Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_K01
(553 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 100 4e-21
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 96 6e-20
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 95 1e-19
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 95 1e-19
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 92 1e-18
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 91 1e-18
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 91 2e-18
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 90 3e-18
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 89 5e-18
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 89 7e-18
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 99.8 bits (247), Expect = 4e-21
Identities = 60/162 (37%), Positives = 81/162 (50%), Gaps = 1/162 (0%)
Frame = +3
Query: 9 TIIHPSYRHEYAYLE-GNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 185
+I HP YR +L +D+ L++ + YI L N PG C V GWG
Sbjct: 106 SIPHPEYRRSPTHLNHDHDIMLLELQSPVQLT--GYIQTLPLSHNNRLTPGTTCRVSGWG 163
Query: 186 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 365
+ P + + LQ A I + S+ EC +++ + +CAG+ SC GDSGGPL
Sbjct: 164 TTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLCAGTKEGGKDSCEGDSGGPL 222
Query: 366 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 491
C + GIVS+G PCGQP+ P VYTRVS WIR
Sbjct: 223 VC-----NRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 95.9 bits (237), Expect = 6e-20
Identities = 54/162 (33%), Positives = 86/162 (53%)
Frame = +3
Query: 3 TKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGW 182
TK+ HP Y + ND+ L++ D + + ++ +L + PG C V GW
Sbjct: 92 TKSFRHPGYSTK---THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVSGW 145
Query: 183 GSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGP 362
G+ P L + + +IS+ EC +++ ++ ++ +CAG T++C GDSGGP
Sbjct: 146 GTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSGGP 204
Query: 363 LFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
L C D + G+VS+GT PCGQPN P VYT+V + W+
Sbjct: 205 LVCNDTLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +3
Query: 27 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGD--RCEVVGWGSML 194
YRH + Y DVAL++ G + +++ + + ++P D RC + GWGS L
Sbjct: 909 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPARPPDGARCVITGWGS-L 963
Query: 195 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 374
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 964 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1022
Query: 375 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 497
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1023 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +3
Query: 156 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 335
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 336 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 76.3 bits (186), Expect = 5e-14
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +3
Query: 153 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 332
PG +C + GWG + LQKA + ++ S C ++ + R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 333 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
SC+GDSGGPL C + GIVS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +3
Query: 27 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--GDRCEVVGWGSML 194
YRH + Y DVAL++ G + +++ + + ++P G RC + GWGS L
Sbjct: 905 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPTRPPEGARCVITGWGS-L 959
Query: 195 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 374
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 960 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1018
Query: 375 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 497
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1019 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +3
Query: 156 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 335
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 336 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 71.6 bits (174), Expect = 1e-12
Identities = 37/112 (33%), Positives = 56/112 (50%)
Frame = +3
Query: 153 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 332
P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 333 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
SC+GDSGGPL C + G+VS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 91.7 bits (226), Expect = 1e-18
Identities = 54/162 (33%), Positives = 83/162 (51%), Gaps = 1/162 (0%)
Frame = +3
Query: 12 IIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGS 188
+I+P Y + ND+A++ + + N DYI L + N + PG C + GWG+
Sbjct: 863 VINPHYNRRR---KDNDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIAGWGT 917
Query: 189 MLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLF 368
++ G T+ LQ+A + ++SN C + + ICAG SC+GDSGGPL
Sbjct: 918 VVYQGT-TANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLM 976
Query: 369 CTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 494
