Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_017_P23
(660 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 127 3e-29
sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydra... 121 1e-27
sp|P43165|CAH5A_RAT Carbonic anhydrase 5A, mitochondrial pr... 119 5e-27
sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 117 2e-26
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 117 3e-26
sp|P23589|CAH5A_MOUSE Carbonic anhydrase 5A, mitochondrial ... 116 6e-26
sp|P35218|CAH5A_HUMAN Carbonic anhydrase VA, mitochondrial ... 115 1e-25
sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 114 2e-25
sp|Q9QZA0|CAH5B_MOUSE Carbonic anhydrase 5B, mitochondrial ... 111 1e-24
sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydr... 111 1e-24
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 127 bits (318), Expect = 3e-29
Identities = 64/175 (36%), Positives = 104/175 (59%), Gaps = 4/175 (2%)
Frame = +3
Query: 45 LSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXX 224
L F FHWG++D GSEH ++G +PAELH+V +N +KY F EA +PDG
Sbjct: 90 LKQFHFHWGASDGKGSEHTVDGKCYPAELHLVHWN-TKYASFGEAANKPDGLAVVGVFLQ 148
Query: 225 XGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYYTYPGSLTTPPCYE 404
G N +++++ + +I + + + D T +LP+++ Y+TYPGSLTTPP YE
Sbjct: 149 IGEDNPKLQKILDAMDAI---KSKGKQTSFTNFDPTCLLPKSL-EYWTYPGSLTTPPLYE 204
Query: 405 SVTWLIFEETVGIDTDQLCMFRKI----HMGDSCCGPDNFRPICPIGERIVCKNF 557
SVTW++ ++ + + ++Q+ FR + +CC +N+RP P+ +R VC +F
Sbjct: 205 SVTWIVCKQPISVSSEQMKKFRSLLFTAEEEKACCMVNNYRPPQPLKDRKVCASF 259
>sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 121 bits (304), Expect = 1e-27
Identities = 70/188 (37%), Positives = 106/188 (56%), Gaps = 4/188 (2%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
+ GGP+P ++ L F FHWGSTD GSEHL++G F AELH+V +N++KY F +A
Sbjct: 80 LKGGPLP--ESYRLRQFHFHWGSTDDCGSEHLVDGATFSAELHLVHWNSAKYPSFADAAS 137
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYY 365
Q DG G N +++++ L ++ + + + + D + +LP + Y+
Sbjct: 138 QADGLVVVGVLMKVGQANPNLQKVLDALKTV---KTKNKKAPFTNFDPSVLLP-SCPDYW 193
Query: 366 TYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI---HMGD-SCCGPDNFRPICPIG 533
Y GSLT PP +ESVTW+IF+ET+ + +QL FR + GD C N+RP P+
Sbjct: 194 AYFGSLTHPPLHESVTWIIFKETISVSAEQLAQFRSLLANAEGDKEVCIKQNYRPPQPLK 253
Query: 534 ERIVCKNF 557
R V +F
Sbjct: 254 GRTVKASF 261
>sp|P43165|CAH5A_RAT Carbonic anhydrase 5A, mitochondrial precursor (Carbonic anhydrase
VA) (Carbonate dehydratase VA) (CA-VA)
Length = 304
Score = 119 bits (299), Expect = 5e-27
Identities = 71/189 (37%), Positives = 104/189 (55%), Gaps = 5/189 (2%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
+SGGP+ G L F FHWG+TD GSEH+++GH +PAELH+V +N+ KY +++A
Sbjct: 114 ISGGPL--GNHYRLKQFHFHWGATDEWGSEHMVDGHAYPAELHLVHWNSMKYENYKKATT 171
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCR-Y 362
+G G+ + ++RLV L + R D + D + +LP CR Y
Sbjct: 172 GENGLAVIGVFLKLGAHHEALQRLVDILPEV---RHKDTQVTMGPFDPSCLLP--ACRDY 226
Query: 363 YTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMG----DSCCGPDNFRPICPI 530
+TYPGSLTTPP ESVTW++ + + + QL FR + D +NFRP+ P+
Sbjct: 227 WTYPGSLTTPPLAESVTWIVHKMPIEVSPSQLSTFRTLLFSGRGEDEEVMVNNFRPLQPL 286
Query: 531 GERIVCKNF 557
R V +F
Sbjct: 287 RGRNVRSSF 295
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate
dehydratase VII) (CA-VII)
Length = 264
Score = 117 bits (294), Expect = 2e-26
Identities = 73/194 (37%), Positives = 99/194 (51%), Gaps = 10/194 (5%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
VSGGP+ L FHWG GSEH ++G FP+ELH+V +NA KY F EA
Sbjct: 81 VSGGPLEGPYR--LKQLHFHWGKKRDMGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAAA 138
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYY 365
PDG G ++ ++ RL L ++F D + + S + +LP + Y+
Sbjct: 139 APDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KDTKAQFSCFNPKCLLPTSR-HYW 194
Query: 366 TYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----------KIHMGDSCCGPDNFR 515
TYPGSLTTPP ESVTW++ E + I Q+ FR +IHM DNFR
Sbjct: 195 TYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSLLFTSEDDERIHM------VDNFR 248
Query: 516 PICPIGERIVCKNF 557
P P+ R+V +F
Sbjct: 249 PPQPLKGRVVKASF 262
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 117 bits (292), Expect = 3e-26
Identities = 73/189 (38%), Positives = 103/189 (54%), Gaps = 5/189 (2%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
++GGP+ TG L F FHWGS+D GSEH I G +FP ELH+V +N +KY F EA
Sbjct: 79 LAGGPI-TG-IYRLRQFHFHWGSSDDKGSEHTIAGTKFPCELHLVHWN-TKYPNFGEAAS 135
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHDFRQEHSLLDLTEILPRNMCRY 362
+PDG G+ N +++++ L I+ RQ F D +LP ++ Y
Sbjct: 136 KPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGRQTTFAN----FDPKTLLPASL-DY 190
Query: 363 YTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDS----CCGPDNFRPICPI 530
+TY GSLTTPP ESVTW++ +E + + Q+ FR + CC DN+RP P+
Sbjct: 191 WTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSSEGETPCCMVDNYRPPQPL 250
Query: 531 GERIVCKNF 557
R V +F
Sbjct: 251 KGRKVRASF 259
>sp|P23589|CAH5A_MOUSE Carbonic anhydrase 5A, mitochondrial precursor (Carbonic anhydrase
VA) (Carbonate dehydratase VA) (CA-VA) (CA Y)
Length = 299
Score = 116 bits (290), Expect = 6e-26
Identities = 68/189 (35%), Positives = 105/189 (55%), Gaps = 5/189 (2%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
+SGGP+ G L F FHWG+TD GSEH ++GH +PAELH+V +N++KY +++A
Sbjct: 109 ISGGPL--GNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASV 166
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCR-Y 362
+G G+ + +++LV L + R D + D + +LP CR Y
Sbjct: 167 GENGLAVIGVFLKLGAHHQALQKLVDVLPEV---RHKDTQVAMGPFDPSCLLP--ACRDY 221
Query: 363 YTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMG----DSCCGPDNFRPICPI 530
+TYPGSLTTPP ESVTW++ + V + QL FR + + +N+RP+ P+
Sbjct: 222 WTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEEDVMVNNYRPLQPL 281
Query: 531 GERIVCKNF 557
+R + +F
Sbjct: 282 RDRKLRSSF 290
>sp|P35218|CAH5A_HUMAN Carbonic anhydrase VA, mitochondrial precursor (Carbonate
dehydratase VA) (CA-VA)
Length = 305
Score = 115 bits (288), Expect = 1e-25
Identities = 71/190 (37%), Positives = 103/190 (54%), Gaps = 6/190 (3%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
+SGGP+ L F FHWG+ + GSEH ++GH +PAELH+V +N+ KY+ ++EA+
Sbjct: 115 ISGGPLENHYR--LKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVV 172
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYY 365
+G G+ + T++RLV L I + D R D + +LP Y+
Sbjct: 173 GENGLAVIGVFLKLGAHHQTLQRLVDILPEI---KHKDARAAMRPFDPSTLLP-TCWDYW 228
Query: 366 TYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDSCCGPD------NFRPICP 527
