Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_L04
(869 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Con... 86 1e-16
sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Con... 82 1e-15
sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Con... 67 5e-11
sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-... 64 4e-10
sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1)... 59 2e-08
sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protei... 38 0.042
sp|Q89330|POLG_ZYMVR Genome polyprotein [Contains: P1 prote... 37 0.071
sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucos... 35 0.21
sp|P17129|PSPB_CANFA Pulmonary surfactant-associated protei... 34 0.60
sp|O36979|POLG_ZYMVS Genome polyprotein [Contains: P1 prote... 34 0.60
>sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B-Val; Saposin B (Sphingolipid activator
protein 1) (SAP-1) (Cerebroside sulfate activator)
(CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 524
Score = 86.3 bits (212), Expect = 1e-16
Identities = 58/217 (26%), Positives = 101/217 (46%), Gaps = 5/217 (2%)
Frame = +3
Query: 117 CEICRFAILEVRTLLTDPGFQK-IFENFLINEICPHF-KTKQQQCTNDINQYYSLVVNII 290
CE+C F + EV L+ + +K I + F +++C K+ ++C ++ Y S +++I+
Sbjct: 315 CEVCEFLVKEVTKLIDNNKTEKEILDAF--DKMCSKLPKSLSEECQEVVDTYGSSILSIL 372
Query: 291 VEFLNPSL-CSELGLCNSTIKQVIMRQPLVQINKSKKTSNCRLCCKFYNYL-QTISSKSS 464
+E ++P L CS L LC+ T + V + + K C +C K YL + + S+
Sbjct: 373 LEEVSPELVCSMLHLCSGTRLPALT----VHVTQPKDGGFCEVCKKLVGYLDRNLEKNST 428
Query: 465 HSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKN 641
+L L C+ + + +C + + V+ F C C K
Sbjct: 429 KQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKP 488
Query: 642 PLGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
LG C WGP +WC + + A C AV+HC+ +VW
Sbjct: 489 LLGTEKCIWGPSYWCQNTETAAQC--NAVEHCKRHVW 523
Score = 37.7 bits (86), Expect = 0.042
Identities = 18/38 (47%), Positives = 20/38 (52%)
Frame = +3
Query: 645 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVWRQ 758
LG CT G WC + K A C GAVKHC VW +
Sbjct: 20 LGLKECTRGSAVWCQNVKTASDC--GAVKHCLQTVWNK 55
Score = 32.3 bits (72), Expect = 1.8
Identities = 38/197 (19%), Positives = 77/197 (39%), Gaps = 24/197 (12%)
Frame = +3
Query: 117 CEICRFAILEVRTLL-TDPGF-QKIFENFLINEICPHFKTKQQQ-CTNDINQYYSLVVNI 287
C+ C + +++T + T+ F Q + E+ + E C C N I+QY + + +
Sbjct: 198 CQDCIQMVTDIQTAVRTNSTFVQALVEH--VKEECDRLGPGMADICKNYISQYSEIAIQM 255
Query: 288 IVEFLNPSLCSELGLCNS--------------TIKQVIMRQPLVQ-INKSKKTSNCRLCC 422
++ +C+ +G C+ K VI LV+ I K + + + C
Sbjct: 256 MMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYC 315
Query: 423 KFYNYL-----QTISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSK 587
+ +L + I + + +L C+++ EC + + + I + +
Sbjct: 316 EVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEE 375
Query: 588 TINEF-CEMTKMCSHQR 635
E C M +CS R
Sbjct: 376 VSPELVCSMLHLCSGTR 392
>sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B (Sphingolipid activator protein 1) (SAP-1)
(Cerebroside sulfate activator) (CSAct) (Dispersin)
(Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 525
Score = 82.4 bits (202), Expect = 1e-15
Identities = 56/216 (25%), Positives = 96/216 (44%), Gaps = 4/216 (1%)
Frame = +3
Query: 117 CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 293
