Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00011 (1427 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q13283|G3BP_HUMAN Ras-GTPase-activating protein binding ... 167 9e-41 sp|P97855|G3BP_MOUSE Ras-GTPase-activating protein binding ... 155 2e-37 sp|Q9UN86|G3B2_HUMAN Ras-GTPase-activating protein binding ... 154 5e-37 sp|P97379|G3B2_MOUSE Ras-GTPase-activating protein binding ... 152 3e-36 sp|O94260|G3BP_SCHPO Putative G3BP-like protein 114 5e-25 sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) 53 2e-06 sp|P53741|BRE5_YEAST UBP3-associated protein BRE5 50 2e-05 sp|Q10100|NTF2_SCHPO Nuclear transport factor 2 (NTF-2) 50 2e-05 sp|Q6BWC0|NTF2_DEBHA Nuclear transport factor 2 (NTF-2) 49 3e-05 sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) 49 5e-05
>sp|Q13283|G3BP_HUMAN Ras-GTPase-activating protein binding protein 1 (GAP SH3-domain binding protein 1) (G3BP-1) (DNA helicase VIII) (HDH-VIII) Length = 466 Score = 167 bits (422), Expect = 9e-41 Identities = 128/435 (29%), Positives = 207/435 (47%), Gaps = 54/435 (12%) Frame = +2 Query: 71 MDRELITTVSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQG--------QNEIH 226 M++ V +EFV Q+YT++N+ P LHRFY + S+ + + + G Q EIH Sbjct: 3 MEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIH 62 Query: 227 KYYMNLELSNCKAVVLSLDAVKSHGKSILIQVTGEIANNGCDLRRFMQSFLLVEQD--LG 400 + M+ +NC + +DA + +++QV G ++NN LRRFMQ+F+L + Sbjct: 63 RKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVAN 122 Query: 401 NFYVLNDIFRYQDQTF-----KVEDVEEAPVVEHESKNE------DIHGEINSWNELSRN 547 FYV NDIFRYQD+ F + ++ E V E E + + D G +S + Sbjct: 123 KFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSND 182 Query: 548 CELNNEQIPQSPQLIEHEEGSEEFINYKIMNEEKDISSEIPVEIDSQQ-------DIGQK 706 E + E+ P+ E +E ++ +I E+ + E D+Q+ DI Q Sbjct: 183 MEEHLEEPVAEPEPDPEPEPEQEPVS-EIQEEKPEPVLEETAPEDAQKSSSPAPADIAQT 241 Query: 707 MEEMNIKEKSWAA--------------------IINPMSSRPSXXXXXXXXXXXXXXXXX 826 ++E +++ SWA+ ++ +S+P Sbjct: 242 VQE-DLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRD 300 Query: 827 XXXINSNGDNMEKRKPR-----FNNGNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFF 991 + +R PR G+++ + +PD HQLF+GNLP + + ELKDFF Sbjct: 301 QRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF 360 Query: 992 SEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAH-RLNVEQK 1168 + YG V ++RI N G LPNFGF+VF + E V+++L N+PI + RLNVE+K Sbjct: 361 -QSYGNVVELRI------NSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEK 413 Query: 1169 MGSSRGSHKAGRR*N 1213 +R + + RR N Sbjct: 414 --KTRAAREGDRRDN 426
>sp|P97855|G3BP_MOUSE Ras-GTPase-activating protein binding protein 1 (GAP SH3-domain binding protein 1) (G3BP-1) (DNA helicase VIII) (HDH-VIII) Length = 465 Score = 155 bits (393), Expect = 2e-37 Identities = 126/436 (28%), Positives = 205/436 (47%), Gaps = 55/436 (12%) Frame = +2 Query: 71 MDRELITTVSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQG--------QNEIH 226 M++ V +EFV Q+YT++N+ P LHRFY + S+ + + G Q EIH Sbjct: 3 MEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYAHGGLDSNGKPADAVYGQKEIH 62 Query: 227 KYYMNLELSNCKAVVLSLDAVKSHGKSILIQVTGEIANNGCDLRRFMQSFLLVEQD--LG 400 + M+ +NC + +DA + +++QV G ++NN LRRFMQ+F+L + Sbjct: 63 RKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVAN 122 Query: 401 