Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_F15
(828 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 296 5e-80
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 294 2e-79
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 293 3e-79
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 263 3e-70
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 219 7e-57
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 214 3e-55
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 212 1e-54
sp|Q9RZ06|HUTH_DEIRA Histidine ammonia-lyase (Histidase) 208 2e-53
sp|Q63SH6|HUTH_BURPS Histidine ammonia-lyase (Histidase) 207 3e-53
sp|Q62LJ6|HUTH_BURMA Histidine ammonia-lyase (Histidase) 207 3e-53
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 296 bits (758), Expect = 5e-80
Identities = 148/226 (65%), Positives = 178/226 (78%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
+ITTE+NS+TDNP+VF + G +S GNFHGEYPAKALD+LAIGIHELA++SERRIERL N
Sbjct: 417 IITTELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCN 476
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
P+ S LPAFLV +GG+NSGFM+AH TAAALVSENK L HPSSVDSL+TSA EDHVSMG
Sbjct: 477 PSLSELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGG 536
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
+AARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFM
Sbjct: 537 WAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFM 596
Query: 546 APDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 683
APDIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 597 APDIEAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 294 bits (752), Expect = 2e-79
Identities = 148/226 (65%), Positives = 177/226 (78%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
+ITTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL N
Sbjct: 417 IITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCN 476
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
P+ S LPAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG
Sbjct: 477 PSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGG 536
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
+AARKAL VV +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFM
Sbjct: 537 WAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFM 596
Query: 546 APDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 683
APDIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 597 APDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 293 bits (751), Expect = 3e-79
Identities = 147/226 (65%), Positives = 177/226 (78%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
+ITTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL N
Sbjct: 417 IITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCN 476
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
P+ S LPAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG
Sbjct: 477 PSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGG 536
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
+AARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFM
Sbjct: 537 WAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFM 596
Query: 546 APDIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 683
APDIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 597 APDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 263 bits (673), Expect = 3e-70
Identities = 132/209 (63%), Positives = 159/209 (76%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
+ITTEMNS+TDNPLVF D IIS GNFHGEYPAKALDFLAI + ELA MSERR+ERLVN
Sbjct: 433 IITTEMNSATDNPLVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRLERLVN 492
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
SGLP FL DGG+NSGFM + AA+LVSENKVL HPSSVDS+ TS QEDHVSMG
Sbjct: 493 KELSGLPTFLTPDGGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGG 552
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
FAARKAL VV +VE VLA+ELLA+ Q +EFL+PL ST PL + +L+R+ P ++DR+M
Sbjct: 553 FAARKALTVVEHVEAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYM 612
Query: 546 APDIEHVVNTLKAGEIWNVVEPFIENFES 632
P+I+ V+ ++ IW V P +E E+
Sbjct: 613 KPEIDAVLEMIRENRIWEAVLPHLETLEA 641
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 219 bits (558), Expect = 7e-57
Identities = 114/201 (56%), Positives = 142/201 (70%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
V+ EMN+ TDNPL+FPD +IS GNFHG+ A ALD+LAI + EL ++ERRIERLVN
Sbjct: 300 VLDWEMNAVTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVN 359
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
P SGLPAFL ++GG++SG M+ TAA+LVSENKVL HP+SVDS+ +SA QEDHVSMG
Sbjct: 360 PQLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGT 419
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
AARKA +V++NV VLAIELL + QALEF+ P + A IR V P DR +
