Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_C07
(597 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 104 1e-22
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 96 5e-20
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 96 9e-20
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 95 1e-19
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 95 2e-19
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 95 2e-19
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 94 3e-19
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 92 8e-19
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 91 2e-18
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 90 4e-18
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 104 bits (260), Expect = 1e-22
Identities = 64/177 (36%), Positives = 89/177 (50%), Gaps = 1/177 (0%)
Frame = +3
Query: 12 LYRMYGVEKIFQVTKTIIHPSYRHEYAYLE-GNDVALIKFDGYISKNQYDYIDYNELDVN 188
L R+ E++ +V +I HP YR +L +D+ L++ + YI L N
Sbjct: 91 LGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLT--GYIQTLPLSHN 148
Query: 189 AISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSG 368
PG C V GWG+ P + + LQ A I + S+ EC +++ + +CAG+
Sbjct: 149 NRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLCAGTK 207
Query: 369 RLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 539
SC GDSGGPL C + GIVS+G PCGQP+ P VYTRVS WIR
Sbjct: 208 EGGKDSCEGDSGGPLVC-----NRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 96.3 bits (238), Expect = 5e-20
Identities = 54/164 (32%), Positives = 87/164 (53%)
Frame = +3
Query: 45 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 224
+ TK+ HP Y + ND+ L++ D + + ++ +L + PG C V
Sbjct: 90 KATKSFRHPGYSTK---THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVS 143
Query: 225 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 404
GWG+ P L + + +IS+ EC +++ ++ ++ +CAG T++C GDSG
Sbjct: 144 GWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSG 202
Query: 405 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
GPL C D + G+VS+GT PCGQPN P VYT+V + W+
Sbjct: 203 GPLVCNDTLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 95.5 bits (236), Expect = 9e-20
Identities = 67/187 (35%), Positives = 96/187 (51%), Gaps = 11/187 (5%)
Frame = +3
Query: 9 DLYRMYG-VEKIFQVTKTIIHPSYR-------HEYAYLEGN-DVALIKFDGYISKNQYD- 158
D++R+YG + + ++TK PS R EY EGN D+ALIK ++ ++
Sbjct: 443 DVWRIYGGILSLSEITKET--PSSRIKELIIHQEYKVSEGNYDIALIKLQTPLNYTEFQK 500
Query: 159 -YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVA 335
++ D N I C V GWG G+ T LQKA I ++ N EC + + +
Sbjct: 501 PICLPSKADTNTIYT---NCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDYV 556
Query: 336 YVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRV 515
+ ICAG T +C+GDSGGPL C + + VGI S+G CG+ + P VYT+V
Sbjct: 557 INKQMICAGYKEGGTDACKGDSGGPLVCKHSGRWQL-VGITSWGE-GCGRKDQPGVYTKV 614
Query: 516 SEVAGWI 536
SE WI
Sbjct: 615 SEYMDWI 621
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 95.1 bits (235), Expect = 1e-19
Identities = 57/169 (33%), Positives = 85/169 (50%)
Frame = +3
Query: 33 EKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDR 212
E+ QV ++I HP Y + +D+ LI+ S N D + +L N K G +
Sbjct: 95 EQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQK 151
Query: 213 CEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCR 392
C + GWG++ P ++ L A + I S ++C R + +CAGS +C+
Sbjct: 152 CIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQ 209
Query: 393 GDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 539
GDSGGPL C DG GI S+G+ PCG+P P VYT++ WI+
Sbjct: 210 GDSGGPLVC-DGMLQ----GITSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 94.7 bits (234), Expect = 2e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +3
Query: 75 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGD--RCEVVGWGSML 242
YRH + Y DVAL++ G + +++ + + ++P D RC + GWGS L
Sbjct: 909 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPARPPDGARCVITGWGS-L 963
Query: 243 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 422
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 964 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1022
Query: 423 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 545
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1023 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +3
Query: 204 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 383
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 384 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 76.3 bits (186), Expect = 6e-14
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +3
Query: 201 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 380
PG +C + GWG + LQKA + ++ S C ++ + R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 381 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC+GDSGGPL C + GIVS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 94.7 bits (234), Expect = 2e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +3
Query: 75 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--GDRCEVVGWGSML 242
YRH + Y DVAL++ G + +++ + + ++P G RC + GWGS L
Sbjct: 905 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPTRPPEGARCVITGWGS-L 959
