Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_K08
(771 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 116 6e-26
sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydra... 116 6e-26
sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydr... 116 6e-26
sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 115 2e-25
sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate de... 114 3e-25
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 114 3e-25
sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 114 4e-25
sp|Q9D6N1|CAH13_MOUSE Carbonic anhydrase 13 (Carbonic anhyd... 113 7e-25
sp|P13634|CAH1_MOUSE Carbonic anhydrase 1 (Carbonic anhydra... 112 9e-25
sp|Q8HY33|CAH1_MONDO Carbonic anhydrase 1 (Carbonic anhydra... 111 2e-24
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII)
Length = 264
Score = 116 bits (291), Expect = 6e-26
Identities = 67/171 (39%), Positives = 91/171 (53%), Gaps = 3/171 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGYG DDGP WH +P A G RQSPINI + Y +L +PL +++E LS T
Sbjct: 7 WGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELSYEACMSLSIT-- 62
Query: 214 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+ ++D + V+GGP+ L F FHWG GSEH ++G FP+EL
Sbjct: 63 NNGHSVQVDFNDSDDRTVVTGGPLEGPYR--LKQFHFHWGKKHDVGSEHTVDGKSFPSEL 120
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQF 537
H+V +NA KY F EA PDG G ++ ++ RL L ++F
Sbjct: 121 HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF 171
Score = 50.1 bits (118), Expect = 7e-06
Identities = 21/39 (53%), Positives = 27/39 (69%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y+TYPGSLTTPP ESVTW++ E + I Q+ FR +
Sbjct: 193 YWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSL 231
>sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 116 bits (291), Expect = 6e-26
Identities = 62/170 (36%), Positives = 97/170 (57%), Gaps = 3/170 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGY ++GP W P A G QSPI+I+ + K D +L +PL++++ P ++ +V
Sbjct: 6 WGYDGENGPEHWCKLHPIANGNNQSPIDIKTSETKRDPSL--KPLSISYNPAT--AKEIV 61
Query: 214 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+F + D S + GGP+P ++ L F FHWGSTD GSEHL++G F AEL
Sbjct: 62 NVGHSFHVNFEDSDNRSVLKGGPLP--ESYRLRQFHFHWGSTDDCGSEHLVDGATFSAEL 119
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQ 534
H+V +N++KY F +A Q DG G N +++++ L +++
Sbjct: 120 HLVHWNSAKYPSFADAASQADGLVVVGVLMKVGQANPNLQKVLDALKTVK 169
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/42 (52%), Positives = 30/42 (71%)
Frame = +2
Query: 605 CVVYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
C Y+ Y GSLT PP +ESVTW+IF+ET+ + +QL FR +
Sbjct: 189 CPDYWAYFGSLTHPPLHESVTWIIFKETISVSAEQLAQFRSL 230
>sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 260
Score = 116 bits (291), Expect = 6e-26
Identities = 60/170 (35%), Positives = 97/170 (57%), Gaps = 3/170 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGY + +GP W +P A G QSPI+I+ + K+D +L +P +V+++P ++ +V
Sbjct: 5 WGYDSPNGPZEWVKLYPIANGNNQSPIDIKTSETKHDTSL--KPFSVSYDPAT--AKEIV 60
Query: 214 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+F++ D S + GP+P + F FHWGSTD GSEH ++G ++ AEL
Sbjct: 61 NVGHSFQVKFEDSDNRSVLKDGPLPGSYRLV--QFHFHWGSTDDYGSEHTVDGVKYSAEL 118
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQ 534
H+V +N+SKY F+EA Q DG G N +++++ L ++
Sbjct: 119 HLVHWNSSKYSSFDEASSQADGLAILGVLMKVGEANPKLQKVLDALNEVK 168
Score = 52.4 bits (124), Expect = 1e-06
Identities = 21/39 (53%), Positives = 28/39 (71%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y+TY GSLT PP YESVTW++ +E + I + QL FR +
Sbjct: 191 YWTYSGSLTHPPLYESVTWIVCKENISISSQQLSQFRSL 229
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate
dehydratase VII) (CA-VII)
Length = 264
Score = 115 bits (287), Expect = 2e-25