TY GSLTTPP ESVTW+I +E V + QL FR + S G + N+RP+ P
Sbjct: 229 TYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLF--SALGEEEKMMVNNYRPLQP 286
Query: 528 IGERIVCKNF 557
+ R V +F
Sbjct: 287 LMNRKVWASF 296
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII)
Length = 264
Score = 114 bits (285), Expect = 2e-25
Identities = 71/194 (36%), Positives = 99/194 (51%), Gaps = 10/194 (5%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
V+GGP+ L F FHWG GSEH ++G FP+ELH+V +NA KY F EA
Sbjct: 81 VTGGPLEGPYR--LKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAAS 138
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYY 365
PDG G ++ ++ RL L ++F + + S + +LP + Y+
Sbjct: 139 APDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KGTKAQFSCFNPKCLLPASR-HYW 194
Query: 366 TYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----------KIHMGDSCCGPDNFR 515
TYPGSLTTPP ESVTW++ E + I Q+ FR +IHM +NFR
Sbjct: 195 TYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHM------VNNFR 248
Query: 516 PICPIGERIVCKNF 557
P P+ R+V +F
Sbjct: 249 PPQPLKGRVVKASF 262
>sp|Q9QZA0|CAH5B_MOUSE Carbonic anhydrase 5B, mitochondrial precursor (Carbonic anhydrase
VB) (Carbonate dehydratase VB) (CA-VB)
Length = 317
Score = 111 bits (278), Expect = 1e-24
Identities = 71/190 (37%), Positives = 99/190 (52%), Gaps = 6/190 (3%)
Frame = +3
Query: 6 VSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMG 185
V GGP+ L F FHWG+ D GSEH ++ +PAELH+V +NA K+ FE+A
Sbjct: 115 VEGGPLEHNYR--LKQFHFHWGAIDAWGSEHTVDSKCYPAELHLVHWNAVKFESFEDAAL 172
Query: 186 QPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYY 365
+ +G G + +++LV L SI + D E D + ++P Y+
Sbjct: 173 EENGLAVIGVFLKLGKHHKELQKLVDTLPSI---KHKDTLVEFGSFDPSCLMP-TCPDYW 228
Query: 366 TYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDSCCGP------DNFRPICP 527
TY GSLTTPP ESVTW+I ++ V +D DQL FR + G DNFRP+ P
Sbjct: 229 TYSGSLTTPPLSESVTWIIKKQPVEVDRDQLEQFRTLLFTSE--GEKEKRMVDNFRPLQP 286
Query: 528 IGERIVCKNF 557
+ R V +F
Sbjct: 287 LMNRTVRSSF 296
>sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 260
Score = 111 bits (278), Expect = 1e-24
Identities = 65/181 (35%), Positives = 95/181 (52%), Gaps = 4/181 (2%)
Frame = +3
Query: 15 GPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAELHMVCFNASKYRCFEEAMGQPD 194
GP+P + F FHWGSTD GSEH ++G ++ AELH+V +N+SKY F+EA Q D
Sbjct: 82 GPLPGSYRLV--QFHFHWGSTDDYGSEHTVDGVKYSAELHLVHWNSSKYSSFDEASSQAD 139
Query: 195 GXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQEHSLLDLTEILPRNMCRYYTYP 374
G G N +++++ L + + + D + +LP + Y+TY
Sbjct: 140 GLAILGVLMKVGEANPKLQKVLDALNEV---KTKGKKAPFKNFDPSSLLPSSP-DYWTYS 195
Query: 375 GSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----KIHMGDSCCGPDNFRPICPIGERI 542
GSLT PP YESVTW++ +E + I + QL FR + G + N RP P+ R
Sbjct: 196 GSLTHPPLYESVTWIVCKENISISSQQLSQFRSLLSNVEGGKAVPIQHNNRPPQPLKGRT 255
Query: 543 V 545
V
Sbjct: 256 V 256
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,610,591
Number of Sequences: 369166
Number of extensions: 1541321
Number of successful extensions: 3549
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3312
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3445
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5511356910
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)