Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_O05
(805 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 362 e-100
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 360 3e-99
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 359 4e-99
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 334 1e-91
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 249 5e-66
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 249 6e-66
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 249 6e-66
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 249 8e-66
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 246 7e-65
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 245 9e-65
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 362 bits (930), Expect = e-100
Identities = 177/267 (66%), Positives = 214/267 (80%)
Frame = +3
Query: 3 ALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNP 182
+LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP
Sbjct: 370 SLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTELNSATDNP 429
Query: 183 LVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKD 362
+VF + G +S GNFHGEYPAKALD+LAIGIHELA++SERRIERL NP+ S LPAFLV +
Sbjct: 430 MVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAE 489
Query: 363 GGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNV 542
GG+NSGFM+AH TAAALVSENK L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +V
Sbjct: 490 GGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHV 549
Query: 543 ENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKA 722
E VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L
Sbjct: 550 EQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLE 609
Query: 723 GEIWNVVEPFIENFESYKLPDLWISSP 803
++W V P+IE + +P+ SP
Sbjct: 610 QKVWEVAAPYIEKYRMEHIPESRPLSP 636
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 360 bits (923), Expect = 3e-99
Identities = 177/267 (66%), Positives = 213/267 (79%)
Frame = +3
Query: 3 ALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNP 182
+LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP
Sbjct: 370 SLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNP 429
Query: 183 LVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKD 362
+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +
Sbjct: 430 MVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAE 489
Query: 363 GGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNV 542
GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL VV +V
Sbjct: 490 GGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHV 549
Query: 543 ENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKA 722
E VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L
Sbjct: 550 EQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLD 609
Query: 723 GEIWNVVEPFIENFESYKLPDLWISSP 803
++W V P+IE + +P+ SP
Sbjct: 610 QKVWEVAAPYIEKYRMEHIPESRPLSP 636
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 359 bits (922), Expect = 4e-99
Identities = 176/267 (65%), Positives = 213/267 (79%)
Frame = +3
Query: 3 ALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNP 182
+LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP
Sbjct: 370 SLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNP 429
Query: 183 LVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKD 362
+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +
Sbjct: 430 MVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAE 489
Query: 363 GGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNV 542
GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +V
Sbjct: 490 GGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHV 549
Query: 543 ENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKA 722
E VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L
Sbjct: 550 EQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLD 609
Query: 723 GEIWNVVEPFIENFESYKLPDLWISSP 803
++W V P+IE + +P+ SP
Sbjct: 610 QKVWEVAAPYIEKYRMEHIPESRPLSP 636
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 334 bits (857), Expect = 1e-91
Identities = 166/256 (64%), Positives = 199/256 (77%)
Frame = +3
Query: 3 ALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNP 182
ALLH+ PS+I+ESHR CTKVQDAYTLRC PQVHG+V DT++FVR +ITTEMNS+TDNP
Sbjct: 386 ALLHSEANPSQIAESHRNCTKVQDAYTLRCVPQVHGVVHDTIEFVREIITTEMNSATDNP 445
Query: 183 LVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKD 362
LVF D IIS GNFHGEYPAKALDFLAI + ELA MSERR+ERLVN SGLP FL D
Sbjct: 446 LVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPTFLTPD 505
Query: 363 GGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNV 542
GG+NSGFM + AA+LVSENKVL HPSSVDS+ TS QEDHVSMG FAARKAL VV +V
Sbjct: 506 GGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALTVVEHV 565
Query: 543 ENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKA 722
E VLA+ELLA+ Q +EFL+PL ST PL + +L+R+ P ++DR+M P+I+ V+ ++
Sbjct: 566 EAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVLEMIRE 625
