Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_B16
(775 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 347 3e-95
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 344 2e-94
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 343 2e-94
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 313 3e-85
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 249 4e-66
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 246 6e-65
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 239 5e-63
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 238 2e-62
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 238 2e-62
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 237 2e-62
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 347 bits (889), Expect = 3e-95
Identities = 170/256 (66%), Positives = 204/256 (79%)
Frame = +3
Query: 3 FCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHG 182
FC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF + G +S GNFHG
Sbjct: 387 FCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTELNSATDNPMVFANRGETVSGGNFHG 446
Query: 183 EYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAAL 362
EYPAKALD+LAIGIHELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TAAAL
Sbjct: 447 EYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAAL 506
Query: 363 VSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEF 542
VSENK L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+ Q +EF
Sbjct: 507 VSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEF 566
Query: 543 LRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFESY 722
LRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 567 LRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLEQKVWEVAAPYIEKYRME 626
Query: 723 KLPDLWISSPTTTSLK 770
+P+ SPT SL+
Sbjct: 627 HIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 344 bits (882), Expect = 2e-94
Identities = 170/256 (66%), Positives = 203/256 (79%)
Frame = +3
Query: 3 FCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHG 182
FC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF G IS GNFHG
Sbjct: 387 FCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHG 446
Query: 183 EYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAAL 362
EYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TAAAL
Sbjct: 447 EYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAAL 506
Query: 363 VSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEF 542
VSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL VV +VE VLAIELLA+ Q +EF
Sbjct: 507 VSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEF 566
Query: 543 LRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFESY 722
LRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 567 LRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRME 626
Query: 723 KLPDLWISSPTTTSLK 770
+P+ SPT SL+
Sbjct: 627 HIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 343 bits (881), Expect = 2e-94
Identities = 169/256 (66%), Positives = 203/256 (79%)
Frame = +3
Query: 3 FCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHG 182
FC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF G IS GNFHG
Sbjct: 387 FCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHG 446
Query: 183 EYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAAL 362
EYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TAAAL
Sbjct: 447 EYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAAL 506
Query: 363 VSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEF 542
VSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+ Q +EF
Sbjct: 507 VSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEF 566
Query: 543 LRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFESY 722
LRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 567 LRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRME 626
Query: 723 KLPDLWISSPTTTSLK 770
+P+ SPT SL+
Sbjct: 627 HIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 313 bits (802), Expect = 3e-85
Identities = 155/238 (65%), Positives = 185/238 (77%)
Frame = +3
Query: 6 CTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGE 185
CTKVQDAYTLRC PQVHG+V DT++FVR +ITTEMNS+TDNPLVF D IIS GNFHGE
Sbjct: 404 CTKVQDAYTLRCVPQVHGVVHDTIEFVREIITTEMNSATDNPLVFADREEIISGGNFHGE 463
Query: 186 YPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALV 365
YPAKALDFLAI + ELA MSERR+ERLVN SGLP FL DGG+NSGFM + AA+LV
Sbjct: 464 YPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPTFLTPDGGLNSGFMTVQLCAASLV 523
Query: 366 SENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFL 545
SENKVL HPSSVDS+ TS QEDHVSMG FAARKAL VV +VE VLA+ELLA+ Q +EFL
Sbjct: 524 SENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALTVVEHVEAVLAMELLAACQGIEFL 583
Query: 546 RPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENFES 719
+PL ST PL + +L+R+ P ++DR+M P+I+ V+ ++ IW V P +E E+
Sbjct: 584 KPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVLEMIRENRIWEAVLPHLETLEA 641
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 249 bits (637), Expect = 4e-66
Identities = 127/228 (55%), Positives = 166/228 (72%)
Frame = +3
Query: 12 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 191
+VQDAYTLRC PQVHG V D + ++ V+ E+NS+TDNPL+FPD G +IS GNFHGE
Sbjct: 274 RVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDGEVISGGNFHGEPV 333
Query: 192 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 371
A A+DFL+I + E+A++SERRIERLVN + LP FL + GG+NSG M+A TAA+LVSE