NFYVLNDIFRYQDQTF----------KVEDVEEAPVVEHESKNEDIHGEINSWNE--LSR 544 FYV NDIFRYQD+ F E+VEE E + E + + ++ + +S Sbjct: 123 KFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPE--ERQQTPEVVPDDSGTFYDQTVSN 180 Query: 545 NCELNNEQIPQSPQLIEHEEGSEEFINYKIMNEEKDISSEIPVEIDSQQ-------DIGQ 703 + E + E+ P+ E E ++ I ++ + + E D Q+ D+ Sbjct: 181 DLEEHLEEPVVEPEPEPEPEPEPEPVS-DIQEDKPEAALEEAAPDDVQKSTSPAPADVAP 239 Query: 704 KMEEMNIKEKSWAAIIN---------PMSSRPSXXXXXXXXXXXXXXXXXXXXINSNGDN 856 E+ ++ SWA++ + P++ P Sbjct: 240 AQED--LRTFSWASVTSKNLPPSGAVPVTGTPPHVVKVPASQPRPESKPDSQIPPQRPQR 297 Query: 857 MEK-RKPRFN---------------NGNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDF 988 ++ R+ R N G+V+ + +PD HQLF+GNLP + + ELKDF Sbjct: 298 DQRVREQRINIPPQRGPRPIREAGEPGDVEPRRMVRHPDSHQLFIGNLPHEVDKSELKDF 357 Query: 989 FSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYY-SAHRLNVEQ 1165 F + +G V ++RI N G LPNFGF+VF + E V+++L N+PI + A RLNVE+ Sbjct: 358 F-QNFGNVVELRI------NSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGAVRLNVEE 410 Query: 1166 KMGSSRGSHKAGRR*N 1213 K +R + + RR N Sbjct: 411 K--KTRAAREGDRRDN 424
>sp|Q9UN86|G3B2_HUMAN Ras-GTPase-activating protein binding protein 2 (GAP SH3-domain binding protein 2) (G3BP-2) Length = 482 Score = 154 bits (390), Expect = 5e-37 Identities = 122/416 (29%), Positives = 192/416 (46%), Gaps = 50/416 (12%) Frame = +2 Query: 71 MDRELITTVSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQG--------QNEIH 226 M++ V +EFV Q+YT++NK P LHRFY S+ + V A G QN+IH Sbjct: 3 MEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIH 62 Query: 227 KYYMNLELSNCKAVVLSLDAVKSHGKSILIQVTGEIANNGCDLRRFMQSFLLVEQDL--G 400 ++L S C + +DA + +++QV G ++N+G R+FMQ+F+L + Sbjct: 63 HKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPN 122 Query: 401 NFYVLNDIFRYQDQTF---------KVEDVEEAPVVEHESKNEDIHGEINSW----NELS 541 FYV ND+FRY+D+ F + ED E E + E + NS + ++ Sbjct: 123 KFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEERQPSPEPVQENANSGYYEAHPVT 182 Query: 542 RNCELNNEQIPQSPQLIEHEEGSEEFINYKIMNEEKDISSEIPVEIDSQQDIGQKMEEMN 721 E E+ P+ E E + ++ EEK++ E++ + E ++ Sbjct: 183 NGIEEPLEESSHEPEPEPESETKTEELKPQV--EEKNLE-----ELEEKSTTPPPAEPVS 235 Query: 722 IKEK-----SWAAIIN---PMSS--RPSXXXXXXXXXXXXXXXXXXXXINSNGDNMEKRK 871 + ++ SWA++ + P S S + S + +++ Sbjct: 236 LPQEPPKAFSWASVTSKNLPPSGTVSSSGIPSHVKAPVSQPRVEAKPEVQSQPPRVREQR 295 Query: 872 PRFNNG----------------NVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKY 1003 PR G + + YPD HQLFVGNLP ++ E+ELK+FF + Sbjct: 296 preRPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFM-SF 354 Query: 1004 GPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAH-RLNVEQK 1168 G V ++RI T G LPNFGF+VF + E V+ IL KPI + RLNVE+K Sbjct: 355 GNVVELRI---NTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEK 407
>sp|P97379|G3B2_MOUSE Ras-GTPase-activating protein binding protein 2 (GAP SH3-domain binding protein 2) (G3BP-2) Length = 482 Score = 152 bits (383), Expect = 3e-36 Identities = 122/428 (28%), Positives = 190/428 (44%), Gaps = 62/428 (14%) Frame = +2 Query: 71 MDRELITTVSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQG--------QNEIH 226 M++ V +EFV Q+YT++NK P LHRFY S+ + V A G QN+IH Sbjct: 3 MEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIH 62 Query: 227 KYYMNLELSNCKAVVLSLDAVKSHGKSILIQVTGEIANNGCDLRRFMQSFLLVEQDL--G 400 ++L