Sbjct: 420 TAARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVL 479
Query: 546 APDIEHVVNTLKAGEIWNVVE 608
APDIE + + GE+ VE
Sbjct: 480 APDIEALAELVHNGELVAAVE 500
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 214 bits (544), Expect = 3e-55
Identities = 111/201 (55%), Positives = 146/201 (72%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
V+ E+NS+TDNPL+FPD G +IS GNFHGE A A+DFL+I + E+A++SERRIERLVN
Sbjct: 301 VLGVEINSATDNPLIFPDDGEVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVN 360
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
+ LP FL + GG+NSG M+A TAA+LVSENKVL+HP+SVDS+ +SA QEDHVSMG
Sbjct: 361 YQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHPASVDSIPSSANQEDHVSMGT 420
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
AARKA EV+ NV VLAIELL + QALEF + K + + + RL+R V P +DR +
Sbjct: 421 IAARKAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDREL 480
Query: 546 APDIEHVVNTLKAGEIWNVVE 608
DI + +++G I V++
Sbjct: 481 YIDINACFDIIRSGRIEEVLK 501
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 212 bits (539), Expect = 1e-54
Identities = 108/194 (55%), Positives = 140/194 (72%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
V+ E N+ +DNPLVFPDSG ++S GNFHGE A A D LA+ E+ +++ERRI L++
Sbjct: 302 VLLIEANAVSDNPLVFPDSGEVLSGGNFHGEPVAFAADALALAAAEIGALAERRIALLID 361
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
SGLP FLV +GG+NSGFM+AHVTAAAL SENK+L HP+SVDSL TSA QEDHVSM
Sbjct: 362 ATLSGLPPFLVTEGGVNSGFMIAHVTAAALASENKLLAHPASVDSLPTSANQEDHVSMST 421
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
FAARK E+ N +LAIELLA+ Q +E P +++ L+AV+ LIR+ V +D DR+
Sbjct: 422 FAARKLGELADNTATILAIELLAAAQGVELRAPHRTSPRLQAVLALIRSRVPHYDIDRYF 481
Query: 546 APDIEHVVNTLKAG 587
APDI + + + AG
Sbjct: 482 APDIASIKDEVSAG 495
>sp|Q9RZ06|HUTH_DEIRA Histidine ammonia-lyase (Histidase)
Length = 524
Score = 208 bits (529), Expect = 2e-53
Identities = 111/225 (49%), Positives = 153/225 (68%), Gaps = 1/225 (0%)
Frame = +3
Query: 6 VITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVN 185
V+ E S TDNPL+FP++G ++S GNFHG+ A +D L + + EL S+SERR E+L+N
Sbjct: 299 VLAVEFASVTDNPLIFPETGEVVSGGNFHGQPLAVTIDALKVAVAELGSISERRTEQLLN 358
Query: 186 PAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGA 365
PA SGLPAFL +GG+NSGFM+A T+AALVSENKVL+HP+SVDS+ TSA QEDHVSMGA
Sbjct: 359 PALSGLPAFLTPNGGLNSGFMIAQYTSAALVSENKVLSHPASVDSIPTSANQEDHVSMGA 418
Query: 366 FAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFM 545
AAR+ ++V+NV+ VL+IELL + Q L+F + L++ ++A +RT V +DR+
Sbjct: 419 HAARQLRQIVANVQTVLSIELLCAAQGLDF-QQLRAGRGVQAAYEYVRTFVPTLTEDRYF 477
Query: 546 APDIEHVVNTLKAGEIWNVVEPFIENFES-YKLPDLWISSPTTTS 677
PD+ + L +GE+ V + + KLPD TTS
Sbjct: 478 RPDLLRLRGELVSGELLRVAQAADTQAPAPAKLPDSGDEDRDTTS 522
>sp|Q63SH6|HUTH_BURPS Histidine ammonia-lyase (Histidase)
Length = 507
Score = 207 bits (527), Expect = 3e-53
Identities = 104/193 (53%), Positives = 135/193 (69%)
Frame = +3
Query: 3 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 182
GV+ E N+ +DNPL+FPD+G ++S GNFH E A A D LAI E+ +++ERRI L+
Sbjct: 299 GVLLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLI 358
Query: 183 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 362
+ SGLP FLVKDGG+NSGFM+AHVTAAAL SENK L HP+SVDSL TSA QEDHVSM
Sbjct: 359 DATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMA 418
Query: 363 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 542
FAARK ++ NV N+LAIELLA+ Q ++ P ++ L+ ++ IR V +D D +
Sbjct: 419 TFAARKLADIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHY 478
Query: 543 MAPDIEHVVNTLK 581
APDI V ++
Sbjct: 479 FAPDIAVVARRVR 491
>sp|Q62LJ6|HUTH_BURMA Histidine ammonia-lyase (Histidase)
Length = 507
Score = 207 bits (527), Expect = 3e-53
Identities = 104/193 (53%), Positives = 135/193 (69%)
Frame = +3
Query: 3 GVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLV 182
GV+ E N+ +DNPL+FPD+G ++S GNFH E A A D LAI E+ +++ERRI L+
Sbjct: 299 GVLLIEANAVSDNPLIFPDTGEVLSGGNFHAEPVAFAADNLAIAAAEIGALAERRIALLI 358
Query: 183 NPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMG 362
+ SGLP FLVKDGG+NSGFM+AHVTAAAL SENK L HP+SVDSL TSA QEDHVSM
Sbjct: 359 DATLSGLPPFLVKDGGVNSGFMIAHVTAAALASENKTLAHPASVDSLPTSANQEDHVSMA 418
Query: 363 AFAARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRF 542
FAARK ++ NV N+LAIELLA+ Q ++ P ++ L+ ++ IR V +D D +
Sbjct: 419 TFAARKLTDIAENVANILAIELLAAAQGVDLRAPHATSPALQHAMKTIRADVAHYDLDHY 478
Query: 543 MAPDIEHVVNTLK 581
APDI V ++
Sbjct: 479 FAPDIAVVARRVR 491
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,155,626
Number of Sequences: 369166
Number of extensions: 1853369
Number of successful extensions: 5167
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4924
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5094
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)