Query: 243 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 422
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 960 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1018
Query: 423 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 545
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1019 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +3
Query: 204 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 383
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 384 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 71.6 bits (174), Expect = 1e-12
Identities = 37/112 (33%), Positives = 56/112 (50%)
Frame = +3
Query: 201 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 380
P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 381 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC+GDSGGPL C + G+VS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 94.0 bits (232), Expect = 3e-19
Identities = 54/169 (31%), Positives = 83/169 (49%)
Frame = +3
Query: 33 EKIFQVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDR 212
E+ QV ++I HP + +D+ LI+ S N D + EL N K G +
Sbjct: 95 EQEIQVARSIQHPCFNSSNPEDHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQK 151
Query: 213 CEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCR 392
C + GWG++ P ++ L A + I S ++C R + +CAGS +C+
Sbjct: 152 CIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQ 209
Query: 393 GDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 539
GDSGGPL C + GI ++G+ PCG+P P VYT++ WI+
Sbjct: 210 GDSGGPLVCNG-----VLQGITTWGSDPCGKPEKPGVYTKICRYTNWIK 253
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 92.4 bits (228), Expect = 8e-19
Identities = 54/166 (32%), Positives = 85/166 (51%), Gaps = 1/166 (0%)
Frame = +3
Query: 48 VTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVV 224
+ + +I+P Y + ND+A++ + + N DYI L + N + PG C +
Sbjct: 859 IDEIVINPHYNRRR---KDNDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIA 913
Query: 225 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 404
GWG+++ G T+ LQ+A + ++SN C + + ICAG SC+GDSG
Sbjct: 914 GWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSG 972
Query: 405 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 542
GPL C + + + G+ S+G C PN P VY RVS WI++
Sbjct: 973 GPLMCQENNRWFL-AGVTSFG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 90.9 bits (224), Expect = 2e-18
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Frame = +3
Query: 45 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP------- 203
+V + HP Y Y DVAL++ G + +++ V I P
Sbjct: 897 RVARIYKHPFYN---LYTLDYDVALLELAGPVRRSRL---------VRPICLPEPAPRPP 944
Query: 204 -GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 380
G RC + GWGS+ G +R LQKAA+ ++S C R + V +CAG +
Sbjct: 945 DGTRCVITGWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYP-VQISSRMLCAGFPQGGV 1002
Query: 381 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC GD+GGPL C + + G+ S+G CG+P+ P VYTRV+ V GWI
Sbjct: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 80.9 bits (198), Expect = 2e-15
Identities = 50/161 (31%), Positives = 76/161 (47%)
Frame = +3
Query: 54 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 233
+ ++HP Y D+A+++ ++ N+Y L + G +C + GWG
Sbjct: 577 RVVLHPLYNPGILDF---DLAVLELASPLAFNKYIQPVCLPLAIQKFPV-GRKCMISGWG 632
Query: 234 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 413
+ LQKA++ II C ++ N + ICAG SC+GDSGGPL
Sbjct: 633 NTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFLEGKVDSCQGDSGGPL 691
Query: 414 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
C + GIVS+G + C Q P VYTR++ + GWI
Sbjct: 692 ACEEAPGVFYLAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
Score = 71.2 bits (173), Expect = 2e-12
Identities = 38/115 (33%), Positives = 56/115 (48%)
Frame = +3
Query: 192 ISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGR 371
I P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRM-VCAGYLD 377
Query: 372 LSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 536
SC+GDSGGPL C + GIVS+G + C + P VY RV+ + WI
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 90.1 bits (222), Expect = 4e-18
Identities = 58/166 (34%), Positives = 82/166 (49%), Gaps = 1/166 (0%)
Frame = +3
Query: 48 VTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVV 224
V + +I+P Y ND+A++ + + N DYI L + N I PG C +
Sbjct: 908 VDQIVINPHYDRRRKV---NDIAMMHLEFKV--NYTDYIQPICLPEENQIFIPGRTCSIA 962
Query: 225 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 404
GWG T L++A + +ISN +C + S ICAG SC+GDSG
Sbjct: 963 GWGYDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSG 1022
Query: 405 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 542
GPL C + + + VG+ S+G V C PN P VY RVS+ WI +
Sbjct: 1023 GPLMCQENNRWFL-VGVTSFG-VQCALPNHPGVYVRVSQFIEWIHS 1066
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,611,046
Number of Sequences: 369166
Number of extensions: 1481071
Number of successful extensions: 5098
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4346
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4470
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4553075865
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)