DrC_00602
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00602 (2193 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 688 0.0 sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 686 0.0 sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 683 0.0 sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 615 e-175 sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 456 e-127 sp|Q7NCB3|HUTH_GLOVI Histidine ammonia-lyase (Histidase) 449 e-125 sp|Q93TX3|HUTH_STIAU Histidine ammonia-lyase (Histidase) 436 e-121 sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 428 e-119 sp|Q891Q1|HUTH_CLOTE Histidine ammonia-lyase (Histidase) 421 e-117 sp|Q8RFC2|HUTH1_FUSNN Histidine ammonia-lyase 1 (Histidase 1) 418 e-116
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) Length = 657 Score = 688 bits (1776), Expect = 0.0 Identities = 337/527 (63%), Positives = 423/527 (80%) Frame = +2 Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427 +DG +T EDLV LG G Y IKL+ + +V KSR ++D I+ E VVYGITTGFGKF+ Sbjct: 116 LDGDRLTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFAR 175 Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607 +I ++ ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+ Sbjct: 176 TVIPINKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235 Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSPL 787 FN +P++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A GL P+ Sbjct: 236 MFNASCLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPV 295 Query: 788 KLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHEV 967 LK KEGL LINGTQ ITS+G EA+ RAS IARQAD++AALTLEVLKGTT+AFDT IH + Sbjct: 296 ILKPKEGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHAL 355 Query: 968 RPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVR 1147 RPH GQ++VA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ Sbjct: 356 RPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVK 415 Query: 1148 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 1327 +ITTE+NS+TDNP+VF + G +S GNFHGEYPAKALD+LAIGIHELA++SERRIERL Sbjct: 416 NIITTELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLC 475 Query: 1328 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 1507 NP+ S LPAFLV +GG+NSGFM+AH TAAALVSENK L HPSSVDSL+TSA EDHVSMG Sbjct: 476 NPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMG 535 Query: 1508 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 1687 +AARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRF Sbjct: 536 GWAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRF 595 Query: 1688 MAPDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 1828 MAPDIE L ++W V P+IE + +P+ SPT SL+ Sbjct: 596 MAPDIEAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) Length = 657 Score = 686 bits (1770), Expect = 0.0 Identities = 339/527 (64%), Positives = 422/527 (80%) Frame = +2 Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427 +DG S++ EDLV LG G Y IKL+ + KV +SR ++D I+ E VVYGITTGFGKF+ Sbjct: 116 LDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFAR 175 Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607 +I + ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+ Sbjct: 176 TVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235 Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSPL 787 AFN + ++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A GL P+ Sbjct: 236 AFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPI 295 Query: 788 KLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHEV 