Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_P06
(805 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chape... 270 3e-72
sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chape... 270 3e-72
sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 268 2e-71
sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chapero... 266 5e-71
sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chape... 266 6e-71
sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chape... 245 1e-64
sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chape... 241 2e-63
sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hs... 150 3e-36
sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 57 5e-08
sp|Q9P0W8|SPAT7_HUMAN Spermatogenesis-associated protein 7 ... 33 0.70
>sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 393
Score = 270 bits (691), Expect = 3e-72
Identities = 130/265 (49%), Positives = 180/265 (67%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY 185
+E KEK PWNV ++ K+G +K++ N +EK E+ + K FVE+++ IK +
Sbjct: 109 EELRKKEKNMPWNVHTLSKDGFSKSVFN-VKAEEKEETEEQKEQKHKTFVERHEKQIKHF 167
Query: 186 GLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILEL 365
G+ R+ ++ +++L NPHLVCE+TAN+LVIWCIDL VEEK LME V+HQ IVMQFILEL
Sbjct: 168 GMLRRWDDSQKYLSDNPHLVCEETANYLVIWCIDLEVEEKQALMEQVAHQTIVMQFILEL 227
Query: 366 AKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEE 545
AKSLK DPR C + FF K ++ + +Y F EL+ M + EEEE
Sbjct: 228 AKSLKVDPRACFRQFFTKIKTADQQYMEGFNDELEAFKERVRGRAKARIERAMREYEEEE 287
Query: 546 RQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMW 725
RQKRLGPGGLDPV+V+ +LP ELQ+CF+ K+++MLQ+ +S+MDP EA+ H+Q+CIDSG+W
Sbjct: 288 RQKRLGPGGLDPVDVYESLPPELQKCFDAKDVQMLQDTISRMDPTEAKYHMQRCIDSGLW 347
Query: 726 LPNANKKDNDEANESEASGEYGNAD 800
+PNA K + + A G+ G AD
Sbjct: 348 VPNA-KAAAEGGGQGGAHGQPGGAD 371
>sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 378
Score = 270 bits (690), Expect = 3e-72
Identities = 129/259 (49%), Positives = 181/259 (69%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY 185
+E KEK PWNVD++ K+G +K+++N+ + + +E+ + K FVEKY+ IK +
Sbjct: 103 EEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHF 162
Query: 186 GLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILEL 365
G+ R+ ++ +++L N HLVCE+TAN+LVIWCIDL VEEK LME V+HQ IVMQFILEL
Sbjct: 163 GMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILEL 222
Query: 366 AKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEE 545
AKSLK DPR C + FF K ++ + +Y F EL+ M + EEEE
Sbjct: 223 AKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEE 282
Query: 546 RQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMW 725
R+KRLGPGGLDPVEV+ +LP+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W
Sbjct: 283 RKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW 342
Query: 726 LPNANKKDNDEANESEASG 782
+PN+ EA E E +G
Sbjct: 343 VPNSKA---SEAKEGEEAG 358
>sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 377
Score = 268 bits (684), Expect = 2e-71
Identities = 130/267 (48%), Positives = 182/267 (68%), Gaps = 1/267 (0%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIIN-SFDTQEKPVNEKDVVDRMKAFVEKYDDDIKK 182
+E +EK+ PWNVD++ K+G +K+I+N D+ E EK+ + K FVE+Y+ IK
Sbjct: 107 EEHNHEEKKMPWNVDTLSKDGFSKSIVNVKADSAEDTEEEKE--KKHKTFVERYEKQIKH 164
Query: 183 YGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILE 362
+G+ + ++ +R+L NP LVCE+TAN+LVI CIDL VEEK LME V+HQ IVMQFILE
Sbjct: 165 FGMLHRWDDSQRYLSDNPDLVCEETANYLVIMCIDLEVEEKHALMEQVAHQTIVMQFILE 224
Query: 363 LAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEE 542
LAKSLK DPR C + FF K ++ + +YQ AF EL+ M + EEE
Sbjct: 225 LAKSLKVDPRGCFRQFFEKIKTADQQYQDAFNDELESFKERVRGRAKIRIEKAMKEYEEE 284
Query: 543 ERQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGM 722
ERQKRLGPGGLDPVEV+ +LP E+Q+CF++K+I+MLQ+ ++KMDP EA+ H+++CIDSG+
Sbjct: 285 ERQKRLGPGGLDPVEVYESLPPEMQKCFDEKDIQMLQDVITKMDPTEAKAHMKRCIDSGL 344
Query: 723 WLPNANKKDNDEANESEASGEYGNADE 803
