Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_E18
(883 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 353 4e-97
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 350 2e-96
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 350 3e-96
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 318 1e-86
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 249 5e-66
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 246 8e-65
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 244 3e-64
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 244 3e-64
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 244 3e-64
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 243 4e-64
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 353 bits (906), Expect = 4e-97
Identities = 173/259 (66%), Positives = 207/259 (79%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF + G +S GN
Sbjct: 384 SHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTELNSATDNPMVFANRGETVSGGN 443
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGEYPAKALD+LAIGIHELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TA
Sbjct: 444 FHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTA 503
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
AALVSENK L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+ Q
Sbjct: 504 AALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQG 563
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENF 720
+EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 564 IEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLEQKVWEVAAPYIEKY 623
Query: 721 ESYKLPDLWISSPTTTSLK 777
+P+ SPT SL+
Sbjct: 624 RMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 350 bits (899), Expect = 2e-96
Identities = 173/259 (66%), Positives = 206/259 (79%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF G IS GN
Sbjct: 384 SHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGN 443
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TA
Sbjct: 444 FHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTA 503
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
AALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL VV +VE VLAIELLA+ Q
Sbjct: 504 AALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQG 563
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENF 720
+EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 564 IEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKY 623
Query: 721 ESYKLPDLWISSPTTTSLK 777
+P+ SPT SL+
Sbjct: 624 RMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 350 bits (898), Expect = 3e-96
Identities = 172/259 (66%), Positives = 206/259 (79%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHRFC +VQDAYTLRCCPQVHG+V DT+ FV+ +ITTE+NS+TDNP+VF G IS GN
Sbjct: 384 SHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGN 443
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGEYPAKALD+LAIG+HELA++SERRIERL NP+ S LPAFLV +GG+NSGFM+AH TA
Sbjct: 444 FHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTA 503
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
AALVSE+K L HPSSVDSL+TSA EDHVSMG +AARKAL V+ +VE VLAIELLA+ Q
Sbjct: 504 AALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQG 563
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENF 720
+EFLRPLK+T PLE V L+R+ V+PW KDRFMAPDIE L ++W V P+IE +
Sbjct: 564 IEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKY 623
Query: 721 ESYKLPDLWISSPTTTSLK 777
+P+ SPT SL+
Sbjct: 624 RMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 318 bits (816), Expect = 1e-86
Identities = 158/242 (65%), Positives = 188/242 (77%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHR CTKVQDAYTLRC PQVHG+V DT++FVR +ITTEMNS+TDNPLVF D IIS GN
Sbjct: 400 SHRNCTKVQDAYTLRCVPQVHGVVHDTIEFVREIITTEMNSATDNPLVFADREEIISGGN 459
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGEYPAKALDFLAI + ELA MSERR+ERLVN SGLP FL DGG+NSGFM + A
Sbjct: 460 FHGEYPAKALDFLAIAVAELAQMSERRLERLVNKELSGLPTFLTPDGGLNSGFMTVQLCA 519
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
A+LVSENKVL HPSSVDS+ TS QEDHVSMG FAARKAL VV +VE VLA+ELLA+ Q
Sbjct: 520 ASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFAARKALTVVEHVEAVLAMELLAACQG 579
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVEPFIENF 720
+EFL+PL ST PL + +L+R+ P ++DR+M P+I+ V+ ++ IW V P +E
Sbjct: 580 IEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKPEIDAVLEMIRENRIWEAVLPHLETL 639
Query: 721 ES 726
E+
Sbjct: 640 EA 641
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 249 bits (637), Expect = 5e-66
Identities = 127/228 (55%), Positives = 166/228 (72%)
Frame = +1
Query: 19 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 198
+VQDAYTLRC PQVHG V D + ++ V+ E+NS+TDNPL+FPD G +IS GNFHGE
Sbjct: 274 RVQDAYTLRCIPQVHGAVRDAISYIERVLGVEINSATDNPLIFPDDGEVISGGNFHGEPV 333
Query: 199 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 378
A A+DFL+I + E+A++SERRIERLVN + LP FL + GG+NSG M+A TAA+LVSE
Sbjct: 334 ALAMDFLSIALSEIANISERRIERLVNYQLNDLPPFLTEKGGLNSGMMIAQYTAASLVSE 393
