Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_027_I15
(521 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 92 6e-19
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 92 7e-19
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 92 7e-19
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 92 7e-19
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 91 2e-18
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 90 4e-18
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 89 8e-18
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 89 8e-18
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 87 2e-17
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 85 9e-17
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 92.4 bits (228), Expect = 6e-19
Identities = 52/127 (40%), Positives = 66/127 (51%)
Frame = +2
Query: 83 YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAY 262
YI L N PG C V GWG+ P + + LQ A I + S+ EC +++
Sbjct: 139 YIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KI 197
Query: 263 VRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVS 442
+ +CAG+ SC GDSGGPL C + GIVS+G PCGQP+ P VYTRVS
Sbjct: 198 TDNMLCAGTKEGGKDSCEGDSGGPLVC-----NRTLYGIVSWGDFPCGQPDRPGVYTRVS 252
Query: 443 EVAGWIR 463
WIR
Sbjct: 253 RYVLWIR 259
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 92.0 bits (227), Expect = 7e-19
Identities = 49/144 (34%), Positives = 79/144 (54%)
Frame = +2
Query: 29 NDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAA 208
ND+ L++ D + + ++ +L + PG C V GWG+ P L +
Sbjct: 107 NDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVSGWGTTTSPDVTFPSDLMCSD 163
Query: 209 INIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSY 388
+ +IS+ EC +++ ++ ++ +CAG T++C GDSGGPL C D + G+VS+
Sbjct: 164 VKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQ-----GLVSW 217
Query: 389 GTVPCGQPNVPSVYTRVSEVAGWI 460
GT PCGQPN P VYT+V + W+
Sbjct: 218 GTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 4/160 (2%)
Frame = +2
Query: 2 RHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGD--RCEVVGWGSMLP 169
RH + Y DVAL++ G + +++ + + ++P D RC + GWGS L
Sbjct: 910 RHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPARPPDGARCVITGWGS-LR 964
Query: 170 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 349
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C +
Sbjct: 965 EGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACRE 1023
Query: 350 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 469
+ G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1024 PSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 78.6 bits (192), Expect = 9e-15
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +2
Query: 128 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 307
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 308 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 76.3 bits (186), Expect = 4e-14
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +2
Query: 125 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 304
PG +C + GWG + LQKA + ++ S C ++ + R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 305 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + GIVS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 4/160 (2%)
Frame = +2
Query: 2 RHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--GDRCEVVGWGSMLP 169
RH + Y DVAL++ G + +++ + + ++P G RC + GWGS L
Sbjct: 906 RHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPTRPPEGARCVITGWGS-LR 960
Query: 170 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 349
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C +
Sbjct: 961 EGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACRE 1019
Query: 350 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 469
+ G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1020 PSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 78.6 bits (192), Expect = 9e-15
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +2
Query: 128 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 307
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 308 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 71.6 bits (174), Expect = 1e-12
Identities = 37/112 (33%), Positives = 56/112 (50%)
Frame = +2
Query: 125 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 304
P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 305 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + G+VS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 90.9 bits (224), Expect = 2e-18
Identities = 58/154 (37%), Positives = 80/154 (51%), Gaps = 3/154 (1%)
Frame = +2
Query: 8 EYAYLEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQ 178
EY EGN D+ALIK ++ ++ ++ D N I C V GWG G+
Sbjct: 474 EYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NCWVTGWGYTKEQGE 530
