Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_E12
(915 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kina... 123 6e-28
sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase... 121 3e-27
sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kina... 120 4e-27
sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kina... 85 3e-16
sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [I... 33 1.5
sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor o... 31 5.5
sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome r... 31 5.5
sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF... 31 5.5
sp|Q9DCV6|K0141_MOUSE Protein KIAA0141 31 5.5
sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor o... 31 5.5
>sp|O00418|EF2K_HUMAN Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 725
Score = 123 bits (309), Expect = 6e-28
Identities = 82/249 (32%), Positives = 120/249 (48%)
Frame = +2
Query: 2 QVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKETSNDINWESCLFH 181
+VH + R HE GRF C + W ES +FH
Sbjct: 525 KVHLAMVRYHEGGRF---------CEKGEEWDQ---------------------ESAVFH 554
Query: 182 ERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLWRAADSGDRRSMI 361
HAA LG LEA++ + + H+L D T+ + G DYL +AA++GDR+SMI
Sbjct: 555 LEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMI 614
Query: 362 ELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPDGQLDSKDAEGRY 541
+A + +N + +W EA+ WY A E + +G G Y
Sbjct: 615 LVARAFDSGQNLSPDRCQ----------DWLEALHWYNTALEMTDCDEG--------GEY 656
Query: 542 DSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYEL 721
D D P +LA AE+ F GGYGLE++ Q +G+LY+QAAE A A++GR A +YY+
Sbjct: 657 DGMQD-EPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQK 715
Query: 722 SDIAYSQDE 748
++ A++Q E
Sbjct: 716 AEEAWAQME 724
>sp|P70531|EF2K_RAT Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 724
Score = 121 bits (303), Expect = 3e-27
Identities = 81/249 (32%), Positives = 118/249 (47%)
Frame = +2
Query: 2 QVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKETSNDINWESCLFH 181
+VH + R HE GRF C + W ES +FH
Sbjct: 524 KVHLAMVRYHEGGRF---------CEKDEEWDQ---------------------ESAIFH 553
Query: 182 ERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLWRAADSGDRRSMI 361
HAA LG LEA++ + + H+L D T+ + G DYL +AA++GDR+SMI
Sbjct: 554 LEHAADLGELEAIVGLGLMYSQLPHHILADVSLEETEENKTKGFDYLLKAAEAGDRQSMI 613
Query: 362 ELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPDGQLDSKDAEGRY 541
+A + N + +W EA+ WY A E + +G G Y
Sbjct: 614 LVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDCDEG--------GEY 655
Query: 542 DSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYEL 721
D D P +LA AE+ GG+GL++N Q +G+LY+QAAE A A++GR A +YYE
Sbjct: 656 DGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEK 714
Query: 722 SDIAYSQDE 748
++ A++Q E
Sbjct: 715 AEEAWAQME 723
>sp|O08796|EF2K_MOUSE Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 724
Score = 120 bits (302), Expect = 4e-27
Identities = 81/249 (32%), Positives = 117/249 (46%)
Frame = +2
Query: 2 QVHHELARLHESGRFIKSKQLAAGCLHHQFWSHLLNENDSPEAIVKETSNDINWESCLFH 181
+VH + R HE GRF C + W ES +FH
Sbjct: 524 KVHLAMVRYHEGGRF---------CEKDEEWDR---------------------ESAIFH 553
Query: 182 ERHAAQLGCLEAVIVMARYCLNMSGHMLQDCPFPPTQNDLDCGLDYLWRAADSGDRRSMI 361
HAA LG LEA++ + + H+L D T+ + G DYL +AA++GDR SMI
Sbjct: 554 LEHAADLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRHSMI 613
Query: 362 ELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAANKPDGQLDSKDAEGRY 541
+A + N + +W EA+ WY A E + +G G Y
Sbjct: 614 LVARAFDTGLNLSPDRCQ----------DWSEALHWYNTALETTDCDEG--------GEY 655
Query: 542 DSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYEL 721
D D P +LA AE+ GG+GL++N Q +G+LY+QAAE A A++GR A +YYE
Sbjct: 656 DGIQD-EPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEK 714
Query: 722 SDIAYSQDE 748
++ A++Q E
Sbjct: 715 AEEAWAQME 723
>sp|O01991|EF2K_CAEEL Elongation factor 2 kinase (eEF-2 kinase) (eEF-2K)
(Calcium/calmodulin-dependent eukaryotic elongation