Query: 379 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 558
NKVL+HP+SVDS+ +SA QEDHVSMG AARKA EV+ NV VLAIELL + QALEF +
Sbjct: 394 NKVLSHPASVDSIPSSANQEDHVSMGTIAARKAREVLKNVTTVLAIELLTASQALEFRKG 453
Query: 559 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 702
K + + + RL+R V P +DR + DI + +++G I V++
Sbjct: 454 FKRGKGTDRIYRLVREKVNPLVEDRELYIDINACFDIIRSGRIEEVLK 501
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 246 bits (627), Expect = 8e-65
Identities = 127/228 (55%), Positives = 158/228 (69%)
Frame = +1
Query: 19 KVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGNFHGEYP 198
+ QD YTLRC PQVHG ++ V V+ EMN+ TDNPL+FPD +IS GNFHG+
Sbjct: 273 RTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDEVISGGNFHGQPV 332
Query: 199 AKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTAAALVSE 378
A ALD+LAI + EL ++ERRIERLVNP SGLPAFL ++GG++SG M+ TAA+LVSE
Sbjct: 333 ALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSE 392
Query: 379 NKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQALEFLRP 558
NKVL HP+SVDS+ +SA QEDHVSMG AARKA +V++NV VLAIELL + QALEF+ P
Sbjct: 393 NKVLAHPASVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGP 452
Query: 559 LKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAGEIWNVVE 702
+ A IR V P DR +APDIE + + GE+ VE
Sbjct: 453 ERLAPATRAAYAAIRERVAPLSGDRVLAPDIEALAELVHNGELVAAVE 500
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 244 bits (622), Expect = 3e-64
Identities = 119/220 (54%), Positives = 157/220 (71%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I+S GN
Sbjct: 270 SHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGN 329
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTA
Sbjct: 330 FHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTA 389
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
A+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q
Sbjct: 390 ASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQG 449
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 660
LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 450 LEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 244 bits (622), Expect = 3e-64
Identities = 119/220 (54%), Positives = 157/220 (71%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHR C +VQD Y+LRC PQ+ G VL + FV + E N+ +DNPLVF + G I+S GN
Sbjct: 270 SHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGN 329
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTA
Sbjct: 330 FHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTA 389
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
A+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q
Sbjct: 390 ASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQG 449
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 660
LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 450 LEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 244 bits (622), Expect = 3e-64
Identities = 125/227 (55%), Positives = 160/227 (70%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
+HR C KVQD Y+LRC PQV G LD + V+ E N+ +DNPLVFPDSG ++S GN
Sbjct: 269 AHRDCGKVQDPYSLRCQPQVMGACLDQMRHAARVLLIEANAVSDNPLVFPDSGEVLSGGN 328
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGE A A D LA+ E+ +++ERRI L++ SGLP FLV +GG+NSGFM+AHVTA
Sbjct: 329 FHGEPVAFAADALALAAAEIGALAERRIALLIDATLSGLPPFLVTEGGVNSGFMIAHVTA 388
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
AAL SENK+L HP+SVDSL TSA QEDHVSM FAARK E+ N +LAIELLA+ Q
Sbjct: 389 AALASENKLLAHPASVDSLPTSANQEDHVSMSTFAARKLGELADNTATILAIELLAAAQG 448
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHVVNTLKAG 681
+E P +++ L+AV+ LIR+ V +D DR+ APDI + + + AG
Sbjct: 449 VELRAPHRTSPRLQAVLALIRSRVPHYDIDRYFAPDIASIKDEVSAG 495
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 243 bits (621), Expect = 4e-64
Identities = 118/220 (53%), Positives = 157/220 (71%)
Frame = +1
Query: 1 SHRFCTKVQDAYTLRCCPQVHGIVLDTLDFVRGVITTEMNSSTDNPLVFPDSGMIISAGN 180
SHR C +VQD Y+LRC PQ+ G +L + FV + E N+ +DNPLVF + G I+S GN
Sbjct: 270 SHRHCNRVQDPYSLRCQPQIMGAILHQMQFVGQTLQVEANAISDNPLVFAEQGDILSGGN 329
Query: 181 FHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYSGLPAFLVKDGGINSGFMLAHVTA 360
FHGE A A D LA+ + E+ +ERRI L++ +SGLPAFLV++ G+NSGFM+AHVTA
Sbjct: 330 FHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTA 389
Query: 361 AALVSENKVLTHPSSVDSLTTSAGQEDHVSMGAFAARKALEVVSNVENVLAIELLASVQA 540
A+ S+NK L HP SVDSL TSA QEDHVSM AAR+ E++ N +LAIELLA+ Q
Sbjct: 390 ASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQG 449
Query: 541 LEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDIEHV 660
LEF +PLK++ L+ + + +R+ VK +DKDR+ APDIE +
Sbjct: 450 LEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDIEKI 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,120,826
Number of Sequences: 369166
Number of extensions: 2012416
Number of successful extensions: 5478
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5216
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5404
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8790245790
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)