Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_I07
(795 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 265 8e-71
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 263 4e-70
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 263 5e-70
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 229 5e-60
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 191 3e-48
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 184 2e-46
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 184 2e-46
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 184 2e-46
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 182 9e-46
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 181 3e-45
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 265 bits (678), Expect = 8e-71
Identities = 134/201 (66%), Positives = 158/201 (78%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGEYPAKALD+LAIGIHELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH
Sbjct: 442 GNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHC 501
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAAALVSENK L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+
Sbjct: 502 TAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAAC 561
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIE 540
Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE
Sbjct: 562 QGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLEQKVWEVAAPYIE 621
Query: 541 NFESYKLPDLWISSPTTTSLK 603
+ +P+ SPT SL+
Sbjct: 622 KYRMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 263 bits (672), Expect = 4e-70
Identities = 133/201 (66%), Positives = 158/201 (78%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH
Sbjct: 442 GNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHC 501
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL VV +VE VLAIELLA+
Sbjct: 502 TAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAAC 561
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIE 540
Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE
Sbjct: 562 QGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIE 621
Query: 541 NFESYKLPDLWISSPTTTSLK 603
+ +P+ SPT SL+
Sbjct: 622 KYRMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 263 bits (671), Expect = 5e-70
Identities = 132/201 (65%), Positives = 158/201 (78%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH
Sbjct: 442 GNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHC 501
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+
Sbjct: 502 TAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAAC 561
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIE 540
Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE
Sbjct: 562 QGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIE 621
Query: 541 NFESYKLPDLWISSPTTTSLK 603
+ +P+ SPT SL+
Sbjct: 622 KYRMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 229 bits (585), Expect = 5e-60
Identities = 114/184 (61%), Positives = 139/184 (75%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGEYPAKALDFLAI + ELA MSERR+ERLVN SGLP FL DGG+NSGFM +
Sbjct: 458 GNFHGEYPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPTFLTPDGGLNSGFMTVQL 517
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
AA+LVSENKVL HPSSVDS+ TS QEDHVSMG FAARKAL VV +VE VLA+ELLA+
Sbjct: 518 CAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALTVVEHVEAVLAMELLAAC 577
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIE 540
Q +EFL+PL ST PL + +L+R+ P ++DR+M P+I+ V+ ++ IW V P +E
Sbjct: 578 QGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVLEMIRENRIWEAVLPHLE 637
Query: 541 NFES 552
E+
Sbjct: 638 TLEA 641
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 191 bits (484), Expect = 3e-48
Identities = 100/176 (56%), Positives = 124/176 (70%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHG+ A ALD+LAI + EL ++ERRIERLVNP SGLPAFL ++GG++SG M+
Sbjct: 325 GNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQY 384
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAA+LVSENKVL HP+SVDS+ +SA QEDHVSMG AARKA +V++NV VLAIELL +
Sbjct: 385 TAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAA 444
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 528
QALEF+ P + A IR V P DR +APDIE + + GE+ VE
Sbjct: 445 QALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLAPDIEALAELVHNGELVAAVE 500
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 184 bits (468), Expect = 2e-46
Identities = 90/162 (55%), Positives = 119/162 (73%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHV
Sbjct: 328 GNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHV 387
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+
Sbjct: 388 TAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAAC 447
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 486
Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 448 QGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 184 bits (468), Expect = 2e-46
Identities = 90/162 (55%), Positives = 119/162 (73%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHV
Sbjct: 328 GNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHV 387
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+
Sbjct: 388 TAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAAC 447
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 486
Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 448 QGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 184 bits (468), Expect = 2e-46
Identities = 90/162 (55%), Positives = 119/162 (73%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHV
Sbjct: 328 GNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHV 387
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+
Sbjct: 388 TAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAAC 447
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 486
Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 448 QGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 182 bits (462), Expect = 9e-46
Identities = 94/169 (55%), Positives = 121/169 (71%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGE A A D LA+ E+ +++ERRI L++ SGLP FLV +GG+NSGFM+AHV
Sbjct: 327 GNFHGEPVAFAADALALAAAEIGALAERRIALLIDATLSGLPPFLVTEGGVNSGFMIAHV 386
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAAAL SENK+L HP+SVDSL TSA QEDHVSM FAARK E+ N +LAIELLA+
Sbjct: 387 TAAALASENKLLAHPASVDSLPTSANQEDHVSMSTFAARKLGELADNTATILAIELLAAA 446
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAG 507
Q +E P +++ L+AV+ LIR+ V +D DR+ APDI + + + AG
Sbjct: 447 QGVELRAPHRTSPRLQAVLALIRSRVPHYDIDRYFAPDIASIKDEVSAG 495
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 181 bits (458), Expect = 3e-45
Identities = 96/176 (54%), Positives = 126/176 (71%)
Frame = +1
Query: 1 GNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHV 180
GNFHGE A A+DFL+I + E+A++SERRIERLVN + LP FL + GG+NSG M+A
Sbjct: 326 GNFHGEPVALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQY 385
Query: 181 TAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASV 360
TAA+LVSENKVL+HP+SVDS+ +SA QEDHVSMG AARKA EV+ NV VLAIELL +
Sbjct: 386 TAASLVSENKVLSHPASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTAS 445
Query: 361 QALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 528
QALEF + K + + + RL+R V P +DR + DI + +++G I V++
Sbjct: 446 QALEFRKGFKRGKGTDRIYRLVREKVNPLVEDRELYIDINACFDIIRSGRIEEVLK 501
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,162,826
Number of Sequences: 369166
Number of extensions: 1648219
Number of successful extensions: 4566
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4383
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4529
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)