Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_P11
(739 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chape... 214 3e-55
sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chape... 212 7e-55
sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chape... 209 6e-54
sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chape... 209 6e-54
sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chapero... 209 8e-54
sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 208 1e-53
sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chape... 208 1e-53
sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hs... 129 6e-30
sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 57 4e-08
sp|Q00799|RBP2_PLAVB Reticulocyte binding protein 2 precurs... 49 2e-05
>sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 378
Score = 214 bits (544), Expect = 3e-55
Identities = 105/236 (44%), Positives = 155/236 (65%), Gaps = 2/236 (0%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAE--ENNNEIASK 175
DT SLFRWRH+ARVER ++F EK ++++ +E + + K+K E E +
Sbjct: 24 DTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELER 83
Query: 176 LKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKD 355
L+ E ++L + + +K +E KEK PWNVD++ K+G +K+++N+ + + +E+
Sbjct: 84 LQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEV 143
Query: 356 VVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKT 535
+ K FVEKY+ IK +G+ R+ ++ +++L N HLVCE+TAN+LVIWCIDL VEEK
Sbjct: 144 REQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKC 203
Query: 536 NLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
LME V+HQ IVMQFILELAKSLK DPR C + FF K ++ + +Y F EL+AF
Sbjct: 204 ALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAF 259
>sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit)
Length = 399
Score = 212 bits (540), Expect = 7e-55
Identities = 108/236 (45%), Positives = 159/236 (67%), Gaps = 2/236 (0%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIASKLK 181
DTPSLFRWRH+ARVER E EK +++K + + + N ++ I E +E+A LK
Sbjct: 24 DTPSLFRWRHQARVERMAESEKEKEELKKKRQSYQARLINVKELISKKE--GDEVA--LK 79
Query: 182 EELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQE--KPVNEKD 355
+EL K+E + E +++ +E L +EK+ PWNVD+I K G KT+IN ++ + + E++
Sbjct: 80 KELEKIENEGKELDRQENELLKREKKTPWNVDTISKPGFEKTVINKKPPRKAAEDLTEEE 139
Query: 356 VVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKT 535
RMK FV++ + K+YG+ RK ++ +RFL ++ LVCE+TAN+LVIW I+L +EEK
Sbjct: 140 REQRMKQFVKENEKLCKQYGMLRKYDDSKRFLQEHLDLVCEETANYLVIWSINLEMEEKH 199
Query: 536 NLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
+LM HV+HQCI MQ+ILELAK L DPR C+ FF+K + PEY+ F SE++ F
Sbjct: 200 DLMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQQCVPEYRQQFESEIEGF 255
>sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 209 bits (532), Expect = 6e-54
Identities = 102/237 (43%), Positives = 158/237 (66%), Gaps = 3/237 (1%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAE--ENNNEIA-S 172
DT SLFRWRH+ARVER ++F EK ++++ +E + + K+K E E++ ++
Sbjct: 24 DTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAESDGQVELE 83
Query: 173 KLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEK 352
+L+ E ++L + + +K ++ KEK PWNVD++ K+G +K+++N+ + + +E+
Sbjct: 84 RLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEE 143
Query: 353 DVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEK 532
+ K FVEKY+ IK +G+ + ++ +++L N HLVCE+TAN+LVIWCIDL VEEK
Sbjct: 144 AREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEK 203
Query: 533 TNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
LME V+HQ +VMQFILELAKSLK DPR C + FF K ++ + +Y F EL+AF
Sbjct: 204 CALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAF 260
>sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 393
Score = 209 bits (532), Expect = 6e-54
Identities = 106/242 (43%), Positives = 152/242 (62%), Gaps = 8/242 (3%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIAS--- 172
DT SLFRWRH+ARVER ++F EK +++K +E + + K+K E S
Sbjct: 24 DTASLFRWRHQARVERMEQFQKEKEELDKGCRECKRKLAECQKKLKELEVAEPGGGSGGG 83
