Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_K18
(611 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13283|G3BP_HUMAN Ras-GTPase-activating protein binding ... 89 1e-17
sp|P97855|G3BP_MOUSE Ras-GTPase-activating protein binding ... 88 2e-17
sp|P97379|G3B2_MOUSE Ras-GTPase-activating protein binding ... 82 8e-16
sp|Q9UN86|G3B2_HUMAN Ras-GTPase-activating protein binding ... 82 8e-16
sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) 53 7e-07
sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) 49 1e-05
sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotei... 48 2e-05
sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotei... 48 2e-05
sp|P48809|RB27C_DROME Heterogeneous nuclear ribonucleoprote... 48 2e-05
sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoprotei... 47 4e-05
>sp|Q13283|G3BP_HUMAN Ras-GTPase-activating protein binding protein 1 (GAP SH3-domain
binding protein 1) (G3BP-1) (DNA helicase VIII)
(HDH-VIII)
Length = 466
Score = 88.6 bits (218), Expect = 1e-17
Identities = 48/110 (43%), Positives = 70/110 (63%), Gaps = 1/110 (0%)
Frame = +1
Query: 205 GNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLP 384
G+++ + +PD HQLF+GNLP + + ELKDFF + YG V ++RI N G LP
Sbjct: 326 GDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF-QSYGNVVELRI------NSGGKLP 378
Query: 385 NFGFLVFHNHEVVEEILKNKPIYYSAH-RLNVEQKMGSSRGSHKAGRR*N 531
NFGF+VF + E V+++L N+PI + RLNVE+K +R + + RR N
Sbjct: 379 NFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEK--KTRAAREGDRRDN 426
>sp|P97855|G3BP_MOUSE Ras-GTPase-activating protein binding protein 1 (GAP SH3-domain
binding protein 1) (G3BP-1) (DNA helicase VIII)
(HDH-VIII)
Length = 465
Score = 88.2 bits (217), Expect = 2e-17
Identities = 49/110 (44%), Positives = 71/110 (64%), Gaps = 1/110 (0%)
Frame = +1
Query: 205 GNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLP 384
G+V+ + +PD HQLF+GNLP + + ELKDFF + +G V ++RI N G LP
Sbjct: 324 GDVEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFF-QNFGNVVELRI------NSGGKLP 376
Query: 385 NFGFLVFHNHEVVEEILKNKPIYY-SAHRLNVEQKMGSSRGSHKAGRR*N 531
NFGF+VF + E V+++L N+PI + A RLNVE+K +R + + RR N
Sbjct: 377 NFGFVVFDDSEPVQKVLSNRPIMFRGAVRLNVEEK--KTRAAREGDRRDN 424
>sp|P97379|G3B2_MOUSE Ras-GTPase-activating protein binding protein 2 (GAP SH3-domain
binding protein 2) (G3BP-2)
Length = 482
Score = 82.4 bits (202), Expect = 8e-16
Identities = 50/107 (46%), Positives = 66/107 (61%), Gaps = 6/107 (5%)
Frame = +1
Query: 184 RKPRFNNGNVKTPSTLN-----YPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQ 348
R PR G+++ + N YPD HQLFVGNLP ++ E+ELK+FF +G V ++RI
Sbjct: 305 RGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFM-SFGNVVELRI- 362
Query: 349 KSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAH-RLNVEQK 486
T G LPNFGF+VF + E V+ IL KPI + RLNVE+K
Sbjct: 363 --NTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEK 407
>sp|Q9UN86|G3B2_HUMAN Ras-GTPase-activating protein binding protein 2 (GAP SH3-domain
binding protein 2) (G3BP-2)
Length = 482
Score = 82.4 bits (202), Expect = 8e-16
Identities = 50/107 (46%), Positives = 66/107 (61%), Gaps = 6/107 (5%)
Frame = +1
