DrC_00252
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00252 (1363 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kina... 135 4e-31 sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase... 131 5e-30 sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kina... 130 7e-30 sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kina... 93 2e-18 sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [I... 33 2.5 sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor o... 31 9.5 sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome r... 31 9.5 sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF... 31 9.5 sp|Q9DCV6|K0141_MOUSE Protein KIAA0141 31 9.5 sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor o... 31 9.5
>sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Length = 725 Score = 135 bits (339), Expect = 4e-31 Identities = 88/261 (33%), Positives = 130/261 (49%) Frame = +1 Query: 415 NLDQEIGHSILAQVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKET 594 +L+++IG SIL +VH + R HE GRF C + W Sbjct: 513 DLEKKIGKSILGKVHLAMVRYHEGGRF---------CEKGEEWDQ--------------- 548 Query: 595 SNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLW 774 ES +FH HAA LG LEA++ + + H+L D T+ + G DYL Sbjct: 549 ------ESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLL 602 Query: 775 RAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPD 954 +AA++GDR+SMI +A + +N + +W EA+ WY A E + + Sbjct: 603 KAAEAGDRQSMILVARAFDSGQNLSPDRCQ----------DWLEALHWYNTALEMTDCDE 652 Query: 955 GQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNA 1134 G G YD D P +LA AE+ F GGYGLE++ Q +G+LY+QAAE A A Sbjct: 653 G--------GEYDGMQD-EPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEA 703 Query: 1135 LQGRQAVKYYELSDIAYSQDE 1197 ++GR A +YY+ ++ A++Q E Sbjct: 704 MKGRLANQYYQKAEEAWAQME 724
>sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Length = 724 Score = 131 bits (329), Expect = 5e-30 Identities = 86/261 (32%), Positives = 127/261 (48%) Frame = +1 Query: 415 NLDQEIGHSILAQVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKET 594 +L ++IG S+L +VH + R HE GRF C + W Sbjct: 512 DLGRKIGKSVLGKVHLAMVRYHEGGRF---------CEKDEEWDQ--------------- 547 Query: 595 SNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLW 774 ES +FH HAA LG LEA++ + + H+L D T+ + G DYL Sbjct: 548 ------ESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLEETEENKTKGFDYLL 601 Query: 775 RAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPD 954 +AA++GDR+SMI +A + N + +W EA+ WY A E + + Sbjct: 602 KAAEAGDRQSMILVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDCDE 651 Query: 955 GQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNA 1134 G G YD D P +LA AE+ GG+GL++N Q +G+LY+QAAE A A Sbjct: 652 G--------GEYDGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEA 702 Query: 1135 LQGRQAVKYYELSDIAYSQDE 1197 ++GR A +YYE ++ A++Q E Sbjct: 703 MKGRLANQYYEKAEEAWAQME 723
>sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Length = 724 Score = 130 bits (328), Expect = 7e-30 Identities = 86/261 (32%), Positives = 126/261 (48%) Frame = +1 Query: 415 NLDQEIGHSILAQVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKET 594 +L ++IG S+L +VH + R HE GRF C + W Sbjct: 512 DLGRKIGKSVLGKVHLAMVRYHEGGRF---------CEKDEEWDR--------------- 547 Query: 595 SNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLW 774 ES +FH HAA LG LEA++ + + H+L D T+ + G DYL Sbjct: 548 ------ESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLL 601 Query: 775 RAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPD 954 +AA++GDR SMI +A + N + +W EA+ WY A E + + Sbjct: 602 KAAEAGDRHSMILVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDCDE 651 Query: 955 GQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNA 1134 G G YD D P +LA AE+ GG+GL++N Q +G+LY+QAAE A A Sbjct: 652 G--------GEYDGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEA 702 Query: 1135 LQGRQAVKYYELSDIAYSQDE 1197 ++GR A +YYE ++ A++Q E Sbjct: 703 MKGRLANQYYEKAEEAWAQME 723
>sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Length = 768 Score = 92.8 bits (229), Expect = 2e-18 Identities = 81/296 (27%), Positives = 144/296 (48%), Gaps = 26/296 (8%) Frame = +1 Query: 370 SMRENQKPSSATHPTNLDQEIGH--SILAQVHHELARLHESGRFIK----SKQLAAGCLH 531 S++ Q ++ + ++ Q GH S+L Q+H +L+R HE GRF++ K++ G Sbjct: 500 SLQLQQMAANLENDEDVPQVTGHQFSVLGQIHIDLSRYHELGRFVEVDSEHKEMLEG--- 556 Query: 532 HQFWSHLLNENDSPEAIVKETSNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHM 711 +END+ I + +S +FH A + G LEAV+ A L + + Sbjct: 557 --------SENDARVPIKYDK------QSAIFHLDIARKCGILEAVLTSAHIVLGLPHEL 602 Query: 712 LQDCP--------FPPTQNDL------------DCGLDYLWRAADSGDRRSMIELANLYR 831 L++ F +N + + G D + AA+ GD+ +M+ +A+ Y Sbjct: 603 LKEVTVDDLFPNGFGEQENGIRADKGQKPCDLEEFGSDLMEIAAEMGDKGAMLYMAHAY- 661 Query: 832 KTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPDGQLDSKDAEGRYDSADDLM 1011 E + G +T ++ +++ WY+R + + +LDS + + S L Sbjct: 662 -----ETGQHLGPNRRT----DYKKSIDWYQRV--VGFQEEEELDSDCGKTTFSSFAPLT 710 Query: 1012 PPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDI 1179 EILA MAE++ +GGYGL ++ + A L+++AAE A A+ G+ A KYYE +++ Sbjct: 711 R-HEILAKMAEMYKEGGYGLNQDFERAYGLFNEAAEAAMEAMNGKLANKYYEKAEM 765
>sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [Includes: Biotin carboxylase ] Length = 2483 Score = 32.7 bits (73), Expect = 2.5 Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 3/56 (5%) Frame = +1 Query: 919 YKRAFEAANKPD-GQLDSKDAEGRYDSADDLMPP--QEILAAMAELHFKGGYGLER 1077 YK+ E +PD D KD EGR + +DL+ P ++ A+ H G LE+ Sbjct: 2280 YKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEK 2335
>sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L) Length = 794 Score = 30.8 bits (68), Expect = 9.5 Identities = 17/54 (31%), Positives = 26/54 (48%) Frame = +1 Query: 1036 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 1197 + +LH GG G+E+N Q A + ++ AA + Y E SDI +E Sbjct: 379 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 432
>sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX-interacting protein-like) Length = 852 Score = 30.8 bits (68), Expect = 9.5 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 3/61 (4%) Frame = +1 Query: 817 ANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKW---YKRAFEAANKPDGQLDSKDAEGR 987 A+ +RK E EGN K ++V E KW YK+ ++ D L K AEGR Sbjct: 154 ADAHRKPEAV---VLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGR 210 Query: 988 Y 990 + Sbjct: 211 W 211
>sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2 transforming protein; DBL transforming protein] Length = 925 Score = 30.8 bits (68), Expect = 9.5 Identities = 15/52 (28%), Positives = 27/52 (51%) Frame = +2 Query: 1076 EIASWLANYTVKLQKLPQMLFKDAKLLNIMNFLILHIHKMNVLNSFLLPFIC 1231 ++ +A K++KL + +LL+ F+ILH HK+ + + L IC Sbjct: 246 DVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLIC 297
>sp|Q9DCV6|K0141_MOUSE Protein KIAA0141 Length = 510 Score = 30.8 bits (68), Expect = 9.5 Identities = 20/62 (32%), Positives = 26/62 (41%) Frame = +1 Query: 766 YLWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAAN 945 YLW AA +GD +S L Y K + N EAVK Y++A N Sbjct: 376 YLWLAASNGDSQSRFHLGICYEKGLGAQR--------------NLGEAVKCYQQAAAMGN 421 Query: 946 KP 951 +P Sbjct: 422 EP 423
>sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L) Length = 790 Score = 30.8 bits (68), Expect = 9.5 Identities = 17/54 (31%), Positives = 26/54 (48%) Frame = +1 Query: 1036 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 1197 + +LH GG G+E+N Q A + ++ AA + Y E SDI +E Sbjct: 375 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 428
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 143,214,166
Number of Sequences: 369166
Number of extensions: 2810957
Number of successful extensions: 6761
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6473
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6753
length of database: 68,354,980
effective HSP length: 114
effective length of database: 47,295,190
effective search space used: 16033069410
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
