Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00145 (881 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 140 6e-33 sp|P80646|CTRB_GADMO Chymotrypsin B [Contains: Chymotrypsin... 127 3e-29 sp|P47796|CTRA_GADMO Chymotrypsin A precursor 126 9e-29 sp|Q9JHJ7|TEST_MOUSE Testisin precursor (Tryptase 4) 124 3e-28 sp|P40313|CTRL_HUMAN Chymotrypsin-like protease CTRL-1 prec... 124 5e-28 sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 123 6e-28 sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 121 2e-27 sp|P00765|TRYP_ASTFL Trypsin I 120 4e-27 sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 120 4e-27 sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 120 4e-27
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4) Length = 277 Score = 140 bits (352), Expect = 6e-33 Identities = 88/249 (35%), Positives = 125/249 (50%), Gaps = 1/249 (0%) Frame = +3 Query: 63 TSGWKIINGSQAIMHEYPQMVSIKVQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFK 242 TSG+ + G H P ++ VQG CGG L++ VLTAAHC+ + Sbjct: 32 TSGF-LPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKE---------- 80 Query: 243 YYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLE-GNDVALIKFDGYISKNQ 419 +KVY+G++ L R+ E++ +V +I HP YR +L +D+ L++ + Sbjct: 81 --GLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLT- 137 Query: 420 YDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNV 599 YI L N PG C V GWG+ P + + LQ A I + S+ EC +++ Sbjct: 138 -GYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG- 195 Query: 600 AYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTR 779 + +CAG+ SC GDSGGPL C + GIVS+G PCGQP+ P VYTR Sbjct: 196 KITDNMLCAGTKEGGKDSCEGDSGGPLVC-----NRTLYGIVSWGDFPCGQPDRPGVYTR 250 Query: 780 VSEVAGWIR 806 VS WIR Sbjct: 251 VSRYVLWIR 259
>sp|P80646|CTRB_GADMO Chymotrypsin B [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B] Length = 245 Score = 127 bits (320), Expect = 3e-29 Identities = 89/251 (35%), Positives = 127/251 (50%), Gaps = 3/251 (1%) Frame = +3 Query: 60 VTSGWKIINGSQAIMHEYPQMVSIKVQ-GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNT 236 VT +I+NG +A+ H +P VS++ G HFCGG+L+N N V+TAAHC NV T Sbjct: 10 VTGYARIVNGEEAVPHSWPWQVSLQQSNGFHFCGGSLINENWVVTAAHC-------NVRT 62 Query: 237 FKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKF--DGYIS 410 + +V +GE+D ++ I + + HP + ND++LIK + Sbjct: 63 YH----RVIVGEHDKASDENIQ-ILKPSMVFTHPKWDSRTI---NNDISLIKLASPAVLG 114 Query: 411 KNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIF 590 N DV A PG +C GWG T LQ+AA+ ++SN EC + + Sbjct: 115 TNVSPVCLGESSDVFA---PGMKCVTSGWGLTRYNAPGTPNKLQQAALPLMSNEECSQTW 171 Query: 591 SNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSV 770 N ICAG+ +SC GDSGGPL C + VGIVS+G+ C P+V Sbjct: 172 GNNMISDVMICAGAA--GATSCMGDSGGPLVCQKDNVWTL-VGIVSWGSSRC-SVTTPAV 227 Query: 771 YTRVSEVAGWI 803 Y RV+E+ GW+ Sbjct: 228 YARVTELRGWV 238
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor Length = 263 Score = 126 bits (316), Expect = 9e-29 Identities = 82/250 (32%), Positives = 131/250 (52%), Gaps = 2/250 (0%) Frame = +3 Query: 60 VTSGWKIINGSQAIMHEYPQMVSIKVQ-GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNT 236 +T +I+NG +A+ H + VS++ Q G HFCGG+L+N N V+TAAHC +++N++ Sbjct: 28 ITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYH--- 82 Query: 237 FKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKN 416 +V +GE+D ++ V + HP Y + ND+ L+K + N Sbjct: 83 ------RVVLGEHDRSSNSEGVQVMTVGQVFKHPRYN---GFTINNDILLVKLATPATLN 133 Query: 417 -QYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFS 593 + + E D + + G +C GWG DT LQ+AA+ +++N +C + + Sbjct: 134 MRVSPVCLAETD--DVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQCKKFWG 191 Query: 594 NVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVY 773 N S++ +G SSC GDSGGPL C + VGIVS+G+ C P +P VY Sbjct: 192 NKI---SDLMICAGAAGASSCMGDSGGPLVCQKAGSWTL-VGIVSWGSGTC-TPTMPGVY 246 Query: 774 TRVSEVAGWI 803 RV+E+ W+ Sbjct: 247 ARVTELRAWV 256
