Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_007_G12
(781 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase) 291 1e-78
sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase) 289 5e-78
sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase) 289 7e-78
sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Hist... 255 1e-67
sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase) 213 4e-55
sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase) 207 2e-53
sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase) 204 2e-52
sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase) 202 6e-52
sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase) 202 6e-52
sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase) 202 6e-52
>sp|P42357|HUTH_HUMAN Histidine ammonia-lyase (Histidase)
Length = 657
Score = 291 bits (746), Expect = 1e-78
Identities = 146/224 (65%), Positives = 176/224 (78%)
Frame = +3
Query: 3 TTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPA 182
TTE+NS+TDNP+VF + G +S GNFHGEYPAKALD+LAIGIHELA++SERRIERL NP+
Sbjct: 419 TTELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPS 478
Query: 183 YSGVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFA 362
S +PAFLV +GG+NSGFM+AH TAAALVSENK L HPSSVDSL+TSA EDHVSMG +A
Sbjct: 479 LSELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWA 538
Query: 363 ARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAP 542
ARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAP
Sbjct: 539 ARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAP 598
Query: 543 DIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 674
DIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 599 DIEAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQ 642
>sp|P35492|HUTH_MOUSE Histidine ammonia-lyase (Histidase)
Length = 657
Score = 289 bits (740), Expect = 5e-78
Identities = 146/224 (65%), Positives = 175/224 (78%)
Frame = +3
Query: 3 TTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPA 182
TTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+
Sbjct: 419 TTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPS 478
Query: 183 YSGVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFA 362
S +PAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +A
Sbjct: 479 LSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWA 538
Query: 363 ARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAP 542
ARKAL VV +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAP
Sbjct: 539 ARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAP 598
Query: 543 DIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 674
DIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 599 DIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|P21213|HUTH_RAT Histidine ammonia-lyase (Histidase)
Length = 657
Score = 289 bits (739), Expect = 7e-78
Identities = 145/224 (64%), Positives = 175/224 (78%)
Frame = +3
Query: 3 TTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPA 182
TTE+NS+TDNP+VF G IS GNFHGEYPAKALD+LAIG+HELA++SERRIERL NP+
Sbjct: 419 TTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPS 478
Query: 183 YSGVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFA 362
S +PAFLV +GG+NSGFM+AH TAAALVSE+K L HPSSVDSL+TSA EDHVSMG +A
Sbjct: 479 LSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWA 538
Query: 363 ARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAP 542
ARKAL V+ +VE VLAIELLA+ Q +EFLRPLK+T PLE V L+R+ V+PW KDRFMAP
Sbjct: 539 ARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAP 598
Query: 543 DIEHVVNTLKAGEIWNVVEPFIENFESYKLPDLWISSPTTTSLK 674
DIE L ++W V P+IE + +P+ SPT SL+
Sbjct: 599 DIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLE 642
>sp|Q20502|HUTH_CAEEL Probable histidine ammonia-lyase (Histidase)
Length = 677
Score = 255 bits (651), Expect = 1e-67
Identities = 129/207 (62%), Positives = 155/207 (74%)
Frame = +3
Query: 3 TTEMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPA 182
TTEMNS+TDNPLVF D IIS GNFHGEYPAKALDFLAI + ELA MSERR+ERLVN
Sbjct: 435 TTEMNSATDNPLVFADREEIISGGNFHGEYPAKALDFLAIAVAELAQMSERRLERLVNKE 494
Query: 183 YSGVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFA 362
SG+P FL DGG+NSGFM AA+LVSENK L HPSSVDS+ TS QEDHVSMG FA
Sbjct: 495 LSGLPTFLTPDGGLNSGFMTVQLCAASLVSENKVLCHPSSVDSIPTSCNQEDHVSMGGFA 554
Query: 363 ARKALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAP 542
ARKAL VV +VE VLA+ELLA+ Q +EFL+PL ST PL + +L+R+ P ++DR+M P
Sbjct: 555 ARKALTVVEHVEAVLAMELLAACQGIEFLKPLISTAPLHKIYQLVRSVAPPLNEDRYMKP 614
Query: 543 DIEHVVNTLKAGEIWNVVEPFIENFES 623
+I+ V+ ++ IW V P +E E+
Sbjct: 615 EIDAVLEMIRENRIWEAVLPHLETLEA 641
>sp|Q67JH4|HUTH_SYMTH Histidine ammonia-lyase (Histidase)
Length = 507
Score = 213 bits (543), Expect = 4e-55
Identities = 111/197 (56%), Positives = 139/197 (70%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
EMN+ TDNPL+FPD +IS GNFHG+ A ALD+LAI + EL ++ERRIERLVNP S