967 LK KEGL LINGTQ ITS+G EAL RAS IARQAD++AALTLEVLKGTT+AFDT IH V Sbjct: 296 VLKPKEGLALINGTQMITSLGCEALERASAIARQADIVAALTLEVLKGTTKAFDTDIHAV 355 Query: 968 RPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVR 1147 RPH GQ++VA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ Sbjct: 356 RPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVK 415 Query: 1148 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 1327 +ITTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL Sbjct: 416 DIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLC 475 Query: 1328 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 1507 NP+ S LPAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG Sbjct: 476 NPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMG 535 Query: 1508 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 1687 +AARKAL VV +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRF Sbjct: 536 GWAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRF 595 Query: 1688 MAPDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 1828 MAPDIE L ++W V P+IE + +P+ SPT SL+ Sbjct: 596 MAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) Length = 657 Score = 683 bits (1762), Expect = 0.0 Identities = 336/527 (63%), Positives = 421/527 (79%) Frame = +2 Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427 +DG S++ EDLV LG G Y IKL+ + KV +SR ++D I+ E VVYGITTGFGKF+ Sbjct: 116 LDGDSLSTEDLVNLGKGHYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFAR 175 Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607 +I + ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+ Sbjct: 176 TVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235 Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSPL 787 FN + ++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A GL P+ Sbjct: 236 VFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPI 295 Query: 788 KLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHEV 967 LK KEGL LINGTQ ITS+G EA+ RAS IARQAD++AALTLEVLKGTT+AFDT IH V Sbjct: 296 VLKPKEGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHAV 355 Query: 968 RPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVR 1147 RPH GQ++VA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ Sbjct: 356 RPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVK 415 Query: 1148 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 1327 +ITTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL Sbjct: 416 DIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLC 475 Query: 1328 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 1507 NP+ S LPAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG Sbjct: 476 NPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMG 535 Query: 1508 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 1687 +AARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRF Sbjct: 536 GWAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRF 595 Query: 1688 MAPDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 1828 MAPDIE L ++W V P+IE + +P+ SPT SL+ Sbjct: 596 MAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase) Length = 677 Score = 615 bits (1587), Expect = e-175 Identities = 309/514 (60%), Positives = 389/514 (75%) Frame = +2 Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415 ++ I+DG S+ PEDLV G I+LS +S +++ K+R +++I SE+R VYG+TTGFG Sbjct: 128 KLLILDGNSLLPEDLVRCEKGECAIQLSMESEDRIRKARTFLEKIASEHRAVYGVTTGFG 187 Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595 FS+V I +++LQ +LIRSH+ G G P++ +ARM+LALRIN LAKG+SGI++E + Sbjct: 188 TFSNVTIPPEKLKKLQLNLIRSHATGYGEPLAPNRARMLLALRINILAKGHSGISVENIK 247 Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACG 775 K+I AFN V ++P +G+VG SGDL PLAHLALGL+GEG++WSP TGW + L Sbjct: 248 KMIAAFNAFCVSYVPQQGTVGCSGDLCPLAHLALGLLGEGKMWSPTTGWQPADVVLKKNN 307 Query: 776 LSPLKLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTV 955 L PL+L KEGL LINGTQ +T++GA L RA NIARQADVIAAL+L+VLKGTTRA+D Sbjct: 308 LEPLELGPKEGLALINGTQMVTALGAYTLERAHNIARQADVIAALSLDVLKGTTRAYDPD 367 Query: 956 IHEVRPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTL 1135 IH +RPH GQ A L+ALLH+ PS+I+ESHR CTKVQDAYTLRC PQVHG+V DT+ Sbjct: 368 IHRIRPHRGQNLSALRLRALLHSEANPSQIAESHRNCTKVQDAYTLRCVPQVHGVVHDTI 427 Query: 1136 DFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRI 1315 +FVR +ITTEMNS+TDNPLVF D IIS GNFHGEYPAKALDFLAI + ELA MSERR+ Sbjct: 428 EFVREIITTEMNSATDNPLVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRL 487 Query: 1316 ERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDH 1495 ERLVN SGLP FL DGG+NSGFM + AA+LVSENKVL HPSSVDS+ TS QEDH Sbjct: 488 ERLVNKELSGLPTFLTPDGGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDH 547 Query: 1496 VSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWD 1675 VSMG FAARKAL VV +VE VLA+ELLA+ Q +EFL+PL ST PL + +L+R+ P + Sbjct: 548 VSMGGFAARKALTVVEHVEAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLN 607 Query: 1676 KDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFES 1777 +DR+M P+I+ V+ ++ IW V P +E E+ Sbjct: 608 EDRYMKPEIDAVLEMIRENRIWEAVLPHLETLEA 641
Score = 35.4 bits (80), Expect = 0.69
Identities = 18/45 (40%), Positives = 27/45 (60%)
Frame = +1
Query: 49 DITAIRRTKNSALLDPEDLVTSVLVAEEYITLDINTNEGNISKGA 183
D +RRT ++LLDPEDLV+ VL ++I + + E +K A
Sbjct: 45 DYFEVRRTVGNSLLDPEDLVSDVLKDSDFIIVAASVEETEDAKEA 89
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) Length = 508 Score = 456 bits (1172), Expect = e-127 Identities = 242/503 (48%), Positives = 335/503 (66%) Frame = +2 Query: 245 IIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFS 424 +IDG ++T ED+V + + + LSE + ++ SR +VD V E +VVYGITTGFGKFS Sbjct: 5 VIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGFGKFS 64 Query: 425 DVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLI 604 DV+I + LQ++LI SHS +G P+ E R ++ LR N LAKG+SG+ +ET+ LI Sbjct: 65 DVVISKEDTEALQKNLIMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETVETLI 124 Query: 605 DAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSP 784 + N VVP IP KGS+GASGDLAPLAH+ L ++G G + + A+ G+ Sbjct: 125 EMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGRGEAFYAGER-VSGEEAMRRAGIPT 183 Query: 785 LKLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHE 964 + L +KEGL LINGTQ ++++G + A I AD +A++TLE L+G AFD + Sbjct: 184 ITLSSKEGLALINGTQVMSALGCLNVYDAKRIIAVADAVASITLEALRGIIDAFDDRVQM 243 Query: 965 VRPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFV 1144 VRPH GQ+ A++++ ++ S+ + E +VQDAYTLRC PQVHG V D + ++ Sbjct: 244 VRPHKGQIVSAKNVRKMVEGSELITRQGE-----IRVQDAYTLRCIPQVHGAVRDAISYI 298 Query: 1145 RGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERL 1324 V+ E+NS+TDNPL+FPD G +IS GNFHGE A A+DFL+I + E+A++SERRIERL Sbjct: 299 ERVLGVEINSATDNPLIFPDDGEVISGGNFHGEPVALAMDFLSIALSEIANISERRIERL 358 Query: 1325 VNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSM 1504 VN + LP FL + GG+NSG M+A TAA+LVSENKVL+HP+SVDS+ +SA QEDHVSM Sbjct: 359 VNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHPASVDSIPSSANQEDHVSM 418 Query: 1505 GAFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDR 1684 G AARKA EV+ NV VLAIELL + QALEF + K + + + RL+R V P +DR Sbjct: 419 GTIAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDR 478 Query: 1685 FMAPDIEHVVNTLKAGEIWNVVE 1753 + DI + +++G I V++ Sbjct: 479 ELYIDINACFDIIRSGRIEEVLK 501