Query: 184 RKPRFNNGNVKTPSTLN-----YPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQ 348
R PR G+++ + N YPD HQLFVGNLP ++ E+ELK+FF +G V ++RI
Sbjct: 305 RGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFM-SFGNVVELRI- 362
Query: 349 KSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAH-RLNVEQK 486
T G LPNFGF+VF + E V+ IL KPI + RLNVE+K
Sbjct: 363 --NTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEK 407
>sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43)
Length = 414
Score = 52.8 bits (125), Expect = 7e-07
Identities = 37/109 (33%), Positives = 55/109 (50%), Gaps = 6/109 (5%)
Frame = +1
Query: 214 KTPSTLNYPDE----HQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPL 381
K P++ DE ++FVG ++MTEDEL++FFS+ YG V DV I KP
Sbjct: 176 KLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQ-YGDVMDVFIP--------KPF 226
Query: 382 PNFGFLVFHNHEVVEEILKNKPIY--YSAHRLNVEQKMGSSRGSHKAGR 522
F F+ F + ++ + + I S H N E K S+R ++GR
Sbjct: 227 RAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGR 275
>sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43)
Length = 414
Score = 48.5 bits (114), Expect = 1e-05
Identities = 36/109 (33%), Positives = 53/109 (48%), Gaps = 6/109 (5%)
Frame = +1
Query: 214 KTPSTLNYPDE----HQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPL 381
K P++ PDE ++FVG ++MT +EL+ FF + YG V DV I KP
Sbjct: 176 KLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQ-YGEVVDVFIP--------KPF 226
Query: 382 PNFGFLVFHNHEVVEEILKNKPIY--YSAHRLNVEQKMGSSRGSHKAGR 522
F F+ F + +V + + I S H N E K S+R ++GR
Sbjct: 227 RAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGR 275
Score = 36.6 bits (83), Expect = 0.052
Identities = 27/97 (27%), Positives = 44/97 (45%)
Frame = +1
Query: 154 INSNGDNMEKRKPRFNNGNVKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVK 333
+N DN K + VK + + L V LP TE +LKD+FS +G V
Sbjct: 75 VNYPKDNKRKMDETDASSAVKVKRAVQKTSD--LIVLGLPWKTTEQDLKDYFS-TFGEVL 131
Query: 334 DVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNK 444
V+++K + K FGF+ F +E +++ +
Sbjct: 132 MVQVKKDLKTGHSK---GFGFVRFTEYETQVKVMSQR 165
>sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Length = 378
Score = 48.1 bits (113), Expect = 2e-05
Identities = 27/93 (29%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Frame = +1
Query: 250 QLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEE 429
++FVG + ++ E L+D+F EKYG ++ + + + R S + + F F+ F +H+ V++
Sbjct: 127 KIFVGGIKEDTEEYNLRDYF-EKYGKIETIEVMEDRQSGKKR---GFAFVTFDDHDTVDK 182
Query: 430 ILKNKPIYYSAHRLNVE--------QKMGSSRG 504
I+ K + H V+ Q GS RG
Sbjct: 183 IVVQKYHTINGHNCEVKKALSKQEMQSAGSQRG 215
Score = 33.9 bits (76), Expect = 0.34
Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Frame = +1
Query: 169 DNMEKRKPRFNNGN-VKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRI 345
D+ +R+ R G+ K P L +LF+G L T+D L++ F EK+G + D +
Sbjct: 13 DSGRRRRRRGEEGHDPKEPEQLR-----KLFIGGLSFETTDDSLREHF-EKWGTLTDCVV 66
Query: 346 QKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAHRLN---VEQKMGSSR 501
+ + + FGF+ + E V+ + +P H+++ VE K SR
Sbjct: 67 MRDPQTKRSR---GFGFVTYSCVEEVDAAMCARP-----HKVDGRVVEPKRAVSR 113
>sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
