Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_C15
(779 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Con... 72 2e-12
sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Con... 67 7e-11
sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Con... 56 1e-07
sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-... 52 2e-06
sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1)... 45 2e-04
sp|O04057|ASPR_CUCPE Aspartic proteinase precursor 39 0.016
sp|Q89330|POLG_ZYMVR Genome polyprotein [Contains: P1 prote... 37 0.061
sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor 37 0.079
sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucos... 35 0.18
sp|P17129|PSPB_CANFA Pulmonary surfactant-associated protei... 34 0.51
>sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B-Val; Saposin B (Sphingolipid activator
protein 1) (SAP-1) (Cerebroside sulfate activator)
(CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 524
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/200 (25%), Positives = 90/200 (45%), Gaps = 5/200 (2%)
Frame = +3
Query: 180 CEICRFAILEVRTLLTDPGFQK-IFENFLINEICPHF-KTKQQQCTNDINQYYSLVVNII 353
CE+C F + EV L+ + +K I + F +++C K+ ++C ++ Y S +++I+
Sbjct: 315 CEVCEFLVKEVTKLIDNNKTEKEILDAF--DKMCSKLPKSLSEECQEVVDTYGSSILSIL 372
Query: 354 VEFLNPSL-CSELGLCNSTIKQVIMRQPLVQINRSKKTSNCRLCCKFYKYL-QTISSKSS 527
+E ++P L CS L LC+ T + V + + K C +C K YL + + S+
Sbjct: 373 LEEVSPELVCSMLHLCSGTRLPALT----VHVTQPKDGGFCEVCKKLVGYLDRNLEKNST 428
Query: 528 HSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKN 704
+L L C+ + + +C + + V+ F C C K
Sbjct: 429 KQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKP 488
Query: 705 PLGKNPCTWGPGFWCVSRNT 764
LG C WGP +WC + T
Sbjct: 489 LLGTEKCIWGPSYWCQNTET 508
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/143 (26%), Positives = 70/143 (48%), Gaps = 5/143 (3%)
Frame = +3
Query: 9 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC--TLLSKKKISFLMNRSGNETLKC 182
+ EC +VDTY I SI ++ +++C+ L LC T L + + G C
Sbjct: 353 LSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG---FC 409
Query: 183 EICRFAILEV-RTLLTDPGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 356
E+C+ + + R L + Q+I + + C Q+QC + +Y +++ I+V
Sbjct: 410 EVCKKLVGYLDRNLEKNSTKQEILA--ALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILV 467
Query: 357 EFLNPS-LCSELGLCNSTIKQVI 422
E ++PS +C ++G C S K ++
Sbjct: 468 EVMDPSFVCLKIGACPSAHKPLL 490
Score = 37.7 bits (86), Expect = 0.035
Identities = 56/290 (19%), Positives = 109/290 (37%), Gaps = 64/290 (22%)
Frame = +3
Query: 21 CVIIVDTYLPVIFSIARSTLNSK-VICTELKLCTLLSKKKISFLMNRSGNETLK------ 179
C IVD+YLPVI I + ++ +C+ L LC L +K ++ L ++ E+ K
Sbjct: 106 CKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESL-QKHLAELNHQKQLESNKIPELDM 164
Query: 180 ---------------------------------CEICRFAILEVRTLL-TDPGF-QKIFE 254
C+ C + +++T + T+ F Q + E
Sbjct: 165 TEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVE 224
Query: 255 NFLINEICPHFKTKQQQ-CTNDINQYYSLVVNIIVEFLNPSLCSELGLCNS--------- 404
+ + E C C N I+QY + + +++ +C+ +G C+
Sbjct: 225 H--VKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTL 282
Query: 405 -----TIKQVIMRQPLVQ-INRSKKTSNCRLCCKFYKYL-----QTISSKSSHSNLLFGL 551
K VI LV+ I + + + + C+ ++L + I + + +L
Sbjct: 283 VPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAF 342
Query: 552 VSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQR 698
C+++ EC + + + I + + E C M +CS R
