Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_L12
(535 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 99 6e-21
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 95 1e-19
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 95 1e-19
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 93 5e-19
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 91 2e-18
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 91 2e-18
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 90 3e-18
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 89 5e-18
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 89 9e-18
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 88 1e-17
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 99.0 bits (245), Expect = 6e-21
Identities = 59/159 (37%), Positives = 79/159 (49%), Gaps = 1/159 (0%)
Frame = +1
Query: 4 HPSYRHEYAYLE-GNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSML 180
HP YR +L +D+ L++ + YI L N PG C V GWG+
Sbjct: 109 HPEYRRSPTHLNHDHDIMLLELQSPVQLT--GYIQTLPLSHNNRLTPGTTCRVSGWGTTT 166
Query: 181 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 360
P + + LQ A I + S+ EC +++ + +CAG+ SC GDSGGPL C
Sbjct: 167 SPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLCAGTKEGGKDSCEGDSGGPLVC- 224
Query: 361 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 477
+ GIVS+G PCGQP+ P VYTRVS WIR
Sbjct: 225 ----NRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +1
Query: 13 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGD--RCEVVGWGSML 180
YRH + Y DVAL++ G + +++ + + ++P D RC + GWGS L
Sbjct: 909 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPARPPDGARCVITGWGS-L 963
Query: 181 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 360
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 964 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1022
Query: 361 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 483
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1023 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 78.6 bits (192), Expect = 9e-15
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +1
Query: 142 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 321
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 322 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 76.3 bits (186), Expect = 4e-14
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +1
Query: 139 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 318
PG +C + GWG + LQKA + ++ S C ++ + R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 319 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + GIVS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +1
Query: 13 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--GDRCEVVGWGSML 180
YRH + Y DVAL++ G + +++ + + ++P G RC + GWGS L
Sbjct: 905 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPTRPPEGARCVITGWGS-L 959
Query: 181 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 360
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 960 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1018
Query: 361 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 483
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1019 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 78.6 bits (192), Expect = 9e-15
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +1
Query: 142 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 321
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 322 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 71.6 bits (174), Expect = 1e-12
Identities = 37/112 (33%), Positives = 56/112 (50%)
Frame = +1
Query: 139 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 318
P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 319 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + G+VS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 92.8 bits (229), Expect = 5e-19
Identities = 52/157 (33%), Positives = 83/157 (52%)
Frame = +1
Query: 4 HPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLP 183
HP Y + ND+ L++ D + + ++ +L + PG C V GWG+
Sbjct: 97 HPGYSTK---THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVSGWGTTTS 150
Query: 184 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 363
P L + + +IS+ EC +++ ++ ++ +CAG T++C GDSGGPL C D
Sbjct: 151 PDVTFPSDLMCSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSGGPLVCND 209
Query: 364 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
+ G+VS+GT PCGQPN P VYT+V + W+
Sbjct: 210 TLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 90.9 bits (224), Expect = 2e-18
Identities = 58/154 (37%), Positives = 80/154 (51%), Gaps = 3/154 (1%)
Frame = +1
Query: 22 EYAYLEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRCEVVGWGSMLPPGQ 192
EY EGN D+ALIK ++ ++ ++ D N I C V GWG G+
Sbjct: 474 EYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NCWVTGWGYTKEQGE 530
Query: 193 DTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRK 372
T LQKA I ++ N EC + + + + ICAG T +C+GDSGGPL C +
