Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00156 (1524 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 172 2e-42 sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 164 8e-40 sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 163 1e-39 sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydra... 162 2e-39 sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 160 9e-39 sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 159 2e-38 sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehyd... 157 6e-38 sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydra... 157 8e-38 sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydr... 156 2e-37 sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate de... 155 2e-37
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase II) (CA-II) Length = 260 Score = 172 bits (436), Expect = 2e-42 Identities = 95/266 (35%), Positives = 151/266 (56%), Gaps = 7/266 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGY +GP W +FP A G RQSPI+I+ YD TL +PL + ++P L ++ Sbjct: 5 WGYADHNGPQKWCENFPIANGPRQSPIDIQTKGASYDDTL--KPLKLKYDPTTSLD--IL 60 Query: 826 YTGHNFRIDVAG---GSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F++ A S ++ GP+ L F FHWG++D GSEH ++G +PAEL Sbjct: 61 NNGHSFQVTFADDNDSSMLTEGPISGKYR--LKQFHFHWGASDGKGSEHTVDGKCYPAEL 118 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N +KY F EA +PDG G N +++++ + +I + + Sbjct: 119 HLVHWN-TKYASFGEAANKPDGLAVVGVFLQIGEDNPKLQKILDAMDAI---KSKGKQTS 174 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI----H 1344 + D T +LP+++ Y+TYPGSLTTPP YESVTW++ ++ + + ++Q+ FR + Sbjct: 175 FTNFDPTCLLPKSL-EYWTYPGSLTTPPLYESVTWIVCKQPISVSSEQMKKFRSLLFTAE 233 Query: 1345 MGDSCCGPDNFRPICPIGERIVCKNF 1422 +CC +N+RP P+ +R VC +F Sbjct: 234 EEKACCMVNNYRPPQPLKDRKVCASF 259
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase) Length = 260 Score = 164 bits (414), Expect = 8e-40 Identities = 101/267 (37%), Positives = 149/267 (55%), Gaps = 8/267 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGYG DGP +W SFP A G RQSPI+I + ++D +L + L + ++P +++++ Sbjct: 5 WGYGPADGPESWAESFPIANGPRQSPIDIVPTQAQHDPSL--KHLKLKYDPAT--TKSIL 60 Query: 826 YTGHNFRIDVA---GGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F++D S ++GGP+ TG L F FHWGS+D GSEH I G +FP EL Sbjct: 61 NNGHSFQVDFVDDDNSSTLAGGPI-TG-IYRLRQFHFHWGSSDDKGSEHTIAGTKFPCEL 118 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHDFRQ 1173 H+V +N +KY F EA +PDG G+ N +++++ L I+ RQ F Sbjct: 119 HLVHWN-TKYPNFGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGRQTTFAN 177 Query: 1174 EHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGD 1353 D +LP ++ Y+TY GSLTTPP ESVTW++ +E + + Q+ FR + Sbjct: 178 ----FDPKTLLPASL-DYWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSS 232 Query: 1354 S----CCGPDNFRPICPIGERIVCKNF 1422 CC DN+RP P+ R V +F Sbjct: 233 EGETPCCMVDNYRPPQPLKGRKVRASF 259
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate dehydratase VII) (CA-VII) Length = 264 Score = 163 bits (413), Expect = 1e-39 Identities = 104/272 (38%), Positives = 140/272 (51%), Gaps = 13/272 (4%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGYG DDGP WH +P A G RQSPINI + Y +L +PL + +E LS T Sbjct: 7 WGYGQDDGPSNWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELFYEACMSLSIT-- 62 Query: 826 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+ ++D + VSGGP+ L FHWG GSEH ++G FP+EL Sbjct: 63 NNGHSVQVDFNDSDDRTVVSGGPLEGPYR--LKQLHFHWGKKRDMGSEHTVDGKSFPSEL 120 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +NA KY F EA PDG G ++ ++ RL L ++F D + + Sbjct: 121 HLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KDTKAQ 177 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR------- 1335 S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR Sbjct: 178 FSCFNPKCLLPTSR-HYWTYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSLLFTSE 236 Query: 1336 ---KIHMGDSCCGPDNFRPICPIGERIVCKNF 1422 +IHM DNFRP P+ R+V +F Sbjct: 237 DDERIHM------VDNFRPPQPLKGRVVKASF 262
>sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase I) (CA-I) Length = 261 Score = 162 bits (411), Expect = 2e-39 Identities = 96/266 (36%), Positives = 148/266 (55%), Gaps = 7/266 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGY ++GP W P A G QSPI+I+ + K D +L +PL++++ P ++ +V Sbjct: 6 WGYDGENGPEHWCKLHPIANGNNQSPIDIKTSETKRDPSL--KPLSISYNPAT--AKEIV 61 Query: 826 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F + D S + GGP+P ++ L F FHWGSTD GSEHL++G F AEL Sbjct: 62 NVGHSFHVNFEDSDNRSVLKGGPLP--ESYRLRQFHFHWGSTDDCGSEHLVDGATFSAEL 119 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N++KY F +A Q DG G N +++++ L ++ + + + Sbjct: 120 HLVHWNSAKYPSFADAASQADGLVVVGVLMKVGQANPNLQKVLDALKTV---KTKNKKAP 176 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI---HM 1347 + D + +LP + Y+ Y GSLT PP +ESVTW+IF+ET+ + +QL FR + Sbjct: 177 FTNFDPSVLLP-SCPDYWAYFGSLTHPPLHESVTWIIFKETISVSAEQLAQFRSLLANAE 235 Query: 1348 GD-SCCGPDNFRPICPIGERIVCKNF 1422 GD C N+RP P+ R V +F Sbjct: 236 GDKEVCIKQNYRPPQPLKGRTVKASF 261
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII) Length = 264 Score = 160 bits (405), Expect = 9e-39 Identities = 102/272 (37%), Positives = 141/272 (51%), Gaps = 13/272 (4%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGYG DDGP WH +P A G RQSPINI + Y +L +PL +++E LS T Sbjct: 7 WGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELSYEACMSLSIT-- 62 Query: 826 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+ ++D + V+GGP+ L F FHWG GSEH ++G FP+EL Sbjct: 63 NNGHSVQVDFNDSDDRTVVTGGPLEGPYR--LKQFHFHWGKKHDVGSEHTVDGKSFPSEL 120 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +NA KY F EA PDG G ++ ++ RL L ++F + + Sbjct: 121 HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KGTKAQ 177 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR------- 1335 S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR Sbjct: 178 FSCFNPKCLLPASR-HYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSE 236 Query: 1336 ---KIHMGDSCCGPDNFRPICPIGERIVCKNF 1422 +IHM +NFRP P+ R+V +F Sbjct: 237 DDERIHM------VNNFRPPQPLKGRVVKASF 262
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase II) (CA-II) Length = 259 Score = 159 bits (402), Expect = 2e-38 Identities = 96/270 (35%), Positives = 146/270 (54%), Gaps = 11/270 (4%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGYG +GP WH FP A G RQSPI+I+ + K+D +L +PL V +E +S+ ++ Sbjct: 4 WGYGKHNGPEHWHKDFPIANGERQSPIDIDTNAAKHDPSL--KPLRVCYE--HPISRRII 59 Query: 826 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F + D + + GP+ T L F FHWGS+D GSEH +N ++ AEL Sbjct: 60 NNGHSFNVEFDDSHDKTVLKEGPLEG--TYRLIQFHFHWGSSDGQGSEHTVNKKKYAAEL 117 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N +KY F +A+ PDG GS ++++V L+SI + + Sbjct: 118 HLVHWN-TKYGDFGKAVKHPDGLAVLGIFLKIGSATPGLQKVVDTLSSI--------KTK 168 Query: 1177 HSLLDLTEILPRNMCR----YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIH 1344 +D T+ PR + Y+TYPGSLTTPP E VTW++ +E + + ++Q+ FR ++ Sbjct: 169 GKSVDFTDFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMLKFRNLN 228 Query: 1345 MGDSCCGP----DNFRPICPIGERIVCKNF 1422 DN+RP P+ R V +F Sbjct: 229 FNKEAEPEEPMVDNWRPTQPLKGRQVKASF 258
>sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehydratase II) (CA-II) (Carbonic anhydrase C) Length = 260 Score = 157 bits (398), Expect = 6e-38 Identities = 97/267 (36%), Positives = 146/267 (54%), Gaps = 8/267 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGYG +GP WH FP A G RQSP++I+ KYD +L +PL+V+++ L ++ Sbjct: 5 WGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSL--KPLSVSYDQATSLR--IL 60 Query: 826 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH F + D + + GGP+ T L F FHWGS D GSEH ++ ++ AEL Sbjct: 61 NNGHAFNVEFDDSQDKAVLKGGPLDG--TYRLIQFHFHWGSLDGQGSEHTVDKKKYAAEL 118 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHDFRQ 1173 H+V +N +KY F +A+ QPDG GS ++++V L SI+ + DF Sbjct: 119 HLVHWN-TKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTN 177 Query: 1174 EHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGD 1353 D +LP ++ Y+TYPGSLTTPP E VTW++ +E + + ++Q+ FRK++ Sbjct: 178 ----FDPRGLLPESL-DYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNG 232 Query: 1354 SC----CGPDNFRPICPIGERIVCKNF 1422 DN+RP P+ R + +F Sbjct: 233 EGEPEELMVDNWRPAQPLKNRQIKASF 259
>sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase II) (CA-II) Length = 260 Score = 157 bits (397), Expect = 8e-38 Identities = 91/266 (34%), Positives = 144/266 (54%), Gaps = 7/266 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGY +GP WH FP A G RQSP++I+ +D L +PL ++++ + S+++V Sbjct: 5 WGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAHHDPAL--QPLLISYD--KAASKSIV 60 Query: 826 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F + D + + GGP+ I F FHWGS+D GSEH +N ++ AEL Sbjct: 61 NNGHSFNVEFDDSQDNAVLKGGPLSDSYRLI--QFHFHWGSSDGQGSEHTVNKKKYAAEL 118 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N +KY F +A+ QPDG G + +++++ L SI + R Sbjct: 119 HLVHWN-TKYGDFGKAVQQPDGLAVLGYFLKIGPASQGLQKVLEALHSI---KTKGKRAA 174 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDS 1356 + D +LP N+ Y+TYPGSLTTPP E VTW++ E + + ++Q+ FR ++ + Sbjct: 175 FANFDPCSLLPGNL-DYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEE 233 Query: 1357 CCGP----DNFRPICPIGERIVCKNF 1422 DN+RP P+ R + +F Sbjct: 234 GDAEEAMVDNWRPAQPLKNRKIKASF 259
>sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydratase I) (CA-I) Length = 260 Score = 156 bits (394), Expect = 2e-37 Identities = 91/262 (34%), Positives = 141/262 (53%), Gaps = 7/262 (2%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGY + +GP W +P A G QSPI+I+ + K+D +L +P +V+++P ++ +V Sbjct: 5 WGYDSPNGPZEWVKLYPIANGNNQSPIDIKTSETKHDTSL--KPFSVSYDPAT--AKEIV 60 Query: 826 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 GH+F++ D S + GP+P + F FHWGSTD GSEH ++G ++ AEL Sbjct: 61 NVGHSFQVKFEDSDNRSVLKDGPLPGSYRLV--QFHFHWGSTDDYGSEHTVDGVKYSAEL 118 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N+SKY F+EA Q DG G N +++++ L + + + Sbjct: 119 HLVHWNSSKYSSFDEASSQADGLAILGVLMKVGEANPKLQKVLDALNEV---KTKGKKAP 175 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----KIH 1344 D + +LP + Y+TY GSLT PP YESVTW++ +E + I + QL FR + Sbjct: 176 FKNFDPSSLLPSSP-DYWTYSGSLTHPPLYESVTWIVCKENISISSQQLSQFRSLLSNVE 234 Query: 1345 MGDSCCGPDNFRPICPIGERIV 1410 G + N RP P+ R V Sbjct: 235 GGKAVPIQHNNRPPQPLKGRTV 256
>sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate dehydratase XIII) (CA-XIII) Length = 262 Score = 155 bits (393), Expect = 2e-37 Identities = 88/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%) Frame = +1 Query: 646 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 825 WGY +GP W FP A G +QSPI I+ ++KYD +L RPL++ ++P ++ + Sbjct: 6 WGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSL--RPLSIKYDPSS--AKIIS 61 Query: 826 YTGHNFRID---VAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 996 +GH+F +D S + GGP+ TG + L HWGS D GSEH+++G + AEL Sbjct: 62 NSGHSFNVDFDDTENKSVLRGGPL-TG-SYRLRQVHLHWGSADDHGSEHIVDGVSYAAEL 119 Query: 997 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 1176 H+V +N+ KY F EA +PDG G NS ++++ L SI ++ + Sbjct: 120 HVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSI---KEKGKQTR 176 Query: 1177 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 1341 + DL +LP + Y+TYPGSLT PP ESVTW++ ++ + I + QL FR + Sbjct: 177 FTNFDLLSLLPPSW-DYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSL 230
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 172,115,743 Number of Sequences: 369166 Number of extensions: 3605423 Number of successful extensions: 9060 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 8353 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 8892 length of database: 68,354,980 effective HSP length: 115 effective length of database: 47,110,455 effective search space used: 18467298360 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)