNDYVDNYVPKFMSEIQSTMTPQQICNTNHFCMAPSIP 965
K C +V+ + P+ +S + + IC C+A P
Sbjct: 320 -------DKQECEQFVELHTPQLLSLLSRGWDARAICQALGACVATLSP 361
>sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein B precursor (SP-B) (Pulmonary surfactant-associated proteolipid SPL(Phe)) Length = 376 Score = 49.3 bits (116), Expect = 6e-05 Identities = 63/359 (17%), Positives = 124/359 (34%), Gaps = 51/359 (14%) Frame = +3 Query: 42 DCLKGPNFWCATFKNAEKCGKITECFMDKMNSKKENKLPYVASKSETCNTCIQFVRVVES 221 DC +GP FWC + + A +C + C + A ++ C C V ++ + Sbjct: 29 DCAQGPKFWCQSLEQAIQCRALGHCLQEVWGH---------AGANDLCQECEDIVHLL-T 78 Query: 222 KIPKLTEKEFINLINTFI---CDRIQVNTHW-KCRDFVAEFGPLIYEEIKTEATPEKICG 389 K+ K E F + I F+ CD + + +CR + + PL+ + + + P+ IC Sbjct: 79 KMTK--EDAFQDTIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQGQIKPKAICS 136 Query: 390 LIQAC-------ENQKEM----------------------------SXXXXXXXXXXXXE 464 + C E + EM + Sbjct: 137 HVGLCPLGQTKPEQKPEMLDAIPNPLLNKLVLPALPGAFLARPGPHTQDLSEQQLPIPLP 196 Query: 465 LCAKCKEIFDFLDAMFSKVTPDEFKYLLETLVCSQLPSEFRDTCKALLDGYVTQLYYLIK 644 C C+ + + A V P + + VC +P C+ L + Y L + Sbjct: 197 FCWLCRTLIKRVQA----VIPKGVLAVAVSQVCHVVPLVVGGICQCLAERYTVLLLDALL 252 Query: 645 SLLDGDRICPLIHFCPSNTTV---------TLNSWNCQTCLDVVVMLKKDMVNVPASEVE 797 + +C L+ C + + + W Q D K ++N + E Sbjct: 253 GRVVPQLVCGLVLRCSTADAIGPALPALEPLIEKWPLQ---DTECHFCKSVINQAWNTSE 309 Query: 798 ALI---KNNICAKLNFVAKPICNDYVDNYVPKFMSEIQSTMTPQQICNTNHFCMAPSIP 965 + + C + ++ + C +V+ ++P+ ++ + + C C AP+ P Sbjct: 310 QAMPQAMHQACLRF-WLDRQKCEQFVEQHMPQLLALVPRSQDAHTSCQALGVCEAPASP 367
Score = 48.9 bits (115), Expect = 7e-05
Identities = 56/320 (17%), Positives = 110/320 (34%), Gaps = 49/320 (15%)
Frame = +3
Query: 726 CQTCLDVVVMLKKDMVNVPASEVEALIKNNICAKLNF-VAKPICNDYVDNYVPKFMSEIQ 902
CQ C D+V +L K + C L + P C +D Y+P + Q
Sbjct: 67 CQECEDIVHLLTKMTKEDAFQDTIRKFLEQECDILPLKLLVPRCRQVLDVYLPLVIDYFQ 126
Query: 903 STMTPQQICNTNHFC-------------------------MAPSIPKPNVDMKGPVT--- 998
+ P+ IC+ C + P++P + GP T
Sbjct: 127 GQIKPKAICSHVGLCPLGQTKPEQKPEMLDAIPNPLLNKLVLPALPGAFLARPGPHTQDL 186
Query: 999 -----------CNLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDR 1145
C LC + +++ I + +R
Sbjct: 187 SEQQLPIPLPFCWLCRTLIKRVQAVIPK----GVLAVAVSQVCHVVPLVVGGICQCLAER 242
Query: 1146 YGDILMTFIINHMDAKSICKLIHACTSVNV------QLKPIRK---MKGIECDACRLVVK 1298
Y +L+ ++ + + +C L+ C++ + L+P+ + ++ EC C+ V+
Sbjct: 243 YTVLLLDALLGRVVPQLVCGLVLRCSTADAIGPALPALEPLIEKWPLQDTECHFCKSVIN 302
Query: 1299 KFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICK 1478
+ T + + C F D+ +C+Q V+++ +L + D C+
Sbjct: 303 QAWN------TSEQAMPQAMHQACLRFWLDRQKCEQFVEQHMPQLLALVPRSQDAHTSCQ 356
Query: 1479 FFGLCNAKLSGIECELCEHV 1538
G+C A S ++C H+
Sbjct: 357 ALGVCEAPASPLQCFQTPHL 376
Score = 40.8 bits (94), Expect = 0.020
Identities = 23/98 (23%), Positives = 48/98 (48%), Gaps = 7/98 (7%)
Frame = +3
Query: 1473 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 1631
C+ G C ++ G C+ CE ++ + K+ + ++ + F++ + I P L +
Sbjct: 47 CRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQDTIRKFLEQECDILP-LKL 105
Query: 1632 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTL 1745
+ C ++D YLP++ + + K IC+ + LC L
Sbjct: 106 LVPRCRQVLDVYLPLVIDYFQGQIKPKAICSHVGLCPL 143
>sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2) Length = 81 Score = 49.3 bits (116), Expect = 6e-05 Identities = 26/78 (33%), Positives = 41/78 (52%) Frame = +3 Query: 1260 KGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILN 1439 + + C AC VVKK E I + TE +I + L + + S CQ++VD Y + I+ Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60 Query: 1440 FILAEVDVDKICKFFGLC 1493 +L E+ + +C GLC Sbjct: 61 LLLQEMSPELVCSELGLC 78
Score = 45.8 bits (107), Expect = 6e-04
Identities = 22/77 (28%), Positives = 47/77 (61%), Gaps = 1/77 (1%)
Frame = +3
Query: 1512 IECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNE-CVIIVDTYLPVIFSI 1688