W+PN+ ++DE + E E
Sbjct: 345 WVPNSKMDESDEKEDGSTYEEVKQEQE 371
>sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 266 bits (680), Expect = 5e-71
Identities = 126/259 (48%), Positives = 181/259 (69%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY 185
++ KEK PWNVD++ K+G +K+++N+ + + +E+ + K FVEKY+ IK +
Sbjct: 104 EDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHF 163
Query: 186 GLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILEL 365
G+ + ++ +++L N HLVCE+TAN+LVIWCIDL VEEK LME V+HQ +VMQFILEL
Sbjct: 164 GMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILEL 223
Query: 366 AKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEE 545
AKSLK DPR C + FF K ++ + +Y F EL+ M + EEEE
Sbjct: 224 AKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEE 283
Query: 546 RQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMW 725
R+KRLGPGGLDPVEV+ +LP+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W
Sbjct: 284 RKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW 343
Query: 726 LPNANKKDNDEANESEASG 782
+PN+ + EA E E +G
Sbjct: 344 VPNSK---SGEAKEGEEAG 359
>sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 266 bits (679), Expect = 6e-71
Identities = 126/259 (48%), Positives = 181/259 (69%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKPVNEKDVVDRMKAFVEKYDDDIKKY 185
++ KEK PWNVD++ K+G +K+++N+ + + +E+ + K FVEKY+ IK +
Sbjct: 104 EDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQIKHF 163
Query: 186 GLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFILEL 365
G+ + ++ +++L N HLVCE+TAN+LVIWCIDL VEEK LME V+HQ +VMQFILEL
Sbjct: 164 GMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQFILEL 223
Query: 366 AKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEE 545
AKSLK DPR C + FF K ++ + +Y F EL+ M + EEEE
Sbjct: 224 AKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEE 283
Query: 546 RQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMW 725
R+KRLGPGGLDPVEV+ +LP+ELQ+CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W
Sbjct: 284 RKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLW 343
Query: 726 LPNANKKDNDEANESEASG 782
+PN+ + EA E E +G
Sbjct: 344 VPNSK---SGEAKEGEEAG 359
>sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit)
Length = 399
Score = 245 bits (625), Expect = 1e-64
Identities = 119/264 (45%), Positives = 178/264 (67%), Gaps = 6/264 (2%)
Frame = +3
Query: 6 DEFLSKEKRRPWNVDSICKEGKTKTIINSFDTQE--KPVNEKDVVDRMKAFVEKYDDDIK 179
+E L +EK+ PWNVD+I K G KT+IN ++ + + E++ RMK FV++ + K
Sbjct: 97 NELLKREKKTPWNVDTISKPGFEKTVINKKPPRKAAEDLTEEEREQRMKQFVKENEKLCK 156
Query: 180 KYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFIL 359
+YG+ RK ++ +RFL ++ LVCE+TAN+LVIW I+L +EEK +LM HV+HQCI MQ+IL
Sbjct: 157 QYGMLRKYDDSKRFLQEHLDLVCEETANYLVIWSINLEMEEKHDLMAHVAHQCICMQYIL 216
Query: 360 ELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEE 539
ELAK L DPR C+ FF+K + PEY+ F SE++ MA++EE
Sbjct: 217 ELAKQLDVDPRACVSSFFSKIQQCVPEYRQQFESEIEGFKERIQKRAQEKLQEAMAQLEE 276
Query: 540 EERQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSG 719
EE+Q+R+GPGGLDP +VF +LP+EL+ CFE ++IE+LQ+ ++ M +A+ H+++C+DSG
Sbjct: 277 EEKQERMGPGGLDPADVFESLPEELKACFESRDIELLQKTIATMPVDQAKYHMKRCVDSG 336
Query: 720 MWLPNANK----KDNDEANESEAS 779
+W+PNA D EA + E +
Sbjct: 337 LWVPNAADVQLGNDETEAKDDETT 360
>sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (Enhancer of sevenless 3B)
Length = 389
Score = 241 bits (615), Expect = 2e-63
Identities = 118/268 (44%), Positives = 176/268 (65%), Gaps = 3/268 (1%)
Frame = +3
Query: 9 EFLSKEKRRPWNVDSICKEGKTKTIINSFDTQEKP---VNEKDVVDRMKAFVEKYDDDIK 179
E + KEK+ PWNVD+I K G KT+IN KP ++E++ RMK FV++ + +
Sbjct: 98 EMIKKEKKTPWNVDTISKPGFEKTVINK-KAGRKPDENLSEEEREQRMKQFVKENEKLCQ 156
Query: 180 KYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFIL 359
+YG+ RK ++ +RFL ++ HLV E+TAN+LVIW I+L +EEK LM HV+HQCI MQ+IL
Sbjct: 157 QYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYIL 216
Query: 360 ELAKSLKRDPRDCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEE 539
ELAK L DPR C+ FF+K + PEY+ F SE++ +A+ EE
Sbjct: 217 ELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEE 276
Query: 540 EERQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSG 719
EER++RLGPGGLDP +VF +LP EL+ CFE +++E+LQ+ ++ M A+ H+++C+DSG
Sbjct: 277 EERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVDSG 336
Query: 720 MWLPNANKKDNDEANESEASGEYGNADE 803
+W+PNA + D+ E ++ G ++
Sbjct: 337 LWVPNAADLEGDKKEEDDSDDVAGGEEK 364
>sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein
kinase-targeting subunit)
Length = 370
Score = 150 bits (380), Expect = 3e-36
Identities = 87/266 (32%), Positives = 141/266 (53%), Gaps = 7/266 (2%)
Frame = +3
Query: 9 EFLSKEKRRPWNVDSICKEGKTKTIINSFDTQ--EKPVNEKDVVDRMKAFVEKYDDDIKK 182
E KE+ PWNVD+I E + + IN + + P +++ M F E ++ ++K
Sbjct: 100 ELEEKERLEPWNVDTIGHEAFSTSRINKITEKKPQAPKTDEEDTHAMSTFFETHESLLEK 159
Query: 183 YGLFRK-VEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSHQCIVMQFIL 359
+ + + E FL ++PH+ E TAN L I ++ A++ M+ ++ QCI++Q++L
Sbjct: 160 MAVLKNGAKSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLL 219
Query: 360 ELAKSLKRDPRDCI--KPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXXXXXXXXMAKI 533
EL+KSL + K FF KF + EP Y + E+ M +
Sbjct: 220 ELSKSLNAVATNTTVQKQFFKKFEAAEPVYMKHYQDEVKAFEDRLRTRAQTKRDAAMEEA 279
Query: 534 EEEERQKRL--GPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQKC 707
E EE+ +R+ PGG+DP EVF LP+E+++CFE +IE L+ KMD + + H +C
Sbjct: 280 EAEEKAERMKSAPGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRC 339
Query: 708 IDSGMWLPNANKKDNDEANESEASGE 785
I SG+W+P K D+D+ +E A E
Sbjct: 340 IASGLWVP--GKADDDDDDEEAAPAE 363
>sp|Q8X1E6|CDC37_CANAL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (Cell division control protein 37)
Length = 508
Score = 57.4 bits (137), Expect = 5e-08
Identities = 68/305 (22%), Positives = 128/305 (41%), Gaps = 41/305 (13%)
Frame = +3
Query: 12 FLSKEK--RRPWNVDSICKEGKTKTIINSFDT--QEKPVNE---KDVVDRM------KAF 152
FL+K+K + N D KT + + +T KPV E K+++D + K F
Sbjct: 202 FLNKDKPEEKEENQDKPKAPEAKKTTVTTTETINSPKPVEENTDKEILDELEILPATKEF 261
Query: 153 VEKYDDDIKKYGLFRKVEEMERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLMEHVSH 332
+ D++ K FL+K+P + E + L++ DL +E K++ +H+ H
Sbjct: 262 AKIPSDNLSKAA---------EFLIKHPSICTEQQKDALIMTAFDLQLENKSDEAKHIVH 312
Query: 333 QCIVMQFILELAKSLKRDPR---DCIKPFFAKFRSQEPEYQTAFTSELDXXXXXXXXXXX 503
Q +++Q++ +L+ + K P + IK FF+K ++ + AF +++
Sbjct: 313 QSLLLQYVGQLSDNGKAAPANVINAIKLFFSKIAAESSPAKHAFLEDVNQTFNHIKGRCE 372
Query: 504 XXXXXXMAKI-------EEEERQKRLGPGGLD---------------PVEVF-ANLPKEL 614
EEEE + + LD E+F LP E
Sbjct: 373 IIKEEQKQNAANKEGTGEEEEEEALIQLKALDDNTELSVNIPQEGTKEYEIFTTKLPIEF 432
Query: 615 QECFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANE--SEASGEY 788
Q + ++I+ + + +K+ ++AE L+ + G+ + +D E E E + E
Sbjct: 433 QNAIKTESIDEVNKEFAKLKIEDAERILEIFNECGVIGISGYIEDEKEFEELKKEYAHET 492
Query: 789 GNADE 803
N +E
Sbjct: 493 ANQEE 497
>sp|Q9P0W8|SPAT7_HUMAN Spermatogenesis-associated protein 7 (Spermatogenesis-associated
protein HSD3) (HSD-3.1)
Length = 599
Score = 33.5 bits (75), Expect = 0.70
Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 3/105 (2%)
Frame = +3
Query: 147 AFVEKYDDDIKKYGLF--RKVEEM-ERFLMKNPHLVCEDTANHLVIWCIDLAVEEKTNLM 317
+F+E D+I K GLF R +E + ER + +N HL E + L + +DL + N
Sbjct: 369 SFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHLEEEKMRHLLHVLKVDLGCTSEEN-- 426
Query: 318 EHVSHQCIVMQFILELAKSLKRDPRDCIKPFFAKFRSQEPEYQTA 452
V + M + + K+ +P + + + +YQ A
Sbjct: 427 -SVKQNDVDMLNVFDFEKAGNSEPNELKNESEVTIQQERQQYQKA 470
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,424,278
Number of Sequences: 369166
Number of extensions: 1670161
Number of successful extensions: 5981
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5707
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5967
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)