Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01081 (1436 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chape... 359 1e-98 sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chape... 355 2e-97 sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chapero... 355 2e-97 sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 353 7e-97 sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chape... 353 9e-97 sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chape... 339 1e-92 sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chape... 334 3e-91 sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hs... 238 3e-62 sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 65 5e-10 sp|P06101|CDC37_YEAST Hsp90 co-chaperone Cdc37 (Hsp90 chape... 60 2e-08
>sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) Length = 378 Score = 359 bits (922), Expect = 1e-98 Identities = 174/360 (48%), Positives = 246/360 (68%), Gaps = 2/360 (0%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS WDHIEVSDDED+THPNIDT SLFRWRH+ARVER ++F EK ++++ +E + Sbjct: 2 VDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKV 61 Query: 200 QNTRDKIKSAE--ENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICK 373 + K+K E E +L+ E ++L + + +K +E KEK PWNVD++ K Sbjct: 62 AECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSK 121 Query: 374 EGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHL 553 +G +K+++N+ + + +E+ + K FVEKY+ IK +G+ R+ ++ +++L N HL Sbjct: 122 DGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHL 181 Query: 554 VCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKF 733 VCE+TAN+LVIWCIDL VEEK LME V+HQ IVMQFILELAKSLK DPR C + FF K Sbjct: 182 VCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKI 241 Query: 734 RSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANL 913 ++ + +Y F EL+ M + EEEER+KRLGPGGLDPVEV+ +L Sbjct: 242 KTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESL 301 Query: 914 PKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASG 1093 P+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ EA E E +G Sbjct: 302 PEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKA---SEAKEGEEAG 358
>sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) Length = 379 Score = 355 bits (911), Expect = 2e-97 Identities = 171/361 (47%), Positives = 250/361 (69%), Gaps = 3/361 (0%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS WDHIEVSDDED+THPNIDT SLFRWRH+ARVER ++F EK ++++ +E + Sbjct: 2 VDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKV 61 Query: 200 QNTRDKIKSAE--ENNNEIA-SKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSIC 370 + K+K E E++ ++ +L+ E ++L + + +K ++ KEK PWNVD++ Sbjct: 62 AECQRKLKELEVAESDGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLS 121 Query: 371 KEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPH 550 K+G +K+++N+ + + +E+ + K FVEKY+ IK +G+ + ++ +++L N H Sbjct: 122 KDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVH 181 Query: 551 LVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAK 730 LVCE+TAN+LVIWCIDL VEEK LME V+HQ +VMQFILELAKSLK DPR C + FF K Sbjct: 182 LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTK 241 Query: 731 FRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFAN 910 ++ + +Y F EL+ M + EEEER+KRLGPGGLDPVEV+ + Sbjct: 242 IKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES 301 Query: 911 LPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEAS 1090 LP+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ + EA E E + Sbjct: 302 LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSK---SGEAKEGEEA 358 Query: 1091 G 1093 G Sbjct: 359 G 359
>sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) Length = 379 Score = 355 bits (910), Expect = 2e-97 Identities = 171/361 (47%), Positives = 248/361 (68%), Gaps = 3/361 (0%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS WDHIEVSDDED+THPNIDT SLFRWRH+ARVER ++F EK ++++ +E + Sbjct: 2 VDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKV 61 Query: 200 QNTRDKIKSAE--ENNNEIA-SKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSIC 370 + K+K E E ++ +L+ E ++L + + +K ++ KEK PWNVD++ Sbjct: 62 AECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLS 121 Query: 371 KEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPH 550 K+G +K+++N+ + + +E+ + K FVEKY+ IK +G+ + ++ +++L N H Sbjct: 122 KDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVH 181 Query: 551 LVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAK 730 LVCE+TAN+LVIWCIDL VEEK LME V+HQ +VMQFILELAKSLK DPR C + FF K Sbjct: 182 LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTK 241 Query: 731 FRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFAN 910 ++ + +Y F EL+ M + EEEER+KRLGPGGLDPVEV+ + Sbjct: 242 IKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES 301 Query: 911 LPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEAS 1090 LP+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ + EA E E + Sbjct: 302 LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSK---SGEAKEGEEA 358 Query: 1091 G 1093 G Sbjct: 359 G 359
>sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) Length = 377 Score = 353 bits (906), Expect = 7e-97 Identities = 175/364 (48%), Positives = 248/364 (68%), Gaps = 5/364 (1%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 IDYS WDHIEVSDDED +HPNIDTPSLFRWRH+ARVER ++F + +D+ K +E + Sbjct: 4 IDYSVWDHIEVSDDEDVSHPNIDTPSLFRWRHQARVERMEDFKKKGDDLNKGLQECRRKL 63 Query: 200 QNTRDKIK----SAEENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSI 367 + K++ SA + +K + E +KL+ + ++ +K +E +EK+ PWNVD++ Sbjct: 64 AEAQKKVRELSISAAGDAKAELTKTQTEEKKLKKEERDWARKLEEHNHEEKKMPWNVDTL 123 Query: 368 CKEGKTKTIIN-SFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKN 544 K+G +K+I+N D+ E EK+ + K FVE+Y+ IK +G+ + ++ +R+L N Sbjct: 124 SKDGFSKSIVNVKADSAEDTEEEKE--KKHKTFVERYEKQIKHFGMLHRWDDSQRYLSDN 181 Query: 545 PHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFF 724 P LVCE+TAN+LVI CIDL VEEK LME V+HQ IVMQFILELAKSLK DPR C + FF Sbjct: 182 PDLVCEETANYLVIMCIDLEVEEKHALMEQVAHQTIVMQFILELAKSLKVDPRGCFRQFF 241 Query: 725 AKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVF 904 K ++ + +YQ AF EL+ M + EEEERQKRLGPGGLDPVEV+ Sbjct: 242 EKIKTADQQYQDAFNDELESFKERVRGRAKIRIEKAMKEYEEEERQKRLGPGGLDPVEVY 301 Query: 905 ANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESE 1084 +LP E+Q+CF++K+I+MLQ+ ++KMDP EA+ H+++CIDSG+W+PN+ ++DE + Sbjct: 302 ESLPPEMQKCFDEKDIQMLQDVITKMDPTEAKAHMKRCIDSGLWVPNSKMDESDEKEDGS 361 Query: 1085 ASGE 1096 E Sbjct: 362 TYEE 365
>sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) Length = 393 Score = 353 bits (905), Expect = 9e-97 Identities = 175/371 (47%), Positives = 243/371 (65%), Gaps = 8/371 (2%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS WDHIEVSDDED+THPNIDT SLFRWRH+ARVER ++F EK +++K +E + Sbjct: 2 VDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDKGCRECKRKL 61 Query: 200 QNTRDKIKSAEENNNEIAS--------KLKEELRKLETDFDEFNKKRDEFLSKEKRRPWN 355 + K+K E S +L+ E ++L + + K +E KEK PWN Sbjct: 62 AECQKKLKELEVAEPGGGSGGGRGERERLQAEAQQLRHEERNWESKMEELRKKEKNMPWN 121 Query: 356 VDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFL 535 V ++ K+G +K++ N +EK E+ + K FVE+++ IK +G+ R+ ++ +++L Sbjct: 122 VHTLSKDGFSKSVFN-VKAEEKEETEEQKEQKHKTFVERHEKQIKHFGMLRRWDDSQKYL 180 Query: 536 MKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIK 715 NPHLVCE+TAN+LVIWCIDL VEEK LME V+HQ IVMQFILELAKSLK DPR C + Sbjct: 181 SDNPHLVCEETANYLVIWCIDLEVEEKQALMEQVAHQTIVMQFILELAKSLKVDPRACFR 240 Query: 716 PFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPV 895 FF K ++ + +Y F EL+ M + EEEERQKRLGPGGLDPV Sbjct: 241 QFFTKIKTADQQYMEGFNDELEAFKERVRGRAKARIERAMREYEEEERQKRLGPGGLDPV 300 Query: 896 EVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEAN 1075 +V+ +LP ELQ+CF+ K+++MLQ+ +S+MDP EA+ H+Q+CIDSG+W+PNA K + Sbjct: 301 DVYESLPPELQKCFDAKDVQMLQDTISRMDPTEAKYHMQRCIDSGLWVPNA-KAAAEGGG 359 Query: 1076 ESEASGEYGNA 1108 + A G+ G A Sbjct: 360 QGGAHGQPGGA 370
>sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) Length = 399 Score = 339 bits (870), Expect = 1e-92 Identities = 166/363 (45%), Positives = 247/363 (68%), Gaps = 6/363 (1%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS+W +IE+SDDED+THPNIDTPSLFRWRH+ARVER E EK +++K + + + Sbjct: 2 VDYSKWKNIEISDDEDETHPNIDTPSLFRWRHQARVERMAESEKEKEELKKKRQSYQARL 61 Query: 200 QNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEG 379 N ++ I E +E+A LK+EL K+E + E +++ +E L +EK+ PWNVD+I K G Sbjct: 62 INVKELISKKE--GDEVA--LKKELEKIENEGKELDRQENELLKREKKTPWNVDTISKPG 117 Query: 380 KTKTIINSFDTQE--KPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHL 553 KT+IN ++ + + E++ RMK FV++ + K+YG+ RK ++ +RFL ++ L Sbjct: 118 FEKTVINKKPPRKAAEDLTEEEREQRMKQFVKENEKLCKQYGMLRKYDDSKRFLQEHLDL 177 Query: 554 VCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKF 733 VCE+TAN+LVIW I+L +EEK +LM HV+HQCI MQ+ILELAK L DPR C+ FF+K Sbjct: 178 VCEETANYLVIWSINLEMEEKHDLMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKI 237 Query: 734 RSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANL 913 + PEY+ F SE++ MA++EEEE+Q+R+GPGGLDP +VF +L Sbjct: 238 QQCVPEYRQQFESEIEGFKERIQKRAQEKLQEAMAQLEEEEKQERMGPGGLDPADVFESL 297 Query: 914 PKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANK----KDNDEANES 1081 P+EL+ CFE ++IE+LQ+ ++ M +A+ H+++C+DSG+W+PNA D EA + Sbjct: 298 PEELKACFESRDIELLQKTIATMPVDQAKYHMKRCVDSGLWVPNAADVQLGNDETEAKDD 357 Query: 1082 EAS 1090 E + Sbjct: 358 ETT 360
>sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (Enhancer of sevenless 3B) Length = 389 Score = 334 bits (857), Expect = 3e-91 Identities = 164/364 (45%), Positives = 247/364 (67%), Gaps = 3/364 (0%) Frame = +2 Query: 20 IDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNI 199 +DYS+W +IE+SDDEDDTHPNIDTPSLFRWRH+ARVER E + EK++++K + + + Sbjct: 2 VDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARL 61 Query: 200 QNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEG 379 + +++I ++++ +E A LK+EL K+E + E ++ E + KEK+ PWNVD+I K G Sbjct: 62 MDVKERI--SKKDGDEEA--LKKELEKIEAEGKELDRIESEMIKKEKKTPWNVDTISKPG 117 Query: 380 KTKTIINSFDTQEKP---VNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPH 550 KT+IN KP ++E++ RMK FV++ + ++YG+ RK ++ +RFL ++ H Sbjct: 118 FEKTVINK-KAGRKPDENLSEEEREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLH 176 Query: 551 LVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAK 730 LV E+TAN+LVIW I+L +EEK LM HV+HQCI MQ+ILELAK L DPR C+ FF+K Sbjct: 177 LVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSK 236 Query: 731 FRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFAN 910 + PEY+ F SE++ +A+ EEEER++RLGPGGLDP +VF + Sbjct: 237 IQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERLGPGGLDPADVFES 296 Query: 911 LPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEAS 1090 LP EL+ CFE +++E+LQ+ ++ M A+ H+++C+DSG+W+PNA + D+ E ++ Sbjct: 297 LPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSD 356 Query: 1091 GEYG 1102 G Sbjct: 357 DVAG 360
>sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) Length = 370 Score = 238 bits (607), Expect = 3e-62 Identities = 132/368 (35%), Positives = 207/368 (56%), Gaps = 7/368 (1%) Frame = +2 Query: 14 MPIDYSRWDHIEVSDDEDDTHPNIDTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLT 193 MPIDYS+W IEVSDDEDDTHPNIDTPSLFRWRH+AR+ER E ME+ I+K Sbjct: 1 MPIDYSKWKDIEVSDDEDDTHPNIDTPSLFRWRHQARLERMAEKKMEQEKIDKEKGTTSK 60 Query: 194 NIQNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICK 373 ++ K+ +A+ + S +++++ +++ + + KK E KE+ PWNVD+I Sbjct: 61 KMEELEKKLAAADVTDK---SDIQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTIGH 117 Query: 374 EGKTKTIINSFDTQ--EKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRK-VEEMERFLMKN 544 E + + IN + + P +++ M F E ++ ++K + + + E FL ++ Sbjct: 118 EAFSTSRINKITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGAKSTELFLAEH 177 Query: 545 PHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCI--KP 