Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_L21
(731 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 133 4e-31
sp|Q9JHJ7|TEST_MOUSE Testisin precursor (Tryptase 4) 114 3e-25
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 113 5e-25
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 113 5e-25
sp|P00765|TRYP_ASTFL Trypsin I 113 6e-25
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 111 2e-24
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 111 2e-24
sp|P80646|CTRB_GADMO Chymotrypsin B [Contains: Chymotrypsin... 111 2e-24
sp|P40313|CTRL_HUMAN Chymotrypsin-like protease CTRL-1 prec... 110 3e-24
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 109 7e-24
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 133 bits (335), Expect = 4e-31
Identities = 82/225 (36%), Positives = 115/225 (51%), Gaps = 1/225 (0%)
Frame = +2
Query: 2 VQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQ 181
VQG CGG L++ VLTAAHC+ + +KVY+G++ L R+ E++ +
Sbjct: 55 VQGRLLCGGVLVHPKWVLTAAHCLKE------------GLKVYLGKHALGRVEAGEQVRE 102
Query: 182 VTKTIIHPSYRHEYAYLE-GNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 358
V +I HP YR +L +D+ L++ + YI L N PG C V
Sbjct: 103 VVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLT--GYIQTLPLSHNNRLTPGTTCRVS 160
Query: 359 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 538
GWG+ P + + LQ A I + S+ EC +++ + +CAG+ SC GDSG
Sbjct: 161 GWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLCAGTKEGGKDSCEGDSG 219
Query: 539 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 673
GPL C + GIVS+G PCGQP+ P VYTRVS WIR
Sbjct: 220 GPLVC-----NRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|Q9JHJ7|TEST_MOUSE Testisin precursor (Tryptase 4)
Length = 324
Score = 114 bits (284), Expect = 3e-25
Identities = 85/239 (35%), Positives = 120/239 (50%), Gaps = 14/239 (5%)
Frame = +2
Query: 2 VQGNHFCGGTLLNGNTVLTAAHCVW---DMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEK 172
V GNH CG TLLN VLTAAHC D +W V Q L+ +
Sbjct: 74 VWGNHLCGATLLNRRWVLTAAHCFQKDNDPFDWTV------QFGELTSRPSLWNLQAYSN 127
Query: 173 IFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDR-- 346
+Q+ + P Y +Y ND+AL+K ++ N ++I L +N+ K +R
Sbjct: 128 RYQIEDIFLSPKYSEQYP----NDIALLKLSSPVTYN--NFIQPICL-LNSTYKFENRTD 180
Query: 347 CEVVGWGSMLPPGQDTS----RFLQKAAINIISNSECGRIFSNVAYVRSNI-----CAGS 499
C V GWG++ G+D S LQ+ + II+NS C ++ + R+NI CAG+
Sbjct: 181 CWVTGWGAI---GEDESLPSPNTLQEVQVAIINNSMCNHMYKKPDF-RTNIWGDMVCAGT 236
Query: 500 GRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 676
+C GDSGGPL C D QVG+VS+G + CG+PN P VYT +S WI++
Sbjct: 237 PEGGKDACFGDSGGPLAC-DQDTVWYQVGVVSWG-IGCGRPNRPGVYTNISHHYNWIQS 293
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 113 bits (283), Expect = 5e-25
Identities = 72/218 (33%), Positives = 105/218 (48%)
Frame = +2
Query: 20 CGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTII 199
CGG L+ VLTAAHC K + V +G++ L E+ QV ++I
Sbjct: 58 CGGVLVGDRWVLTAAHC------------KKQKYSVRLGDHSLQSRDQPEQEIQVAQSIQ 105
Query: 200 HPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLP 379
HP Y + +D+ LI+ S N D + +L N K G +C + GWG++
Sbjct: 106 HPCYNNSNPEDHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQKCIISGWGTVTS 162
Query: 380 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 559
P ++ L A + I S ++C R + +CAGS +C+GDSGGPL C D
Sbjct: 163 PQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVC-D 219
Query: 560 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 673