Sbjct: 531 -TQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGR 589
Query: 373 HHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
+ VGI S+G CG+ + P VYT+VSE WI
Sbjct: 590 WQL-VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 90.5 bits (223), Expect = 2e-18
Identities = 54/161 (33%), Positives = 82/161 (50%), Gaps = 1/161 (0%)
Frame = +1
Query: 1 IHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSM 177
I+P Y + ND+A++ + + N DYI L + N + PG C + GWG++
Sbjct: 864 INPHYNRRR---KDNDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIAGWGTV 918
Query: 178 LPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFC 357
+ G T+ LQ+A + ++SN C + + ICAG SC+GDSGGPL C
Sbjct: 919 VYQGT-TANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMC 977
Query: 358 TDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 480
+ + + G+ S+G C PN P VY RVS WI++
Sbjct: 978 QENNRWFL-AGVTSFG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 90.1 bits (222), Expect = 3e-18
Identities = 57/164 (34%), Positives = 82/164 (50%), Gaps = 10/164 (6%)
Frame = +1
Query: 13 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--------GDRCEVV 162
Y+H + Y DVAL++ G + +++ V I P G RC +
Sbjct: 902 YKHPFYNLYTLDYDVALLELAGPVRRSRL---------VRPICLPEPAPRPPDGTRCVIT 952
Query: 163 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 342
GWGS+ G +R LQKAA+ ++S C R + V +CAG + SC GD+G
Sbjct: 953 GWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAG 1010
Query: 343 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
GPL C + + G+ S+G CG+P+ P VYTRV+ V GWI
Sbjct: 1011 GPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 80.5 bits (197), Expect = 2e-15
Identities = 42/111 (37%), Positives = 57/111 (51%)
Frame = +1
Query: 142 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 321
G +C + GWG+ LQKA++ II C ++ N + ICAG
Sbjct: 623 GRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFLEGKVD 681
Query: 322 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + GIVS+G + C Q P VYTR++ + GWI
Sbjct: 682 SCQGDSGGPLACEEAPGVFYLAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
Score = 71.2 bits (173), Expect = 1e-12
Identities = 38/115 (33%), Positives = 56/115 (48%)
Frame = +1
Query: 130 ISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGR 309
I P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRM-VCAGYLD 377
Query: 310 LSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 474
SC+GDSGGPL C + GIVS+G + C + P VY RV+ + WI
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 89.4 bits (220), Expect = 5e-18
Identities = 53/158 (33%), Positives = 78/158 (49%)
Frame = +1
Query: 4 HPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLP 183
HP Y + +D+ LI+ S N D + +L N K G +C + GWG++
Sbjct: 106 HPCYNNSNPEDHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQKCIISGWGTVTS 162
Query: 184 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 363
P ++ L A + I S ++C R + +CAGS +C+GDSGGPL C D
Sbjct: 163 PQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVC-D 219
Query: 364 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 477
G GI S+G+ PCG+P P VYT++ WI+
Sbjct: 220 GMLQ----GITSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 88.6 bits (218), Expect = 9e-18
Identities = 54/147 (36%), Positives = 75/147 (51%), Gaps = 1/147 (0%)
Frame = +1
Query: 43 NDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVVGWGSMLPPGQDTSRFLQKA 219
ND+A++ + + N DYI L + N I PG C + GWG T L++A
Sbjct: 924 NDIAMMHLEFKV--NYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAGSTVDVLKEA 981
Query: 220 AINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTDGRKHHIQVGIVS 399
+ +ISN +C + S ICAG SC+GDSGGPL C + + + VG+ S
Sbjct: 982 DVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL-VGVTS 1040
Query: 400 YGTVPCGQPNVPSVYTRVSEVAGWIRA 480
+G V C PN P VY RVS+ WI +
Sbjct: 1041 FG-VQCALPNHPGVYVRVSQFIEWIHS 1066
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 87.8 bits (216), Expect = 1e-17
Identities = 50/158 (31%), Positives = 76/158 (48%)
Frame = +1
Query: 4 HPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWGSMLP 183
HP + +D+ LI+ S N D + EL N K G +C + GWG++
Sbjct: 106 HPCFNSSNPEDHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIISGWGTVTS 162
Query: 184 PGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCTD 363
P ++ L A + I S ++C R + +CAGS +C+GDSGGPL C
Sbjct: 163 PQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSGGPLVCNG 220
Query: 364 GRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 477
+ GI ++G+ PCG+P P VYT++ WI+
Sbjct: 221 -----VLQGITTWGSDPCGKPEKPGVYTKICRYTNWIK 253
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,674,623
Number of Sequences: 369166
Number of extensions: 1331523
Number of successful extensions: 4655
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3948
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4056
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3650218350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)