Identities = 67/171 (39%), Positives = 89/171 (52%), Gaps = 3/171 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGYG DDGP WH +P A G RQSPINI + Y +L +PL + +E LS T
Sbjct: 7 WGYGQDDGPSNWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELFYEACMSLSIT-- 62
Query: 214 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+ ++D + VSGGP+ L FHWG GSEH ++G FP+EL
Sbjct: 63 NNGHSVQVDFNDSDDRTVVSGGPLEGPYR--LKQLHFHWGKKRDMGSEHTVDGKSFPSEL 120
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQF 537
H+V +NA KY F EA PDG G ++ ++ RL L ++F
Sbjct: 121 HLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF 171
Score = 50.1 bits (118), Expect = 7e-06
Identities = 21/39 (53%), Positives = 27/39 (69%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y+TYPGSLTTPP ESVTW++ E + I Q+ FR +
Sbjct: 193 YWTYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSL 231
>sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate dehydratase XIII) (CA-XIII)
Length = 262
Score = 114 bits (285), Expect = 3e-25
Identities = 68/191 (35%), Positives = 104/191 (54%), Gaps = 3/191 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGY +GP W FP A G +QSPI I+ ++KYD +L RPL++ ++P ++ +
Sbjct: 6 WGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSL--RPLSIKYDPSS--AKIIS 61
Query: 214 YTGHNFRID---VAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
+GH+F +D S + GGP+ TG + L HWGS D GSEH+++G + AEL
Sbjct: 62 NSGHSFNVDFDDTENKSVLRGGPL-TG-SYRLRQVHLHWGSADDHGSEHIVDGVSYAAEL 119
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 564
H+V +N+ KY F EA +PDG G NS ++++ L SI ++ +
Sbjct: 120 HVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSI---KEKGKQTR 176
Query: 565 HSLLDLTEILP 597
+ DL +LP
Sbjct: 177 FTNFDLLSLLP 187
Score = 52.4 bits (124), Expect = 1e-06
Identities = 20/39 (51%), Positives = 28/39 (71%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y+TYPGSLT PP ESVTW++ ++ + I + QL FR +
Sbjct: 192 YWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSL 230
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 114 bits (285), Expect = 3e-25
Identities = 66/170 (38%), Positives = 100/170 (58%), Gaps = 3/170 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGYG DGP +W SFP A G RQSPI+I + ++D +L + L + ++P +++++
Sbjct: 5 WGYGPADGPESWAESFPIANGPRQSPIDIVPTQAQHDPSL--KHLKLKYDPAT--TKSIL 60
Query: 214 YTGHNFRIDVA---GGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+F++D S ++GGP+ TG L F FHWGS+D GSEH I G +FP EL
Sbjct: 61 NNGHSFQVDFVDDDNSSTLAGGPI-TG-IYRLRQFHFHWGSSDDKGSEHTIAGTKFPCEL 118
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQ 534
H+V +N +KY F EA +PDG G+ N +++++ L I+
Sbjct: 119 HLVHWN-TKYPNFGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIK 167
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 4/56 (7%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDS----CCGPDNFR 769
Y+TY GSLTTPP ESVTW++ +E + + Q+ FR + CC DN+R
Sbjct: 190 YWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSSEGETPCCMVDNYR 245
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 259
Score = 114 bits (284), Expect = 4e-25
Identities = 69/194 (35%), Positives = 105/194 (54%), Gaps = 3/194 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
WGYG +GP WH FP A G RQSPI+I+ + K+D +L +PL V + E +S+ ++
Sbjct: 4 WGYGKHNGPEHWHKDFPIANGERQSPIDIDTNAAKHDPSL--KPLRVCY--EHPISRRII 59
Query: 214 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
GH+F + D + + GP+ T L F FHWGS+D GSEH +N ++ AEL
Sbjct: 60 NNGHSFNVEFDDSHDKTVLKEGPLE--GTYRLIQFHFHWGSSDGQGSEHTVNKKKYAAEL 117
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 564
H+V +N +KY F +A+ PDG GS ++++V L+SI + +
Sbjct: 118 HLVHWN-TKYGDFGKAVKHPDGLAVLGIFLKIGSATPGLQKVVDTLSSI--------KTK 168
Query: 565 HSLLDLTEILPRNM 606
+D T+ PR +
Sbjct: 169 GKSVDFTDFDPRGL 182
Score = 52.4 bits (124), Expect = 1e-06