>sp|Q7NCB3|HUTH_GLOVI Histidine ammonia-lyase (Histidase) Length = 514 Score = 449 bits (1156), Expect = e-125 Identities = 249/506 (49%), Positives = 327/506 (64%), Gaps = 3/506 (0%) Frame = +2 Query: 245 IIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFS 424 ++DG S+ +DLVA+ G ++LS S+ V +SRA V+ ++ + +VYGITTGFG F Sbjct: 9 VLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFK 68 Query: 425 DVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLI 604 + I S + +LQ++L+ S +AG+G P E R ML LR NTLA+GYSG+ ETL L+ Sbjct: 69 NRRIPRSAVEQLQQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLV 128 Query: 605 DAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGW--TDSKHALAACGL 778 N GV P +P +GSVGASGDLAPLAHLAL L GEG + G ALA GL Sbjct: 129 AMLNRGVHPVVPCRGSVGASGDLAPLAHLALVLTGEGEA---EVGGEVLPGAAALARAGL 185 Query: 779 SPLKLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVI 958 P++L AKEGL LINGTQ ++++GA + RA +A+ AD+ A+TLE G+ AF Sbjct: 186 EPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSAFLPHF 245 Query: 959 HEVRPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLD 1138 H +RPH GQ AR+L L + S + SH C +VQDAY+LRC PQVHG LD + Sbjct: 246 HRLRPHPGQQSSARNLLVLTED----SALIASHAGCDRVQDAYSLRCAPQVHGASLDAIS 301 Query: 1139 FVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIE 1318 + GVI E+NS TDNPL+F D+G +++ G+FHG+ A A D LAI + ELA +SERR E Sbjct: 302 YAAGVIAIEINSVTDNPLIFADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRTE 361 Query: 1319 RLVNPAYS-GLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDH 1495 RLVN YS GLP FL + GG++SG+M+A TAA+LVSENKVL HP+ VDS+ TSAGQEDH Sbjct: 362 RLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSENKVLAHPACVDSIPTSAGQEDH 421 Query: 1496 VSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWD 1675 VSMG AARKA+ V N E V+AIEL+ + QAL+ L + +IR V + Sbjct: 422 VSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHLE 481 Query: 1676 KDRFMAPDIEHVVNTLKAGEIWNVVE 1753 DR ++ DIE VV + G + VE Sbjct: 482 SDRIVSRDIEKVVELMADGHLLEAVE 507
>sp|Q93TX3|HUTH_STIAU Histidine ammonia-lyase (Histidase) Length = 510 Score = 436 bits (1121), Expect = e-121 Identities = 236/501 (47%), Positives = 335/501 (66%) Frame = +2 Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427 IDG ++ E+++ + T++L+ + +V +R LVD + + + YGI TGFG ++ Sbjct: 8 IDGDTLKLEEILQVARHTVTVELAPAAAARVKAARDLVDRVAAGDTPSYGINTGFGTLAE 67 Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607 V ID ++RELQ +LI SH+AG+G P+ + +AR++L LR N LAKGYSGI ETL+ ++ Sbjct: 68 VRIDKKDLRELQRNLILSHAAGVGSPLPLPEARVLLLLRCNVLAKGYSGIRPETLALALE 127 Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSPL 787 N VVP +P +GSVGASGDLAPLAHLAL +GEG + K + AL GL P+ Sbjct: 128 MLNRDVVPVVPERGSVGASGDLAPLAHLALVFIGEGEAFY-KGERLPAAQALERAGLKPV 186 Query: 788 KLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHEV 967 L+AKEGL L+NGTQ + ++G RA +A AD+ A+TLE L G+ + F I +V Sbjct: 187 VLEAKEGLALVNGTQAMCAVGTLLQLRAEMLADLADLAGAMTLEGLLGSHKPFIPEIQDV 246 Query: 968 RPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVR 1147 R H GQ A HL+ LL +S + ESH C+KVQD Y+LRC PQVHG + L F R Sbjct: 247 RAHEGQKACAAHLRELLADSA----LVESHVNCSKVQDPYSLRCMPQVHGAAREGLSFAR 302 Query: 1148 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 1327 ++ E+NS+TDNPLVF ++ I+S GNFHG+ + ALD A+ + +L+++SERR+E+LV Sbjct: 303 RILEVEINSATDNPLVFVETERIVSGGNFHGQPVSLALDVAAMALTQLSAISERRVEQLV 362 Query: 1328 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 1507 NPA SGLP FL K+ G+NSGFM+A VT+AALV+E++VL+HP+SVDS+ +SAG+EDHVSMG Sbjct: 363 NPALSGLPPFLAKNSGLNSGFMIAQVTSAALVAESRVLSHPASVDSIPSSAGREDHVSMG 422 Query: 1508 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 1687 AA K +V + LAIELL + QAL++ +P ++ + +A LIR+ + +KDR Sbjct: 423 MTAALKGRQVADFTRSCLAIELLVAAQALDYRQPTRAGKGPQAAYELIRSKIPTMEKDRE 482 Query: 1688 MAPDIEHVVNTLKAGEIWNVV 1750 + DI V + +GE+ N V Sbjct: 483 LHRDIAAVSALIDSGELLNAV 503
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) Length = 507 Score = 428 bits (1101), Expect = e-119 Identities = 235/500 (47%), Positives = 317/500 (63%) Frame = +2 Query: 254 GISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSDVI 433 G +T ++VA+ + L+ + +V ++ +V+ +V E R VYGITTGFGKFSDV Sbjct: 7 GAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFGKFSDVP 66 Query: 434 IDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLIDAF 613 I LQ +L+ SH+ +G P++ E R ML LR L++G+SGI ETL L+ Sbjct: 67 ISAEQTEALQRNLLMSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLEMLVAFL 126 Query: 614 NVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSPLKL 793 N+G+ P +P +GS+GASGDLAPLAH++L L+G G + ++ AL GL PL L Sbjct: 127 NLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLGEAVVNGERLSGAE-ALQRVGLRPLTL 185 Query: 794 KAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHEVRP 973 AKEGL LINGTQ +T++G+ L A + + AD+ AA+T E L A+D + +R Sbjct: 186 TAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRVQALRL 245 Query: 974 HSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGV 1153 H+GQ AR+L+ L S+ + + + QD YTLRC PQVHG ++ V V Sbjct: 246 HTGQQAAARNLRRLTEGSRLTTRPGQM-----RTQDPYTLRCLPQVHGASRTAIEHVAQV 300 Query: 1154 ITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNP 1333 + EMN+ TDNPL+FPD +IS GNFHG+ A ALD+LAI + EL ++ERRIERLVNP Sbjct: 301 LDWEMNAVTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNP 360 Query: 1334 AYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAF 1513 SGLPAFL ++GG++SG M+ TAA+LVSENKVL HP+SVDS+ +SA QEDHVSMG Sbjct: 361 QLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTT 420 Query: 1514 AARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMA 1693 AARKA +V++NV VLAIELL + QALEF+ P + A IR V P DR +A Sbjct: 421 AARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA 480 Query: 1694 PDIEHVVNTLKAGEIWNVVE 1753 PDIE + + GE+ VE Sbjct: 481 PDIEALAELVHNGELVAAVE 500
>sp|Q891Q1|HUTH_CLOTE Histidine ammonia-lyase (Histidase) Length = 514 Score = 421 bits (1082), Expect = e-117 Identities = 234/511 (45%), Positives = 326/511 (63%), Gaps = 4/511 (0%) Frame = +2 Query: 245 IIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFS 424 I+ G +T E+LV + Y + LSE++ + V +SR ++D+IV +VVYG+TTGFG+F Sbjct: 8 ILTGNDLTLEELVLVAREGYKVALSEEAKDSVLESRKIIDDIVENEKVVYGVTTGFGEFC 67 Query: 425 DVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLI 604 +V I + + LQE+LIRSH+ G G S + R ++ R N L+KGYSGI I TL+ LI Sbjct: 68 NVSISKEDCKTLQENLIRSHACGYGPKFSTDIVRAIMLTRANALSKGYSGIRIGTLNTLI 127 Query: 605 DAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSP 784 + N GV P I KGS+GASGDLAPLAH+ L ++G G K K A+ G+ Sbjct: 128 EMLNAGVHPQIHEKGSLGASGDLAPLAHMVLPMLGLGEA-EYKGEIMSGKEAMDKAGIPI 186 Query: 785 LKLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIHE 964 ++L AKEGL LINGTQ +T+ GA A+ A + + D+ AALT+E L+G AFD +H Sbjct: 187 