Sbjct: 343 DKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTR 392
>sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B (Sphingolipid activator protein 1) (SAP-1)
(Cerebroside sulfate activator) (CSAct) (Dispersin)
(Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 525
Score = 66.6 bits (161), Expect = 7e-11
Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 4/194 (2%)
Frame = +3
Query: 180 CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 356
CE+C F + EV L+ + ++ + L +++C T +QC ++ Y +++I++
Sbjct: 316 CEVCEFVVKEVAKLIDNNRTEEEILHAL-DKVCSKLPTSLAEQCQEVVDTYGRSILSILL 374
Query: 357 EFLNPSL-CSELGLCNSTIKQVIMRQPLVQINRSKKTSNCRLCCKFYKYL-QTISSKSSH 530
+ +P L CS L LC+S + V++ K C +C K YL + + S+
Sbjct: 375 DEASPELVCSMLHLCSSRG----LPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTK 430
Query: 531 SNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNP 707
+L L C+ + R +C + + V+ F C C K
Sbjct: 431 EQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPL 490
Query: 708 LGKNPCTWGPGFWC 749
LG C WGP +WC
Sbjct: 491 LGAEKCVWGPSYWC 504
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/143 (23%), Positives = 71/143 (49%), Gaps = 5/143 (3%)
Frame = +3
Query: 9 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTL--LSKKKISFLMNRSGNETLKC 182
+ +C +VDTY I SI + +++C+ L LC+ L + + + G C
Sbjct: 354 LAEQCQEVVDTYGRSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGG---FC 410
Query: 183 EICRFAILEV-RTLLTDPGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 356
E+C+ + + R L + ++I + + C + ++QC + +Y +++ I+V
Sbjct: 411 EVCKKLVGYLDRNLEKNSTKEQILA--ALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILV 468
Query: 357 EFLNPS-LCSELGLCNSTIKQVI 422
E ++PS +C ++G C + K ++
Sbjct: 469 EVMDPSFVCLKIGACPAAHKPLL 491
Score = 34.7 bits (78), Expect = 0.30
Identities = 52/285 (18%), Positives = 96/285 (33%), Gaps = 62/285 (21%)
Frame = +3
Query: 21 CVIIVDTYLPVIFSIARSTLNSK-VICTELKLCTLLSK---------------------- 131
C IVD+YLPVI + + ++ +C+ L LC L K
Sbjct: 106 CKEIVDSYLPVILDMIKGQMSHPGEVCSALNLCESLQKHLAELNHQKQLESNQIPELDMA 165
Query: 132 -------KKISFLMNRSGNETLK----------CEICRFAILEVR-TLLTDPGFQKIFEN 257
I FL+ K C+ C + +V+ L T+ F + +
Sbjct: 166 EVVAPFMANIPFLLYPQDGSHSKPQPKKANGNVCQDCIQLVTDVQEALRTNSTFVEALVD 225
Query: 258 FLINEICPHFKTKQQQCTNDINQYYSLVVNIIVEFLNPSLCSELGLCNS----------- 404
E C N INQY + + +++ +C G C+
Sbjct: 226 HAKEECDRLGPGMSDMCKNYINQYSEVAIQMVMHMQPKEICVLAGFCDEVKEMPMKTLVP 285
Query: 405 ---TIKQVIMRQPLVQ-INRSKKTSNCRLCCKFYKYL-----QTISSKSSHSNLLFGLVS 557
+ VI LV+ I + + + C+ +++ + I + + +L L
Sbjct: 286 AEVVSENVIPALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDK 345
Query: 558 FCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCS 689
C+++ +C + + I + + E C M +CS
Sbjct: 346 VCSKLPTSLAEQCQEVVDTYGRSILSILLDEASPELVCSMLHLCS 390
>sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Contains: Saposin A; Saposin B;
Saposin C; Saposin D]
Length = 518
Score = 55.8 bits (133), Expect = 1e-07
Identities = 56/262 (21%), Positives = 109/262 (41%), Gaps = 11/262 (4%)
Frame = +3
Query: 12 KNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTL----LSKKKISFLMNRSGNETLK 179
K+ C ++ + P + S+ TL + E+K+ T+ + +K S
Sbjct: 264 KDICAMV--GFCPSVKSVPLQTLVPAQVVHEVKMETVEKATVQEKTFSV----------- 310
Query: 180 CEICRFAILEVRTLLTDPGFQK--IFENFLINEICPHFKTKQQQCTNDINQYYSLVVNII 353
CEIC + EV LL ++ + E ++ + P + + QC + I Y +++++
