Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_O24
(708 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 131 2e-30
sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydra... 128 2e-29
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 125 1e-28
sp|P43165|CAH5A_RAT Carbonic anhydrase 5A, mitochondrial pr... 122 9e-28
sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 120 4e-27
sp|P35218|CAH5A_HUMAN Carbonic anhydrase VA, mitochondrial ... 119 6e-27
sp|P23589|CAH5A_MOUSE Carbonic anhydrase 5A, mitochondrial ... 119 8e-27
sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydr... 118 1e-26
sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydr... 117 3e-26
sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 117 4e-26
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 131 bits (330), Expect = 2e-30
Identities = 71/208 (34%), Positives = 119/208 (57%), Gaps = 7/208 (3%)
Frame = +1
Query: 4 LVYTGHNFRIDVAG---GSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPA 174
++ GH+F++ A S ++ GP+ L F FHWG++D GSEH ++G +PA
Sbjct: 59 ILNNGHSFQVTFADDNDSSMLTEGPISGKYR--LKQFHFHWGASDGKGSEHTVDGKCYPA 116
Query: 175 ELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFR 354
ELH+V +N +KY F EA +PDG G N +++++ + +I + +
Sbjct: 117 ELHLVHWN-TKYASFGEAANKPDGLAVVGVFLQIGEDNPKLQKILDAMDAI---KSKGKQ 172
Query: 355 QEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI--- 525
+ D T +LP+++ Y+TYPGSLTTPP YESVTW++ ++ + + ++Q+ FR +
Sbjct: 173 TSFTNFDPTCLLPKSL-EYWTYPGSLTTPPLYESVTWIVCKQPISVSSEQMKKFRSLLFT 231
Query: 526 -HMGDSCCGPDNFRPICPIGERIVCKNF 606
+CC +N+RP P+ +R VC +F
Sbjct: 232 AEEEKACCMVNNYRPPQPLKDRKVCASF 259
>sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 128 bits (321), Expect = 2e-29
Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 7/208 (3%)
Frame = +1
Query: 4 LVYTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPA 174
+V GH+F + D S + GGP+P ++ L F FHWGSTD GSEHL++G F A
Sbjct: 60 IVNVGHSFHVNFEDSDNRSVLKGGPLP--ESYRLRQFHFHWGSTDDCGSEHLVDGATFSA 117
Query: 175 ELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFR 354
ELH+V +N++KY F +A Q DG G N +++++ L ++ + + +
Sbjct: 118 ELHLVHWNSAKYPSFADAASQADGLVVVGVLMKVGQANPNLQKVLDALKTV---KTKNKK 174
Query: 355 QEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI--- 525
+ D + +LP + Y+ Y GSLT PP +ESVTW+IF+ET+ + +QL FR +
Sbjct: 175 APFTNFDPSVLLP-SCPDYWAYFGSLTHPPLHESVTWIIFKETISVSAEQLAQFRSLLAN 233
Query: 526 HMGD-SCCGPDNFRPICPIGERIVCKNF 606
GD C N+RP P+ R V +F
Sbjct: 234 AEGDKEVCIKQNYRPPQPLKGRTVKASF 261
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 125 bits (313), Expect = 1e-28
Identities = 78/210 (37%), Positives = 114/210 (54%), Gaps = 8/210 (3%)
Frame = +1
Query: 1 TLVYTGHNFRIDVA---GGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFP 171
+++ GH+F++D S ++GGP+ TG L F FHWGS+D GSEH I G +FP
Sbjct: 58 SILNNGHSFQVDFVDDDNSSTLAGGPI-TG-IYRLRQFHFHWGSSDDKGSEHTIAGTKFP 115
Query: 172 AELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHD 348
ELH+V +N +KY F EA +PDG G+ N +++++ L I+ RQ
Sbjct: 116 CELHLVHWN-TKYPNFGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGRQTT 174
Query: 349 FRQEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIH 528
F D +LP ++ Y+TY GSLTTPP ESVTW++ +E + + Q+ FR +
Sbjct: 175 FAN----FDPKTLLPASL-DYWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLL 229
Query: 529 MGDS----CCGPDNFRPICPIGERIVCKNF 606
CC DN+RP P+ R V +F
Sbjct: 230 FSSEGETPCCMVDNYRPPQPLKGRKVRASF 259
>sp|P43165|CAH5A_RAT Carbonic anhydrase 5A, mitochondrial precursor (Carbonic anhydrase
