Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_K10
(688 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 119 6e-27
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 105 1e-22
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 105 1e-22
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 102 9e-22
sp|P00765|TRYP_ASTFL Trypsin I 101 2e-21
sp|P15949|KLK9_MOUSE Glandular kallikrein K9 precursor (Tis... 97 5e-20
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 96 7e-20
sp|P04187|GRAB_MOUSE Granzyme B(G,H) precursor (Cytotoxic c... 96 7e-20
sp|P15120|UROK_CHICK Urokinase-type plasminogen activator p... 96 7e-20
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 96 9e-20
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 119 bits (299), Expect = 6e-27
Identities = 75/209 (35%), Positives = 106/209 (50%), Gaps = 1/209 (0%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC+ + +KVY+G++ L R+ E++ +V +I HP YR +
Sbjct: 71 VLTAAHCLKE------------GLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTH 118
Query: 187 LE-GNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFL 363
L +D+ L++ + YI L N PG C V GWG+ P + + L
Sbjct: 119 LNHDHDIMLLELQSPVQLT--GYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTL 176
Query: 364 QKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAG 543
Q A I + S+ EC +++ + +CAG+ SC GDSGGPL C + G
Sbjct: 177 QCANIQLRSDEECRQVYPG-KITDNMLCAGTKEGGKDSCEGDSGGPLVC-----NRTLYG 230
Query: 544 IVSYGTVPCGQPNVPSVYTRVSEVAGWIR 630
IVS+G PCGQP+ P VYTRVS WIR
Sbjct: 231 IVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 105 bits (261), Expect = 1e-22
Identities = 68/208 (32%), Positives = 101/208 (48%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC K + V +G++ L E+ QV ++I HP Y +
Sbjct: 68 VLTAAHC------------KKQKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPE 115
Query: 187 LEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQ 366
+D+ LI+ S N D + +L N K G +C + GWG++ P ++ L
Sbjct: 116 DHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQKCIISGWGTVTSPQENFPNTLN 172
Query: 367 KAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAGI 546
A + I S ++C R + +CAGS +C+GDSGGPL C DG + GI
Sbjct: 173 CAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVC-DG----MLQGI 225
Query: 547 VSYGTVPCGQPNVPSVYTRVSEVAGWIR 630
S+G+ PCG+P P VYT++ WI+
Sbjct: 226 TSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 105 bits (261), Expect = 1e-22
Identities = 67/208 (32%), Positives = 100/208 (48%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC D KY V +G++ L + E+ QV ++I HP +
Sbjct: 68 VLTAAHCKKD---------KY---SVRLGDHSLQKRDEPEQEIQVARSIQHPCFNSSNPE 115
Query: 187 LEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQ 366
+D+ LI+ S N D + EL N K G +C + GWG++ P ++ L
Sbjct: 116 DHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIISGWGTVTSPQENFPNTLN 172
Query: 367 KAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAGI 546
A + I S ++C R + +CAGS +C+GDSGGPL C + GI
Sbjct: 173 CAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVCNG-----VLQGI 225
Query: 547 VSYGTVPCGQPNVPSVYTRVSEVAGWIR 630
++G+ PCG+P P VYT++ WI+
Sbjct: 226 TTWGSDPCGKPEKPGVYTKICRYTNWIK 253
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 102 bits (254), Expect = 9e-22
Identities = 68/207 (32%), Positives = 104/207 (50%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC K Q +V +G D +KI + TK+ HP Y +
