Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_D09
(879 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Con... 73 9e-13
sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Con... 72 2e-12
sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Con... 68 4e-11
sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-... 54 7e-07
sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1)... 53 1e-06
sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucos... 49 1e-05
sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein ... 48 4e-05
sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor 47 5e-05
sp|P15285|PSPB_RABIT Pulmonary surfactant-associated protei... 47 5e-05
sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protei... 46 2e-04
>sp|P26779|SAP_BOVIN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B (Sphingolipid activator protein 1) (SAP-1)
(Cerebroside sulfate activator) (CSAct) (Dispersin)
(Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 525
Score = 73.2 bits (178), Expect = 9e-13
Identities = 58/253 (22%), Positives = 106/253 (41%), Gaps = 39/253 (15%)
Frame = +3
Query: 12 LSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQ------------------ 137
+S C + +++Y ++ + ++ HM K IC L C V
Sbjct: 238 MSDMCKNYINQYSEVAIQMVM-HMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIPA 296
Query: 138 ---LKPIRK-----MKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKI 293
++PI+K I C+ C VVK+ + I + TE EI + L + S
Sbjct: 297 LGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAE 356
Query: 294 QCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA------------KLSGIECELCEHV 437
QCQ++VD Y IL+ +L E + +C LC++ + G CE+C+ +
Sbjct: 357 QCQEVVDTYGRSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKL 416
Query: 438 MDEVIKVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSIARSTLNSKV 614
+ + + + N ++E + ++ K C L + +C V Y PV+ I ++
Sbjct: 417 VGYLDRNLEKNSTKEQILAALE-KGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSF 475
Query: 615 ICTELKLCTLLSK 653
+C ++ C K
Sbjct: 476 VCLKIGACPAAHK 488
Score = 63.9 bits (154), Expect = 6e-10
Identities = 32/133 (24%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Frame = +3
Query: 9 SLSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQLKPIRKM---KGIECDA 179
SL+ +C VVD YG +++ +++ + +C ++H C+S + +R M G C+
Sbjct: 353 SLAEQCQEVVDTYGRSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEV 412
Query: 180 CRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVD 359
C+ +V + +T+ +I L+ ++ + QC Q V EY +++ ++ +D
Sbjct: 413 CKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMD 472
Query: 360 VDKICKFFGLCNA 398
+C G C A
Sbjct: 473 PSFVCLKIGACPA 485
Score = 56.2 bits (134), Expect = 1e-07
Identities = 68/375 (18%), Positives = 140/375 (37%), Gaps = 85/375 (22%)
Frame = +3
Query: 9 SLSSECSSVVDRYGDILMTFIINHMDAKS-ICKLIHACTSVNVQLKPIRKMKGIE----- 170
++S+ C +VD Y +++ I M +C ++ C S+ L + K +E
Sbjct: 101 NMSASCKEIVDSYLPVILDMIKGQMSHPGEVCSALNLCESLQKHLAELNHQKQLESNQIP 160
Query: 171 --------------------------------------CDACRLVVKKFKEYISDPATET 236
C C +V +E + +T
Sbjct: 161 ELDMAEVVAPFMANIPFLLYPQDGSHSKPQPKKANGNVCQDCIQLVTDVQEALRTNSTFV 220
Query: 237 EIKNFLKNDFCYIFGSDKIQ-CQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA----- 398
E + C G C+ +++Y + + ++ + +IC G C+
Sbjct: 221 EALVDHAKEECDRLGPGMSDMCKNYINQYSEVAIQMVM-HMQPKEICVLAGFCDEVKEMP 279
Query: 399 ------------------------------KLSGIECELCEHVMDEVIKVVTSNHSEEVV 488