VA) (Carbonate dehydratase VA) (CA-VA)
Length = 304
Score = 122 bits (306), Expect = 9e-28
Identities = 76/206 (36%), Positives = 112/206 (54%), Gaps = 8/206 (3%)
Frame = +1
Query: 13 TGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELH 183
TG+ F++ D S +SGGP+ G L F FHWG+TD GSEH+++GH +PAELH
Sbjct: 97 TGYFFQVEFDDSCEESGISGGPL--GNHYRLKQFHFHWGATDEWGSEHMVDGHAYPAELH 154
Query: 184 MVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEH 363
+V +N+ KY +++A +G G+ + ++RLV L + R D +
Sbjct: 155 LVHWNSMKYENYKKATTGENGLAVIGVFLKLGAHHEALQRLVDILPEV---RHKDTQVTM 211
Query: 364 SLLDLTEILPRNMCR-YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMG-- 534
D + +LP CR Y+TYPGSLTTPP ESVTW++ + + + QL FR +
Sbjct: 212 GPFDPSCLLP--ACRDYWTYPGSLTTPPLAESVTWIVHKMPIEVSPSQLSTFRTLLFSGR 269
Query: 535 --DSCCGPDNFRPICPIGERIVCKNF 606
D +NFRP+ P+ R V +F
Sbjct: 270 GEDEEVMVNNFRPLQPLRGRNVRSSF 295
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate
dehydratase VII) (CA-VII)
Length = 264
Score = 120 bits (301), Expect = 4e-27
Identities = 76/215 (35%), Positives = 108/215 (50%), Gaps = 13/215 (6%)
Frame = +1
Query: 1 TLVYTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFP 171
++ GH+ ++D + VSGGP+ L FHWG GSEH ++G FP
Sbjct: 60 SITNNGHSVQVDFNDSDDRTVVSGGPLEGPYR--LKQLHFHWGKKRDMGSEHTVDGKSFP 117
Query: 172 AELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDF 351
+ELH+V +NA KY F EA PDG G ++ ++ RL L ++F D
Sbjct: 118 SELHLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KDT 174
Query: 352 RQEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR---- 519
+ + S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR
Sbjct: 175 KAQFSCFNPKCLLPTSR-HYWTYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSLLF 233
Query: 520 ------KIHMGDSCCGPDNFRPICPIGERIVCKNF 606
+IHM DNFRP P+ R+V +F
Sbjct: 234 TSEDDERIHM------VDNFRPPQPLKGRVVKASF 262
>sp|P35218|CAH5A_HUMAN Carbonic anhydrase VA, mitochondrial precursor (Carbonate
dehydratase VA) (CA-VA)
Length = 305
Score = 119 bits (299), Expect = 6e-27
Identities = 76/207 (36%), Positives = 111/207 (53%), Gaps = 9/207 (4%)
Frame = +1
Query: 13 TGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELH 183
TG+ F++ D S +SGGP+ L F FHWG+ + GSEH ++GH +PAELH
Sbjct: 98 TGYLFQVEFDDATEASGISGGPLENHYR--LKQFHFHWGAVNEGGSEHTVDGHAYPAELH 155
Query: 184 MVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEH 363
+V +N+ KY+ ++EA+ +G G+ + T++RLV L I + D R
Sbjct: 156 LVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEI---KHKDARAAM 212
Query: 364 SLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDSC 543
D + +LP Y+TY GSLTTPP ESVTW+I +E V + QL FR + S
Sbjct: 213 RPFDPSTLLP-TCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLF--SA 269
Query: 544 CGPD------NFRPICPIGERIVCKNF 606
G + N+RP+ P+ R V +F
Sbjct: 270 LGEEEKMMVNNYRPLQPLMNRKVWASF 296
>sp|P23589|CAH5A_MOUSE Carbonic anhydrase 5A, mitochondrial precursor (Carbonic anhydrase
VA) (Carbonate dehydratase VA) (CA-VA) (CA Y)
Length = 299
Score = 119 bits (298), Expect = 8e-27
Identities = 73/206 (35%), Positives = 113/206 (54%), Gaps = 8/206 (3%)
Frame = +1
Query: 13 TGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELH 183
TG+ F++ D S +SGGP+ G L F FHWG+TD GSEH ++GH +PAELH
Sbjct: 92 TGYFFQVEFDDSCEDSGISGGPL--GNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELH 149
Query: 184 MVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEH 363
+V +N++KY +++A +G G+ + +++LV L + R D +
