Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_B18
(557 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 101 1e-21
sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneu... 96 5e-20
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 95 1e-19
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 95 1e-19
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 94 2e-19
sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) ... 93 5e-19
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 92 7e-19
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 92 7e-19
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 91 2e-18
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 90 3e-18
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 101 bits (252), Expect = 1e-21
Identities = 61/166 (36%), Positives = 83/166 (50%), Gaps = 1/166 (0%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLE-GNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEV 181
+V +I HP YR +L +D+ L++ + YI L N PG C V
Sbjct: 102 EVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLT--GYIQTLPLSHNNRLTPGTTCRV 159
Query: 182 VGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDS 361
GWG+ P + + LQ A I + S+ EC +++ + +CAG+ SC GDS
Sbjct: 160 SGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLCAGTKEGGKDSCEGDS 218
Query: 362 GGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 499
GGPL C + GIVS+G PCGQP+ P VYTRVS WIR
Sbjct: 219 GGPLVC-----NRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIR 259
>sp|Q91VE3|KLK7_MOUSE Kallikrein-7 precursor (Stratum corneum chymotryptic enzyme)
(Thymopsin)
Length = 249
Score = 96.3 bits (238), Expect = 5e-20
Identities = 54/164 (32%), Positives = 87/164 (53%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 184
+ TK+ HP Y + ND+ L++ D + + ++ +L + PG C V
Sbjct: 90 KATKSFRHPGYSTK---THVNDIMLVRLDEPVKMSSK--VEAVQLPEHC-EPPGTSCTVS 143
Query: 185 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 364
GWG+ P L + + +IS+ EC +++ ++ ++ +CAG T++C GDSG
Sbjct: 144 GWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLG-KTMLCAGIPDSKTNTCNGDSG 202
Query: 365 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
GPL C D + G+VS+GT PCGQPN P VYT+V + W+
Sbjct: 203 GPLVCNDTLQ-----GLVSWGTYPCGQPNDPGVYTQVCKYKRWV 241
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +2
Query: 35 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGD--RCEVVGWGSML 202
YRH + Y DVAL++ G + +++ + + ++P D RC + GWGS L
Sbjct: 909 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPARPPDGARCVITGWGS-L 963
Query: 203 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 382
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 964 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1022
Query: 383 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 505
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1023 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +2
Query: 164 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 343
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 344 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 76.3 bits (186), Expect = 5e-14
Identities = 40/112 (35%), Positives = 57/112 (50%)
Frame = +2
Query: 161 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 340
PG +C + GWG + LQKA + ++ S C ++ + R +CAG
Sbjct: 324 PGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 341 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC+GDSGGPL C + GIVS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 94.7 bits (234), Expect = 1e-19
Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 4/161 (2%)
Frame = +2
Query: 35 YRHEY--AYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP--GDRCEVVGWGSML 202
YRH + Y DVAL++ G + +++ + + ++P G RC + GWGS L
Sbjct: 905 YRHPFYNIYTLDYDVALLELAGPVRRSRL----VRPICLPGPTRPPEGARCVITGWGS-L 959
Query: 203 PPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPLFCT 382
G +R LQKAA+ ++S C R + V +CAG + SC GD+GGPL C
Sbjct: 960 REGGSMARQLQKAAVRVLSEQTCRRFYP-VQISSRMLCAGFPQGGVDSCSGDAGGPLACR 1018
Query: 383 DGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRAN 505
+ + G+ S+G CG+P+ P VYTRV+ V GWI N
Sbjct: 1019 EPSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 78.6 bits (192), Expect = 1e-14
Identities = 41/111 (36%), Positives = 57/111 (51%)
Frame = +2
Query: 164 GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTS 343
G +C + GWG+M LQKA++ II CG ++ N + +CAG
Sbjct: 625 GRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALY-NFSLTDRMLCAGFLEGRVD 683
Query: 344 SCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC+GDSGGPL C + GIVS+G + C Q P VY R++ + WI
Sbjct: 684 SCQGDSGGPLACEETPGVFYLAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
Score = 71.6 bits (174), Expect = 1e-12
Identities = 37/112 (33%), Positives = 56/112 (50%)
Frame = +2
Query: 161 PGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 340
P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 324 PRKKCLISGWGYLKEDFLVKPEVLQKATVELLDQNLCSSLYGHSLTDRM-VCAGYLDGKV 382
Query: 341 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC+GDSGGPL C + G+VS+G + C + P VYTRV+ + WI
Sbjct: 383 DSCQGDSGGPLVCEEPSGRFFLAGVVSWG-IGCAEARRPGVYTRVTRLRDWI 433
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 94.0 bits (232), Expect = 2e-19
Identities = 56/165 (33%), Positives = 83/165 (50%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 184
QV ++I HP Y + +D+ LI+ S N D + +L N K G +C +
Sbjct: 99 QVAQSIQHPCYNNSNPEDHSHDIMLIRLQN--SANLGDKVKPVQL-ANLCPKVGQKCIIS 155