IELDAKEGLALINGTQVLTATGALAVYDAIELLKVGDIAAALTIEALRGIKDAFDPRLHV 246 Query: 965 VRPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFV 1144 +R H GQM AR++ L+ S Y + E +VQDAY+LRC PQ+HG DT+DFV Sbjct: 247 IRAHEGQMATARNILKLIEGSTYVTRQGE-----LRVQDAYSLRCVPQIHGASKDTIDFV 301 Query: 1145 RGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERL 1324 + + E+NS TDNP+V + G +IS GNFHGE A+ DFL IG E+A++SERR+ERL Sbjct: 302 KEKVEIEINSVTDNPIVTRE-GDVISGGNFHGEPMAQPFDFLGIGAAEIANVSERRLERL 360 Query: 1325 VNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSM 1504 +N + LPAFL K GG+NSGFM+ AAALVSENKVL HP+SVDS+ +SA QED VSM Sbjct: 361 INHQLNDLPAFLAKHGGLNSGFMITQYAAAALVSENKVLAHPASVDSIPSSANQEDLVSM 420 Query: 1505 GAFAARKALEVVSNVENVLAIELLASVQALEFL--RPLKSTEPLEAVVRLIRTTVK--PW 1672 G AARKA ++V N + VLA EL+A+ QA++F + + + + ++IR + + Sbjct: 421 GTIAARKARDIVDNAKRVLATELMAACQAIDFRADKGFELGKGTKEAYKVIREAIDFIEY 480 Query: 1673 DKDRFMAPDIEHVVNTLKAGEIWNVVEPFIE 1765 D D M +++ + G++ VE +E Sbjct: 481 DTDIQMYKELDKATELITNGKLLEAVEKAVE 511
>sp|Q8RFC2|HUTH1_FUSNN Histidine ammonia-lyase 1 (Histidase 1) Length = 516 Score = 418 bits (1075), Expect = e-116 Identities = 226/513 (44%), Positives = 332/513 (64%), Gaps = 3/513 (0%) Frame = +2 Query: 245 IIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFS 424 ++ ++T EDL+ + Y + +SE++ K++K+RALVD+ V E +V YGITTGFGKF+ Sbjct: 9 VLGSKNITLEDLINVTRKGYKVSISEEAYEKIDKARALVDKYVEEGKVSYGITTGFGKFA 68 Query: 425 DVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLI 604 +V I +LQ++++ SHS +G P+ ++ A+ ++ LR LAKGYSG + KL+ Sbjct: 69 EVSISKEQTGQLQKNIVMSHSCNVGNPLPIDIAKGIVLLRAVNLAKGYSGARRIVIEKLV 128 Query: 605 DAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAACGLSP 784 + N V PWIP KGSVG+SGDL+PLAH++L L+G G+ + K ++K ALA + P Sbjct: 129 ELLNKDVTPWIPEKGSVGSSGDLSPLAHMSLVLIGLGKAYY-KGELLEAKDALAKADIEP 187 Query: 785 L-KLKAKEGLCLINGTQFITSIGAEALSRASNIARQADVIAALTLEVLKGTTRAFDTVIH 961 + L +KEGL L NGTQ +TS GA L A N+++ D+ A+LT+E L G A+D I Sbjct: 188 IPALSSKEGLALTNGTQALTSTGAHVLYDAINLSKHLDIAASLTMEGLHGIIDAYDPRIG 247 Query: 962 EVRPHSGQMKVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDF 1141 EVR H GQ+ A++++ +L SK + + + +VQD+Y LRC PQ+HG DTL++ Sbjct: 248 EVRGHLGQINTAKNMRNILAGSK-----NVTKQGVERVQDSYVLRCIPQIHGASKDTLEY 302 Query: 1142 VRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIER 1321 V+ + E+N+ TDNP++F D+ +IS GNFHG+ A DFL I + E+A++SERRIE+ Sbjct: 303 VKQKVELELNAVTDNPIIFVDTDEVISGGNFHGQPMALPFDFLGIALSEMANVSERRIEK 362 Query: 1322 LVNPAY-SGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHV 1498 +VNPA +GLPAFLV+ GG+NSGFM+ +AA+LVSENKVL HP+SVDS+ TSA QEDHV Sbjct: 363 MVNPAINNGLPAFLVEKGGLNSGFMIVQYSAASLVSENKVLAHPASVDSIPTSANQEDHV 422 Query: 1499 SMGAFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVV-RLIRTTVKPWD 1675 SMG+ AA+K+ ++ NV V+ +EL+ + QA++ P V +R + Sbjct: 423 SMGSVAAKKSKDIFENVRKVIGMELITACQAIDLKEAKDKLSPATKVAYDEVRKIISYVS 482 Query: 1676 KDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFE 1774 +DR M DI + +K +I VE I E Sbjct: 483 EDRPMYIDIHAAEDLIKTNKIVENVEKAIGKLE 515
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 236,850,477
Number of Sequences: 369166
Number of extensions: 4855070
Number of successful extensions: 13437
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 12101
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 13061
length of database: 68,354,980
effective HSP length: 118
effective length of database: 46,556,250
effective search space used: 28492425000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