G GI S+G+ PCG+P P VYT++ WI+
Sbjct: 220 GMLQ----GITSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 113 bits (283), Expect = 5e-25
Identities = 71/218 (32%), Positives = 105/218 (48%)
Frame = +2
Query: 20 CGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKTII 199
CGG L+ VLTAAHC D KY V +G++ L + E+ QV ++I
Sbjct: 58 CGGVLVGDRWVLTAAHCKKD---------KY---SVRLGDHSLQKRDEPEQEIQVARSIQ 105
Query: 200 HPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLP 379
HP + +D+ LI+ S N D + EL N K G +C + GWG++
Sbjct: 106 HPCFNSSNPEDHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIISGWGTVTS 162
Query: 380 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 559
P ++ L A + I S ++C R + +CAGS +C+GDSGGPL C
Sbjct: 163 PQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVCNG 220
Query: 560 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 673
+ GI ++G+ PCG+P P VYT++ WI+
Sbjct: 221 -----VLQGITTWGSDPCGKPEKPGVYTKICRYTNWIK 253
>sp|P00765|TRYP_ASTFL Trypsin I
Length = 237
Score = 113 bits (282), Expect = 6e-25
Identities = 76/227 (33%), Positives = 114/227 (50%), Gaps = 4/227 (1%)
Frame = +2
Query: 14 HFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVTKT 193
HFCG ++ N N +TA HCV+ N + +++ GE D+ G E+ V+K
Sbjct: 28 HFCGASIYNENYAITAGHCVYGDDYENPSG-----LQIVAGELDMSVNEGSEQTITVSKI 82
Query: 194 IIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCE----VVG 361
I+H ++ ++ L ND++L+K G ++ N N + A+ G V G
Sbjct: 83 ILHENFDYD---LLDNDISLLKLSGSLTFN-------NNVAPIALPAQGHTATGNVIVTG 132
Query: 362 WGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGG 541
WG+ G +T LQK + ++S++EC + S ICAG SC+GDSGG
Sbjct: 133 WGTT-SEGGNTPDVLQKVTVPLVSDAECRDDYGADEIFDSMICAGVPEGGKDSCQGDSGG 191
Query: 542 PLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRANA 682
PL +D ++ GIVS+G C +P P VYT VS WI+ANA
Sbjct: 192 PLAASDTGSTYL-AGIVSWG-YGCARPGYPGVYTEVSYHVDWIKANA 236
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 111 bits (278), Expect = 2e-24
Identities = 73/222 (32%), Positives = 114/222 (51%), Gaps = 1/222 (0%)
Frame = +2
Query: 8 GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVT 187
G HFCGG+L+N N V+TAAHC +++N++ +V +GE+D ++ V
Sbjct: 56 GFHFCGGSLINENWVVTAAHC--NVKNYH---------RVVLGEHDRSSNSEGVQVMTVG 104
Query: 188 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKN-QYDYIDYNELDVNAISKPGDRCEVVGW 364
+ HP Y + ND+ L+K + N + + E D + + G +C GW
Sbjct: 105 QVFKHPRYN---GFTINNDILLVKLATPATLNMRVSPVCLAETD--DVFEGGMKCVTSGW 159
Query: 365 GSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGP 544
G DT LQ+AA+ +++N +C + + N S++ +G SSC GDSGGP
Sbjct: 160 GLTRYNAADTPALLQQAALPLLTNEQCKKFWGNKI---SDLMICAGAAGASSCMGDSGGP 216
Query: 545 LFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 670
L C + VGIVS+G+ C P +P VY RV+E+ W+
Sbjct: 217 LVCQKAGSWTL-VGIVSWGSGTC-TPTMPGVYARVTELRAWV 256
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 111 bits (277), Expect = 2e-24
Identities = 74/224 (33%), Positives = 114/224 (50%), Gaps = 1/224 (0%)
Frame = +2
Query: 2 VQGNHF-CGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIF 178
++GN CGG L++ VLTAAHC K Q +V +G D +KI
Sbjct: 44 LKGNQLHCGGVLVDKYWVLTAAHC------------KMGQYQVQLGS-DKIGDQSAQKI- 89
Query: 179 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 358
+ TK+ HP Y + ND+ L++ D + + ++ +L + PG C V
Sbjct: 90 KATKSFRHPGYSTK---THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVS 143
Query: 359 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 538
GWG+ P L + + +IS+ EC +++ ++ ++ +CAG T++C GDSG