Query: 185 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 364
GWG++ P ++ L A + I S ++C R + +CAGS +C+GDSG
Sbjct: 156 GWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSG 213
Query: 365 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 499
GPL C DG GI S+G+ PCG+P P VYT++ WI+
Sbjct: 214 GPLVC-DGMLQ----GITSWGSDPCGKPEKPGVYTKICRYTTWIK 253
>sp|O88780|NRPN_RAT Neuropsin precursor (NP) (Kallikrein-8) (Brain serine protease 1)
Length = 260
Score = 92.8 bits (229), Expect = 5e-19
Identities = 53/165 (32%), Positives = 81/165 (49%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVV 184
QV ++I HP + +D+ LI+ S N D + EL N K G +C +
Sbjct: 99 QVARSIQHPCFNSSNPEDHSHDIMLIRLQN--SANLGDKVKPIEL-ANLCPKVGQKCIIS 155
Query: 185 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 364
GWG++ P ++ L A + I S ++C R + +CAGS +C+GDSG
Sbjct: 156 GWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-KITEGMVCAGSSN-GADTCQGDSG 213
Query: 365 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIR 499
GPL C + GI ++G+ PCG+P P VYT++ WI+
Sbjct: 214 GPLVCNG-----VLQGITTWGSDPCGKPEKPGVYTKICRYTNWIK 253
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 92.4 bits (228), Expect = 7e-19
Identities = 54/166 (32%), Positives = 85/166 (51%), Gaps = 1/166 (0%)
Frame = +2
Query: 8 VTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVV 184
+ + +I+P Y + ND+A++ + + N DYI L + N + PG C +
Sbjct: 859 IDEIVINPHYNRRR---KDNDIAMMHLEFKV--NYTDYIQPICLPEENQVFPPGRNCSIA 913
Query: 185 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 364
GWG+++ G T+ LQ+A + ++SN C + + ICAG SC+GDSG
Sbjct: 914 GWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSG 972
Query: 365 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 502
GPL C + + + G+ S+G C PN P VY RVS WI++
Sbjct: 973 GPLMCQENNRWFL-AGVTSFG-YKCALPNRPGVYARVSRFTEWIQS 1016
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 92.4 bits (228), Expect = 7e-19
Identities = 61/167 (36%), Positives = 86/167 (51%), Gaps = 3/167 (1%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLEGN-DVALIKFDGYISKNQYD--YIDYNELDVNAISKPGDRC 175
++ + IIH EY EGN D+ALIK ++ ++ ++ D N I C
Sbjct: 465 RIKELIIH----QEYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYT---NC 517
Query: 176 EVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRG 355
V GWG G+ T LQKA I ++ N EC + + + + ICAG T +C+G
Sbjct: 518 WVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKG 576
Query: 356 DSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
DSGGPL C + + VGI S+G CG+ + P VYT+VSE WI
Sbjct: 577 DSGGPLVCKHSGRWQL-VGITSWGE-GCGRKDQPGVYTKVSEYMDWI 621
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 90.9 bits (224), Expect = 2e-18
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Frame = +2
Query: 5 QVTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKP------- 163
+V + HP Y Y DVAL++ G + +++ V I P
Sbjct: 897 RVARIYKHPFYN---LYTLDYDVALLELAGPVRRSRL---------VRPICLPEPAPRPP 944
Query: 164 -GDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLST 340
G RC + GWGS+ G +R LQKAA+ ++S C R + V +CAG +
Sbjct: 945 DGTRCVITGWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYP-VQISSRMLCAGFPQGGV 1002
Query: 341 SSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC GD+GGPL C + + G+ S+G CG+P+ P VYTRV+ V GWI
Sbjct: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWI 1053
Score = 80.9 bits (198), Expect = 2e-15
Identities = 50/161 (31%), Positives = 76/161 (47%)
Frame = +2
Query: 14 KTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNELDVNAISKPGDRCEVVGWG 193
+ ++HP Y D+A+++ ++ N+Y L + G +C + GWG
Sbjct: 577 RVVLHPLYNPGILDF---DLAVLELASPLAFNKYIQPVCLPLAIQKFPV-GRKCMISGWG 632
Query: 194 SMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSGGPL 373
+ LQKA++ II C ++ N + ICAG SC+GDSGGPL
Sbjct: 633 NTQEGNATKPELLQKASVGIIDQKTCSVLY-NFSLTDRMICAGFLEGKVDSCQGDSGGPL 691
Query: 374 FCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
C + GIVS+G + C Q P VYTR++ + GWI
Sbjct: 692 ACEEAPGVFYLAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
Score = 71.2 bits (173), Expect = 2e-12
Identities = 38/115 (33%), Positives = 56/115 (48%)
Frame = +2
Query: 152 ISKPGDRCEVVGWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGR 331
I P +C + GWG + LQKA + ++ + C ++ + R +CAG
Sbjct: 319 IFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRM-VCAGYLD 377
Query: 332 LSTSSCRGDSGGPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWI 496
SC+GDSGGPL C + GIVS+G + C + P VY RV+ + WI
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 90.1 bits (222), Expect = 3e-18
Identities = 58/166 (34%), Positives = 82/166 (49%), Gaps = 1/166 (0%)
Frame = +2
Query: 8 VTKTIIHPSYRHEYAYLEGNDVALIKFDGYISKNQYDYIDYNEL-DVNAISKPGDRCEVV 184
V + +I+P Y ND+A++ + + N DYI L + N I PG C +
Sbjct: 908 VDQIVINPHYDRRRKV---NDIAMMHLEFKV--NYTDYIQPICLPEENQIFIPGRTCSIA 962
Query: 185 GWGSMLPPGQDTSRFLQKAAINIISNSECGRIFSNVAYVRSNICAGSGRLSTSSCRGDSG 364
GWG T L++A + +ISN +C + S ICAG SC+GDSG
Sbjct: 963 GWGYDKINAGSTVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSG 1022
Query: 365 GPLFCTDGRKHHIQVGIVSYGTVPCGQPNVPSVYTRVSEVAGWIRA 502
GPL C + + + VG+ S+G V C PN P VY RVS+ WI +
Sbjct: 1023 GPLMCQENNRWFL-VGVTSFG-VQCALPNHPGVYVRVSQFIEWIHS 1066
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,618,400
Number of Sequences: 369166
Number of extensions: 1360933
Number of successful extensions: 4742
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4031
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4140
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)