Sbjct: 311 CEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLP--ASVKDQCKDFIEVYGQALIDML 368
Query: 354 VEFLNP-SLCSELGLC--NSTIKQVIMRQPLVQINRSKKTSNCRLCCKFYKYLQTISSKS 524
+E NP ++C L C N +Q ++ +P C +C Y K+
Sbjct: 369 LEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGF--------CDICKMIVAYADKELEKN 420
Query: 525 SHSNLLFGLVS-FCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQR 698
+ + + L+ C+ + +C++ + V+ F C +C +
Sbjct: 421 ATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAK 480
Query: 699 KNPLGKNPCTWGPGFWCVSRNT 764
K LG++ C WGPG+WC + T
Sbjct: 481 KPLLGEDACVWGPGYWCKNMET 502
Score = 51.6 bits (122), Expect = 2e-06
Identities = 31/141 (21%), Positives = 66/141 (46%), Gaps = 3/141 (2%)
Frame = +3
Query: 9 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSGNETLKCEI 188
+K++C ++ Y + + N + +C LK C + ++ +G C+I
Sbjct: 349 VKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVVKPAGG---FCDI 405
Query: 189 CRFAILEVRTLLTDPGFQKIFENFLINEICPHF--KTKQQQCTNDINQYYSLVVNIIVEF 362
C+ + L E L+ ++C HF ++ QC + QY +VV ++ E
Sbjct: 406 CKMIVAYADKELEKNATTTEIE-ALLEKVC-HFLPESVSDQCVQFVEQYEPVVVQLLAEM 463
Query: 363 LNPS-LCSELGLCNSTIKQVI 422
++P+ +C++LG+C + K ++
Sbjct: 464 MDPTFVCTKLGVCGAAKKPLL 484
Score = 36.2 bits (82), Expect = 0.10
Identities = 17/42 (40%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Frame = +3
Query: 9 IKNECVIIVDTYLPVIFSIARSTLNS-KVICTELKLCTLLSK 131
+ +EC IVD+YLPVI + + + +V+C+ L LC L K
Sbjct: 103 LASECKEIVDSYLPVIMDMIKEEFDKPEVVCSALSLCQSLQK 144
>sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 557
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/230 (18%), Positives = 84/230 (36%), Gaps = 30/230 (13%)
Frame = +3
Query: 165 NETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVV 344
+ + C+ C+F + + L+ + +++ L N + +C + + ++
Sbjct: 312 HNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLL 371
Query: 345 NIIVEFLNPS-LCSELGLCNS-------------TIKQVIMRQPL--------------V 440
+I + +NPS LC +GLC + I ++++P
Sbjct: 372 DIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPA 431
Query: 441 QINRSKKTSNCRLCCKFYKYLQ-TISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNF 617
+ K C +C K YL+ + S+ +L L C+ + + +C +
Sbjct: 432 HVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEY 491
Query: 618 NAVIAAFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGFWCVSRNT 764
++ F C +C K LG C WGP +WC + T
Sbjct: 492 EPLLLEILVEVMDPGFVCSKIGVCPSAYKLLLGTEKCVWGPSYWCQNMET 541
Score = 40.4 bits (93), Expect = 0.005
Identities = 32/131 (24%), Positives = 62/131 (47%), Gaps = 6/131 (4%)
Frame = +3
Query: 84 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 257
S V+C ++K K + ++ ++L C+IC+ + E LL D Q+ +
Sbjct: 29 SAVLCRDVKTAVDCGAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATQEEILH 88
Query: 258 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVIM 425
+L + C H + C ++ Y +++++I E NP +CS L LC S +++ +
Sbjct: 89 YL-EKTCEWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS-LQEYLA 146
Query: 426 RQPLVQINRSK 458
Q Q+ +K
Sbjct: 147 EQNQKQLESNK 157
Score = 35.4 bits (80), Expect = 0.18
Identities = 61/296 (20%), Positives = 113/296 (38%), Gaps = 67/296 (22%)
Frame = +3
Query: 3 SVIKNECVIIVDTYLPVIFSIARSTL-NSKVICTELKLCTLL-------SKKKIS----- 143
S + C +VD+YLPVI + + + N +C+ L LC L ++K++
Sbjct: 100 SSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQKQLESNKIP 159
Query: 144 ----------FLMN----------------RSGNETLKCEICRFAILEVRTLL-TDPGFQ 242
F+ N NE + C+ C + +V+T + T+ F