+ I CE+CE V+ EV K++ +N +EE +
Sbjct: 280 MKTLVPAEVVSENVIPALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEI 339
Query: 489 SNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTL--LSKKK 659
+ + K+C +L + + +C +VDTY I SI + +++C+ L LC+ L
Sbjct: 340 LHALD-KVCSKLPTSLAEQCQEVVDTYGRSILSILLDEASPELVCSMLHLCSSRGLPAAT 398
Query: 660 ISFLMNRSGNETLKCEICRFAILEV-RTLLTDPGFQKIFENFLINEICPHFKTK-QQQCT 833
+ + + G CE+C+ + + R L + ++I + + C + ++QC
Sbjct: 399 VRVMPRKDGG---FCEVCKKLVGYLDRNLEKNSTKEQILA--ALEKGCSFLPDQYRKQCD 453
Query: 834 NDINQYYSLVVNIIV 878
+ +Y +++ I+V
Sbjct: 454 QFVTEYEPVLIEILV 468
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 2/102 (1%)
Frame = +3
Query: 99 CKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF 278
C + C V KP +K + CD C+ V+ + D ATE EI +L+ ++
Sbjct: 42 CGAVQHCLQT-VWSKPT--VKSLPCDICKDVITAAGNLLKDNATEQEILMYLERTCDWLP 98
Query: 279 GSD-KIQCQQIVDEYFNLILNFILAEVD-VDKICKFFGLCNA 398
+ C++IVD Y +IL+ I ++ ++C LC +
Sbjct: 99 KPNMSASCKEIVDSYLPVILDMIKGQMSHPGEVCSALNLCES 140
Score = 38.5 bits (88), Expect = 0.025
Identities = 22/87 (25%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Frame = +3
Query: 402 LSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSV--IKNECVIIVDTYLPV 575
+ + C++C+ V+ ++ N +E+ + +++ + C L + C IVD+YLPV
Sbjct: 58 VKSLPCDICKDVITAAGNLLKDNATEQEILMYLE-RTCDWLPKPNMSASCKEIVDSYLPV 116
Query: 576 IFSIARSTLNSK-VICTELKLCTLLSK 653
I + + ++ +C+ L LC L K
Sbjct: 117 ILDMIKGQMSHPGEVCSALNLCESLQK 143
>sp|O13035|SAP_CHICK Proactivator polypeptide precursor [Contains: Saposin A; Saposin B;
Saposin C; Saposin D]
Length = 518
Score = 72.4 bits (176), Expect = 2e-12
Identities = 55/248 (22%), Positives = 108/248 (43%), Gaps = 34/248 (13%)
Frame = +3
Query: 12 LSSECSSVVDRYGDILMTFIINHMDA--KSICKLIHACTSVN---------VQLKPIRKM 158
+S C S + Y D+ + +++ D K IC ++ C SV Q+ KM
Sbjct: 236 MSDMCKSYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSVKSVPLQTLVPAQVVHEVKM 295
Query: 159 KGIE-----------CDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF-GSDKIQCQ 302
+ +E C+ C +VK+ + TE EI + ++ CY+ S K QC+
Sbjct: 296 ETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEV-VCYLLPASVKDQCK 354
Query: 303 QIVDEYFNLILNFILAEVDVDKICKFFGLCNA----------KLSGIECELCEHVMDEVI 452
++ Y +++ +L + + +C C A K +G C++C+ ++
Sbjct: 355 DFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGFCDICKMIVAYAD 414
Query: 453 KVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSIARSTLNSKVICTEL 629
K + N + + ++ K+C L + ++CV V+ Y PV+ + ++ +CT+L
Sbjct: 415 KELEKNATTTEIEALLE-KVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPTFVCTKL 473
Query: 630 KLCTLLSK 653
+C K
Sbjct: 474 GVCGAAKK 481
Score = 63.9 bits (154), Expect = 6e-10
Identities = 72/365 (19%), Positives = 132/365 (36%), Gaps = 75/365 (20%)
Frame = +3
Query: 6 KSLSSECSSVVDRYGDILMTFIINHMD-AKSICKLIHACTSVNVQL-------------- 140
+ L+SEC +VD Y ++M I D + +C + C S+ L
Sbjct: 101 QGLASECKEIVDSYLPVIMDMIKEEFDKPEVVCSALSLCQSLQKHLAAMKLQKQLQSNKI 160
Query: 141 ------------------------KPIRKMKGIE--CDACRLVVKKFKEYISDPATETEI 242
KP +K K E C C +V +E + AT +
Sbjct: 161 PELDFSELTSPFMANVPLLLYPQDKPKQKSKATEDVCQDCIRLVTDVQEAVRTNATFVKS 220
Query: 243 KNFLKNDFCYIFGSD-KIQCQQIVDEYFNLILNFILAEVDVD--KICKFFGLC------- 392
+ C G C+ + EY +L + ++ D IC G C
Sbjct: 221 LVAHAKEECDRLGPGMSDMCKSYISEYSDLAIQMMMHMKDQQPKDICAMVGFCPSVKSVP 280
Query: 393 -----------NAKLSGIE-----------CELCEHVMDEVIKVVTSNHSEEVVSNFIKL 506
K+ +E CE+CE ++ EV ++ SN +EE + + +++
Sbjct: 281 LQTLVPAQVVHEVKMETVEKATVQEKTFSVCEICETMVKEVTGLLESNKTEEEIVHEMEV 340