Sbjct: 150 LVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEV---RHKDTQVAM 206
Query: 364 SLLDLTEILPRNMCR-YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMG-- 534
D + +LP CR Y+TYPGSLTTPP ESVTW++ + V + QL FR +
Sbjct: 207 GPFDPSCLLP--ACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGR 264
Query: 535 --DSCCGPDNFRPICPIGERIVCKNF 606
+ +N+RP+ P+ +R + +F
Sbjct: 265 GEEEDVMVNNYRPLQPLRDRKLRSSF 290
>sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 260
Score = 118 bits (296), Expect = 1e-26
Identities = 71/204 (34%), Positives = 106/204 (51%), Gaps = 7/204 (3%)
Frame = +1
Query: 4 LVYTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPA 174
+V GH+F++ D S + GP+P + F FHWGSTD GSEH ++G ++ A
Sbjct: 59 IVNVGHSFQVKFEDSDNRSVLKDGPLPGSYRLV--QFHFHWGSTDDYGSEHTVDGVKYSA 116
Query: 175 ELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFR 354
ELH+V +N+SKY F+EA Q DG G N +++++ L + + +
Sbjct: 117 ELHLVHWNSSKYSSFDEASSQADGLAILGVLMKVGEANPKLQKVLDALNEV---KTKGKK 173
Query: 355 QEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----K 522
D + +LP + Y+TY GSLT PP YESVTW++ +E + I + QL FR
Sbjct: 174 APFKNFDPSSLLPSSP-DYWTYSGSLTHPPLYESVTWIVCKENISISSQQLSQFRSLLSN 232
Query: 523 IHMGDSCCGPDNFRPICPIGERIV 594
+ G + N RP P+ R V
Sbjct: 233 VEGGKAVPIQHNNRPPQPLKGRTV 256
>sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 261
Score = 117 bits (293), Expect = 3e-26
Identities = 70/208 (33%), Positives = 111/208 (53%), Gaps = 7/208 (3%)
Frame = +1
Query: 4 LVYTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPA 174
++ GH+F + D S + GGP+ L F FHWGST+ GSEH ++G ++ A
Sbjct: 60 IINVGHSFHVTFEDNDNRSVLKGGPLSDSYR--LFQFHFHWGSTNEHGSEHTVDGVKYSA 117
Query: 175 ELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFR 354
ELH+ +N++KY EA + DG G N ++++ L ++Q + R
Sbjct: 118 ELHLTHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKI---LDALQAIKTKGKR 174
Query: 355 QEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHM- 531
+ D + +LP ++ ++TYPGSLT PP YESVTW+I +E++ + ++QL FR +
Sbjct: 175 APFTNFDPSTLLPSSL-DFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSN 233
Query: 532 --GDSCCG-PDNFRPICPIGERIVCKNF 606
GD+ N RP P+ R V +F
Sbjct: 234 VEGDNAVPMQHNNRPTQPLKGRTVRASF 261
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII)
Length = 264
Score = 117 bits (292), Expect = 4e-26
Identities = 74/215 (34%), Positives = 108/215 (50%), Gaps = 13/215 (6%)
Frame = +1
Query: 1 TLVYTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFP 171
++ GH+ ++D + V+GGP+ L F FHWG GSEH ++G FP
Sbjct: 60 SITNNGHSVQVDFNDSDDRTVVTGGPLEGPYR--LKQFHFHWGKKHDVGSEHTVDGKSFP 117
Query: 172 AELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDF 351
+ELH+V +NA KY F EA PDG G ++ ++ RL L ++F
Sbjct: 118 SELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KGT 174
Query: 352 RQEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR---- 519
+ + S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR
Sbjct: 175 KAQFSCFNPKCLLPASR-HYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLF 233
Query: 520 ------KIHMGDSCCGPDNFRPICPIGERIVCKNF 606
+IHM +NFRP P+ R+V +F
Sbjct: 234 TSEDDERIHM------VNNFRPPQPLKGRVVKASF 262
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,154,805
Number of Sequences: 369166
Number of extensions: 1727237
Number of successful extensions: 4187
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3908
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4083
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6219306880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)