C + + + G+ S+G C PN P VY RVS WI++
Sbjct: 977 CQENNRWFL-AGVTSFG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 91.3 bits (225), Expect = 1e-18
Identities = 61/162 (37%), Positives = 83/162 (51%), Gaps = 3/162 (1%)
Frame = +3
Query: 12 IIHPSYRHEYAYLEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCEVVGW 182
IIH EY EGN D+ALIK ++ ++ ++ D N I C V GW
Sbjct: 470 IIH----QEYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NCWVTGW 522
Query: 183 GSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGP 362
G G+ T LQKA I ++ N EC + + + + ICAG T +C+GDSGGP
Sbjct: 523 GYTKEQGE-TQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGP 581
Query: 363 LFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
L C + + VGI S+G CG+ + P VYT+VSE WI
Sbjct: 582 LVCKHSGRWQL-VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 90.5 bits (223), Expect = 2e-18
Identities = 54/162 (33%), Positives = 81/162 (50%)
Frame = +3
Query: 6 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 185
++I HP Y + +D+ LI+ S N D + +L N K G +C + GWG
Sbjct: 102 QSIQHPCYNNSNPEDHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQKCIISGWG 158
Query: 186 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 365
++ P ++ L A + I S ++C R + +CAGS +C+GDSGGPL
Sbjct: 159 TVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPL 216
Query: 366 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 491
C DG GI S+G+ PCG+P P VYT++ WI+
Sbjct: 217 VC-DGMLQ----GITSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 90.1 bits (222), Expect = 3e-18
Identities = 57/164 (34%), Positives = 82/164 (50%), Gaps = 10/164 (6%)
Frame = +3
Query: 27 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--------GDRCEVV 176
Y+H + Y DVAL++ G + +++ V I P G RC +
Sbjct: 902 YKHPFYNLYTLDYDVALLELAGPVRRSRL---------VRPICLPEPAPRPPDGTRCVIT 952
Query: 177 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 356
GWGS+ G +R LQKAA+ ++S C R + V +CAG + SC GD+G
Sbjct: 953 GWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAG 1010
Query: 357 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
GPL C + + G+ S+G CG+P+ P VYTRV+ V GWI
Sbjct: 1011 GPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 80.9 bits (198), Expect = 2e-15
Identities = 50/161 (31%), Positives = 76/161 (47%)
Frame = +3
Query: 6 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 185
+ ++HP Y D+A+++ ++ N+Y L + G +C + GWG
Sbjct: 577 RVVLHPLYNPGILDF---DLAVLELASPLAFNKYIQPVCLPLAIQKFPV-GRKCMISGWG 632
Query: 186 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 365
+ LQKA++ II C ++ N + ICAG SC+GDSGGPL
Sbjct: 633 NTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFLEGKVDSCQGDSGGPL 691
Query: 366 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
C + GIVS+G + C Q P VYTR++ + GWI
Sbjct: 692 ACEEAPGVFYLAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
Score = 71.2 bits (173), Expect = 2e-12
Identities = 38/115 (33%), Positives = 56/115 (48%)
Frame = +3
Query: 144 ISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGR 323
I P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRM-VCAGYLD 377
Query: 324 LSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 488
SC+GDSGGPL C + GIVS+G + C + P VY RV+ + WI
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 89.4 bits (220), Expect = 5e-18
Identities = 51/162 (31%), Positives = 79/162 (48%)
Frame = +3
Query: 6 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 185
++I HP + +D+ LI+ S N D + EL N K G +C + GWG
Sbjct: 102 RSIQHPCFNSSNPEDHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIISGWG 158
Query: 186 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 365
++ P ++ L A + I S ++C R + +CAGS +C+GDSGGPL
Sbjct: 159 TVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPL 216
Query: 366 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 491
C + GI ++G+ PCG+P P VYT++ WI+
Sbjct: 217 VCNG-----VLQGITTWGSDPCGKPEKPGVYTKICRYTNWIK 253
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 89.0 bits (219), Expect = 7e-18
Identities = 57/162 (35%), Positives = 80/162 (49%), Gaps = 1/162 (0%)
Frame = +3
Query: 12 IIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGS 188
+I+P Y ND+A++ + + N DYI L + N I PG C + GWG
Sbjct: 912 VINPHYDRRRKV---NDIAMMHLEFKV--NYTDYIQPICLPEENQIFIPGRTCSIAGWGY 966
Query: 189 MLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLF 368
T L++A + +ISN +C + S ICAG SC+GDSGGPL
Sbjct: 967 DKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLM 1026
Query: 369 CTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 494
C + + + VG+ S+G V C PN P VY RVS+ WI +
Sbjct: 1027 CQENNRWFL-VGVTSFG-VQCALPNHPGVYVRVSQFIEWIHS 1066
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,276,781
Number of Sequences: 369166
Number of extensions: 1355634
Number of successful extensions: 4753
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4048
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4150
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3882260660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)