Sbjct: 304 EMNAVTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLS 363
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
G+PAFL ++GG++SG M+ TAA+LVSENK L HP+SVDS+ +SA QEDHVSMG AAR
Sbjct: 364 GLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTTAAR 423
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
KA +V++NV VLAIELL + QALEF+ P + A IR V P DR +APDI
Sbjct: 424 KARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLAPDI 483
Query: 549 EHVVNTLKAGEIWNVVE 599
E + + GE+ VE
Sbjct: 484 EALAELVHNGELVAAVE 500
>sp|Q8RBH4|HUTH_THETN Histidine ammonia-lyase (Histidase)
Length = 508
Score = 207 bits (528), Expect = 2e-53
Identities = 108/197 (54%), Positives = 143/197 (72%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
E+NS+TDNPL+FPD G +IS GNFHGE A A+DFL+I + E+A++SERRIERLVN +
Sbjct: 305 EINSATDNPLIFPDDGEVISGGNFHGEPVALAMDFLSIALSEIANISERRIERLVNYQLN 364
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
+P FL + GG+NSG M+A TAA+LVSENK L+HP+SVDS+ +SA QEDHVSMG AAR
Sbjct: 365 DLPPFLTEKGGLNSGMMIAQYTAASLVSENKVLSHPASVDSIPSSANQEDHVSMGTIAAR 424
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
KA EV+ NV VLAIELL + QALEF + K + + + RL+R V P +DR + DI
Sbjct: 425 KAREVLKNVTTVLAIELLTASQALEFRKGFKRGKGTDRIYRLVREKVNPLVEDRELYIDI 484
Query: 549 EHVVNTLKAGEIWNVVE 599
+ +++G I V++
Sbjct: 485 NACFDIIRSGRIEEVLK 501
>sp|Q5NZX8|HUTH_AZOSE Histidine ammonia-lyase (Histidase)
Length = 526
Score = 204 bits (520), Expect = 2e-52
Identities = 105/190 (55%), Positives = 136/190 (71%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
E N+ +DNPLVFPDSG ++S GNFHGE A A D LA+ E+ +++ERRI L++ S
Sbjct: 306 EANAVSDNPLVFPDSGEVLSGGNFHGEPVAFAADALALAAAEIGALAERRIALLIDATLS 365
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
G+P FLV +GG+NSGFM+AH TAAAL SENK L HP+SVDSL TSA QEDHVSM FAAR
Sbjct: 366 GLPPFLVTEGGVNSGFMIAHVTAAALASENKLLAHPASVDSLPTSANQEDHVSMSTFAAR 425
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
K E+ N +LAIELLA+ Q +E P +++ L+AV+ LIR+ V +D DR+ APDI
Sbjct: 426 KLGELADNTATILAIELLAAAQGVELRAPHRTSPRLQAVLALIRSRVPHYDIDRYFAPDI 485
Query: 549 EHVVNTLKAG 578
+ + + AG
Sbjct: 486 ASIKDEVSAG 495
>sp|Q5WWW8|HUTH_LEGPL Histidine ammonia-lyase (Histidase)
Length = 506
Score = 202 bits (515), Expect = 6e-52
Identities = 99/183 (54%), Positives = 133/183 (72%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
E N+ +DNPLVF + G I+S GNFHGE A A D LA+ + E+ +ERRI L++ +S
Sbjct: 307 EANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFS 366
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
G+PAFLV++ G+NSGFM+AH TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR
Sbjct: 367 GLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAAR 426
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
+ E++ N +LAIELLA+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDI
Sbjct: 427 RLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDI 486
Query: 549 EHV 557
E +
Sbjct: 487 EKI 489
>sp|Q5X5I5|HUTH_LEGPA Histidine ammonia-lyase (Histidase)
Length = 506
Score = 202 bits (515), Expect = 6e-52
Identities = 99/183 (54%), Positives = 133/183 (72%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
E N+ +DNPLVF + G I+S GNFHGE A A D LA+ + E+ +ERRI L++ +S
Sbjct: 307 EANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFS 366
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
G+PAFLV++ G+NSGFM+AH TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR
Sbjct: 367 GLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAAR 426
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
+ E++ N +LAIELLA+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDI
Sbjct: 427 RLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDI 486
Query: 549 EHV 557
E +
Sbjct: 487 EKI 489
>sp|Q5ZVR0|HUTH_LEGPH Histidine ammonia-lyase (Histidase)
Length = 506
Score = 202 bits (515), Expect = 6e-52
Identities = 99/183 (54%), Positives = 133/183 (72%)
Frame = +3
Query: 9 EMNSSTDNPLVFPDSGMIISAGNFHGEYPAKALDFLAIGIHELASMSERRIERLVNPAYS 188
E N+ +DNPLVF + G I+S GNFHGE A A D LA+ + E+ +ERRI L++ +S
Sbjct: 307 EANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFS 366
Query: 189 GVPAFLVKDGGINSGFMLAHGTAAALVSENKGLTHPSSVDSLTTSAGQEDHVSMGAFAAR 368
G+PAFLV++ G+NSGFM+AH TAA+ S+NK L HP SVDSL TSA QEDHVSM AAR
Sbjct: 367 GLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSMATSAAR 426
Query: 369 KALEVVSNVENVLAIELLASVQALEFLRPLKSTEPLEAVVRLIRTTVKPWDKDRFMAPDI 548
+ E++ N +LAIELLA+ Q LEF +PLK++ L+ + + +R+ VK +DKDR+ APDI
Sbjct: 427 RLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRYFAPDI 486
Query: 549 EHV 557
E +
Sbjct: 487 EKI 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,998,275
Number of Sequences: 369166
Number of extensions: 1877662
Number of successful extensions: 5254
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5015
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5181
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)