Sbjct: 160 EVDMARVVAPFMSNIPLLLYPQDHPRSQPQPKANEDV-CQDCMKLVSDVQTAVKTNSSFI 218
Query: 243 KIFENFLINEICPHFKTKQQQ-CTNDINQYYSLVVNIIVEFLN---PSLCSELGLCN--- 401
+ F + + E C C N ++QY + V +++ + +C G CN
Sbjct: 219 QGFVDH-VKEDCDRLGPGVSDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVK 277
Query: 402 -----------STIKQVI----MRQPLVQINRSKKTSNCRLC--CKFY--KYLQTISSKS 524
TIK ++ M P Q + N LC C+F K+ + I + +
Sbjct: 278 RVPMKTLVPATETIKNILPALEMMDPYEQ--NLVQAHNVILCQTCQFVMNKFSELIVNNA 335
Query: 525 SHSNLLFGLVSFCNQISAHERLECLKQFRNFN-AVIAAFNKSKTINEFCEMTKMCS 689
+ L+ GL + C + R +C + F +++ F + C + +C+
Sbjct: 336 TEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCA 391
>sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 554
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/225 (17%), Positives = 83/225 (36%), Gaps = 30/225 (13%)
Frame = +3
Query: 180 CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVNIIVE 359
C++C+ + ++ L+ + +++ L +C + + ++++++
Sbjct: 314 CQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMH 373
Query: 360 FLNPS-LCSELGLCNSTIKQV-IMRQPLVQINRS-------------------------- 455
+NP+ LC + LC++ V + QP I +
Sbjct: 374 EVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQ 433
Query: 456 KKTSNCRLCCKFYKYLQ-TISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIA 632
K C +C K YL+ + S+ +L L C+ + + +C + + ++
Sbjct: 434 KNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLL 493
Query: 633 AFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGFWCVSRNT 764
F C +C K LG C WGPG+WC + T
Sbjct: 494 EILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNSET 538
Score = 38.9 bits (89), Expect = 0.016
Identities = 31/131 (23%), Positives = 62/131 (47%), Gaps = 6/131 (4%)
Frame = +3
Query: 84 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 257
S V+C ++K K + ++ ++L C+IC+ + E LL D ++ +
Sbjct: 29 SAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILH 88
Query: 258 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVIM 425
+L + C H + C ++ Y +++++I E NP +CS L LC S +++ +
Sbjct: 89 YL-EKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS-LQEYLA 146
Query: 426 RQPLVQINRSK 458
Q Q+ +K
Sbjct: 147 EQNQRQLESNK 157
Score = 37.0 bits (84), Expect = 0.061
Identities = 57/293 (19%), Positives = 112/293 (38%), Gaps = 64/293 (21%)
Frame = +3
Query: 3 SVIKNECVIIVDTYLPVIFSIARSTL-NSKVICTELKLCTLLSK------------KKI- 140
S + C +VD+YLPVI + + + N +C+ L LC L + KI
Sbjct: 100 SSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIP 159
Query: 141 ---------SFLMN----------------RSGNETLKCEICRFAILEVRTLL-TDPGF- 239
F+ N NE + C+ C + +++T + T+ F
Sbjct: 160 EVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDV-CQDCMKLVTDIQTAVRTNSSFV 218
Query: 240 QKIFENFLINEICPHFKTKQQQ-CTNDINQYYSLVVNIIVEFLNPSLCSELGLCNSTIKQ 416
Q + ++ + E C C N ++QY + V +++ +C +G C+ +K+
Sbjct: 219 QGLVDH--VKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDE-VKR 275
Query: 417 VIMRQ------------PLVQIN--------RSKKTSNCRLC-CKFYKYLQTISSKSSHS 533
V MR P +++ +++ C++C K + I + ++
Sbjct: 276 VPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEE 335
Query: 534 NLLFGLVSFCNQISAHERLECLKQFRNFN-AVIAAFNKSKTINEFCEMTKMCS 689
L+ GL C+ + A +C + F +++ N C + +CS
Sbjct: 336 LLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCS 388
>sp|O04057|ASPR_CUCPE Aspartic proteinase precursor
Length = 513
Score = 38.9 bits (89), Expect = 0.016
Identities = 26/121 (21%), Positives = 49/121 (40%), Gaps = 10/121 (8%)
Frame = +3