Query: 507 KICPRLSVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKISFLMNRSG 686
+ +K++C ++ Y + + N + +C LK C + ++ +G
Sbjct: 341 VCYLLPASVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVVKPAG 400
Query: 687 NETLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHF--KTKQQQCTNDINQYYSL 860
C+IC+ + L E L+ ++C HF ++ QC + QY +
Sbjct: 401 G---FCDICKMIVAYADKELEKNATTTEIE-ALLEKVC-HFLPESVSDQCVQFVEQYEPV 455
Query: 861 VVNII 875
VV ++
Sbjct: 456 VVQLL 460
Score = 61.6 bits (148), Expect = 3e-09
Identities = 31/131 (23%), Positives = 65/131 (49%), Gaps = 1/131 (0%)
Frame = +3
Query: 9 SLSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQLKPIR-KMKGIECDACR 185
S+ +C ++ YG L+ ++ + +++C ++ C + +P+ K G CD C+
Sbjct: 348 SVKDQCKDFIEVYGQALIDMLLEATNPEAVCVMLKCCAANKPPQQPVVVKPAGGFCDICK 407
Query: 186 LVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEVDVD 365
++V + + AT TEI+ L+ ++ S QC Q V++Y +++ + +D
Sbjct: 408 MIVAYADKELEKNATTTEIEALLEKVCHFLPESVSDQCVQFVEQYEPVVVQLLAEMMDPT 467
Query: 366 KICKFFGLCNA 398
+C G+C A
Sbjct: 468 FVCTKLGVCGA 478
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 52/87 (59%), Gaps = 3/87 (3%)
Frame = +3
Query: 402 LSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL--SVIKNECVIIVDTYLPV 575
++ I C+LC+ ++ V KV+ N +E+ + ++++ K C L + +EC IVD+YLPV
Sbjct: 59 VNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLE-KRCEFLPDQGLASECKEIVDSYLPV 117
Query: 576 IFSIARSTLNS-KVICTELKLCTLLSK 653
I + + + +V+C+ L LC L K
Sbjct: 118 IMDMIKEEFDKPEVVCSALSLCQSLQK 144
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Frame = +3
Query: 93 SICKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCY 272
S C + C NV KP + I CD C+ +V + + D TE EI+++L+ C
Sbjct: 41 SQCGAVKHCQQ-NVWSKPA--VNSIPCDLCKELVTVVGKVLKDNGTEDEIRSYLEKR-CE 96
Query: 273 IFGSDKI--QCQQIVDEYFNLILNFILAEVD-VDKICKFFGLCNA 398
+ +C++IVD Y +I++ I E D + +C LC +
Sbjct: 97 FLPDQGLASECKEIVDSYLPVIMDMIKEEFDKPEVVCSALSLCQS 141
>sp|P07602|SAP_HUMAN Proactivator polypeptide precursor [Contains: Saposin A (Protein
A); Saposin B-Val; Saposin B (Sphingolipid activator
protein 1) (SAP-1) (Cerebroside sulfate activator)
(CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C
(Co-beta-glucosidase) (A1 activator) (Glucosylceramidase
activator) (Sphingolipid activator protein 2) (SAP-2);
Saposin D (Protein C) (Component C)]
Length = 524
Score = 67.8 bits (164), Expect = 4e-11
Identities = 53/244 (21%), Positives = 103/244 (42%), Gaps = 39/244 (15%)
Frame = +3
Query: 24 CSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQ---------------------L 140
C + + +Y +I + ++ HM K IC L+ C V +
Sbjct: 241 CKNYISQYSEIAIQMMM-HMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELV 299
Query: 141 KPIRKMK-----GIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQ 305
+PI+K + + C+ C +VK+ + I + TE EI + + S +CQ+
Sbjct: 300 EPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQE 359
Query: 306 IVDEYFNLILNFILAEVDVDKICKFFGLCNA------------KLSGIECELCEHVMDEV 449
+VD Y + IL+ +L EV + +C LC+ G CE+C+ ++ +
Sbjct: 360 VVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYL 419
Query: 450 IKVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIFSIARSTLNSKVICTE 626
+ + N +++ + ++ K C L + +C V Y PV+ I ++ +C +
Sbjct: 420 DRNLEKNSTKQEILAALE-KGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLK 478
Query: 627 LKLC 638
+ C
Sbjct: 479 IGAC 482
Score = 64.3 bits (155), Expect = 4e-10