Sbjct: 61 VLTAAHC------------KMGQYQVQLGS-DKIGDQSAQKI-KATKSFRHPGYSTK--- 103
Query: 187 LEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQ 366
ND+ L++ D + + ++ +L + PG C V GWG+ P L
Sbjct: 104 THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVSGWGTTTSPDVTFPSDLM 160
Query: 367 KAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAGI 546
+ + +IS+ EC +++ ++ ++ +CAG T++C GDSGGPL C D + G+
Sbjct: 161 CSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQ-----GL 214
Query: 547 VSYGTVPCGQPNVPSVYTRVSEVAGWI 627
VS+GT PCGQPN P VYT+V + W+
Sbjct: 215 VSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P00765|TRYP_ASTFL Trypsin I
Length = 237
Score = 101 bits (251), Expect = 2e-21
Identities = 72/217 (33%), Positives = 108/217 (49%), Gaps = 4/217 (1%)
Frame = +1
Query: 1 NTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEY 180
N +TA HCV+ N + +++ GE D+ G E+ V+K I+H ++ ++
Sbjct: 38 NYAITAGHCVYGDDYENPSG-----LQIVAGELDMSVNEGSEQTITVSKIILHENFDYD- 91
Query: 181 AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCE----VVGWGSMLPPGQD 348
L ND++L+K G ++ N N + A+ G V GWG+ G +
Sbjct: 92 --LLDNDISLLKLSGSLTFN-------NNVAPIALPAQGHTATGNVIVTGWGTT-SEGGN 141
Query: 349 TSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKH 528
T LQK + ++S++EC + S ICAG SC+GDSGGPL +D
Sbjct: 142 TPDVLQKVTVPLVSDAECRDDYGADEIFDSMICAGVPEGGKDSCQGDSGGPLAASDTGST 201
Query: 529 HIQAGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRANA 639
++ AGIVS+G C +P P VYT VS WI+ANA
Sbjct: 202 YL-AGIVSWG-YGCARPGYPGVYTEVSYHVDWIKANA 236
>sp|P15949|KLK9_MOUSE Glandular kallikrein K9 precursor (Tissue kallikrein 9) (mGK-9)
(Epidermal growth factor-binding protein type C) (EGF-BP
C)
Length = 261
Score = 96.7 bits (239), Expect = 5e-20
Identities = 73/230 (31%), Positives = 104/230 (45%), Gaps = 20/230 (8%)
Frame = +1
Query: 1 NTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEY 180
N VLTAAHC Y + KV +G+ +LY + V+K+ +HP Y
Sbjct: 58 NWVLTAAHCY------------YEENKVSLGKNNLYEEEPSAQHRLVSKSFLHPGYNRS- 104
Query: 181 AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV--------------- 315
L N +I +YDY N+L + +SKP D +VV
Sbjct: 105 --LHRN---------HIRHPEYDYS--NDLMLLRLSKPADITDVVKPIALPTEEPKLGST 151
Query: 316 ----GWGSMLPPGQDTSRFLQKAAINIISNSECGRI-FSNVAYVRSNICAGSGRLSTSSC 480
GWGS P ++ LQ + ++ N +CG+ V V +CAG +C
Sbjct: 152 CLASGWGSTTPFKFQNAKDLQCVNLKLLPNEDCGKAHIEKVTDVM--LCAGETDGGKDTC 209
Query: 481 RGDSGGPLFCTDGRKHHIQAGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 630
+GDSGGPL C DG + GI S+G PCG+P P VYT++ + WI+
Sbjct: 210 KGDSGGPLIC-DG----VLQGITSWGFTPCGEPKKPGVYTKLIKFTSWIK 254
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 96.3 bits (238), Expect = 7e-20
Identities = 64/210 (30%), Positives = 106/210 (50%), Gaps = 1/210 (0%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
+++AAHCV+ N+ K+ + + +L V ++ + + +I+P Y
Sbjct: 820 LVSAAHCVYGR---NLEPSKWTAILGLHMKSNLTSPQTVPRL--IDEIVINPHYNRRR-- 872
Query: 187 LEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSMLPPGQDTSRFL 363
+ ND+A++ + + N DYI L + N + PG C + GWG+++ G T+ L
Sbjct: 873 -KDNDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANIL 928
Query: 364 QKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAG 543
Q+A + ++SN C + + ICAG SC+GDSGGPL C + + + AG
Sbjct: 929 QEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL-AG 987
Query: 544 IVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 633
