Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_002_K06
(884 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 172 1e-42
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 164 4e-40
sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 163 5e-40
sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydra... 162 9e-40
sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 160 4e-39
sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 159 1e-38
sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehyd... 157 3e-38
sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydra... 157 4e-38
sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydr... 156 8e-38
sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate de... 155 1e-37
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 172 bits (436), Expect = 1e-42
Identities = 95/266 (35%), Positives = 151/266 (56%), Gaps = 7/266 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGY +GP W +FP A G RQSPI+I+ YD TL +PL + ++P L ++
Sbjct: 5 WGYADHNGPQKWCENFPIANGPRQSPIDIQTKGASYDDTL--KPLKLKYDPTTSLD--IL 60
Query: 187 YTGHNFRIDVAG---GSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F++ A S ++ GP+ L F FHWG++D GSEH ++G +PAEL
Sbjct: 61 NNGHSFQVTFADDNDSSMLTEGPISGKYR--LKQFHFHWGASDGKGSEHTVDGKCYPAEL 118
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N +KY F EA +PDG G N +++++ + +I + +
Sbjct: 119 HLVHWN-TKYASFGEAANKPDGLAVVGVFLQIGEDNPKLQKILDAMDAI---KSKGKQTS 174
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI----H 705
+ D T +LP+++ Y+TYPGSLTTPP YESVTW++ ++ + + ++Q+ FR +
Sbjct: 175 FTNFDPTCLLPKSL-EYWTYPGSLTTPPLYESVTWIVCKQPISVSSEQMKKFRSLLFTAE 233
Query: 706 MGDSCCGPDNFRPICPIGERIVCKNF 783
+CC +N+RP P+ +R VC +F
Sbjct: 234 EEKACCMVNNYRPPQPLKDRKVCASF 259
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 164 bits (414), Expect = 4e-40
Identities = 101/267 (37%), Positives = 149/267 (55%), Gaps = 8/267 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGYG DGP +W SFP A G RQSPI+I + ++D +L + L + ++P +++++
Sbjct: 5 WGYGPADGPESWAESFPIANGPRQSPIDIVPTQAQHDPSL--KHLKLKYDPAT--TKSIL 60
Query: 187 YTGHNFRIDVA---GGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F++D S ++GGP+ TG L F FHWGS+D GSEH I G +FP EL
Sbjct: 61 NNGHSFQVDFVDDDNSSTLAGGPI-TG-IYRLRQFHFHWGSSDDKGSEHTIAGTKFPCEL 118
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHDFRQ 534
H+V +N +KY F EA +PDG G+ N +++++ L I+ RQ F
Sbjct: 119 HLVHWN-TKYPNFGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGRQTTFAN 177
Query: 535 EHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGD 714
D +LP ++ Y+TY GSLTTPP ESVTW++ +E + + Q+ FR +
Sbjct: 178 ----FDPKTLLPASL-DYWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSS 232
Query: 715 S----CCGPDNFRPICPIGERIVCKNF 783
CC DN+RP P+ R V +F
Sbjct: 233 EGETPCCMVDNYRPPQPLKGRKVRASF 259
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate
dehydratase VII) (CA-VII)
Length = 264
Score = 163 bits (413), Expect = 5e-40
Identities = 104/272 (38%), Positives = 140/272 (51%), Gaps = 13/272 (4%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGYG DDGP WH +P A G RQSPINI + Y +L +PL + +E LS T
Sbjct: 7 WGYGQDDGPSNWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELFYEACMSLSIT-- 62
Query: 187 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+ ++D + VSGGP+ L FHWG GSEH ++G FP+EL
Sbjct: 63 NNGHSVQVDFNDSDDRTVVSGGPLEGPYR--LKQLHFHWGKKRDMGSEHTVDGKSFPSEL 120
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +NA KY F EA PDG G ++ ++ RL L ++F D + +
Sbjct: 121 HLVHWNAKKYSTFGEAAAAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KDTKAQ 177
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR------- 696
S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR
Sbjct: 178 FSCFNPKCLLPTSR-HYWTYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSLLFTSE 236
Query: 697 ---KIHMGDSCCGPDNFRPICPIGERIVCKNF 783
