Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_L07
(774 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 221 2e-57
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 218 1e-56
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 217 3e-56
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 192 9e-49
sp|Q8K5L5|HUTH_STRP3 Histidine ammonia-lyase (Histidase) 163 6e-40
sp|Q8NZ46|HUTH_STRP8 Histidine ammonia-lyase (Histidase) 163 6e-40
sp|Q5X9K4|HUTH_STRP6 Histidine ammonia-lyase (Histidase) 163 6e-40
sp|P58083|HUTH_STRP1 Histidine ammonia-lyase (Histidase) 162 1e-39
sp|Q8NYY3|HUTH_STAAW Histidine ammonia-lyase (Histidase) >g... 157 3e-38
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 157 3e-38
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 221 bits (563), Expect = 2e-57
Identities = 102/174 (58%), Positives = 140/174 (80%)
Frame = +2
Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427
+DG +T EDLV LG G Y IKL+ + +V KSR ++D I+ E VVYGITTGFGKF+
Sbjct: 116 LDGDRLTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFAR 175
Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607
+I ++ ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+
Sbjct: 176 TVIPINKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235
Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAA 769
FN +P++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A
Sbjct: 236 MFNASCLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEA 289
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 218 bits (556), Expect = 1e-56
Identities = 102/174 (58%), Positives = 140/174 (80%)
Frame = +2
Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427
+DG S++ EDLV LG G Y IKL+ + KV +SR ++D I+ E VVYGITTGFGKF+
Sbjct: 116 LDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFAR 175
Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607
+I + ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+
Sbjct: 176 TVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235
Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAA 769
AFN + ++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A
Sbjct: 236 AFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEA 289
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 217 bits (552), Expect = 3e-56
Identities = 101/174 (58%), Positives = 139/174 (79%)
Frame = +2
Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427
+DG S++ EDLV LG G Y IKL+ + KV +SR ++D I+ E VVYGITTGFGKF+
Sbjct: 116 LDGDSLSTEDLVNLGKGHYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFAR 175
Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607
+I + ++ELQ +L+RSHS+G+G+P+S E+ RM+LALRIN LAKGYSGI++ETL ++I+
Sbjct: 176 TVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIE 235
Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGWTDSKHALAA 769
FN + ++P KG+VGASGDLAPL+HLALGL+GEG++WSPK+GW D+K+ L A
Sbjct: 236 VFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEA 289
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 192 bits (488), Expect = 9e-49
Identities = 91/169 (53%), Positives = 128/169 (75%)
Frame = +2
Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415
++ I+DG S+ PEDLV G I+LS +S +++ K+R +++I SE+R VYG+TTGFG
Sbjct: 128 KLLILDGNSLLPEDLVRCEKGECAIQLSMESEDRIRKARTFLEKIASEHRAVYGVTTGFG 187
Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595
FS+V I +++LQ +LIRSH+ G G P++ +ARM+LALRIN LAKG+SGI++E +
Sbjct: 188 TFSNVTIPPEKLKKLQLNLIRSHATGYGEPLAPNRARMLLALRINILAKGHSGISVENIK 247
Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVWSPKTGW 742
K+I AFN V ++P +G+VG SGDL PLAHLALGL+GEG++WSP TGW
Sbjct: 248 KMIAAFNAFCVSYVPQQGTVGCSGDLCPLAHLALGLLGEGKMWSPTTGW 296
Score = 35.4 bits (80), Expect = 0.17
Identities = 18/45 (40%), Positives = 27/45 (60%)
Frame = +1
Query: 49 DITAIRRTKNSALLDPEDLVTSVLVAEEYITLDINTNEGNISKGA 183
D +RRT ++LLDPEDLV+ VL ++I + + E +K A
Sbjct: 45 DYFEVRRTVGNSLLDPEDLVSDVLKDSDFIIVAASVEETEDAKEA 89
>sp|Q8K5L5|HUTH_STRP3 Histidine ammonia-lyase (Histidase)
Length = 513
Score = 163 bits (412), Expect = 6e-40
Identities = 78/163 (47%), Positives = 115/163 (70%)
Frame = +2
Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415
R+ +DG S+T ED++A+ ++ + +I VN SR +VD+IVSE RVVYG+TTGFG
Sbjct: 3 RVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFG 62
Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595
+V I + +LQE+LIR+H++G G P+ + R ++ +RIN+L KGYSGI + T+