Identities = 19/40 (47%), Positives = 30/40 (75%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIH 733
Y+TYPGSLTTPP E VTW++ +E + + ++Q+ FR ++
Sbjct: 189 YWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMLKFRNLN 228
>sp|Q9D6N1|CAH13_MOUSE Carbonic anhydrase 13 (Carbonic anhydrase XIII) (Carbonate
dehydratase XIII) (CA-XIII)
Length = 262
Score = 113 bits (282), Expect = 7e-25
Identities = 65/175 (37%), Positives = 98/175 (56%), Gaps = 5/175 (2%)
Frame = +1
Query: 25 MAR--WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQL 198
MAR WGYG +GP W+ FP A G +QSPI I+ ++KYD +L RPL++ ++P
Sbjct: 1 MARLSWGYGEHNGPIHWNELFPIADGDQQSPIEIKTKEVKYDSSL--RPLSIKYDPAS-- 56
Query: 199 SQTLVYTGHNFRID---VAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQ 369
++ + +GH+F +D S + GGP+ L F HWGS D GSEH+++G +
Sbjct: 57 AKIISNSGHSFNVDFDDTEDKSVLRGGPLTGNYR--LRQFHLHWGSADDHGSEHVVDGVR 114
Query: 370 FPAELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQ 534
+ AELH+V +N+ KY F EA + DG G N ++++ L SI+
Sbjct: 115 YAAELHVVHWNSDKYPSFVEAAHESDGLAVLGVFLQIGEHNPQLQKITDILDSIK 169
Score = 52.4 bits (124), Expect = 1e-06
Identities = 20/39 (51%), Positives = 28/39 (71%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y+TYPGSLT PP ESVTW++ ++ + I + QL FR +
Sbjct: 192 YWTYPGSLTVPPLLESVTWIVLKQPISISSQQLARFRSL 230
>sp|P13634|CAH1_MOUSE Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 112 bits (281), Expect = 9e-25
Identities = 64/205 (31%), Positives = 113/205 (55%), Gaps = 3/205 (1%)
Frame = +1
Query: 28 ARWGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQT 207
A WGYG+++GP W +P A G QSPI+I+ + +D +L +PL++++ P ++
Sbjct: 4 ADWGYGSENGPDQWSKLYPIANGNNQSPIDIKTSEANHDSSL--KPLSISYNPAT--AKE 59
Query: 208 LVYTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPA 378
+V GH+F + D + S + GGP+ L+ F FHWG+++ GSEH ++G ++
Sbjct: 60 IVNVGHSFHVIFDDSSNQSVLKGGPLADSYR--LTQFHFHWGNSNDHGSEHTVDGTRYSG 117
Query: 379 ELHMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFR 558
ELH+V +N++KY EA+ + DG G N ++++++ L S+ + R
Sbjct: 118 ELHLVHWNSAKYSSASEAISKADGLAILGVLMKVGPANPSLQKVLDALNSV---KTKGKR 174
Query: 559 QEHSLLDLTEILPRNMCSLLYLSWF 633
+ D + +LP SL Y ++F
Sbjct: 175 APFTNFDPSSLLP---SSLDYWTYF 196
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/37 (48%), Positives = 27/37 (72%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR 724
Y+TY GSLT PP +ESVTW+I ++++ + +QL R
Sbjct: 192 YWTYFGSLTHPPLHESVTWVICKDSISLSPEQLAQLR 228
>sp|Q8HY33|CAH1_MONDO Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 262
Score = 111 bits (278), Expect = 2e-24
Identities = 60/170 (35%), Positives = 98/170 (57%), Gaps = 3/170 (1%)
Frame = +1
Query: 34 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 213
W Y ++GP W +P A G QSPI+I+ ++K+D +L +P++V++ P ++ +V
Sbjct: 6 WSYEGENGPEHWSKLYPIANGDNQSPIDIKTKEVKHDASL--KPISVSYNPAT--AKEIV 61
Query: 214 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 384
HNF++ D S + GGP TG + L F FHWG+ D GSEH ++G ++ +EL
Sbjct: 62 NVSHNFQVNFEDKDNQSVLKGGPF-TG-SFRLRQFHFHWGTADDHGSEHTVDGVKYSSEL 119
Query: 385 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQ 534
H+V +N+ KY F EA +PDG G N +++++ L+SI+
Sbjct: 120 HIVHWNSEKYSSFSEAAEKPDGLAIIAVFIKAGQANPGLQKVIDALSSIK 169
Score = 48.9 bits (115), Expect = 2e-05
Identities = 19/39 (48%), Positives = 28/39 (71%)
Frame = +2
Query: 614 YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 730
Y++Y GSLT PP +ESVTW+I+ E + ++QL FR +
Sbjct: 192 YWSYHGSLTHPPLHESVTWIIYREPISASSEQLAKFRSL 230
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,964,077
Number of Sequences: 369166
Number of extensions: 2010534
Number of successful extensions: 5063
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4731
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4983
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)