+IHM DNFRP P+ R+V +F
Sbjct: 237 DDERIHM------VDNFRPPQPLKGRVVKASF 262
>sp|P48282|CAH1_SHEEP Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 162 bits (411), Expect = 9e-40
Identities = 96/266 (36%), Positives = 148/266 (55%), Gaps = 7/266 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGY ++GP W P A G QSPI+I+ + K D +L +PL++++ P ++ +V
Sbjct: 6 WGYDGENGPEHWCKLHPIANGNNQSPIDIKTSETKRDPSL--KPLSISYNPAT--AKEIV 61
Query: 187 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F + D S + GGP+P ++ L F FHWGSTD GSEHL++G F AEL
Sbjct: 62 NVGHSFHVNFEDSDNRSVLKGGPLP--ESYRLRQFHFHWGSTDDCGSEHLVDGATFSAEL 119
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N++KY F +A Q DG G N +++++ L ++ + + +
Sbjct: 120 HLVHWNSAKYPSFADAASQADGLVVVGVLMKVGQANPNLQKVLDALKTV---KTKNKKAP 176
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI---HM 708
+ D + +LP + Y+ Y GSLT PP +ESVTW+IF+ET+ + +QL FR +
Sbjct: 177 FTNFDPSVLLP-SCPDYWAYFGSLTHPPLHESVTWIIFKETISVSAEQLAQFRSLLANAE 235
Query: 709 GD-SCCGPDNFRPICPIGERIVCKNF 783
GD C N+RP P+ R V +F
Sbjct: 236 GDKEVCIKQNYRPPQPLKGRTVKASF 261
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII)
Length = 264
Score = 160 bits (405), Expect = 4e-39
Identities = 102/272 (37%), Positives = 141/272 (51%), Gaps = 13/272 (4%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGYG DDGP WH +P A G RQSPINI + Y +L +PL +++E LS T
Sbjct: 7 WGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSL--QPLELSYEACMSLSIT-- 62
Query: 187 YTGHNFRIDVAGG---SCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+ ++D + V+GGP+ L F FHWG GSEH ++G FP+EL
Sbjct: 63 NNGHSVQVDFNDSDDRTVVTGGPLEGPYR--LKQFHFHWGKKHDVGSEHTVDGKSFPSEL 120
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +NA KY F EA PDG G ++ ++ RL L ++F + +
Sbjct: 121 HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRF---KGTKAQ 177
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR------- 696
S + +LP + Y+TYPGSLTTPP ESVTW++ E + I Q+ FR
Sbjct: 178 FSCFNPKCLLPASR-HYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSE 236
Query: 697 ---KIHMGDSCCGPDNFRPICPIGERIVCKNF 783
+IHM +NFRP P+ R+V +F
Sbjct: 237 DDERIHM------VNNFRPPQPLKGRVVKASF 262
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 259
Score = 159 bits (402), Expect = 1e-38
Identities = 96/270 (35%), Positives = 146/270 (54%), Gaps = 11/270 (4%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGYG +GP WH FP A G RQSPI+I+ + K+D +L +PL V +E +S+ ++
Sbjct: 4 WGYGKHNGPEHWHKDFPIANGERQSPIDIDTNAAKHDPSL--KPLRVCYE--HPISRRII 59
Query: 187 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F + D + + GP+ T L F FHWGS+D GSEH +N ++ AEL
Sbjct: 60 NNGHSFNVEFDDSHDKTVLKEGPLEG--TYRLIQFHFHWGSSDGQGSEHTVNKKKYAAEL 117
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N +KY F +A+ PDG GS ++++V L+SI + +
Sbjct: 118 HLVHWN-TKYGDFGKAVKHPDGLAVLGIFLKIGSATPGLQKVVDTLSSI--------KTK 168
Query: 538 HSLLDLTEILPRNMCR----YYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIH 705
+D T+ PR + Y+TYPGSLTTPP E VTW++ +E + + ++Q+ FR ++
Sbjct: 169 GKSVDFTDFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMLKFRNLN 228
Query: 706 MGDSCCGP----DNFRPICPIGERIVCKNF 783
DN+RP P+ R V +F
Sbjct: 229 FNKEAEPEEPMVDNWRPTQPLKGRQVKASF 258
>sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehydratase II) (CA-II) (Carbonic
anhydrase C)
Length = 260
Score = 157 bits (398), Expect = 3e-38
Identities = 97/267 (36%), Positives = 146/267 (54%), Gaps = 8/267 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGYG +GP WH FP A G RQSP++I+ KYD +L +PL+V+++ L ++
Sbjct: 5 WGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSL--KPLSVSYDQATSLR--IL 60
Query: 187 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH F + D + + GGP+ T L F FHWGS D GSEH ++ ++ AEL
Sbjct: 61 NNGHAFNVEFDDSQDKAVLKGGPLDG--TYRLIQFHFHWGSLDGQGSEHTVDKKKYAAEL 118
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFF-RQHDFRQ 534
