Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_F10
(860 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 371 e-102
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 369 e-102
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 368 e-101
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 337 3e-92
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 249 5e-66
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 249 7e-66
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 249 7e-66
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 249 9e-66
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 247 3e-65
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 245 1e-64
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 371 bits (953), Expect = e-102
Identities = 183/280 (65%), Positives = 222/280 (79%)
Frame = +1
Query: 1 EVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEM 180
EVA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+
Sbjct: 363 EVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTEL 422
Query: 181 NSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGL 360
NS+TDNP+VF + G +S GNFHGEYPAKALD+LAIGIHELA++SERRIERL NP+ S L
Sbjct: 423 NSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSEL 482
Query: 361 PAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKA 540
PAFLV +GG+NSGFM+AH TAAALVSENK L HPSSVDSL+TSA EDHVSMG +AARKA
Sbjct: 483 PAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKA 542
Query: 541 LEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEH 720
L V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE
Sbjct: 543 LRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEA 602
Query: 721 VVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 840
L ++W V P+IE + +P+ SPT SL+
Sbjct: 603 AHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 369 bits (946), Expect = e-102
Identities = 183/280 (65%), Positives = 221/280 (78%)
Frame = +1
Query: 1 EVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEM 180
EVA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+
Sbjct: 363 EVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTEL 422
Query: 181 NSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGL 360
NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S L
Sbjct: 423 NSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSEL 482
Query: 361 PAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKA 540
PAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKA
Sbjct: 483 PAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKA 542
Query: 541 LEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEH 720
L VV +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE
Sbjct: 543 LRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEA 602
Query: 721 VVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 840
L ++W V P+IE + +P+ SPT SL+
Sbjct: 603 AHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 368 bits (945), Expect = e-101
Identities = 182/280 (65%), Positives = 221/280 (78%)
Frame = +1
Query: 1 EVARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEM 180
EVA ++LL + +PSEI+ESHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+
Sbjct: 363 EVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTEL 422
Query: 181 NSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGL 360
NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S L
Sbjct: 423 NSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSEL 482
Query: 361 PAFLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKA 540
PAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKA
Sbjct: 483 PAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKA 542
Query: 541 LEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEH 720
L V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE
Sbjct: 543 LRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEA 602
Query: 721 VVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 840
L ++W V P+IE + +P+ SPT SL+
Sbjct: 603 AHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 337 bits (864), Expect = 3e-92
Identities = 168/261 (64%), Positives = 202/261 (77%)
Frame = +1
Query: 7 ARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNS 186
A L+ALLH+ PS+I+ESHR CTKVQDAYTLRC PQVHG+V DT++FVR +ITTEMNS
Sbjct: 381 ALRLRALLHSEANPSQIAESHRNCTKVQDAYTLRCVPQVHGVVHDTIEFVREIITTEMNS 440
Query: 187 STDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPA 366
+TDNPLVF D IIS GNFHGEYPAKALDFLAI + ELA MSERR+ERLVN SGLP
Sbjct: 441 ATDNPLVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPT 500
Query: 367 FLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALE 546
FL DGG+NSGFM + AA+LVSENKVL HPSSVDS+ TS QEDHVSMG FAARKAL
Sbjct: 501 FLTPDGGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALT 560
Query: 547 VVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVV 726
VV +VE VLA+ELLA+ Q +EFL+PL ST PL + +L+R+ P ++DR+M P+I+ V+
Sbjct: 561 VVEHVEAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVL 620
Query: 727 NTLKAGEIWNVVEPFIENFES 789
++ IW V P +E E+
Sbjct: 621 EMIRENRIWEAVLPHLETLEA 641
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 249 bits (637), Expect = 5e-66
Identities = 127/228 (55%), Positives = 166/228 (72%)
Frame = +1