718 PH+ E TAN L I ++ A++ M+ ++ QCI++Q++LEL+KSL + K Sbjct: 178 PHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLLELSKSLNAVATNTTVQKQ 237 Query: 719 FFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRL--GPGGLDP 892 FF KF + EP Y + E+ M + E EE+ +R+ PGG+DP Sbjct: 238 FFKKFEAAEPVYMKHYQDEVKAFEDRLRTRAQTKRDAAMEEAEAEEKAERMKSAPGGIDP 297 Query: 893 VEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEA 1072 EVF LP+E+++CFE +IE L+ KMD + + H +CI SG+W+P K D+D+ Sbjct: 298 QEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLWVP--GKADDDDD 355 Query: 1073 NESEASGE 1096 +E A E Sbjct: 356 DEEAAPAE 363
>sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (Cell division control protein 37) Length = 508 Score = 65.1 bits (157), Expect = 5e-10 Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 6/113 (5%) Frame = +2 Query: 14 MPIDYSRWDHIEVSDDED-DTHPNIDTPSLFRWRHKARVERDQEFNMEKNDI---EKVYK 181 MPIDYS+WD IE+SDD D + HPN+D S RW+ + E+ + N+E I +Y Sbjct: 1 MPIDYSKWDKIEISDDSDVEVHPNVDKQSFIRWKQRDIHEKRMQRNIEIKSILIQLTMYA 60 Query: 182 EFLTNIQNTRDKIKSAEENNNE-IASKLKEELRKLET-DFDEFNKKRDEFLSK 334 + + +K+ S E ++E + SKL E E D+D+ K + L K Sbjct: 61 KLNERVDYLLEKLTSTELLDSEKVMSKLNSEFDPQEKFDYDKLIKDKGSTLRK 113
Score = 58.2 bits (139), Expect = 6e-08 Identities = 71/355 (20%), Positives = 144/355 (40%), Gaps = 61/355 (17%) Frame = +2 Query: 131 RDQEFNMEKNDIEKVYKEFLTNI-QNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFN 307 +D +F+ E+ + Y E + ++ +D + + +++ LKE +++ + Sbjct: 116 KDLKFDREEIENTPCYNEMIEDLFVQIKDDHPETKTDGDKLIEYLKEHRNRIDDVLSKQT 175 Query: 308 KKRDE---------------------FLSKEK--RRPWNVDSICKEGKTKTIINSFDT-- 412 K D+ FL+K+K + N D KT + + +T Sbjct: 176 IKLDDLLYQKAQLIVSDDLHTGFDRSFLNKDKPEEKEENQDKPKAPEAKKTTVTTTETIN 235 Query: 413 QEKPVNE---KDVVDRM------KAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCED 565 KPV E K+++D + K F + D++ K FL+K+P + E Sbjct: 236 SPKPVEENTDKEILDELEILPATKEFAKIPSDNLSKAA---------EFLIKHPSICTEQ 286 Query: 566 TANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPR---DCIKPFFAKFR 736 + L++ DL +E K++ +H+ HQ +++Q++ +L+ + K P + IK FF+K Sbjct: 287 QKDALIMTAFDLQLENKSDEAKHIVHQSLLLQYVGQLSDNGKAAPANVINAIKLFFSKIA 346 Query: 737 SQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKI-------EEEERQKRLGPGGLD-- 889 ++ + AF +++ EEEE + + LD Sbjct: 347 AESSPAKHAFLEDVNQTFNHIKGRCEIIKEEQKQNAANKEGTGEEEEEEALIQLKALDDN 406 Query: 890 -------------PVEVF-ANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQ 1012 E+F LP E Q + ++I+ + + +K+ ++AE L+ Sbjct: 407 TELSVNIPQEGTKEYEIFTTKLPIEFQNAIKTESIDEVNKEFAKLKIEDAERILE 461
>sp|P06101|CDC37_YEAST Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (Cell division control protein 37) Length = 506 Score = 60.1 bits (144), Expect = 2e-08 Identities = 47/189 (24%), Positives = 87/189 (46%), Gaps = 5/189 (2%) Frame = +2 Query: 14 MPIDYSRWDHIEVSDDED-DTHPNIDTPSLFRWR----HKARVERDQEFNMEKNDIEKVY 178 M IDYS+WD IE+SDD D + HPN+D S +W+ H+ R +R+Q+ + + Sbjct: 1 MAIDYSKWDKIELSDDSDVEVHPNVDKKSFIKWKQQSIHEQRFKRNQDIKNLETQV---- 56 Query: 179 KEFLTNIQNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNV 358 + +++ D+I S ++ + L + L +FD+ K + E + E + Sbjct: 57 -DMYSHLNKRVDRILSNLPESS--LTDLPAVTKFLNANFDKMEKSKGENVDPEIATYNEM 113 Query: 359 DSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLM 538 E K + + P +D + + +A ++ + KK K++E+ + Sbjct: 114 VEDLFEQLAKDLDKEGKDSKSPSLIRDAILKHRAKIDSVTVEAKK-----KLDEL--YKE 166 Query: 539 KNPHLVCED 565 KN H+ ED Sbjct: 167 KNAHISSED 175
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 147,394,156 Number of Sequences: 369166 Number of extensions: 2899368 Number of successful extensions: 11407 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 10106 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 11324 length of database: 68,354,980 effective HSP length: 114 effective length of database: 47,295,190 effective search space used: 17215449160 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)