sp|Q6URK4|ROA3_RAT Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Length = 379
Score = 48.1 bits (113), Expect = 2e-05
Identities = 27/93 (29%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Frame = +1
Query: 250 QLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEE 429
++FVG + ++ E L+D+F EKYG ++ + + + R S + + F F+ F +H+ V++
Sbjct: 127 KIFVGGIKEDTEEYNLRDYF-EKYGKIETIEVMEDRQSGKKR---GFAFVTFDDHDTVDK 182
Query: 430 ILKNKPIYYSAHRLNVE--------QKMGSSRG 504
I+ K + H V+ Q GS RG
Sbjct: 183 IVVQKYHTINGHNCEVKKALSKQEMQSAGSQRG 215
Score = 33.9 bits (76), Expect = 0.34
Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Frame = +1
Query: 169 DNMEKRKPRFNNGN-VKTPSTLNYPDEHQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRI 345
D+ +R+ R G+ K P L +LF+G L T+D L++ F EK+G + D +
Sbjct: 13 DSGRRRRRRGEEGHDPKEPEQLR-----KLFIGGLSFETTDDSLREHF-EKWGTLTDCVV 66
Query: 346 QKSRTSNEGKPLPNFGFLVFHNHEVVEEILKNKPIYYSAHRLN---VEQKMGSSR 501
+ + + FGF+ + E V+ + +P H+++ VE K SR
Sbjct: 67 MRDPQTKRSR---GFGFVTYSCVEEVDAAMCARP-----HKVDGRVVEPKRAVSR 113
>sp|P48809|RB27C_DROME Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (hnRNP 48)
(HRP48.1)
Length = 421
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 3/91 (3%)
Frame = +1
Query: 220 PSTLNYPDE---HQLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNF 390
P TL P + +++F+G LP N+TE +L+ FF+ +YG V +V I + E K F
Sbjct: 84 PRTLQKPKKGGGYKVFLGGLPSNVTETDLRTFFN-RYGKVTEVVIMYDQ---EKKKSRGF 139
Query: 391 GFLVFHNHEVVEEILKNKPIYYSAHRLNVEQ 483
GFL F VE + + I + ++ +++
Sbjct: 140 GFLSFEEESSVEHVTNERYINLNGKQVEIKK 170
Score = 35.0 bits (79), Expect = 0.15
Identities = 21/66 (31%), Positives = 34/66 (51%)
Frame = +1
Query: 250 QLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEE 429
+LFVG L T++ L +F ++G + D + K+ NE FGF+ F + V
Sbjct: 8 KLFVGGLSWETTQENLSRYFC-RFGDIIDCVVMKN---NESGRSRGFGFVTFADPTNVNH 63
Query: 430 ILKNKP 447
+L+N P
Sbjct: 64 VLQNGP 69
>sp|P22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2 / hnRNP
B1)
Length = 353
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/84 (32%), Positives = 48/84 (57%)
Frame = +1
Query: 250 QLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEE 429
+LFVG + ++ E L+D+F E+YG + + I R S + + FGF+ F +H+ V++
Sbjct: 113 KLFVGGIKEDTEEHHLRDYF-EEYGKIDTIEIITDRQSGKKR---GFGFVTFDDHDPVDK 168
Query: 430 ILKNKPIYYSAHRLNVEQKMGSSR 501
I+ K Y++ + N E + SR
Sbjct: 169 IVLQK--YHTINGHNAEVRKALSR 190
Score = 33.1 bits (74), Expect = 0.57
Identities = 17/66 (25%), Positives = 35/66 (53%)
Frame = +1
Query: 250 QLFVGNLPQNMTEDELKDFFSEKYGPVKDVRIQKSRTSNEGKPLPNFGFLVFHNHEVVEE 429
+LF+G L TE+ L++++ E++G + D + + S + FGF+ F + V+
Sbjct: 22 KLFIGGLSFETTEESLRNYY-EQWGKLTDCVVMRDPASKRSR---GFGFVTFSSMAEVDA 77
Query: 430 ILKNKP 447
+ +P
Sbjct: 78 AMAARP 83
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,088,343
Number of Sequences: 369166
Number of extensions: 1252832
Number of successful extensions: 3453
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3263
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3440
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4797864890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)