Identities = 32/132 (24%), Positives = 63/132 (47%), Gaps = 3/132 (2%)
Frame = +3
Query: 6 KSLSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQLKPI---RKMKGIECD 176
KSLS EC VVD YG +++ ++ + + +C ++H C+ + + + G C+
Sbjct: 351 KSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCE 410
Query: 177 ACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEV 356
C+ +V + +T+ EI L+ ++ + QC Q V EY +++ ++ +
Sbjct: 411 VCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVM 470
Query: 357 DVDKICKFFGLC 392
D +C G C
Sbjct: 471 DPSFVCLKIGAC 482
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/163 (26%), Positives = 81/163 (49%), Gaps = 5/163 (3%)
Frame = +3
Query: 405 SGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL-SVIKNECVIIVDTYLPVIF 581
S + CE+CE ++ EV K++ +N +E+ + + K+C +L + EC +VDTY I
Sbjct: 311 SDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFD-KMCSKLPKSLSEECQEVVDTYGSSIL 369
Query: 582 SIARSTLNSKVICTELKLC--TLLSKKKISFLMNRSGNETLKCEICRFAILEV-RTLLTD 752
SI ++ +++C+ L LC T L + + G CE+C+ + + R L +
Sbjct: 370 SILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGG---FCEVCKKLVGYLDRNLEKN 426
Query: 753 PGFQKIFENFLINEICPHFKTK-QQQCTNDINQYYSLVVNIIV 878
Q+I + + C Q+QC + +Y +++ I+V
Sbjct: 427 STKQEILA--ALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILV 467
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/83 (30%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Frame = +3
Query: 156 MKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSD-KIQCQQIVDEYFNLI 332
+K + CD C+ VV + + D ATE EI +L+ ++ + C++IVD Y +I
Sbjct: 58 VKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVI 117
Query: 333 LNFILAEVD-VDKICKFFGLCNA 398
L+ I E+ ++C LC +
Sbjct: 118 LDIIKGEMSRPGEVCSALNLCES 140
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Frame = +3
Query: 402 LSGIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSV--IKNECVIIVDTYLPV 575
+ + C++C+ V+ ++ N +EE + +++ K C L + C IVD+YLPV
Sbjct: 58 VKSLPCDICKDVVTAAGDMLKDNATEEEILVYLE-KTCDWLPKPNMSASCKEIVDSYLPV 116
Query: 576 IFSIARSTLNSK-VICTELKLCTLLSK 653
I I + ++ +C+ L LC L K
Sbjct: 117 ILDIIKGEMSRPGEVCSALNLCESLQK 143
>sp|Q61207|SAP_MOUSE Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 557
Score = 53.5 bits (127), Expect = 7e-07
Identities = 39/163 (23%), Positives = 68/163 (41%), Gaps = 28/163 (17%)
Frame = +3
Query: 12 LSSECSSVVDRYGDILMTFIINHMDA--KSICKLIHACTSVN-VQLKP------------ 146
+S C + VD+Y ++ + +++ D K IC L C V V +K
Sbjct: 236 VSDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVKRVPMKTLVPATETIKNIL 295
Query: 147 -------------IRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSD 287
++ I C C+ V+ KF E I + ATE + L N +
Sbjct: 296 PALEMMDPYEQNLVQAHNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPA 355
Query: 288 KIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNAKLSGIE 416
+ +CQ++V + +L+ + EV+ +C GLC A+ +E
Sbjct: 356 RTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVE 398
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/111 (28%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Frame = +3
Query: 159 KGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSD-KIQCQQIVDEYFNLIL 335
K + CD C+ VV + + D AT+ EI ++L+ +I S C+++VD Y +IL
Sbjct: 59 KSLPCDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSYLPVIL 118
Query: 336 NFILAEV-DVDKICKFFGLCNAKLSGIECELCEHVMDEVIKVVTSNHSEEV 485
+ I E+ + ++C LC + L E++ ++ K + SN EV
Sbjct: 119 DMIKGEMSNPGEVCSALNLCQS--------LQEYLAEQNQKQLESNKIPEV 161
Score = 43.5 bits (101), Expect = 8e-04