>sp|Q9JHJ7|TEST_MOUSE Testisin precursor (Tryptase 4) Length = 324 Score = 124 bits (312), Expect = 3e-28 Identities = 90/259 (34%), Positives = 131/259 (50%), Gaps = 14/259 (5%) Frame = +3 Query: 75 KIINGSQAIMHEYPQMVSIKVQGNHFCGGTLLNGNTVLTAAHCVW---DMRNWNVNTFKY 245 +I+ G A + +P S++V GNH CG TLLN VLTAAHC D +W V Sbjct: 54 RIVGGDDAELGRWPWQGSLRVWGNHLCGATLLNRRWVLTAAHCFQKDNDPFDWTV----- 108 Query: 246 YQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYD 425 Q L+ + +Q+ + P Y +Y ND+AL+K ++ N + Sbjct: 109 -QFGELTSRPSLWNLQAYSNRYQIEDIFLSPKYSEQYP----NDIALLKLSSPVTYN--N 161 Query: 426 YIDYNELDVNAISKPGDR--CEVVGWGSMLPPGQDTS----RFLQKAAINIISNSECGRI 587 +I L +N+ K +R C V GWG++ G+D S LQ+ + II+NS C + Sbjct: 162 FIQPICL-LNSTYKFENRTDCWVTGWGAI---GEDESLPSPNTLQEVQVAIINNSMCNHM 217 Query: 588 FSNVAYVRSNI-----CAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQ 752 + + R+NI CAG+ +C GDSGGPL C D QVG+VS+G + CG+ Sbjct: 218 YKKPDF-RTNIWGDMVCAGTPEGGKDACFGDSGGPLAC-DQDTVWYQVGVVSWG-IGCGR 274 Query: 753 PNVPSVYTRVSEVAGWIRA 809 PN P VYT +S WI++ Sbjct: 275 PNRPGVYTNISHHYNWIQS 293
>sp|P40313|CTRL_HUMAN Chymotrypsin-like protease CTRL-1 precursor Length = 264 Score = 124 bits (310), Expect = 5e-28 Identities = 87/252 (34%), Positives = 130/252 (51%), Gaps = 3/252 (1%) Frame = +3 Query: 57 AVTSGWKIINGSQAIMHEYPQMVSIK-VQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVN 233 A++ +I+NG A++ +P VS++ G HFCGG+L++ + V+TAAHC NV+ Sbjct: 27 ALSFSQRIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTAAHC-------NVS 79 Query: 234 TFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISK 413 +++ V +GEYD ++ V++ I HPS+ + NDV L+K S Sbjct: 80 PGRHF---VVLGEYDRSSNAEPLQVLSVSRAITHPSWN---STTMNNDVTLLKL---ASP 130 Query: 414 NQYD--YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRI 587 QY N G C GWG + G T LQ+ A+ +++ ++C R Sbjct: 131 AQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALPLVTVNQC-RQ 189 Query: 588 FSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPS 767 + + S ICAG SSC+GDSGGPL C G + +GIVS+GT C P+ Sbjct: 190 YWGSSITDSMICAGGA--GASSCQGDSGGPLVCQKGNT-WVLIGIVSWGTKNC-NVRAPA 245 Query: 768 VYTRVSEVAGWI 803 VYTRVS+ + WI Sbjct: 246 VYTRVSKFSTWI 257
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) Length = 260 Score = 123 bits (309), Expect = 6e-28 Identities = 79/246 (32%), Positives = 116/246 (47%) Frame = +3 Query: 69 GWKIINGSQAIMHEYPQMVSIKVQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYY 248 G KI+ G + I H P ++ CGG L+ VLTAAHC K Sbjct: 30 GSKILEGRECIPHSQPWQAALFQGERLICGGVLVGDRWVLTAAHC------------KKQ 77 Query: 249 QMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDY 428 + V +G++ L E+ QV ++I HP Y + +D+ LI+ S N D Sbjct: 78 KYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQN--SANLGDK 135 Query: 429 IDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYV 608 + +L N K G +C + GWG++ P ++ L A + I S ++C R + Sbjct: 136 VKPVQL-ANLCPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KIT 193 Query: 609 RSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSE 788 +CAGS +C+GDSGGPL C DG GI S+G+ PCG+P P VYT++ Sbjct: 194 EGMVCAGSSN-GADTCQGDSGGPLVC-DGMLQ----GITSWGSDPCGKPEKPGVYTKICR 247 Query: 789 VAGWIR 806 WI+ Sbjct: 248 YTTWIK 253
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Length = 638 Score = 121 bits (304), Expect = 2e-27 Identities = 85/256 (33%), Positives = 126/256 (49%), Gaps = 6/256 (2%) Frame = +3 Query: 54 CAVTSGWKIINGSQAIMHEYPQMVSIKVQ---GNHFCGGTLLNGNTVLTAAHCVWDMRNW 224 C +I+ G+ A + E+P VS++V+ H CGG+++ VLTAAHC + Sbjct: 383 CTTKINARIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYP 442 Query: 225 NVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGN-DVALIKFDG 401 +V ++Y G L + ++ + IIH EY EGN D+ALIK Sbjct: 443 DV-------WRIYGGILSLSEITKETPSSRIKELIIH----QEYKVSEGNYDIALIKLQT 491 Query: 402 YISKNQYD--YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSE 575 ++ ++ ++ D N I C V GWG G+ T LQKA I ++ N E Sbjct: 492 PLNYTEFQKPICLPSKADTNTIYT---NCWVTGWGYTKEQGE-TQNILQKATIPLVPNEE 547 Query: 576 CGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQP 755 C + + + + ICAG T +C+GDSGGPL C + + VGI S+G CG+ Sbjct: 548 CQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGRWQL-VGITSWGE-GCGRK 605 Query: 756 NVPSVYTRVSEVAGWI 803 + P VYT+VSE WI Sbjct: 606 DQPGVYTKVSEYMDWI 621