Query: 6 VIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSGNETL--- 176
V+ +C +V Y I + S + K IC+++ LCT + +S + +E
Sbjct: 319 VVSQQCKAVVAQYGQTIMDLLLSEADPKKICSQINLCTFDGTRGVSMGIESVVDENAGKS 378
Query: 177 -------KCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYS 335
C +C ++ ++ L ++ N+ INE+C + Q D Q S
Sbjct: 379 SDSLHDGMCSVCEMTVVWMQNQLRQNQTKERIINY-INELCDRMPSPMGQSAVDCGQLSS 437
Query: 336 L 338
+
Sbjct: 438 M 438
>sp|Q89330|POLG_ZYMVR Genome polyprotein [Contains: P1 proteinase (N-terminal protein);
Helper component proteinase (HC-pro); Protein P3; 6 kDa
protein 1 (6K1); Cytoplasmic inclusion protein (CI); 6
kDa protein 2 (6K2); Viral genome-linked protein (VPg);
Nuclear inclusion protein A (NI-a) (NIa) (NIa-pro) (49
kDa proteinase) (49 kDa-Pro); Nuclear inclusion protein B
(NI-b) (NIb) (RNA-directed RNA polymerase); Coat protein
(CP)]
Length = 3083
Score = 37.0 bits (84), Expect = 0.061
Identities = 20/48 (41%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = -1
Query: 260 KIFKNFLKSRISQQCSDFKNSKSAYFTLQCFITTSIHKK--RDFLFRK 123
K F F + +++QQ D K S F +CFITT +H K RD RK
Sbjct: 948 KRFSIFTERKLTQQAKDGKRVSSLQFVHECFITTRVHAKSIRDVGMRK 995
>sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor
Length = 496
Score = 36.6 bits (83), Expect = 0.079
Identities = 20/112 (17%), Positives = 50/112 (44%), Gaps = 5/112 (4%)
Frame = +3
Query: 6 VIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKI-----SFLMNRSGNE 170
+I EC +V Y +I ++ + + + +C+++ LC K+ + S + +
Sbjct: 307 IISTECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGS 366
Query: 171 TLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQ 326
C +C A++ + L + +++ N+ N++C + + T +Q
Sbjct: 367 DAMCSVCEMAVVWIENQLRENKTKELILNY-ANQLCERLPSPNGESTVSCHQ 417
>sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucosylceramidase activator)
(Sphingolipid activator protein 2) (SAP-2)
Length = 81
Score = 35.4 bits (80), Expect = 0.18
Identities = 19/80 (23%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Frame = +3
Query: 168 ETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVN 347
E++ C+ C + + +V L+ + ++ + L + ++ + C ++ Y +V
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 348 IIVEFLNPSL-CSELGLCNS 404
++++ ++P L CSELGLC S
Sbjct: 61 LLLQEMSPELVCSELGLCMS 80
>sp|P17129|PSPB_CANFA Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa
protein) (Pulmonary surfactant-associated proteolipid
SPL(Phe)) (Pulmonary surfactant protein 18) (SP 18)
Length = 363
Score = 33.9 bits (76), Expect = 0.51
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Frame = +3
Query: 180 CEICRFAILEVRTLLTDPGFQKIFENFLINE--ICPHFKTKQQQCTNDINQYYSLVVNII 353
C+ C+ + + + + FQ + FL +E + P K QC + + Y+ +VV+
Sbjct: 62 CQECQDIVRILTKMTKEAIFQDMVRKFLEHECDVLP-LKLLTPQCHHMLGTYFPVVVDYF 120
Query: 354 VEFLNPS-LCSELGLC 398
+NP +C LGLC
Sbjct: 121 QSQINPKIICKHLGLC 136
Score = 33.1 bits (74), Expect = 0.87
Identities = 13/33 (39%), Positives = 20/33 (60%)
Frame = +3
Query: 18 ECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 116
+C ++ TY PV+ +S +N K+IC L LC
Sbjct: 104 QCHHMLGTYFPVVVDYFQSQINPKIICKHLGLC 136
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,657,814
Number of Sequences: 369166
Number of extensions: 1748863
Number of successful extensions: 4841
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4650
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4834
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)