Query: 82 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 261
+VQDAYTLRC PQVHG V D + ++ V+ E+NS+TDNPL+FPD G +IS GNFHGE
Sbjct: 274 RVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDGEVISGGNFHGEPV 333
Query: 262 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 441
A A+DFL+I + E+A++SERRIERLVN + LP FL + GG+NSG M+A TAA+LVSE
Sbjct: 334 ALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSE 393
Query: 442 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 621
NKVL+HP+SVDS+ +SA QEDHVSMG AARKA EV+ NV VLAIELL + QALEF +
Sbjct: 394 NKVLSHPASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKG 453
Query: 622 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 765
K + + + RL+R V P +DR + DI + +++G I V++
Sbjct: 454 FKRGKGTDRIYRLVREKVNPLVEDRELYIDINACFDIIRSGRIEEVLK 501
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (636), Expect = 7e-66
Identities = 122/225 (54%), Positives = 161/225 (71%)
Frame = +1
Query: 49 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 228
S+I ESHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 229 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 408
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 409 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 588
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 589 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 723
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (636), Expect = 7e-66
Identities = 122/225 (54%), Positives = 161/225 (71%)
Frame = +1
Query: 49 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 228
S+I ESHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 229 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 408
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 409 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 588
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 589 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 723
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 249 bits (635), Expect = 9e-66
Identities = 121/225 (53%), Positives = 161/225 (71%)
Frame = +1
Query: 49 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 228
S+I ESHR C +VQD Y+LRC PQ+ G +L + FV + E N+ +DNPLVF + G I
Sbjct: 265 SQIRESHRHCNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDI 324
Query: 229 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 408
+S GNFHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+
Sbjct: 325 LSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMI 384
Query: 409 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 588
AHVTAA+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELL
Sbjct: 385 AHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELL 444
Query: 589 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 723
A+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 445 AACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 247 bits (631), Expect = 3e-65
Identities = 132/253 (52%), Positives = 168/253 (66%)
Frame = +1
Query: 7 ARHLQALLHNSKYPSEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNS 186
AR+L+ L S+ + + + QD YTLRC PQVHG ++ V V+ EMN+
Sbjct: 253 ARNLRRLTEGSRLTTRPGQM-----RTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNA 307
Query: 187 STDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPA 366
TDNPL+FPD +IS GNFHG+ A ALD+LAI + EL ++ERRIERLVNP SGLPA
Sbjct: 308 VTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLSGLPA 367
Query: 367 FLVKDGGINSGFMLAHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALE 546
FL ++GG++SG M+ TAA+LVSENKVL HP+SVDS+ +SA QEDHVSMG AARKA +
Sbjct: 368 FLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTTAARKARQ 427
Query: 547 VVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVV 726
V++NV VLAIELL + QALEF+ P + A IR V P DR +APDIE +
Sbjct: 428 VIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLAPDIEALA 487
Query: 727 NTLKAGEIWNVVE 765
+ GE+ VE
Sbjct: 488 ELVHNGELVAAVE 500
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 245 bits (626), Expect = 1e-64
Identities = 127/232 (54%), Positives = 163/232 (70%)
Frame = +1
Query: 49 SEISESHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMI 228
S I+ +HR C KVQD Y+LRC PQV G LD + V+ E N+ +DNPLVFPDSG +
Sbjct: 264 SGINLAHRDCGKVQDPYSLRCQPQVMGACLDQMRHAARVLLIEANAVSDNPLVFPDSGEV 323
Query: 229 ISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFML 408
+S GNFHGE A A D LA+ E+ +++ERRI L++ SGLP FLV +GG+NSGFM+
Sbjct: 324 LSGGNFHGEPVAFAADALALAAAEIGALAERRIALLIDATLSGLPPFLVTEGGVNSGFMI 383
Query: 409 AHVTAAALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELL 588
AHVTAAAL SENK+L HP+SVDSL TSA QEDHVSM FAARK E+ N +LAIELL
Sbjct: 384 AHVTAAALASENKLLAHPASVDSLPTSANQEDHVSMSTFAARKLGELADNTATILAIELL 443
Query: 589 ASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAG 744
A+ Q +E P +++ L+AV+ LIR+ V +D DR+ APDI + + + AG
Sbjct: 444 AAAQGVELRAPHRTSPRLQAVLALIRSRVPHYDIDRYFAPDIASIKDEVSAG 495
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,378,916
Number of Sequences: 369166
Number of extensions: 2050367
Number of successful extensions: 5529
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5262
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5454
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8534739105
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)