+ S+G C PN P VY RVS WI++
Sbjct: 988 VTSFG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|P04187|GRAB_MOUSE Granzyme B(G,H) precursor (Cytotoxic cell protease 1) (CCP1)
(CTLA-1)
Length = 247
Score = 96.3 bits (238), Expect = 7e-20
Identities = 69/209 (33%), Positives = 98/209 (46%), Gaps = 1/209 (0%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC + N V +G +++ +++ + K I HP Y +
Sbjct: 59 VLTAAHCEGSIIN------------VTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTF- 105
Query: 187 LEGNDVALIKFDGYISKNQ-YDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFL 363
ND+ L+K + + ++ +VN KPGD C V GWG M P G+ S L
Sbjct: 106 --SNDIMLLKLKSKAKRTRAVRPLNLPRRNVNV--KPGDVCYVAGWGRMAPMGK-YSNTL 160
Query: 364 QKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQAG 543
Q+ + + + EC F N + ICAG + +S RGDSGGPL C + AG
Sbjct: 161 QEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVC-----KKVAAG 215
Query: 544 IVSYGTVPCGQPNVPSVYTRVSEVAGWIR 630
IVSYG G P P +T+VS WI+
Sbjct: 216 IVSYG-YKDGSP--PRAFTKVSSFLSWIK 241
>sp|P15120|UROK_CHICK Urokinase-type plasminogen activator precursor (uPA) (U-plasminogen
activator) [Contains: Urokinase-type plasminogen
activator chain A; Urokinase-type plasminogen activator
chain B]
Length = 434
Score = 96.3 bits (238), Expect = 7e-20
Identities = 68/218 (31%), Positives = 104/218 (47%), Gaps = 6/218 (2%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC ++ N Y KV++G+ L E++F V + I HP + ++
Sbjct: 212 VLTAAHCFYNPTKKQPNKSVY---KVFLGKSILNTNDEHEQVFMVDEIISHPDFT-DHTG 267
Query: 187 LEGNDVALIKF-----DGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDT 351
ND+ALI+ + N + E ++N CE+ G+G
Sbjct: 268 GNDNDIALIRIRTASGQCAVESNYVRTVCLPEKNLNLYDNTW--CEIAGYGKQNSYDIYY 325
Query: 352 SRFLQKAAINIISNSECGRIFSNVAYVRSN-ICAGSGRLSTSSCRGDSGGPLFCTDGRKH 528
++ L A +N+IS +C + + V N +CAG T +C+GDSGGP+ C +
Sbjct: 326 AQRLMSATVNLISQDDCKNKYYDSTRVTDNMVCAGDPLWETDACKGDSGGPMVCEHNGRM 385
Query: 529 HIQAGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRANAN 642
+ GIVS+G C + N P VYTRV+ WI +N N
Sbjct: 386 TLY-GIVSWGD-GCAKKNKPGVYTRVTRYLNWIDSNMN 421
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 95.9 bits (237), Expect = 9e-20
Identities = 71/210 (33%), Positives = 101/210 (48%), Gaps = 3/210 (1%)
Frame = +1
Query: 7 VLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTIIHPSYRHEYAY 186
VLTAAHC + +V ++Y G L + ++ + IIH EY
Sbjct: 429 VLTAAHCFDGIPYPDV-------WRIYGGILSLSEITKETPSSRIKELIIH----QEYKV 477
Query: 187 LEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSR 357
EGN D+ALIK ++ ++ ++ D N I C V GWG G+ T
Sbjct: 478 SEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NCWVTGWGYTKEQGE-TQN 533
Query: 358 FLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQ 537
LQKA I ++ N EC + + + + ICAG T +C+GDSGGPL C + +
Sbjct: 534 ILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGRWQL- 592
Query: 538 AGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 627
GI S+G CG+ + P VYT+VSE WI
Sbjct: 593 VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,599,312
Number of Sequences: 369166
Number of extensions: 1768275
Number of successful extensions: 5773
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4847
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5003
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5879188535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)