Sbjct: 63 SLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIE 122
Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVW 724
KL++ N GV P+IP KGS+GASGDLAPLAH+ L ++G G+ +
Sbjct: 123 KLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAY 165
>sp|Q8NZ46|HUTH_STRP8 Histidine ammonia-lyase (Histidase)
Length = 513
Score = 163 bits (412), Expect = 6e-40
Identities = 78/163 (47%), Positives = 115/163 (70%)
Frame = +2
Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415
R+ +DG S+T ED++A+ ++ + +I VN SR +VD+IVSE RVVYG+TTGFG
Sbjct: 3 RVINLDGESLTLEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFG 62
Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595
+V I + +LQE+LIR+H++G G P+ + R ++ +RIN+L KGYSGI + T+
Sbjct: 63 SLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIE 122
Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVW 724
KL++ N GV P+IP KGS+GASGDLAPLAH+ L ++G G+ +
Sbjct: 123 KLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAY 165
>sp|Q5X9K4|HUTH_STRP6 Histidine ammonia-lyase (Histidase)
Length = 513
Score = 163 bits (412), Expect = 6e-40
Identities = 78/163 (47%), Positives = 115/163 (70%)
Frame = +2
Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415
R+ +DG S+T ED++A+ ++ + +I VN SR +VD+IVSE RVVYG+TTGFG
Sbjct: 3 RVINLDGESLTIEDVIAIARQGVACRIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFG 62
Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595
+V I + +LQE+LIR+H++G G P+ + R ++ +RIN+L KGYSGI + T+
Sbjct: 63 SLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIE 122
Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVW 724
KL++ N GV P+IP KGS+GASGDLAPLAH+ L ++G G+ +
Sbjct: 123 KLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAY 165
>sp|P58083|HUTH_STRP1 Histidine ammonia-lyase (Histidase)
Length = 513
Score = 162 bits (409), Expect = 1e-39
Identities = 78/163 (47%), Positives = 114/163 (69%)
Frame = +2
Query: 236 RIYIIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFG 415
R+ +DG S+T ED++A+ + + +I VN SR +VD+IVSE RVVYG+TTGFG
Sbjct: 3 RVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFG 62
Query: 416 KFSDVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLS 595
+V I + +LQE+LIR+H++G G P+ + R ++ +RIN+L KGYSGI + T+
Sbjct: 63 SLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIE 122
Query: 596 KLIDAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVW 724
KL++ N GV P+IP KGS+GASGDLAPLAH+ L ++G G+ +
Sbjct: 123 KLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAY 165
>sp|Q8NYY3|HUTH_STAAW Histidine ammonia-lyase (Histidase)
sp|Q6GD82|HUTH_STAAS Histidine ammonia-lyase (Histidase)
Length = 504
Score = 157 bits (397), Expect = 3e-38
Identities = 80/158 (50%), Positives = 112/158 (70%)
Frame = +2
Query: 248 IDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFSD 427
+DG ++T ED+ + I++ +D++ +V KSRA+V+ I+ VYGITTGFG FSD
Sbjct: 5 LDGETLTIEDIKSFLQQQSKIEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSD 64
Query: 428 VIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLID 607
V ID + ELQ +LIRSH+ G+G P S E A +M+ LR+NTL KG+SG T+E + +L
Sbjct: 65 VRIDPTQYNELQVNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQF 124
Query: 608 AFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRV 721
N ++P IP +GS+GASGDLAPL+HLAL L+GEG+V
Sbjct: 125 FINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKV 162
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 157 bits (397), Expect = 3e-38
Identities = 79/160 (49%), Positives = 109/160 (68%)
Frame = +2
Query: 245 IIDGISMTPEDLVALGNGCYTIKLSEDSINKVNKSRALVDEIVSENRVVYGITTGFGKFS 424
+IDG ++T ED+V + + + LSE + ++ SR +VD V E +VVYGITTGFGKFS
Sbjct: 5 VIDGNNLTIEDVVKVARDKWEVVLSEVAKERIVHSREIVDRYVKEGKVVYGITTGFGKFS 64
Query: 425 DVIIDLSNMRELQESLIRSHSAGIGRPMSVEQARMMLALRINTLAKGYSGITIETLSKLI 604
DV+I + LQ++LI SHS +G P+ E R ++ LR N LAKG+SG+ +ET+ LI
Sbjct: 65 DVVISKEDTEALQKNLIMSHSCAVGDPLPEEVVRAIMLLRANALAKGFSGVRLETVETLI 124
Query: 605 DAFNVGVVPWIPLKGSVGASGDLAPLAHLALGLMGEGRVW 724
+ N VVP IP KGS+GASGDLAPLAH+ L ++G G +
Sbjct: 125 EMINKNVVPVIPEKGSLGASGDLAPLAHMVLVMIGRGEAF 164
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,489,510
Number of Sequences: 369166
Number of extensions: 1746325
Number of successful extensions: 4922
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4728
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4872
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7212136400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)