H+V +N +KY F +A+ QPDG GS ++++V L SI+ + DF
Sbjct: 119 HLVHWN-TKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTN 177
Query: 535 EHSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGD 714
D +LP ++ Y+TYPGSLTTPP E VTW++ +E + + ++Q+ FRK++
Sbjct: 178 ----FDPRGLLPESL-DYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNG 232
Query: 715 SC----CGPDNFRPICPIGERIVCKNF 783
DN+RP P+ R + +F
Sbjct: 233 EGEPEELMVDNWRPAQPLKNRQIKASF 259
>sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 157 bits (397), Expect = 4e-38
Identities = 91/266 (34%), Positives = 144/266 (54%), Gaps = 7/266 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGY +GP WH FP A G RQSP++I+ +D L +PL ++++ + S+++V
Sbjct: 5 WGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAHHDPAL--QPLLISYD--KAASKSIV 60
Query: 187 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F + D + + GGP+ I F FHWGS+D GSEH +N ++ AEL
Sbjct: 61 NNGHSFNVEFDDSQDNAVLKGGPLSDSYRLI--QFHFHWGSSDGQGSEHTVNKKKYAAEL 118
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N +KY F +A+ QPDG G + +++++ L SI + R
Sbjct: 119 HLVHWN-TKYGDFGKAVQQPDGLAVLGYFLKIGPASQGLQKVLEALHSI---KTKGKRAA 174
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKIHMGDS 717
+ D +LP N+ Y+TYPGSLTTPP E VTW++ E + + ++Q+ FR ++ +
Sbjct: 175 FANFDPCSLLPGNL-DYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEE 233
Query: 718 CCGP----DNFRPICPIGERIVCKNF 783
DN+RP P+ R + +F
Sbjct: 234 GDAEEAMVDNWRPAQPLKNRKIKASF 259
>sp|P00917|CAH1_HORSE Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 260
Score = 156 bits (394), Expect = 8e-38
Identities = 91/262 (34%), Positives = 141/262 (53%), Gaps = 7/262 (2%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGY + +GP W +P A G QSPI+I+ + K+D +L +P +V+++P ++ +V
Sbjct: 5 WGYDSPNGPZEWVKLYPIANGNNQSPIDIKTSETKHDTSL--KPFSVSYDPAT--AKEIV 60
Query: 187 YTGHNFRI---DVAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
GH+F++ D S + GP+P + F FHWGSTD GSEH ++G ++ AEL
Sbjct: 61 NVGHSFQVKFEDSDNRSVLKDGPLPGSYRLV--QFHFHWGSTDDYGSEHTVDGVKYSAEL 118
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N+SKY F+EA Q DG G N +++++ L + + +
Sbjct: 119 HLVHWNSSKYSSFDEASSQADGLAILGVLMKVGEANPKLQKVLDALNEV---KTKGKKAP 175
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFR----KIH 705
D + +LP + Y+TY GSLT PP YESVTW++ +E + I + QL FR +
Sbjct: 176 FKNFDPSSLLPSSP-DYWTYSGSLTHPPLYESVTWIVCKENISISSQQLSQFRSLLSNVE 234
Query: 706 MGDSCCGPDNFRPICPIGERIV 771
G + N RP P+ R V
Sbjct: 235 GGKAVPIQHNNRPPQPLKGRTV 256
>sp|Q8N1Q1|CAH13_HUMAN Carbonic anhydrase XIII (Carbonate dehydratase XIII) (CA-XIII)
Length = 262
Score = 155 bits (393), Expect = 1e-37
Identities = 88/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)
Frame = +1
Query: 7 WGYGADDGPHTWHASFPSAGGCRQSPINIELDKLKYDITLNIRPLTVAFEPERQLSQTLV 186
WGY +GP W FP A G +QSPI I+ ++KYD +L RPL++ ++P ++ +
Sbjct: 6 WGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSL--RPLSIKYDPSS--AKIIS 61
Query: 187 YTGHNFRID---VAGGSCVSGGPVPTGQTCILSHFSFHWGSTDYSGSEHLINGHQFPAEL 357
+GH+F +D S + GGP+ TG + L HWGS D GSEH+++G + AEL
Sbjct: 62 NSGHSFNVDFDDTENKSVLRGGPL-TG-SYRLRQVHLHWGSADDHGSEHIVDGVSYAAEL 119
Query: 358 HMVCFNASKYRCFEEAMGQPDGXXXXXXXXXXGSKNSTIERLVGPLTSIQFFRQHDFRQE 537
H+V +N+ KY F EA +PDG G NS ++++ L SI ++ +
Sbjct: 120 HVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSI---KEKGKQTR 176
Query: 538 HSLLDLTEILPRNMCRYYTYPGSLTTPPCYESVTWLIFEETVGIDTDQLCMFRKI 702
+ DL +LP + Y+TYPGSLT PP ESVTW++ ++ + I + QL FR +
Sbjct: 177 FTNFDLLSLLPPSW-DYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSL 230
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,192,422
Number of Sequences: 369166
Number of extensions: 2140045
Number of successful extensions: 5704
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5302
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5537
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)