Query: 179 DTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRK 358
T LQKA I ++ N EC + + + + ICAG T +C+GDSGGPL C +
Sbjct: 531 -TQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGR 589
Query: 359 HHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
+ VGI S+G CG+ + P VYT+VSE WI
Sbjct: 590 WQL-VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 89.7 bits (221), Expect = 4e-18
Identities = 51/147 (34%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Frame = +2
Query: 29 NDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKA 205
ND+A++ + + N DYI L + N + PG C + GWG+++ G T+ LQ+A
Sbjct: 875 NDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEA 931
Query: 206 AINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVS 385
+ ++SN C + + ICAG SC+GDSGGPL C + + + G+ S
Sbjct: 932 DVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL-AGVTS 990
Query: 386 YGTVPCGQPNVPSVYTRVSEVAGWIRA 466
+G C PN P VY RVS WI++
Sbjct: 991 FG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 88.6 bits (218), Expect = 8e-18
Identities = 46/111 (41%), Positives = 63/111 (56%)
Frame = +2
Query: 128 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 307
G RC + GWGS+ G +R LQKAA+ ++S C R + V +CAG +
Sbjct: 946 GTRCVITGWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYP-VQISSRMLCAGFPQGGVD 1003
Query: 308 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC GD+GGPL C + + G+ S+G CG+P+ P VYTRV+ V GWI
Sbjct: 1004 SCSGDAGGPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 80.5 bits (197), Expect = 2e-15
Identities = 42/111 (37%), Positives = 57/111 (51%)
Frame = +2
Query: 128 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 307
G +C + GWG+ LQKA++ II C ++ N + ICAG
Sbjct: 623 GRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFLEGKVD 681
Query: 308 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + GIVS+G + C Q P VYTR++ + GWI
Sbjct: 682 SCQGDSGGPLACEEAPGVFYLAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
Score = 71.2 bits (173), Expect = 1e-12
Identities = 38/115 (33%), Positives = 56/115 (48%)
Frame = +2
Query: 116 ISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGR 295
I P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRM-VCAGYLD 377
Query: 296 LSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 460
SC+GDSGGPL C + GIVS+G + C + P VY RV+ + WI
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 88.6 bits (218), Expect = 8e-18
Identities = 54/147 (36%), Positives = 75/147 (51%), Gaps = 1/147 (0%)
Frame = +2
Query: 29 NDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKA 205
ND+A++ + + N DYI L + N I PG C + GWG T L++A
Sbjct: 924 NDIAMMHLEFKV--NYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTVDVLKEA 981
Query: 206 AINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVS 385
+ +ISN +C + S ICAG SC+GDSGGPL C + + + VG+ S
Sbjct: 982 DVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL-VGVTS 1040
Query: 386 YGTVPCGQPNVPSVYTRVSEVAGWIRA 466
+G V C PN P VY RVS+ WI +
Sbjct: 1041 FG-VQCALPNHPGVYVRVSQFIEWIHS 1066
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/149 (32%), Positives = 78/149 (52%), Gaps = 1/149 (0%)
Frame = +2
Query: 23 EGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQ 199
+ ND+A++ + + N DYI L + N + PG C + GWG+++ G T+ LQ
Sbjct: 889 KNNDIAMMHLE--MKVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQGS-TADVLQ 945
Query: 200 KAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGI 379
+A + ++SN +C + + +CAG SC+GDSGGPL C + + + G+
Sbjct: 946 EADVPLLSNEKCQQQMPEYNITENMVCAGYEAGGVDSCQGDSGGPLMCQENNR-WLLAGV 1004
Query: 380 VSYGTVPCGQPNVPSVYTRVSEVAGWIRA 466
S+G C PN P VY RV WI++
Sbjct: 1005 TSFG-YQCALPNRPGVYARVPRFTEWIQS 1032
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 85.1 bits (209), Expect = 9e-17
Identities = 48/145 (33%), Positives = 73/145 (50%)
Frame = +2
Query: 29 NDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAA 208
+D+ LI+ S N D + EL N K G +C + GWG++ P ++ L A
Sbjct: 119 HDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIISGWGTVTSPQENFPNTLNCAE 175
Query: 209 INIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSY 388
+ I S ++C R + +CAGS +C+GDSGGPL C + GI ++
Sbjct: 176 VKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVCNG-----VLQGITTW 228
Query: 389 GTVPCGQPNVPSVYTRVSEVAGWIR 463
G+ PCG+P P VYT++ WI+
Sbjct: 229 GSDPCGKPEKPGVYTKICRYTNWIK 253
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,481,060
Number of Sequences: 369166
Number of extensions: 1306882
Number of successful extensions: 4588
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3892
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3990
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3452909250
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)