S C + +DA + +++QV G ++N+G R+FMQ+F+L + Sbjct: 63 HKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPN 122 Query: 401 NFYVLNDIFRYQDQTFKVEDVEEAPVVEHESKNEDIHGEINSWNELSRNCELNNEQIPQS 580 FYV ND+FRY+D+ F + P ++ ES++E E E S Sbjct: 123 KFYVHNDMFRYEDEVFG----DSEPELDEESEDE---------------VEEEQEDRQPS 163 Query: 581 PQLIEHEEGSEEFINYKIMNEEKDISSEIPVEIDSQQDIGQKMEEM--NIKEK------- 733 P+ ++ S + + + N ++ E E + + + K EE+ ++EK Sbjct: 164 PEPVQENANSAYYDAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKHLEELEE 223 Query: 734 ---------------------SWAAIIN---PMSS--RPSXXXXXXXXXXXXXXXXXXXX 835 SWA++ + P S S Sbjct: 224 KSATPPPAEPASLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVDAKPE 283 Query: 836 INSNGDNMEKRKPRFNNG----------------NVKTPSTLNYPDEHQLFVGNLPQNMT 967 + S + +++PR G + + YPD HQLFVGNLP ++ Sbjct: 284 VQSQPPRVREQRpreRPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDID 343 Query: 968 EDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAH 1147 E+ELK+FF +G V ++RI T G LPNFGF+VF + E V+ IL KPI + Sbjct: 344 ENELKEFFM-SFGNVVELRI---NTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGE 399 Query: 1148 -RLNVEQK 1168 RLNVE+K Sbjct: 400 VRLNVEEK 407
>sp|O94260|G3BP_SCHPO Putative G3BP-like protein Length = 434 Score = 114 bits (286), Expect = 5e-25 Identities = 108/388 (27%), Positives = 170/388 (43%), Gaps = 34/388 (8%) Frame = +2 Query: 107 FVLQFYTIMNKHPGSLHRFYKEESTLIR-DEVHA----QGQNEIHKYYMNLELSNCKAVV 271 FV ++YT +NK P LH FY ++STLI DE + GQ EIH ++L+ NCK ++ Sbjct: 22 FVQEYYTYLNKEPNRLHCFYTKKSTLIHGDEGESISLCHGQQEIHNKILDLDFQNCKVLI 81 Query: 272 LSLDAVKSHGKSILIQVTGEIANNGCDLRRFMQSFLLVEQDLGNFYVLNDIFRYQDQTFK 451 ++D++ S I+IQV GE++N G R+F Q+F L EQ G ++VLNDIFR+ + Sbjct: 82 SNVDSLASSNGGIVIQVLGEMSNKGKLSRKFAQTFFLAEQPNG-YFVLNDIFRFLRE--D 138 Query: 452 VEDVEEAP-VVEHESK---NEDIHGEINSWNELSRNCELNNEQIPQSPQ-------LIEH 598 VE+ EE+P VE E K +E + S L E + Q P + + LI + Sbjct: 139 VEEEEESPDAVEKEKKDVASEPYVNGVQSQEHLPSAKEEGHYQDPAATENNFATAALISN 198 Query: 599 EEGSEEFINYKIMNE------EKDISSEIPVEIDSQQD------------IGQKMEEMNI 724 E S + E E + S + + + QD IG + Sbjct: 199 ETDSLNQATLAVPEEPVIQVTEASVPSFVSQQENQLQDEALTSNSKNADAIGASDANVAT 258 Query: 725 KEKSWAAIINPMSSRPSXXXXXXXXXXXXXXXXXXXXINSNGDNMEKRKPRFNNGNVKTP 904 KSWA +I + P +N+ D ++ + N Sbjct: 259 APKSWADLI--ARNHPDVKSQASVSSTASTTGQTVKGVNA--DQTQQPTAPYTQSNELL- 313 Query: 905 STLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLV 1084 E +FV N+P ++ LK S +GPVK + + + + ++ Sbjct: 314 -------ETSVFVKNIPPETSDVSLKSAMS-IFGPVKAIEFARRKGT---------AYVD 356 Query: 1085 FHNHEVVEEILKNKPIYYSAHRLNVEQK 1168 F NHE V+ L K + + LN+E++ Sbjct: 357 FVNHECVQLALNKKTLQINNATLNIEER 384
>sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) Length = 414 Score = 52.8 bits (125), Expect = 2e-06 Identities = 37/109 (33%), Positives = 55/109 (50%), Gaps = 6/109 (5%) Frame = +2 Query: 896 KTPSTLNYPDE----HQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPL 1063 K P++ DE ++FVG ++MTEDEL++FFS+ YG V DV I KP Sbjct: 176 KLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQ-YGDVMDVFIP--------KPF 226 Query: 1064 PNFGFLVFHNHEVVEEILKNKPIY--YSAHRLNVEQKMGSSRGSHKAGR 1204 F F+ F + ++ + + I S H N E K S+R ++GR Sbjct: 227 RAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGR 275