factor 2 kinase)
Length = 768
Score = 84.7 bits (208), Expect = 3e-16
Identities = 74/267 (27%), Positives = 129/267 (48%), Gaps = 24/267 (8%)
Frame = +2
Query: 2 QVHHELARLHESGRFIK----SKQLAAGCLHHQFWSHLLNENDSPEAIVKETSNDINWES 169
Q+H +L+R HE GRF++ K++ G +END+ I + +S
Sbjct: 529 QIHIDLSRYHELGRFVEVDSEHKEMLEG-----------SENDARVPIKYDK------QS 571
Query: 170 CLFHERHAAQLGCLEAVIVMARYCLNMSGHMLQDCP--------FPPTQNDL-------- 301
+FH A + G LEAV+ A L + +L++ F +N +
Sbjct: 572 AIFHLDIARKCGILEAVLTSAHIVLGLPHELLKEVTVDDLFPNGFGEQENGIRADKGQKP 631
Query: 302 ----DCGLDYLWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKW 469
+ G D + AA+ GD+ +M+ +A+ Y E + G +T ++ +++ W
Sbjct: 632 CDLEEFGSDLMEIAAEMGDKGAMLYMAHAY------ETGQHLGPNRRT----DYKKSIDW 681
Query: 470 YKRAFEAANKPDGQLDSKDAEGRYDSADDLMPPQEILAAMAELHFKGGYGLERNCQLAGE 649
Y+R + + +LDS + + S L EILA MAE++ +GGYGL ++ + A
Sbjct: 682 YQRV--VGFQEEEELDSDCGKTTFSSFAPLTR-HEILAKMAEMYKEGGYGLNQDFERAYG 738
Query: 650 LYSQAAEIATNALQGRQAVKYYELSDI 730
L+++AAE A A+ G+ A KYYE +++
Sbjct: 739 LFNEAAEAAMEAMNGKLANKYYEKAEM 765
>sp|O00763|COA2_HUMAN Acetyl-CoA carboxylase 2 (ACC-beta) [Includes: Biotin carboxylase ]
Length = 2483
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 3/56 (5%)
Frame = +2
Query: 470 YKRAFEAANKPD-GQLDSKDAEGRYDSADDLMPP--QEILAAMAELHFKGGYGLER 628
YK+ E +PD D KD EGR + +DL+ P ++ A+ H G LE+
Sbjct: 2280 YKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEK 2335
>sp|Q9UBV2|SEL1L_HUMAN Sel-1 homolog precursor (Suppressor of lin-12-like protein)
(Sel-1L)
Length = 794
Score = 30.8 bits (68), Expect = 5.5
Identities = 17/54 (31%), Positives = 26/54 (48%)
Frame = +2
Query: 587 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 748
+ +LH GG G+E+N Q A + ++ AA + Y E SDI +E
Sbjct: 379 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 432
>sp|Q9NP71|WBS14_HUMAN Williams-Beuren syndrome chromosome region 14 protein (WS
basic-helix-loop-helix leucine zipper protein) (WS-bHLH)
(Mlx interactor) (MLX-interacting protein-like)
Length = 852
Score = 30.8 bits (68), Expect = 5.5
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 3/61 (4%)
Frame = +2
Query: 368 ANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKW---YKRAFEAANKPDGQLDSKDAEGR 538
A+ +RK E EGN K ++V E KW YK+ ++ D L K AEGR
Sbjct: 154 ADAHRKPEAV---VLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGR 210
Query: 539 Y 541
+
Sbjct: 211 W 211
>sp|P10911|MCF2_HUMAN Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2
transforming protein; DBL transforming protein]
Length = 925
Score = 30.8 bits (68), Expect = 5.5
Identities = 15/52 (28%), Positives = 27/52 (51%)
Frame = +3
Query: 627 EIVSWLANYTVKLQKLPQMLFKDAKLLNIMNFLILHIHKMNVLNSFLLPFIC 782
++ +A K++KL + +LL+ F+ILH HK+ + + L IC
Sbjct: 246 DVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLIC 297
>sp|Q9DCV6|K0141_MOUSE Protein KIAA0141
Length = 510
Score = 30.8 bits (68), Expect = 5.5
Identities = 20/62 (32%), Positives = 26/62 (41%)
Frame = +2
Query: 317 YLWRAADSGDRRSMIELANLYRKTENTEEKTYEGNIMKTLLDVNWYEAVKWYKRAFEAAN 496
YLW AA +GD +S L Y K + N EAVK Y++A N
Sbjct: 376 YLWLAASNGDSQSRFHLGICYEKGLGAQR--------------NLGEAVKCYQQAAAMGN 421
Query: 497 KP 502
+P
Sbjct: 422 EP 423
>sp|Q9Z2G6|SEL1L_MOUSE Sel-1 homolog precursor (Suppressor of lin-12-like protein)
(Sel-1L)
Length = 790
Score = 30.8 bits (68), Expect = 5.5
Identities = 17/54 (31%), Positives = 26/54 (48%)
Frame = +2
Query: 587 MAELHFKGGYGLERNCQLAGELYSQAAEIATNALQGRQAVKYYELSDIAYSQDE 748
+ +LH GG G+E+N Q A + ++ AA + Y E SDI +E
Sbjct: 375 LGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNE 428
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,842,321
Number of Sequences: 369166
Number of extensions: 1788927
Number of successful extensions: 4449
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4323
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4442
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9318621220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)