Identities = 23/84 (27%), Positives = 47/84 (55%), Gaps = 3/84 (3%)
Frame = +3
Query: 411 IECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL--SVIKNECVIIVDTYLPVIFS 584
+ C++C+ V+ E ++ N ++E + ++++ K C + S + C +VD+YLPVI
Sbjct: 61 LPCDICKTVVTEAGNLLKDNATQEEILHYLE-KTCEWIHDSSLSASCKEVVDSYLPVILD 119
Query: 585 IARSTL-NSKVICTELKLCTLLSK 653
+ + + N +C+ L LC L +
Sbjct: 120 MIKGEMSNPGEVCSALNLCQSLQE 143
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/160 (21%), Positives = 63/160 (39%), Gaps = 35/160 (21%)
Frame = +3
Query: 18 SECSSVVDRYGDILMTFIINHMDAKSICKLIHACTS---------------VNVQLK--- 143
++C VV +G L+ I+ ++ S+C +I C + V+ LK
Sbjct: 357 TKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPT 416
Query: 144 -----------------PIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCY 272
P +K G C+ C+ +V + + +T+ EI L+ +
Sbjct: 417 PPKQPAQPKQSALPAHVPPQKNGGF-CEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSF 475
Query: 273 IFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLC 392
+ + QC V EY L+L ++ +D +C G+C
Sbjct: 476 LPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVC 515
Score = 39.7 bits (91), Expect = 0.011
Identities = 57/291 (19%), Positives = 105/291 (36%), Gaps = 81/291 (27%)
Frame = +3
Query: 9 SLSSECSSVVDRYGDILMTFIINHM-DAKSICKLIHACTSVNVQL-----KPIRKMKGIE 170
SLS+ C VVD Y +++ I M + +C ++ C S+ L K + K E
Sbjct: 101 SLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQKQLESNKIPE 160
Query: 171 CDACRLVVKKFKEYI-----------SDPATE-------------TEIKNFLKNDFCYIF 278
D R VV F I S P + ++++ +K + +I
Sbjct: 161 VDMAR-VVAPFMSNIPLLLYPQDHPRSQPQPKANEDVCQDCMKLVSDVQTAVKTNSSFIQ 219
Query: 279 G-SDKIQ-------------CQQIVDEYFNLILNFILAEVDVD--KICKFFGLCNAK--- 401
G D ++ C+ VD+Y + + ++ D +IC G CN
Sbjct: 220 GFVDHVKEDCDRLGPGVSDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVKRV 279
Query: 402 ---------------LSGIE-----------------CELCEHVMDEVIKVVTSNHSEEV 485
L +E C+ C+ VM++ +++ +N +EE+
Sbjct: 280 PMKTLVPATETIKNILPALEMMDPYEQNLVQAHNVILCQTCQFVMNKFSELIVNNATEEL 339
Query: 486 VSNFIKLKICPRLSVIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 638
+ + + +C +V T+ P + I +N +C + LC
Sbjct: 340 LVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLC 390
>sp|P10960|SAP_RAT Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin)
Length = 554
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/131 (28%), Positives = 64/131 (48%), Gaps = 2/131 (1%)
Frame = +3
Query: 99 CKLIHACTSVNVQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF 278
C+ + C + V KP K + CD C+ VV + + D ATE EI ++L+ +I
Sbjct: 42 CRAVKHCQQM-VWSKPTAK--SLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIH 98
Query: 279 GSD-KIQCQQIVDEYFNLILNFILAEV-DVDKICKFFGLCNAKLSGIECELCEHVMDEVI 452
S C+++VD Y +IL+ I E+ + ++C LC + L E++ ++
Sbjct: 99 DSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQS--------LQEYLAEQNQ 150
Query: 453 KVVTSNHSEEV 485
+ + SN EV
Sbjct: 151 RQLESNKIPEV 161
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/155 (21%), Positives = 65/155 (41%), Gaps = 26/155 (16%)
Frame = +3
Query: 12 LSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVN-------------------- 131
+S C + VD+Y ++ + ++ HM K IC ++ C V
Sbjct: 236 VSDICKNYVDQYSEVAVQMMM-HMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPA 294
Query: 132 ------VQLKPIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKI 293
+ I+ I C C+LV++K E I + ATE + L +
Sbjct: 295 LELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPAST 354