+ C+ CE+V+ +V++++ +N +EE + + + +C L +E C +VDTY I ++
Sbjct: 3 VTCKACEYVVKKVMELIDNNRTEEKIIHALD-SVCALLPESVSEVCQEVVDTYGDSIVAL 61
Query: 1689 ARSTLNSKVICTELKLC 1739
++ +++C+EL LC
Sbjct: 62 LLQEMSPELVCSELGLC 78
Score = 35.4 bits (80), Expect = 0.83
Identities = 19/80 (23%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Frame = +3
Query: 1791 ETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVN 1970
E++ C+ C + + +V L+ + ++ + L + ++ + C ++ Y +V
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 1971 IIVEFLNPSL-CSELGLCNS 2027
++++ ++P L CSELGLC S
Sbjct: 61 LLLQEMSPELVCSELGLCMS 80
Score = 35.4 bits (80), Expect = 0.83
Identities = 18/78 (23%), Positives = 27/78 (34%)
Frame = +3
Query: 993 VTCNLCEIAVSEMKSFISNTENXXXXXXXXXXXXXXXXXXXXXXXXXVVDRYGDILMTFI 1172
VTC CE V ++ I N VVD YGD ++ +
Sbjct: 3 VTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVALL 62
Query: 1173 INHMDAKSICKLIHACTS 1226
+ M + +C + C S
Sbjct: 63 LQEMSPELVCSELGLCMS 80
Score = 35.0 bits (79), Expect = 1.1
Identities = 19/79 (24%), Positives = 36/79 (45%)
Frame = +3
Query: 717 SWNCQTCLDVVVMLKKDMVNVPASEVEALIKNNICAKLNFVAKPICNDYVDNYVPKFMSE 896
S C+ C VV + + + N E +++CA L +C + VD Y ++
Sbjct: 2 SVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVAL 61
Query: 897 IQSTMTPQQICNTNHFCMA 953
+ M+P+ +C+ CM+
Sbjct: 62 LLQEMSPELVCSELGLCMS 80
Score = 32.3 bits (72), Expect = 7.0
Identities = 20/79 (25%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Frame = +3
Query: 171 KSETCNTCIQFVRVVESKIPK-LTEKEFINLINTFICDRIQVNTHWKCRDFVAEFGPLIY 347
+S TC C V+ V I TE++ I+ +++ +C + + C++ V +G I
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDS-VCALLPESVSEVCQEVVDTYGDSIV 59
Query: 348 EEIKTEATPEKICGLIQAC 404
+ E +PE +C + C
Sbjct: 60 ALLLQEMSPELVCSELGLC 78
>sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor Length = 496 Score = 47.4 bits (111), Expect = 2e-04 Identities = 27/104 (25%), Positives = 50/104 (48%), Gaps = 18/104 (17%) Frame = +3 Query: 1395 QCQQIVDEYFNLILNFILAEVDVDKICKFFGLC-----NAKLSGIE-------------C 1520 +C+++V EY +ILN ++A+ D K+C GLC + +GIE C Sbjct: 311 ECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGSDAMC 370 Query: 1521 ELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNECVI 1652 +CE + + + N ++E++ N+ ++C RL E + Sbjct: 371 SVCEMAVVWIENQLRENKTKELILNYAN-QLCERLPSPNGESTV 413
Score = 36.6 bits (83), Expect = 0.37
Identities = 20/112 (17%), Positives = 50/112 (44%), Gaps = 5/112 (4%)
Frame = +3
Query: 1629 VIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKI-----SFLMNRSGNE 1793
+I EC +V Y +I ++ + + + +C+++ LC K+ + S + +
Sbjct: 307 IISTECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGS 366
Query: 1794 TLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQ 1949
C +C A++ + L + +++ N+ N++C + + T +Q
Sbjct: 367 DAMCSVCEMAVVWIENQLRENKTKELILNY-ANQLCERLPSPNGESTVSCHQ 417
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 281,908,924
Number of Sequences: 369166
Number of extensions: 5882341
Number of successful extensions: 15125
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 13530
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 15074
length of database: 68,354,980
effective HSP length: 119
effective length of database: 46,371,515
effective search space used: 34454035645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
- Dr_sW_012_H23
- Dr_sW_006_N22
- Dr_sW_008_O05
- Dr_sW_004_K10
- Dr_sW_017_D09
- Dr_sW_024_N04
- Dr_sW_023_E20
- Dr_sW_006_I05
- Dr_sW_016_C15
- Dr_sW_010_F13
- Dr_sW_002_B10
- Dr_sW_018_G18
- Dr_sW_005_L04
- Dr_sW_019_H07
- Dr_sW_017_K12
- Dr_sW_026_G24
- Dr_sW_003_J24
- Dr_sW_026_B08
- Dr_sW_008_L11
- Dr_sW_008_P10
- Dr_sW_017_K06
- Dr_sW_018_E17
- Dr_sW_009_A22
- Dr_sW_009_H13
- Dr_sW_011_K22
- Dr_sW_026_H07
- Dr_sW_005_O21
- Dr_sW_026_J13
- Dr_sW_012_O06
- Dr_sW_020_M19
- Dr_sW_005_P06