>sp|P00765|TRYP_ASTFL Trypsin I Length = 237 Score = 120 bits (302), Expect = 4e-27 Identities = 82/254 (32%), Positives = 127/254 (50%), Gaps = 8/254 (3%) Frame = +3 Query: 78 IINGSQAIMHEYPQMVSIKVQ----GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKY 245 I+ G+ A++ E+P +S + HFCG ++ N N +TA HCV+ N + Sbjct: 1 IVGGTDAVLGEFPYQLSFQETFLGFSFHFCGASIYNENYAITAGHCVYGDDYENPSG--- 57 Query: 246 YQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYD 425 +++ GE D+ G E+ V+K I+H ++ ++ L ND++L+K G ++ N Sbjct: 58 --LQIVAGELDMSVNEGSEQTITVSKIILHENFDYD---LLDNDISLLKLSGSLTFN--- 109 Query: 426 YIDYNELDVNAISKPGDRCE----VVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFS 593 N + A+ G V GWG+ G +T LQK + ++S++EC + Sbjct: 110 ----NNVAPIALPAQGHTATGNVIVTGWGTT-SEGGNTPDVLQKVTVPLVSDAECRDDYG 164 Query: 594 NVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVY 773 S ICAG SC+GDSGGPL +D ++ GIVS+G C +P P VY Sbjct: 165 ADEIFDSMICAGVPEGGKDSCQGDSGGPLAASDTGSTYL-AGIVSWG-YGCARPGYPGVY 222 Query: 774 TRVSEVAGWIRANA 815 T VS WI+ANA Sbjct: 223 TEVSYHVDWIKANA 236
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme) (Thymopsin) Length = 249 Score = 120 bits (302), Expect = 4e-27 Identities = 83/263 (31%), Positives = 132/263 (50%), Gaps = 2/263 (0%) Frame = +3 Query: 21 ILSFLFVLITYCAVTSGW--KIINGSQAIMHEYPQMVSIKVQGNHFCGGTLLNGNTVLTA 194 +LS + VL++ T+G +II+G + +P V++ CGG L++ VLTA Sbjct: 5 LLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTA 64 Query: 195 AHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGN 374 AHC K Q +V +G D +KI + TK+ HP Y + N Sbjct: 65 AHC------------KMGQYQVQLGS-DKIGDQSAQKI-KATKSFRHPGYSTK---THVN 107 Query: 375 DVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAI 554 D+ L++ D + + ++ +L + PG C V GWG+ P L + + Sbjct: 108 DIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVSGWGTTTSPDVTFPSDLMCSDV 164 Query: 555 NIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYG 734 +IS+ EC +++ ++ ++ +CAG T++C GDSGGPL C D + G+VS+G Sbjct: 165 KLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQ-----GLVSWG 218 Query: 735 TVPCGQPNVPSVYTRVSEVAGWI 803 T PCGQPN P VYT+V + W+ Sbjct: 219 TYPCGQPNDPGVYTQVCKYKRWV 241
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1) Length = 260 Score = 120 bits (302), Expect = 4e-27 Identities = 77/246 (31%), Positives = 115/246 (46%) Frame = +3 Query: 69 GWKIINGSQAIMHEYPQMVSIKVQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYY 248 G KI+ G + H P ++ CGG L+ VLTAAHC D KY Sbjct: 30 GSKILEGQECKPHSQPWQTALFQGERLVCGGVLVGDRWVLTAAHCKKD---------KY- 79 Query: 249 QMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDY 428 V +G++ L + E+ QV ++I HP + +D+ LI+ S N D Sbjct: 80 --SVRLGDHSLQKRDEPEQEIQVARSIQHPCFNSSNPEDHSHDIMLIRLQN--SANLGDK 135 Query: 429 IDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYV 608 + EL N K G +C + GWG++ P ++ L A + I S ++C R + Sbjct: 136 VKPIEL-ANLCPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KIT 193 Query: 609 RSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSE 788 +CAGS +C+GDSGGPL C + GI ++G+ PCG+P P VYT++ Sbjct: 194 EGMVCAGSSN-GADTCQGDSGGPLVCNG-----VLQGITTWGSDPCGKPEKPGVYTKICR 247 Query: 789 VAGWIR 806 WI+ Sbjct: 248 YTNWIK 253
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 108,371,594 Number of Sequences: 369166 Number of extensions: 2398088 Number of successful extensions: 7456 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 6111 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6355 length of database: 68,354,980 effective HSP length: 110 effective length of database: 48,034,130 effective search space used: 8790245790 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)