Query: 294 QCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNA 398
+CQ+++ + +L+ ++ EV+ + +C LC+A
Sbjct: 355 KCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSA 389
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 3/84 (3%)
Frame = +3
Query: 411 IECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRL--SVIKNECVIIVDTYLPVIFS 584
+ C++C+ V+ E ++ N +EE + ++++ K C + S + C +VD+YLPVI
Sbjct: 61 LPCDICKTVVTEAGNLLKDNATEEEILHYLE-KTCAWIHDSSLSASCKEVVDSYLPVILD 119
Query: 585 IARSTL-NSKVICTELKLCTLLSK 653
+ + + N +C+ L LC L +
Sbjct: 120 MIKGEMSNPGEVCSALNLCQSLQE 143
Score = 37.4 bits (85), Expect = 0.055
Identities = 32/162 (19%), Positives = 63/162 (38%), Gaps = 36/162 (22%)
Frame = +3
Query: 15 SSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQLK----------------- 143
S++C V+ +G L+ +++ ++ +C +I C S N L
Sbjct: 353 STKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLC-SANPNLVGTLEQPAAAIVSALPKE 411
Query: 144 -------------------PIRKMKGIECDACRLVVKKFKEYISDPATETEIKNFLKNDF 266
P +K G C+ C+ +V + + +T+ EI L+
Sbjct: 412 PAPPKQPEEPKQSALRAHVPPQKNGGF-CEVCKKLVIYLEHNLEKNSTKEEILAALEKGC 470
Query: 267 CYIFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLC 392
++ + QC + V EY L+L ++ +D +C G+C
Sbjct: 471 SFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVC 512
>sp|P20097|SAP_CAVPO Saposin C (CO-beta-glucosidase) (Glucosylceramidase activator)
(Sphingolipid activator protein 2) (SAP-2)
Length = 81
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/78 (33%), Positives = 41/78 (52%)
Frame = +3
Query: 159 KGIECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILN 338
+ + C AC VVKK E I + TE +I + L + + S CQ++VD Y + I+
Sbjct: 1 ESVTCKACEYVVKKVMELIDNNRTEEKIIHALDSVCALLPESVSEVCQEVVDTYGDSIVA 60
Query: 339 FILAEVDVDKICKFFGLC 392
+L E+ + +C GLC
Sbjct: 61 LLLQEMSPELVCSELGLC 78
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/77 (28%), Positives = 47/77 (61%), Gaps = 1/77 (1%)
Frame = +3
Query: 411 IECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNE-CVIIVDTYLPVIFSI 587
+ C+ CE+V+ +V++++ +N +EE + + + +C L +E C +VDTY I ++
Sbjct: 3 VTCKACEYVVKKVMELIDNNRTEEKIIHALD-SVCALLPESVSEVCQEVVDTYGDSIVAL 61
Query: 588 ARSTLNSKVICTELKLC 638
++ +++C+EL LC
Sbjct: 62 LLQEMSPELVCSELGLC 78
Score = 34.3 bits (77), Expect = 0.47
Identities = 13/40 (32%), Positives = 22/40 (55%)
Frame = +3
Query: 6 KSLSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACTS 125
+S+S C VVD YGD ++ ++ M + +C + C S
Sbjct: 41 ESVSEVCQEVVDTYGDSIVALLLQEMSPELVCSELGLCMS 80
>sp|P22355|PSPB_RAT Pulmonary surfactant-associated protein B precursor (SP-B)
(Pulmonary surfactant-associated proteolipid SPL(Phe))
Length = 376
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/147 (19%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Frame = +3
Query: 24 CSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNV------QLKPIRK---MKGIECD 176
C + +RY +L+ ++ + + +C L+ C++ + L+P+ + ++ EC
Sbjct: 236 CQCLAERYTVLLLDALLGRVVPQLVCGLVLRCSTADAIGPALPALEPLIEKWPLQDTECH 295
Query: 177 ACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEV 356
C+ V+ + T + + C F D+ +C+Q V+++ +L +
Sbjct: 296 FCKSVINQAWN------TSEQAMPQAMHQACLRFWLDRQKCEQFVEQHMPQLLALVPRSQ 349
Query: 357 DVDKICKFFGLCNAKLSGIECELCEHV 437
D C+ G+C A S ++C H+
Sbjct: 350 DAHTSCQALGVCEAPASPLQCFQTPHL 376
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/98 (23%), Positives = 48/98 (48%), Gaps = 7/98 (7%)
Frame = +3
Query: 372 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 530