Sbjct: 144 GWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSG 202
Query: 539 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 670
GPL C D + G+VS+GT PCGQPN P VYT+V + W+
Sbjct: 203 GPLVCNDTLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P80646|CTRB_GADMO Chymotrypsin B [Contains: Chymotrypsin B chain A; Chymotrypsin B
chain B]
Length = 245
Score = 111 bits (277), Expect = 2e-24
Identities = 79/223 (35%), Positives = 110/223 (49%), Gaps = 2/223 (0%)
Frame = +2
Query: 8 GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVT 187
G HFCGG+L+N N V+TAAHC NV T+ +V +GE+D ++ I + +
Sbjct: 38 GFHFCGGSLINENWVVTAAHC-------NVRTYH----RVIVGEHDKASDENIQ-ILKPS 85
Query: 188 KTIIHPSYRHEYAYLEGNDVALIKF--DGYISKNQYDYIDYNELDVNAISKPGDRCEVVG 361
HP + ND++LIK + N DV A PG +C G
Sbjct: 86 MVFTHPKWDSRTI---NNDISLIKLASPAVLGTNVSPVCLGESSDVFA---PGMKCVTSG 139
Query: 362 WGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGG 541
WG T LQ+AA+ ++SN EC + + N ICAG+ +SC GDSGG
Sbjct: 140 WGLTRYNAPGTPNKLQQAALPLMSNEECSQTWGNNMISDVMICAGAA--GATSCMGDSGG 197
Query: 542 PLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 670
PL C + VGIVS+G+ C P+VY RV+E+ GW+
Sbjct: 198 PLVCQKDNVWTL-VGIVSWGSSRC-SVTTPAVYARVTELRGWV 238
>sp|P40313|CTRL_HUMAN Chymotrypsin-like protease CTRL-1 precursor
Length = 264
Score = 110 bits (276), Expect = 3e-24
Identities = 79/223 (35%), Positives = 113/223 (50%), Gaps = 2/223 (0%)
Frame = +2
Query: 8 GNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQVT 187
G HFCGG+L++ + V+TAAHC NV+ +++ V +GEYD ++ V+
Sbjct: 56 GFHFCGGSLISQSWVVTAAHC-------NVSPGRHF---VVLGEYDRSSNAEPLQVLSVS 105
Query: 188 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCEVVG 361
+ I HPS+ + NDV L+K S QY N G C G
Sbjct: 106 RAITHPSWN---STTMNNDVTLLKL---ASPAQYTTRISPVCLASSNEALTEGLTCVTTG 159
Query: 362 WGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGG 541
WG + G T LQ+ A+ +++ ++C R + + S ICAG SSC+GDSGG
Sbjct: 160 WGRLSGVGNVTPAHLQQVALPLVTVNQC-RQYWGSSITDSMICAGGA--GASSCQGDSGG 216
Query: 542 PLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 670
PL C G + +GIVS+GT C P+VYTRVS+ + WI
Sbjct: 217 PLVCQKGNT-WVLIGIVSWGTKNC-NVRAPAVYTRVSKFSTWI 257
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 109 bits (273), Expect = 7e-24
Identities = 77/226 (34%), Positives = 110/226 (48%), Gaps = 3/226 (1%)
Frame = +2
Query: 2 VQGNHFCGGTLLNGNTVLTAAHCVWDMRNWNVNTFKYYQMKVYMGEYDLYRMYGVEKIFQ 181
V H CGG+++ VLTAAHC + +V ++Y G L + +
Sbjct: 413 VSQTHLCGGSIIGRQWVLTAAHCFDGIPYPDV-------WRIYGGILSLSEITKETPSSR 465
Query: 182 VTKTIIHPSYRHEYAYLEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCE 352
+ + IIH EY EGN D+ALIK ++ ++ ++ D N I C
Sbjct: 466 IKELIIH----QEYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NCW 518
Query: 353 VVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGD 532
V GWG G+ T LQKA I ++ N EC + + + + ICAG T +C+GD
Sbjct: 519 VTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGD 577
Query: 533 SGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 670
SGGPL C + + VGI S+G CG+ + P VYT+VSE WI
Sbjct: 578 SGGPLVCKHSGRWQL-VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,172,591
Number of Sequences: 369166
Number of extensions: 1967183
Number of successful extensions: 6602
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5305
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5510
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6534486000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)