Query: 173 -----KLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEK 337
+L+ E ++L + + K +E KEK PWNV ++ K+G +K++ N +EK
Sbjct: 84 RGERERLQAEAQQLRHEERNWESKMEELRKKEKNMPWNVHTLSKDGFSKSVFN-VKAEEK 142
Query: 338 PVNEKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDL 517
E+ + K FVE+++ IK +G+ R+ ++ +++L NPHLVCE+TAN+LVIWCIDL
Sbjct: 143 EETEEQKEQKHKTFVERHEKQIKHFGMLRRWDDSQKYLSDNPHLVCEETANYLVIWCIDL 202
Query: 518 AVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELD 697
VEEK LME V+HQ IVMQFILELAKSLK DPR C + FF K ++ + +Y F EL+
Sbjct: 203 EVEEKQALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFNDELE 262
Query: 698 AF 703
AF
Sbjct: 263 AF 264
>sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 209 bits (531), Expect = 8e-54
Identities = 102/237 (43%), Positives = 156/237 (65%), Gaps = 3/237 (1%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAE--ENNNEIA-S 172
DT SLFRWRH+ARVER ++F EK ++++ +E + + K+K E E ++
Sbjct: 24 DTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELE 83
Query: 173 KLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEK 352
+L+ E ++L + + +K ++ KEK PWNVD++ K+G +K+++N+ + + +E+
Sbjct: 84 RLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEE 143
Query: 353 DVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEK 532
+ K FVEKY+ IK +G+ + ++ +++L N HLVCE+TAN+LVIWCIDL VEEK
Sbjct: 144 AREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEK 203
Query: 533 TNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
LME V+HQ +VMQFILELAKSLK DPR C + FF K ++ + +Y F EL+AF
Sbjct: 204 CALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAF 260
>sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 377
Score = 208 bits (530), Expect = 1e-53
Identities = 108/239 (45%), Positives = 159/239 (66%), Gaps = 5/239 (2%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIK----SAEENNNEIA 169
DTPSLFRWRH+ARVER ++F + +D+ K +E + + K++ SA +
Sbjct: 26 DTPSLFRWRHQARVERMEDFKKKGDDLNKGLQECRRKLAEAQKKVRELSISAAGDAKAEL 85
Query: 170 SKLKEELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIIN-SFDTQEKPVN 346
+K + E +KL+ + ++ +K +E +EK+ PWNVD++ K+G +K+I+N D+ E
Sbjct: 86 TKTQTEEKKLKKEERDWARKLEEHNHEEKKMPWNVDTLSKDGFSKSIVNVKADSAEDTEE 145
Query: 347 EKDVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVE 526
EK+ + K FVE+Y+ IK +G+ + ++ +R+L NP LVCE+TAN+LVI CIDL VE
Sbjct: 146 EKE--KKHKTFVERYEKQIKHFGMLHRWDDSQRYLSDNPDLVCEETANYLVIMCIDLEVE 203
Query: 527 EKTNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
EK LME V+HQ IVMQFILELAKSLK DPR C + FF K ++ + +YQ AF EL++F
Sbjct: 204 EKHALMEQVAHQTIVMQFILELAKSLKVDPRGCFRQFFEKIKTADQQYQDAFNDELESF 262
>sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (Enhancer of sevenless 3B)
Length = 389
Score = 208 bits (529), Expect = 1e-53
Identities = 107/237 (45%), Positives = 161/237 (67%), Gaps = 3/237 (1%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIASKLK 181
DTPSLFRWRH+ARVER E + EK++++K + + + + +++I ++++ +E A LK
Sbjct: 24 DTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVKERI--SKKDGDEEA--LK 79
Query: 182 EELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKP---VNEK 352
+EL K+E + E ++ E + KEK+ PWNVD+I K G KT+IN KP ++E+
Sbjct: 80 KELEKIEAEGKELDRIESEMIKKEKKTPWNVDTISKPGFEKTVINK-KAGRKPDENLSEE 138
Query: 353 DVVDRMKAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEK 532
+ RMK FV++ + ++YG+ RK ++ +RFL ++ HLV E+TAN+LVIW I+L +EEK
Sbjct: 139 EREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEK 198
Query: 533 TNLMEHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDAF 703
LM HV+HQCI MQ+ILELAK L DPR C+ FF+K + PEY+ F SE++ F
Sbjct: 199 HELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGF 255
>sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein
kinase-targeting subunit)
Length = 370
Score = 129 bits (325), Expect = 6e-30
Identities = 75/239 (31%), Positives = 130/239 (54%), Gaps = 5/239 (2%)
Frame = +2
Query: 2 DTPSLFRWRHKARVERDQEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIASKLK 181
DTPSLFRWRH+AR+ER E ME+ I+K ++ K+ +A+ + S ++
Sbjct: 25 DTPSLFRWRHQARLERMAEKKMEQEKIDKEKGTTSKKMEELEKKLAAADVTDK---SDIQ 81
Query: 182 EELRKLETDFDEFNKKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQ--EKPVNEKD 355
+++ +++ + + KK E KE+ PWNVD+I E + + IN + + P +++
Sbjct: 82 KQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTIGHEAFSTSRINKITEKKPQAPKTDEE 141
Query: 356 VVDRMKAFVEKYDDDIKKYGLFRK-VEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEK 532
M F E ++ ++K + + + E FL ++PH+ E TAN L I ++ A++
Sbjct: 142 DTHAMSTFFETHESLLEKMAVLKNGAKSTELFLAEHPHMASEYTANWLTIEALNAAIDFN 201
Query: 533 TNLMEHVSHQCIVMQFILELAKSLKRDPRDCI--KPFFAKFRSQEPEYQTAFTSELDAF 703
M+ ++ QCI++Q++LEL+KSL + K FF KF + EP Y + E+ AF
Sbjct: 202 EEKMKTMAEQCIIIQYLLELSKSLNAVATNTTVQKQFFKKFEAAEPVYMKHYQDEVKAF 260
>sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (Cell division control protein 37)
Length = 508
Score = 57.4 bits (137), Expect = 4e-08
Identities = 54/255 (21%), Positives = 113/255 (44%), Gaps = 38/255 (14%)
Frame = +2
Query: 47 RDQEFNMEKNDIEKVYKEFLTNI-QNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFN 223
+D +F+ E+ + Y E + ++ +D + + +++ LKE +++ +
Sbjct: 116 KDLKFDREEIENTPCYNEMIEDLFVQIKDDHPETKTDGDKLIEYLKEHRNRIDDVLSKQT 175
Query: 224 KKRDE---------------------FLSKEK--RRPWNVDSICKEGKTKTIINSFDT-- 328
K D+ FL+K+K + N D KT + + +T
Sbjct: 176 IKLDDLLYQKAQLIVSDDLHTGFDRSFLNKDKPEEKEENQDKPKAPEAKKTTVTTTETIN 235
Query: 329 QEKPVNE---KDVVDRM------KAFVEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCED 481
KPV E K+++D + K F + D++ K FL+K+P + E
Sbjct: 236 SPKPVEENTDKEILDELEILPATKEFAKIPSDNLSKAA---------EFLIKHPSICTEQ 286
Query: 482 TANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILELAKSLKRDPR---DCIKPFFAKFR 652
+ L++ DL +E K++ +H+ HQ +++Q++ +L+ + K P + IK FF+K
Sbjct: 287 QKDALIMTAFDLQLENKSDEAKHIVHQSLLLQYVGQLSDNGKAAPANVINAIKLFFSKIA 346
Query: 653 SQEPEYQTAFTSELD 697
++ + AF +++
Sbjct: 347 AESSPAKHAFLEDVN 361
>sp|Q00799|RBP2_PLAVB Reticulocyte binding protein 2 precursor (PvRBP-2)
Length = 2867
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/137 (25%), Positives = 70/137 (51%)
Frame = +2
Query: 53 QEFNMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKR 232
+E +K DI + KEF+ + + K KS N++ + + ++L++LET+F+ NK
Sbjct: 562 EEIKKKKKDILERGKEFINIMNEIKKKKKSNSSNSSTNSKEFTDKLKELETEFEGLNKTV 621
Query: 233 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY 412
+L + + D KE + +++ N + K + D D +K + K +D+I+KY
Sbjct: 622 KGYLQEIE------DIKVKENEDRSLKNQIEQHLKYTS--DNRDNVKTLISK-NDEIQKY 672
Query: 413 GLFRKVEEMERFLMKNP 463
+E++E+ + P
Sbjct: 673 -----IEKIEKLINDAP 684
Score = 32.3 bits (72), Expect = 1.4
Identities = 26/128 (20%), Positives = 60/128 (46%), Gaps = 1/128 (0%)
Frame = +2
Query: 62 NMEKNDIEKVYKEFLTNIQNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFNKKRDEF 241
N + N+I+K Y + + ++ +K + + + + +++ET +E KK+ +
Sbjct: 512 NEKINEIKKNYDQNILKVREFINKSNGLITSVKGTSQLSESDKQQIETKIEEIKKKKKDI 571
Query: 242 LSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY-GL 418
L + K +I E K K NS ++ N K+ D++K +++ K G
Sbjct: 572 LERGK----EFINIMNEIKKKKKSNSSNSS---TNSKEFTDKLKELETEFEGLNKTVKGY 624
Query: 419 FRKVEEME 442
+++E+++
Sbjct: 625 LQEIEDIK 632
Score = 30.0 bits (66), Expect = 6.7
Identities = 35/157 (22%), Positives = 68/157 (43%), Gaps = 22/157 (14%)
Frame = +2
Query: 56 EFNMEKNDIE----KVYKEFLTNIQNTRDKIKSAEENNNEIASKLKEELRKLETDFDEFN 223
+FN ND E ++Y EF ++ + +++A EN ++ S L E
Sbjct: 1756 DFNKNINDYENKMGEIYNEFEGSLNKISENLRNASENTSDYNSAKTLRL--------EAQ 1807
Query: 224 KKRDEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEK----------PVNE-----KDV 358
K++ L+KE+ + + K + I N ++ +K VNE K +
Sbjct: 1808 KEKVNLLNKEEEANKYLRDVKKVESFRFIFNMKESLDKINEMIKKEQLTVNEGHGNVKQL 1867
Query: 359 VDRMKAFVEKYD-DDIKKY--GLFRKVEEMERFLMKN 460
V+ +K V++ + DI K G +++++ +KN
Sbjct: 1868 VENIKELVDENNLSDILKQATGKNEEIQKITHSTLKN 1904
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,459,959
Number of Sequences: 369166
Number of extensions: 1356595
Number of successful extensions: 6345
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5741
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6275
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6631293200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)