Query: 723 GEIWNVVEPFIENFES 770
IW V P +E E+
Sbjct: 626 NRIWEAVLPHLETLEA 641
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 249 bits (637), Expect = 5e-66
Identities = 127/228 (55%), Positives = 166/228 (72%)
Frame = +3
Query: 63 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 242
+VQDAYTLRC PQVHG V D + ++ V+ E+NS+TDNPL+FPD G +IS GNFHGE
Sbjct: 274 RVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDGEVISGGNFHGEPV 333
Query: 243 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 422
A A+DFL+I + E+A++SERRIERLVN + LP FL + GG+NSG M+A TAA+LVSE
Sbjct: 334 ALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSE 393
Query: 423 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 602
NKVL+HP+SVDS+ +SA QEDHVSMG AARKA EV+ NV VLAIELL + QALEF +
Sbjct: 394 NKVLSHPASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKG 453
Query: 603 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 746
K + + + RL+R V P +DR + DI + +++G I V++
Sbjct: 454 FKRGKGTDRIYRLVREKVNPLVEDRELYIDINACFDIIRSGRIEEVLK 501
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (636), Expect = 6e-66
Identities = 122/225 (54%), Positives = 161/225 (71%)
Frame = +3
Query: 30 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 209
S+I ESHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 210 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 389
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 390 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 569
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 570 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 704
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (636), Expect = 6e-66
Identities = 122/225 (54%), Positives = 161/225 (71%)
Frame = +3
Query: 30 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 209
S+I ESHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 210 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 389
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 390 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 569
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 570 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 704
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (635), Expect = 8e-66
Identities = 121/225 (53%), Positives = 161/225 (71%)
Frame = +3
Query: 30 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 209
S+I ESHR C +VQD Y+LRC PQ+ G +L + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 210 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 389
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 390 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 569
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 570 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 704
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 246 bits (627), Expect = 7e-65
Identities = 127/228 (55%), Positives = 158/228 (69%)
Frame = +3
Query: 63 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 242
+ QD YTLRC PQVHG ++ V V+ EMN+ TDNPL+FPD +IS GNFHG+
Sbjct: 273 RTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDEVISGGNFHGQPV 332
Query: 243 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 422
A ALD+LAI + EL ++ERRIERLVNP SGLPAFL ++GG++SG M+ TAA+LVSE
Sbjct: 333 ALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSE 392
Query: 423 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 602
NKVL HP+SVDS+ +SA QEDHVSMG AARKA +V++NV VLAIELL + QALEF+ P
Sbjct: 393 NKVLAHPASVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGP 452
Query: 603 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 746
+ A IR V P DR +APDIE + + GE+ VE
Sbjct: 453 ERLAPATRAAYAAIRERVAPLSGDRVLAPDIEALAELVHNGELVAAVE 500
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 245 bits (626), Expect = 9e-65
Identities = 127/232 (54%), Positives = 163/232 (70%)
Frame = +3
Query: 30 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 209
S I+ +HR C KVQD Y+LRC PQV G LD + V+ E N+ +DNPLVFPDSG +
Sbjct: 264 SGINLAHRDCGKVQDPYSLRCQPQVMGACLDQMRHAARVLLIEANAVSDNPLVFPDSGEV 323
Query: 210 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 389
+S GNFHGE A A D LA+ E+ +++ERRI L++ SGLP FLV +GG+NSGFM+
Sbjct: 324 LSGGNFHGEPVAFAADALALAAAEIGALAERRIALLIDATLSGLPPFLVTEGGVNSGFMI 383
Query: 390 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 569
AHVTAAAL SENK+L HP+SVDSL TSA QEDHVSM FAARK E+ N +LAIELL
Sbjct: 384 AHVTAAALASENKLLAHPASVDSLPTSANQEDHVSMSTFAARKLGELADNTATILAIELL 443
Query: 570 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAG 725
A+ Q +E P +++ L+AV+ LIR+ V +D DR+ APDI + + + AG
Sbjct: 444 AAAQGVELRAPHRTSPRLQAVLALIRSRVPHYDIDRYFAPDIASIKDEVSAG 495
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,469,887
Number of Sequences: 369166
Number of extensions: 1949243
Number of successful extensions: 5224
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4980
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5153
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)