>sp|P53741|BRE5_YEAST UBP3-associated protein BRE5 Length = 515 Score = 50.1 bits (118), Expect = 2e-05 Identities = 40/152 (26%), Positives = 71/152 (46%), Gaps = 21/152 (13%) Frame = +2 Query: 107 FVLQFYTIMNKHPGSL-----------HRFYKEESTLIRDEV----HAQGQNEIHKYYMN 241 F+ +Y M P L H Y+ +ST +D+V G+ I+K++ Sbjct: 12 FLQNYYERMRTDPSKLAYFYASTAELTHTNYQSKSTNEKDDVLPTVKVTGRENINKFFSR 71 Query: 242 LELSNCKAVVLSLDAVKSH-----GKSILIQVTGEIANNGCDLRRFMQSFLLVEQDLGN- 403 + + +++ L LD + KSILI TGE+ G + +F Q+F+L+ G+ Sbjct: 72 ND-AKVRSLKLKLDTIDFQYTGHLHKSILIMATGEMFWTGTPVYKFCQTFILLPSSNGST 130 Query: 404 FYVLNDIFRYQDQTFKVEDVEEAPVVEHESKN 499 F + NDI R+ +FK + +A + + +N Sbjct: 131 FDITNDIIRFISNSFKPYVLTDASLSQSNEEN 162
>sp|Q10100|NTF2_SCHPO Nuclear transport factor 2 (NTF-2) Length = 123 Score = 50.1 bits (118), Expect = 2e-05 Identities = 34/114 (29%), Positives = 59/114 (51%), Gaps = 2/114 (1%) Frame = +2 Query: 95 VSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQGQNEIHKYYMNLELSNCKAVVL 274 ++ +F +Y + L Y+EES L + QG I + ++L + + Sbjct: 7 LATQFTQFYYQTFDSDRSQLSSLYREESMLSFEGAQLQGTKAIVEKLVSLPFQRVQHRIS 66 Query: 275 SLDAVKSHGK-SILIQVTGEIANNGCDL-RRFMQSFLLVEQDLGNFYVLNDIFR 430 +LDA + S+++ VTGE+ + + +R+ Q F LV + GN+YVLND+FR Sbjct: 67 TLDAQPTGTTGSVIVMVTGELLLDEEQMAQRYSQVFHLVNNN-GNYYVLNDLFR 119
>sp|Q6BWC0|NTF2_DEBHA Nuclear transport factor 2 (NTF-2) Length = 124 Score = 49.3 bits (116), Expect = 3e-05 Identities = 37/115 (32%), Positives = 58/115 (50%), Gaps = 2/115 (1%) Frame = +2 Query: 92 TVSQEFVLQFYTIMNKHPGSLHRFYKEESTLIRDEVHAQGQNEIHKYYMNLELSNCKAVV 271 TV+ EF +Y + L Y+E+S L + QG +I + ++L + Sbjct: 7 TVASEFCNFYYQQFDSDRTQLGNLYREQSMLTFETSQLQGAKDIVEKLVSLPFQKVAHRI 66 Query: 272 LSLDAVK-SHGKSILIQVTGE-IANNGCDLRRFMQSFLLVEQDLGNFYVLNDIFR 430 +LDA S IL+ VTGE I ++ + +R+ Q F L+ D ++YV NDIFR Sbjct: 67 STLDAQPGSPNGDILVMVTGELIIDDEQNAQRYSQVFHLI-PDGNSYYVFNDIFR 120
>sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) Length = 414 Score = 48.5 bits (114), Expect = 5e-05 Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%) Frame = +2 Query: 896 KTPSTLNYPDE----HQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPL 1063 K P++ PDE ++FVG ++MT +EL+ FF + YG V DV I KP Sbjct: 176 KLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQ-YGEVVDVFIP--------KPF 226 Query: 1064 PNFGFLVFHNHEVVEEILKNKPIY--YSAHRLNVEQKMGSSRGSHKAGR 1204 F F+ F + +V + + I S H N E K S+R ++GR Sbjct: 227 RAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGR 275
Score = 36.6 bits (83), Expect = 0.18 Identities = 27/97 (27%), Positives = 44/97 (45%) Frame = +2 Query: 836 INSNGDNMEKRKPRFNNGNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVK 1015 +N DN K + VK + + L V LP TE +LKD+FS +G V Sbjct: 75 VNYPKDNKRKMDETDASSAVKVKRAVQKTSD--LIVLGLPWKTTEQDLKDYFS-TFGEVL 131 Query: 1016 DVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNK 1126 V+++K + K FGF+ F +E +++ + Sbjct: 132 MVQVKKDLKTGHSK---GFGFVRFTEYETQVKVMSQR 165
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 144,709,869 Number of Sequences: 369166 Number of extensions: 2822568 Number of successful extensions: 8671 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 8136 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8625 length of database: 68,354,980 effective HSP length: 114 effective length of database: 47,295,190 effective search space used: 17073563590 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)