Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_O03
(525 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chape... 123 2e-28
sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chape... 119 6e-27
sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chape... 118 1e-26
sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chapero... 118 1e-26
sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chape... 117 2e-26
sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chape... 103 3e-22
sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chape... 101 1e-21
sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hs... 77 2e-14
sp|O00634|NET2_HUMAN Netrin-2-like protein precursor 32 0.71
sp|P76237|YEAJ_ECOLI Hypothetical protein yeaJ 32 0.71
>sp|Q9DGQ7|CDC37_TETFL Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 377
Score = 123 bits (309), Expect = 2e-28
Identities = 55/115 (47%), Positives = 78/115 (67%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
YQ AF EL+ M + EEEERQKRLGPGGLDPVEV+ +LP E+Q+
Sbjct: 251 YQDAFNDELESFKERVRGRAKIRIEKAMKEYEEEERQKRLGPGGLDPVEVYESLPPEMQK 310
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASGE 346
CF++K+I+MLQ+ ++KMDP EA+ H+++CIDSG+W+PN+ ++DE + E
Sbjct: 311 CFDEKDIQMLQDVITKMDPTEAKAHMKRCIDSGLWVPNSKMDESDEKEDGSTYEE 365
>sp|Q16543|CDC37_HUMAN Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 378
Score = 119 bits (297), Expect = 6e-27
Identities = 56/114 (49%), Positives = 77/114 (67%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y F EL+ M + EEEER+KRLGPGGLDPVEV+ +LP+ELQ+
Sbjct: 248 YMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQK 307
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASG 343
CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ EA E E +G
Sbjct: 308 CFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKA---SEAKEGEEAG 358
>sp|Q61081|CDC37_MOUSE Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 118 bits (295), Expect = 1e-26
Identities = 56/114 (49%), Positives = 78/114 (68%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y F EL+ M + EEEER+KRLGPGGLDPVEV+ +LP+ELQ+
Sbjct: 249 YMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQK 308
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASG 343
CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ + EA E E +G
Sbjct: 309 CFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSK---SGEAKEGEEAG 359
>sp|Q63692|CDC37_RAT Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 379
Score = 118 bits (295), Expect = 1e-26
Identities = 56/114 (49%), Positives = 78/114 (68%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y F EL+ M + EEEER+KRLGPGGLDPVEV+ +LP+ELQ+
Sbjct: 249 YMEGFKYELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQK 308
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASG 343
CF+ K+++MLQ+A+SKMDP +A+ H+Q+CIDSG+W+PN+ + EA E E +G
Sbjct: 309 CFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSK---SGEAKEGEEAG 359
>sp|O57476|CDC37_CHICK Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (p50Cdc37)
Length = 393
Score = 117 bits (292), Expect = 2e-26
Identities = 56/119 (47%), Positives = 77/119 (64%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y F EL+ M + EEEERQKRLGPGGLDPV+V+ +LP ELQ+
Sbjct: 253 YMEGFNDELEAFKERVRGRAKARIERAMREYEEEERQKRLGPGGLDPVDVYESLPPELQK 312
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASGEYGNA 358
CF+ K+++MLQ+ +S+MDP EA+ H+Q+CIDSG+W+PNA K + + A G+ G A
Sbjct: 313 CFDAKDVQMLQDTISRMDPTEAKYHMQRCIDSGLWVPNA-KAAAEGGGQGGAHGQPGGA 370
>sp|Q24740|CDC37_DROVI Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit)
Length = 399
Score = 103 bits (256), Expect = 3e-22
Identities = 47/117 (40%), Positives = 75/117 (64%), Gaps = 4/117 (3%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y+ F SE++ MA++EEEE+Q+R+GPGGLDP +VF +LP+EL+
Sbjct: 244 YRQQFESEIEGFKERIQKRAQEKLQEAMAQLEEEEKQERMGPGGLDPADVFESLPEELKA 303
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANK----KDNDEANESEAS 340
CFE ++IE+LQ+ ++ M +A+ H+++C+DSG+W+PNA D EA + E +
Sbjct: 304 CFESRDIELLQKTIATMPVDQAKYHMKRCVDSGLWVPNAADVQLGNDETEAKDDETT 360
>sp|Q24276|CDC37_DROME Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting
subunit) (Enhancer of sevenless 3B)
Length = 389
Score = 101 bits (251), Expect = 1e-21
Identities = 45/117 (38%), Positives = 73/117 (62%)
Frame = +2
Query: 2 YQTAFTSELDXXXXXXXXXXXXXXXXXMAKIEEEERQKRLGPGGLDPVEVFANLPKELQE 181
Y+ F SE++ +A+ EEEER++RLGPGGLDP +VF +LP EL+
Sbjct: 244 YRAQFDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERLGPGGLDPADVFESLPDELKA 303
Query: 182 CFEKKNIEMLQEALSKMDPKEAEGHLQKCIDSGMWLPNANKKDNDEANESEASGEYG 352
CFE +++E+LQ+ ++ M A+ H+++C+DSG+W+PNA + D+ E ++ G
Sbjct: 304 CFESRDVELLQKTIAAMPVDVAKLHMKRCVDSGLWVPNAADLEGDKKEEDDSDDVAG 360
>sp|O02108|CDC37_CAEEL Probable Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein
kinase-targeting subunit)
Length = 370
Score = 77.4 bits (189), Expect = 2e-14
Identities = 36/87 (41%), Positives = 55/87 (63%)
Frame = +2
Query: 86 AKIEEEERQKRLGPGGLDPVEVFANLPKELQECFEKKNIEMLQEALSKMDPKEAEGHLQK 265
A+ EE+ + + PGG+DP EVF LP+E+++CFE +IE L+ KMD + + H +
Sbjct: 279 AEAEEKAERMKSAPGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDR 338
Query: 266 CIDSGMWLPNANKKDNDEANESEASGE 346
CI SG+W+P K D+D+ +E A E
Sbjct: 339 CIASGLWVP--GKADDDDDDEEAAPAE 363
>sp|O00634|NET2_HUMAN Netrin-2-like protein precursor
Length = 580
Score = 32.3 bits (72), Expect = 0.71
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 2/58 (3%)
Frame = -1
Query: 276 LSIHFCKWPSASFGSIL--DKASCNISMFFFSKHSCNSFGKLANTSTGSRPPGPNRFC 109
+S+ FC P AS + D + FFS H +G+L + G PGP C
Sbjct: 120 VSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALC 177
>sp|P76237|YEAJ_ECOLI Hypothetical protein yeaJ
Length = 496
Score = 32.3 bits (72), Expect = 0.71
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 6/59 (10%)
Frame = +3
Query: 120 WVLVVLILLKCLPIYQKNYKNVSRRKTSKCYKKLY------PKWIQKRQKAICRNVSIV 278
W+L LILL + ++ + Y+NVSR S LY P+ Q+ QK + S++
Sbjct: 319 WILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVM 377
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,882,138
Number of Sequences: 369166
Number of extensions: 1071429
Number of successful extensions: 4174
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4016
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4173
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3502236525
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)