C+ G C ++ G C+ CE ++ + K+ + ++ + F++ + I P L +
Sbjct: 47 CRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQDTIRKFLEQECDILP-LKL 105
Query: 531 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTL 644
+ C ++D YLP++ + + K IC+ + LC L
Sbjct: 106 LVPRCRQVLDVYLPLVIDYFQGQIKPKAICSHVGLCPL 143
Score = 38.1 bits (87), Expect = 0.033
Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Frame = +3
Query: 171 CDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKI--QCQQIVDEYFNLILNFI 344
C C +V + + A + I+ FL+ + C I + +C+Q++D Y L++++
Sbjct: 67 CQECEDIVHLLTKMTKEDAFQDTIRKFLEQE-CDILPLKLLVPRCRQVLDVYLPLVIDYF 125
Query: 345 LAEVDVDKICKFFGLC 392
++ IC GLC
Sbjct: 126 QGQIKPKAICSHVGLC 141
>sp|P42211|ASPRX_ORYSA Aspartic proteinase precursor
Length = 496
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/104 (25%), Positives = 50/104 (48%), Gaps = 18/104 (17%)
Frame = +3
Query: 294 QCQQIVDEYFNLILNFILAEVDVDKICKFFGLC-----NAKLSGIE-------------C 419
+C+++V EY +ILN ++A+ D K+C GLC + +GIE C
Sbjct: 311 ECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGSDAMC 370
Query: 420 ELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNECVI 551
+CE + + + N ++E++ N+ ++C RL E +
Sbjct: 371 SVCEMAVVWIENQLRENKTKELILNYAN-QLCERLPSPNGESTV 413
Score = 39.3 bits (90), Expect = 0.015
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 13/112 (11%)
Frame = +3
Query: 12 LSSECSSVVDRYGDILMTFIINHMDAKSICKLIHAC-----TSVNVQLKPIRKMKGI--- 167
+S+EC VV YG++++ +I D + +C + C SV+ ++ + + +
Sbjct: 308 ISTECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGSD 367
Query: 168 -ECDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIF----GSDKIQCQQI 308
C C + V + + + T+ I N+ N C G + C QI
Sbjct: 368 AMCSVCEMAVVWIENQLRENKTKELILNY-ANQLCERLPSPNGESTVSCHQI 418
Score = 36.6 bits (83), Expect = 0.095
Identities = 20/112 (17%), Positives = 50/112 (44%), Gaps = 5/112 (4%)
Frame = +3
Query: 528 VIKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLCTLLSKKKI-----SFLMNRSGNE 692
+I EC +V Y +I ++ + + + +C+++ LC K+ + S + +
Sbjct: 307 IISTECKEVVSEYGEMILNLLIAQTDPQKVCSQVGLCMFDGKRSVSNGIESVVDKENLGS 366
Query: 693 TLKCEICRFAILEVRTLLTDPGFQKIFENFLINEICPHFKTKQQQCTNDINQ 848
C +C A++ + L + +++ N+ N++C + + T +Q
Sbjct: 367 DAMCSVCEMAVVWIENQLRENKTKELILNY-ANQLCERLPSPNGESTVSCHQ 417
>sp|P15285|PSPB_RABIT Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa
protein) (Pulmonary surfactant-associated proteolipid
SPL(Phe))
Length = 370
Score = 47.4 bits (111), Expect = 5e-05
Identities = 36/146 (24%), Positives = 65/146 (44%), Gaps = 9/146 (6%)
Frame = +3
Query: 24 CSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNV--QLKPIRKM-------KGIECD 176
C + +RY IL+ ++ H+ + +C L+ C+SV+ Q+ P + + EC
Sbjct: 230 CQCLAERYTVILLEVLLGHVLPQLVCGLVLRCSSVDSIGQVPPTLEALPGEWLPQDPECR 289
Query: 177 ACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEV 356
C V + + IS+ + + C DK +C+Q V+ + +L+ +
Sbjct: 290 LCMSVTTQARN-ISEQTRPQAVYHA-----CLSSQLDKQECEQFVELHTPQLLSLLSRGW 343
Query: 357 DVDKICKFFGLCNAKLSGIECELCEH 434
D IC+ G C A LS ++C H
Sbjct: 344 DARAICQALGACVATLSPLQCIQSPH 369
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/96 (23%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Frame = +3
Query: 372 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 530
CK G C ++ G C+ C+ +++ + K+ ++ + F++ + + P L +
Sbjct: 50 CKALGHCLQEVWGHVGADDLCQECQDIVNILTKMTKEAIFQDTIRKFLEHECDVLP-LKL 108
Query: 531 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 638