CE+C F + EV L+ + ++ + L +++C T +QC ++ Y +++I++
Sbjct: 316 CEVCEFVVKEVAKLIDNNRTEEEILHAL-DKVCSKLPTSLAEQCQEVVDTYGRSILSILL 374
Query: 294 EFLNPSL-CSELGLCNSTIKQVIMRQPLVQINKSKKTSNCRLCCKFYNYL-QTISSKSSH 467
+ +P L CS L LC+S + V++ K C +C K YL + + S+
Sbjct: 375 DEASPELVCSMLHLCSSRG----LPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTK 430
Query: 468 SNLLFGLVSFCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQRKNP 644
+L L C+ + R +C + + V+ F C C K
Sbjct: 431 EQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPL 490
Query: 645 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
LG C WGP +WC + + A C AV+HC +VW
Sbjct: 491 LGAEKCVWGPSYWCQNMESAALC--NAVEHCRRHVW 524
Score = 36.6 bits (83), Expect = 0.093
Identities = 17/36 (47%), Positives = 19/36 (52%)
Frame = +3
Query: 645 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
LG CT G WC + K A C GAV+HC VW
Sbjct: 20 LGLRECTRGSAVWCQNVKTAADC--GAVQHCLQTVW 53
>sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Contains: Saposin A; Saposin B;
Saposin C; Saposin D]
Length = 518
Score = 67.4 bits (163), Expect = 5e-11
Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 7/219 (3%)
Frame = +3
Query: 117 CEICRFAILEVRTLLTDPGFQK--IFENFLINEICPHFKTKQQQCTNDINQYYSLVVNII 290
CEIC + EV LL ++ + E ++ + P + + QC + I Y +++++
Sbjct: 311 CEICETMVKEVTGLLESNKTEEEIVHEMEVVCYLLP--ASVKDQCKDFIEVYGQALIDML 368
Query: 291 VEFLNP-SLCSELGLC--NSTIKQVIMRQPLVQINKSKKTSNCRLCCKFYNYLQTISSKS 461
+E NP ++C L C N +Q ++ +P C +C Y K+
Sbjct: 369 LEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGF--------CDICKMIVAYADKELEKN 420
Query: 462 SHSNLLFGLVS-FCNQISAHERLECLKQFRNFNAVIAAFNKSKTINEF-CEMTKMCSHQR 635
+ + + L+ C+ + +C++ + V+ F C +C +
Sbjct: 421 ATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKLGVCGAAK 480
Query: 636 KNPLGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
K LG++ C WGPG+WC + + A C AV HC +VW
Sbjct: 481 KPLLGEDACVWGPGYWCKNMETAAQC--NAVDHCRRHVW 517
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/36 (50%), Positives = 21/36 (58%)
Frame = +3
Query: 645 LGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
L + C GP WC S + A CG AVKHC+ NVW
Sbjct: 21 LWQKDCAKGPEVWCQSLRTASQCG--AVKHCQQNVW 54
>sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 557
Score = 64.3 bits (155), Expect = 4e-10
Identities = 49/247 (19%), Positives = 94/247 (38%), Gaps = 30/247 (12%)
Frame = +3
Query: 102 NETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVV 281
+ + C+ C+F + + L+ + +++ L N + +C + + ++
Sbjct: 312 HNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLL 371
Query: 282 NIIVEFLNPS-LCSELGLCNS-------------TIKQVIMRQPL--------------V 377
+I + +NPS LC +GLC + I ++++P
Sbjct: 372 DIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPA 431
Query: 378 QINKSKKTSNCRLCCKFYNYLQ-TISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNF 554
+ K C +C K YL+ + S+ +L L C+ + + +C +
Sbjct: 432 HVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEY 491
Query: 555 NAVIAAFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGFWCVSRKHAVACGPGAVK 731
++ F C +C K LG C WGP +WC + + A C AV
Sbjct: 492 EPLLLEILVEVMDPGFVCSKIGVCPSAYKLLLGTEKCVWGPSYWCQNMETAARC--NAVD 549
Query: 732 HCEMNVW 752
HC+ +VW
Sbjct: 550 HCKRHVW 556
Score = 41.6 bits (96), Expect = 0.003
