Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_F04
(769 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kina... 122 1e-27
sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase... 119 9e-27
sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kina... 118 2e-26
sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kina... 74 6e-13
sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [I... 33 1.1
sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor o... 31 4.2
sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome r... 31 4.2
sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF... 31 4.2
sp|Q9DCV6|K0141_MOUSE Protein KIAA0141 31 4.2
sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor o... 31 4.2
>sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 725
Score = 122 bits (305), Expect = 1e-27
Identities = 73/203 (35%), Positives = 110/203 (54%)
Frame = +3
Query: 39 ETSNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDY 218
E + + ES +FH HAA LG LEA++ + + H+L D T+ + G DY
Sbjct: 541 EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY 600
Query: 219 LWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANK 398
L +AA++GDR+SMI +A + +N + +W EA+ WY A E +
Sbjct: 601 LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQ----------DWLEALHWYNTALEMTDC 650
Query: 399 PDGQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIAT 578
+G G YD D P +LA AE+ F GGYGLE++ Q +G+LY+QAAE A
Sbjct: 651 DEG--------GEYDGMQD-EPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAM 701
Query: 579 NALQGRQAVKYYELSDIAYSQDE 647
A++GR A +YY+ ++ A++Q E
Sbjct: 702 EAMKGRLANQYYQKAEEAWAQME 724
>sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 724
Score = 119 bits (298), Expect = 9e-27
Identities = 72/203 (35%), Positives = 108/203 (53%)
Frame = +3
Query: 39 ETSNDINWESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDY 218
E + + ES +FH HAA LG LEA++ + + H+L D T+ + G DY
Sbjct: 540 EKDEEWDQESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLEETEENKTKGFDY 599
Query: 219 LWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANK 398
L +AA++GDR+SMI +A + N + +W EA+ WY A E +
Sbjct: 600 LLKAAEAGDRQSMILVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDC 649
Query: 399 PDGQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIAT 578
+G G YD D P +LA AE+ GG+GL++N Q +G+LY+QAAE A
Sbjct: 650 DEG--------GEYDGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAM 700
Query: 579 NALQGRQAVKYYELSDIAYSQDE 647
A++GR A +YYE ++ A++Q E
Sbjct: 701 EAMKGRLANQYYEKAEEAWAQME 723
>sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 724
Score = 118 bits (296), Expect = 2e-26
Identities = 73/201 (36%), Positives = 106/201 (52%), Gaps = 2/201 (0%)
Frame = +3
Query: 51 DINW--ESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLW 224
D W ES +FH HAA LG LEA++ + + H+L D T+ + G DYL
Sbjct: 542 DEEWDRESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLL 601
Query: 225 RAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPD 404
+AA++GDR SMI +A + N + +W EA+ WY A E + +
Sbjct: 602 KAAEAGDRHSMILVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDCDE 651
Query: 405 GQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNA 584
G G YD D P +LA AE+ GG+GL++N Q +G+LY+QAAE A A
Sbjct: 652 G--------GEYDGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEA 702
Query: 585 LQGRQAVKYYELSDIAYSQDE 647
++GR A +YYE ++ A++Q E
Sbjct: 703 MKGRLANQYYEKAEEAWAQME 723
>sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 768
Score = 73.6 bits (179), Expect = 6e-13
Identities = 59/209 (28%), Positives = 104/209 (49%), Gaps = 20/209 (9%)
Frame = +3
Query: 63 ESCLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCP--------FPPTQNDL------ 200
+S +FH A + G LEAV+ A L + +L++ F +N +
Sbjct: 570 QSAIFHLDIARKCGILEAVLTSAHIVLGLPHELLKEVTVDDLFPNGFGEQENGIRADKGQ 629
Query: 201 ------DCGLDYLWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAV 362
+ G D + AA+ GD+ +M+ +A+ Y E + G +T ++ +++
Sbjct: 630 KPCDLEEFGSDLMEIAAEMGDKGAMLYMAHAY------ETGQHLGPNRRT----DYKKSI 679
Query: 363 KWYKRAFEAANKPDGQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLA 542
WY+R + + +LDS + + S L EILA MAE++ +GGYGL ++ + A
Sbjct: 680 DWYQRV--VGFQEEEELDSDCGKTTFSSFAPLTR-HEILAKMAEMYKEGGYGLNQDFERA 736
Query: 543 GELYSQAAEIATNALQGRQAVKYYELSDI 629
L+++AAE A A+ G+ A KYYE +++
Sbjct: 737 YGLFNEAAEAAMEAMNGKLANKYYEKAEM 765
>sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [Includes: Biotin carboxylase ]
Length = 2483
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Frame = +3
Query: 369 YKRAFEAANKPD-GQLDSKDAEGRYDSADDLMPP--QEILAAMAELHFKGGYGLER 527
YK+ E +PD D KD EGR + +DL+ P ++ A+ H G LE+
Sbjct: 2280 YKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEK 2335
>sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor of lin-12-like protein)
(Sel-1L)
Length = 794
Score = 30.8 bits (68), Expect = 4.2
Identities = 17/54 (31%), Positives = 26/54 (48%)
Frame = +3
Query: 486 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 647
+ +LH GG G+E+N Q A + ++ AA + Y E SDI +E
Sbjct: 379 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 432
>sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome region 14 protein (WS
basic-helix-loop-helix leucine zipper protein) (WS-bHLH)
(Mlx interactor) (MLX-interacting protein-like)
Length = 852
Score = 30.8 bits (68), Expect = 4.2
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 3/61 (4%)
Frame = +3
Query: 267 ANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKW---YKRAFEAANKPDGQLDSKDAEGR 437
A+ +RK E EGN K ++V E KW YK+ ++ D L K AEGR
Sbjct: 154 ADAHRKPEAV---VLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGR 210
Query: 438 Y 440
+
Sbjct: 211 W 211
>sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2
transforming protein; DBL transforming protein]
Length = 925
Score = 30.8 bits (68), Expect = 4.2
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +1
Query: 526 EIASWLANYTVKLQKLPQMLFKDAKLLNIMNFLILHIHKMNVLNSFLLPFIC 681
++ +A K++KL + +LL+ F+ILH HK+ + + L IC
Sbjct: 246 DVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLIC 297
>sp|Q9DCV6|K0141_MOUSE Protein KIAA0141
Length = 510
Score = 30.8 bits (68), Expect = 4.2
Identities = 20/62 (32%), Positives = 26/62 (41%)
Frame = +3
Query: 216 YLWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAAN 395
YLW AA +GD +S L Y K + N EAVK Y++A N
Sbjct: 376 YLWLAASNGDSQSRFHLGICYEKGLGAQR--------------NLGEAVKCYQQAAAMGN 421
Query: 396 KP 401
+P
Sbjct: 422 EP 423
>sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor of lin-12-like protein)
(Sel-1L)
Length = 790
Score = 30.8 bits (68), Expect = 4.2
Identities = 17/54 (31%), Positives = 26/54 (48%)
Frame = +3
Query: 486 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 647
+ +LH GG G+E+N Q A + ++ AA + Y E SDI +E
Sbjct: 375 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 428
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,792,944
Number of Sequences: 369166
Number of extensions: 1608582
Number of successful extensions: 4206
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4097
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4200
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7115329200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)