+ +C ++D Y P+ + +S +N+K IC L LC
Sbjct: 109 LVPQCHHVLDVYFPLTITYFQSQINAKAICQHLGLC 144
Score = 38.9 bits (89), Expect = 0.019
Identities = 18/76 (23%), Positives = 38/76 (50%), Gaps = 2/76 (2%)
Frame = +3
Query: 171 CDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKI--QCQQIVDEYFNLILNFI 344
C C+ +V + + + I+ FL+++ C + + QC ++D YF L + +
Sbjct: 70 CQECQDIVNILTKMTKEAIFQDTIRKFLEHE-CDVLPLKLLVPQCHHVLDVYFPLTITYF 128
Query: 345 LAEVDVDKICKFFGLC 392
++++ IC+ GLC
Sbjct: 129 QSQINAKAICQHLGLC 144
Score = 35.4 bits (80), Expect = 0.21
Identities = 48/260 (18%), Positives = 86/260 (33%), Gaps = 48/260 (18%)
Frame = +3
Query: 3 LKSLSSECSSVVDRYGDILMTFIINHMDAKSICKLIHACT--SVNVQLKPIRKMKGIE-- 170
LK L +C V+D Y + +T+ + ++AK+IC+ + C S L P+ +
Sbjct: 106 LKLLVPQCHHVLDVYFPLTITYFQSQINAKAICQHLGLCQPGSPEPPLDPLPDKLVLPTL 165
Query: 171 --------------------------CDACRLVVKKFKEYISDPATETEIKNFLKNDFCY 272
C CR ++K+ + I +
Sbjct: 166 LGALPAKPGPHTQDLSAQRFPIPLPLCWLCRTLLKRIQAMIPKGVLAMAVAQVCHVVPLV 225
Query: 273 IFGSDKIQCQQIVDEYFNLILNFILAEVDVDKICKFFGLCNAKLS--------------- 407
+ G CQ + + Y ++L +L V +C C++ S
Sbjct: 226 VGGI----CQCLAERYTVILLEVLLGHVLPQLVCGLVLRCSSVDSIGQVPPTLEALPGEW 281
Query: 408 ---GIECELCEHVMDEVIKVVTSNHSEEVVSNFIKLKICPRLSVIKNECVIIVDTYLPVI 578
EC LC V + + + V C + K EC V+ + P +
Sbjct: 282 LPQDPECRLCMSVTTQARNISEQTRPQAVYH------ACLSSQLDKQECEQFVELHTPQL 335
Query: 579 FSIARSTLNSKVICTELKLC 638
S+ +++ IC L C
Sbjct: 336 LSLLSRGWDARAICQALGAC 355
>sp|P50405|PSPB_MOUSE Pulmonary surfactant-associated protein B precursor (SP-B)
(Pulmonary surfactant-associated proteolipid SPL(Phe))
Length = 377
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/147 (19%), Positives = 65/147 (44%), Gaps = 9/147 (6%)
Frame = +3
Query: 24 CSSVVDRYGDILMTFIINHMDAKSICKLIHACTSVNVQ------LKPIRK---MKGIECD 176
C + +RY +L+ ++ + + +C L+ C++ + ++P+ + ++ EC
Sbjct: 237 CQCLAERYTVLLLDALLGRVVPQLVCGLVLRCSTEDAMGPALPAVEPLIEEWPLQDTECH 296
Query: 177 ACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKIQCQQIVDEYFNLILNFILAEV 356
C+ V+ + T + + C F D+ +C+Q V+++ +L +
Sbjct: 297 FCKSVINQAWN------TSEQAMPQAMHQACLRFWLDRQKCEQFVEQHMPQLLALVPRSQ 350
Query: 357 DVDKICKFFGLCNAKLSGIECELCEHV 437
D C+ G+C A S ++C H+
Sbjct: 351 DAHITCQALGVCEAPASPLQCFQTPHL 377
Score = 44.3 bits (103), Expect = 5e-04
Identities = 25/96 (26%), Positives = 48/96 (50%), Gaps = 7/96 (7%)
Frame = +3
Query: 372 CKFFGLCNAKLSGIE-----CELCEHVMDEVIKVVTSNHSEEVVSNFIKLK--ICPRLSV 530
C+ G C ++ G C+ CE ++ + K+ + +E + F++ + I P L +
Sbjct: 48 CRALGHCLQEVWGHAGANDLCQECEDIVHLLTKMTKEDAFQEAIRKFLEQECDILP-LKL 106
Query: 531 IKNECVIIVDTYLPVIFSIARSTLNSKVICTELKLC 638
+ C ++D YLP++ +S +N K IC + LC
Sbjct: 107 LVPRCRQVLDVYLPLVIDYFQSQINPKAICNHVGLC 142
Score = 39.3 bits (90), Expect = 0.015
Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 2/76 (2%)
Frame = +3
Query: 171 CDACRLVVKKFKEYISDPATETEIKNFLKNDFCYIFGSDKI--QCQQIVDEYFNLILNFI 344
C C +V + + A + I+ FL+ + C I + +C+Q++D Y L++++
Sbjct: 68 CQECEDIVHLLTKMTKEDAFQEAIRKFLEQE-CDILPLKLLVPRCRQVLDVYLPLVIDYF 126
Query: 345 LAEVDVDKICKFFGLC 392
++++ IC GLC
Sbjct: 127 QSQINPKAICNHVGLC 142
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,776,525
Number of Sequences: 369166
Number of extensions: 1811859
Number of successful extensions: 5451
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5165
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5433
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8742211660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)