Identities = 35/156 (22%), Positives = 68/156 (43%), Gaps = 7/156 (4%)
Frame = +3
Query: 21 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 194
S V+C ++K K + ++ ++L C+IC+ + E LL D Q+ +
Sbjct: 29 SAVLCRDVKTAVDCGAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATQEEILH 88
Query: 195 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVI- 359
+L + C H + C ++ Y +++++I E NP +CS L LC S + +
Sbjct: 89 YL-EKTCEWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAE 147
Query: 360 MRQPLVQINKSKKTSNCRLCCKFYNYLQTISSKSSH 467
Q ++ NK + R+ F + + + H
Sbjct: 148 QNQKQLESNKIPEVDMARVVAPFMSNIPLLLYPQDH 183
Score = 31.2 bits (69), Expect = 3.9
Identities = 15/31 (48%), Positives = 17/31 (54%)
Frame = +3
Query: 660 CTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
C+ G C K AV CG AVKHC+ VW
Sbjct: 25 CSGGSAVLCRDVKTAVDCG--AVKHCQQMVW 53
>sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 554
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/242 (19%), Positives = 93/242 (38%), Gaps = 30/242 (12%)
Frame = +3
Query: 117 CEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVNIIVE 296
C++C+ + ++ L+ + +++ L +C + + ++++++
Sbjct: 314 CQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMH 373
Query: 297 FLNPS-LCSELGLCNSTIKQV-IMRQPLVQINKS-------------------------- 392
+NP+ LC + LC++ V + QP I +
Sbjct: 374 EVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQ 433
Query: 393 KKTSNCRLCCKFYNYLQ-TISSKSSHSNLLFGLVSFCNQISAHERLECLKQFRNFNAVIA 569
K C +C K YL+ + S+ +L L C+ + + +C + + ++
Sbjct: 434 KNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLL 493
Query: 570 AFNKSKTINEF-CEMTKMCSHQRKNPLGKNPCTWGPGFWCVSRKHAVACGPGAVKHCEMN 746
F C +C K LG C WGPG+WC + + A C AV HC+ +
Sbjct: 494 EILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNSETAARC--NAVDHCKRH 551
Query: 747 VW 752
VW
Sbjct: 552 VW 553
Score = 39.3 bits (90), Expect = 0.014
Identities = 31/131 (23%), Positives = 62/131 (47%), Gaps = 6/131 (4%)
Frame = +3
Query: 21 SKVICTELKLCTLLSKKKI--SFLMNRSGNETLKCEICRFAILEVRTLLTDPGFQKIFEN 194
S V+C ++K K + ++ ++L C+IC+ + E LL D ++ +
Sbjct: 29 SAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILH 88
Query: 195 FLINEICP--HFKTKQQQCTNDINQYYSLVVNIIV-EFLNP-SLCSELGLCNSTIKQVIM 362
+L + C H + C ++ Y +++++I E NP +CS L LC S +++ +
Sbjct: 89 YL-EKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS-LQEYLA 146
Query: 363 RQPLVQINKSK 395
Q Q+ +K
Sbjct: 147 EQNQRQLESNK 157
Score = 30.0 bits (66), Expect = 8.7
Identities = 28/150 (18%), Positives = 61/150 (40%), Gaps = 22/150 (14%)
Frame = +3
Query: 243 CTNDINQYYSLVVNIIVEFLNPSLCSELGLCNSTIKQVIMRQ------------PLVQIN 386
C N ++QY + V +++ +C +G C+ +K+V MR P +++
Sbjct: 240 CKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDE-VKRVPMRTLVPATEAIKNILPALELT 298
Query: 387 --------KSKKTSNCRLCCKFYNYL-QTISSKSSHSNLLFGLVSFCNQISAHERLECLK 539
+++ C++C L + I + ++ L+ GL C+ + A +C +
Sbjct: 299 DPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQE 358
Query: 540 QFRNFN-AVIAAFNKSKTINEFCEMTKMCS 626
F +++ N C + +CS
Sbjct: 359 VLVTFGPSLLDVLMHEVNPNFLCGVISLCS 388
>sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein B precursor (SP-B)
(Pulmonary surfactant-associated proteolipid SPL(Phe))
Length = 377
Score = 37.7 bits (86), Expect = 0.042
Identities = 16/31 (51%), Positives = 18/31 (58%)
Frame = +3