Sbjct: 334 ALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSE 393
Query: 372 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 551
NKVL+HP+SVDS+ +SA QEDHVSMG AARKA EV+ NV VLAIELL + QALEF +
Sbjct: 394 NKVLSHPASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKG 453
Query: 552 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 695
K + + + RL+R V P +DR + DI + +++G I V++
Sbjct: 454 FKRGKGTDRIYRLVREKVNPLVEDRELYIDINACFDIIRSGRIEEVLK 501
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 246 bits (627), Expect = 6e-65
Identities = 127/228 (55%), Positives = 158/228 (69%)
Frame = +3
Query: 12 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 191
+ QD YTLRC PQVHG ++ V V+ EMN+ TDNPL+FPD +IS GNFHG+
Sbjct: 273 RTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDEVISGGNFHGQPV 332
Query: 192 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 371
A ALD+LAI + EL ++ERRIERLVNP SGLPAFL ++GG++SG M+ TAA+LVSE
Sbjct: 333 ALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSE 392
Query: 372 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 551
NKVL HP+SVDS+ +SA QEDHVSMG AARKA +V++NV VLAIELL + QALEF+ P
Sbjct: 393 NKVLAHPASVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGP 452
Query: 552 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 695
+ A IR V P DR +APDIE + + GE+ VE
Sbjct: 453 ERLAPATRAAYAAIRERVAPLSGDRVLAPDIEALAELVHNGELVAAVE 500
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 239 bits (611), Expect = 5e-63
Identities = 123/223 (55%), Positives = 157/223 (70%)
Frame = +3
Query: 6 CTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGE 185
C KVQD Y+LRC PQV G LD + V+ E N+ +DNPLVFPDSG ++S GNFHGE
Sbjct: 273 CGKVQDPYSLRCQPQVMGACLDQMRHAARVLLIEANAVSDNPLVFPDSGEVLSGGNFHGE 332
Query: 186 YPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALV 365
A A D LA+ E+ +++ERRI L++ SGLP FLV +GG+NSGFM+AHVTAAAL
Sbjct: 333 PVAFAADALALAAAEIGALAERRIALLIDATLSGLPPFLVTEGGVNSGFMIAHVTAAALA 392
Query: 366 SENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFL 545
SENK+L HP+SVDSL TSA QEDHVSM FAARK E+ N +LAIELLA+ Q +E
Sbjct: 393 SENKLLAHPASVDSLPTSANQEDHVSMSTFAARKLGELADNTATILAIELLAAAQGVELR 452
Query: 546 RPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAG 674
P +++ L+AV+ LIR+ V +D DR+ APDI + + + AG
Sbjct: 453 APHRTSPRLQAVLALIRSRVPHYDIDRYFAPDIASIKDEVSAG 495
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 238 bits (606), Expect = 2e-62
Identities = 116/216 (53%), Positives = 154/216 (71%)
Frame = +3
Query: 6 CTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGE 185
C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I+S GNFHGE
Sbjct: 274 CNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGE 333
Query: 186 YPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALV 365
A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTAA+
Sbjct: 334 IIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCA 393
Query: 366 SENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFL 545
S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q LEF
Sbjct: 394 SDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFH 453
Query: 546 RPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 653
+PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 454 KPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 238 bits (606), Expect = 2e-62
Identities = 116/216 (53%), Positives = 154/216 (71%)
Frame = +3
Query: 6 CTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGE 185
C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I+S GNFHGE
Sbjct: 274 CNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGE 333
Query: 186 YPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALV 365
A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTAA+
Sbjct: 334 IIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCA 393
Query: 366 SENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFL 545
S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q LEF
Sbjct: 394 SDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFH 453
Query: 546 RPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 653
+PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 454 KPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 237 bits (605), Expect = 2e-62
Identities = 115/216 (53%), Positives = 154/216 (71%)
Frame = +3
Query: 6 CTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGE 185
C +VQD Y+LRC PQ+ G +L + FV + E N+ +DNPLVF + G I+S GNFHGE
Sbjct: 274 CNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGNFHGE 333
Query: 186 YPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALV 365
A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTAA+
Sbjct: 334 IIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCA 393
Query: 366 SENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFL 545
S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q LEF
Sbjct: 394 SDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFH 453
Query: 546 RPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 653
+PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 454 KPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,374,161
Number of Sequences: 369166
Number of extensions: 1853684
Number of successful extensions: 4989
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4754
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4915
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7212136400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)