Query: 660 CTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
C GP FWC S +HAV C A+ HC VW
Sbjct: 31 CAQGPQFWCQSLEHAVQC--RALGHCLQEVW 59
>sp|Q89330|POLG_ZYMVR Genome polyprotein [Contains: P1 proteinase (N-terminal protein);
Helper component proteinase (HC-pro); Protein P3; 6 kDa
protein 1 (6K1); Cytoplasmic inclusion protein (CI); 6
kDa protein 2 (6K2); Viral genome-linked protein (VPg);
Nuclear inclusion protein A (NI-a) (NIa) (NIa-pro) (49
kDa proteinase) (49 kDa-Pro); Nuclear inclusion protein B
(NI-b) (NIb) (RNA-directed RNA polymerase); Coat protein
(CP)]
Length = 3083
Score = 37.0 bits (84), Expect = 0.071
Identities = 20/48 (41%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Frame = -1
Query: 197 KIFKNFLKSRISQQCSDFKNSKSAYFTLQCFITTSIHKK--RDFLFRK 60
K F F + +++QQ D K S F +CFITT +H K RD RK
Sbjct: 948 KRFSIFTERKLTQQAKDGKRVSSLQFVHECFITTRVHAKSIRDVGMRK 995
>sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucosylceramidase activator)
(Sphingolipid activator protein 2) (SAP-2)
Length = 81
Score = 35.4 bits (80), Expect = 0.21
Identities = 19/80 (23%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Frame = +3
Query: 105 ETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQYYSLVVN 284
E++ C+ C + + +V L+ + ++ + L + ++ + C ++ Y +V
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 285 IIVEFLNPSL-CSELGLCNS 341
++++ ++P L CSELGLC S
Sbjct: 61 LLLQEMSPELVCSELGLCMS 80
>sp|P17129|PSPB_CANFA Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa
protein) (Pulmonary surfactant-associated proteolipid
SPL(Phe)) (Pulmonary surfactant protein 18) (SP 18)
Length = 363
Score = 33.9 bits (76), Expect = 0.60
Identities = 14/31 (45%), Positives = 17/31 (54%)
Frame = +3
Query: 660 CTWGPGFWCVSRKHAVACGPGAVKHCEMNVW 752
C GP FWC S + A+ C A+ HC VW
Sbjct: 25 CARGPAFWCQSLEQALQC--RALGHCLQEVW 53
Score = 33.9 bits (76), Expect = 0.60
Identities = 21/76 (27%), Positives = 37/76 (48%), Gaps = 3/76 (3%)
Frame = +3
Query: 117 CEICRFAILEVRTLLTDPGFQKIFENFLINE--ICPHFKTKQQQCTNDINQYYSLVVNII 290
C+ C+ + + + + FQ + FL +E + P K QC + + Y+ +VV+
Sbjct: 62 CQECQDIVRILTKMTKEAIFQDMVRKFLEHECDVLP-LKLLTPQCHHMLGTYFPVVVDYF 120
Query: 291 VEFLNPS-LCSELGLC 335
+NP +C LGLC
Sbjct: 121 QSQINPKIICKHLGLC 136
>sp|O36979|POLG_ZYMVS Genome polyprotein [Contains: P1 proteinase (N-terminal protein);
Helper component proteinase (HC-pro); Protein P3; 6 kDa
protein 1 (6K1); Cytoplasmic inclusion protein (CI); 6
kDa protein 2 (6K2); Viral genome-linked protein (VPg);
Nuclear inclusion protein A (NI-a) (NIa) (NIa-pro) (49
kDa proteinase) (49 kDa-Pro); Nuclear inclusion protein B
(NI-b) (NIb) (RNA-directed RNA polymerase); Coat protein
(CP)]
Length = 3083
Score = 33.9 bits (76), Expect = 0.60
Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 2/48 (4%)
Frame = -1
Query: 197 KIFKNFLKSRISQQCSDFKNSKSAYFTLQCFITTSIHKK--RDFLFRK 60
K F F + ++Q+ + K++ S F +CFITT +H K RD RK
Sbjct: 948 KQFSIFTERNLTQRAKERKHASSLQFVHECFITTRVHAKSIRDAGVRK 995
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,791,838
Number of Sequences: 369166
Number of extensions: 2028264
Number of successful extensions: 5359
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5102
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5347
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)