Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00976 (1440 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P26686|SRR55_DROME Serine-arginine protein 55 (SRP55) (E... 105 3e-22 sp|Q13247|SFRS6_HUMAN Splicing factor, arginine/serine-rich... 104 7e-22 sp|Q08170|SFRS4_HUMAN Splicing factor, arginine/serine-rich... 103 1e-21 sp|Q8VE97|SFRS4_MOUSE Splicing factor, arginine/serine-rich 4 103 1e-21 sp|Q09167|SFRS5_RAT Splicing factor, arginine/serine-rich 5... 100 1e-20 sp|Q13243|SFRS5_HUMAN Splicing factor, arginine/serine-rich... 100 1e-20 sp|Q23121|RSP1_CAEEL Probable splicing factor, arginine/ser... 99 3e-20 sp|Q23120|RSP2_CAEEL Probable splicing factor, arginine/ser... 94 1e-18 sp|O35326|SFRS5_MOUSE Splicing factor, arginine/serine-rich... 93 2e-18 sp|Q10021|RSP5_CAEEL Probable splicing factor, arginine/ser... 83 2e-15
>sp|P26686|SRR55_DROME Serine-arginine protein 55 (SRP55) (Enhancer of deformed) (52-kDa bracketing protein) (B52 protein) Length = 376 Score = 105 bits (262), Expect = 3e-22 Identities = 55/131 (41%), Positives = 76/131 (58%) Frame = +3 Query: 24 RLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKLLG 203 R+Y+G LP + ERD+++FF+ YGR R + +KNGYGFVE +D RDA+DA+++L+G +LLG Sbjct: 5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLG 64 Query: 204 ERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHRII 383 ERV VE AR A P+R+E+R+I Sbjct: 65 ERVVVEPARGTA-RGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLI 123 Query: 384 VDGLSSRVSWQ 416 V+ LSSRVSWQ Sbjct: 124 VENLSSRVSWQ 134
Score = 72.4 bits (176), Expect = 3e-12 Identities = 35/57 (61%), Positives = 44/57 (77%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHED 833 DLKD MR+ GEVT+ADAHK R+N+GVVEF++ SDMK AI+K D EL G + + ED Sbjct: 135 DLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVED 191
>sp|Q13247|SFRS6_HUMAN Splicing factor, arginine/serine-rich 6 (Pre-mRNA splicing factor SRP55) Length = 344 Score = 104 bits (259), Expect = 7e-22 Identities = 56/133 (42%), Positives = 74/133 (55%) Frame = +3 Query: 18 MPRLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKL 197 MPR+YIG L + E+DI++FF YGR+ VDLKNGYGFVE +D RDA+DA+++L+G +L Sbjct: 1 MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKEL 60 Query: 198 LGERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHR 377 GERV VE AR P+R+E+R Sbjct: 61 CGERVIVEHARG---------PRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYR 111 Query: 378 IIVDGLSSRVSWQ 416 +IV+ LSSR SWQ Sbjct: 112 LIVENLSSRCSWQ 124
Score = 76.3 bits (186), Expect = 2e-13 Identities = 35/57 (61%), Positives = 45/57 (78%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHED 833 DLKD MR+ GEVT+ADAHK R N+GV+EF + SDMK A+DK DG E+ G N+++ ED Sbjct: 125 DLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIED 181
>sp|Q08170|SFRS4_HUMAN Splicing factor, arginine/serine-rich 4 (Pre-mRNA splicing factor SRP75) (SRP001LB) Length = 494 Score = 103 bits (257), Expect = 1e-21 Identities = 57/133 (42%), Positives = 73/133 (54%) Frame = +3 Query: 18 MPRLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKL 197 MPR+YIG L + ERD+++FF+ YG+I VDLKNGYGFVE DD RDA+DA+++L+G L Sbjct: 1 MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDL 60 Query: 198 LGERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHR 377 GERV VE AR P R+E+R Sbjct: 61 CGERVIVEHARG---------------PRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYR 105 Query: 378 IIVDGLSSRVSWQ 416 +IV+ LSSR SWQ Sbjct: 106 LIVENLSSRCSWQ 118
Score = 71.6 bits (174), Expect = 5e-12 Identities = 33/57 (57%), Positives = 45/57 (78%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHED 833 DLKD MR+ GEVT+ADAHK R+N+GV+EF + SDMK A++K DG E+ G +++ ED Sbjct: 119 DLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVED 175
>sp|Q8VE97|SFRS4_MOUSE Splicing factor, arginine/serine-rich 4 Length = 489 Score = 103 bits (257), Expect = 1e-21 Identities = 57/133 (42%), Positives = 73/133 (54%) Frame = +3 Query: 18 MPRLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKL 197 MPR+YIG L + ERD+++FF+ YG+I VDLKNGYGFVE DD RDA+DA+++L+G L Sbjct: 1 MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDL 60 Query: 198 LGERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHR 377 GERV VE AR P R+E+R Sbjct: 61 CGERVIVEHARG---------------PRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYR 105 Query: 378 IIVDGLSSRVSWQ 416 +IV+ LSSR SWQ Sbjct: 106 LIVENLSSRCSWQ 118
Score = 71.6 bits (174), Expect = 5e-12 Identities = 33/57 (57%), Positives = 45/57 (78%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHED 833 DLKD MR+ GEVT+ADAHK R+N+GV+EF + SDMK A++K DG E+ G +++ ED Sbjct: 119 DLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVED 175
>sp|Q09167|SFRS5_RAT Splicing factor, arginine/serine-rich 5 (Pre-mRNA splicing factor SRP40) (Insulin-induced growth response protein CL-4) (Delayed-early protein HRS) Length = 269 Score = 100 bits (248), Expect = 1e-20 Identities = 52/131 (39%), Positives = 75/131 (57%) Frame = +3 Query: 24 RLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKLLG 203 R++IG L E+D+++FF+ YGRIR +DLK G+GFVE +D RDA+DA+++LDG +L Sbjct: 5 RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCS 64 Query: 204 ERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHRII 383 ERVT+E AR+ + P+R+E+R+I Sbjct: 65 ERVTIEHARARS-------------RGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLI 111 Query: 384 VDGLSSRVSWQ 416 V+ LSSRVSWQ Sbjct: 112 VENLSSRVSWQ 122
Score = 66.2 bits (160), Expect = 2e-10 Identities = 31/56 (55%), Positives = 42/56 (75%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHE 830 DLKD MR+ GEVTFADAH+ + N+GVVEF++ D+K AI+K G E+ G +K+ E Sbjct: 123 DLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIE 178
>sp|Q13243|SFRS5_HUMAN Splicing factor, arginine/serine-rich 5 (Pre-mRNA splicing factor SRP40) (Delayed-early protein HRS) Length = 272 Score = 100 bits (248), Expect = 1e-20 Identities = 52/131 (39%), Positives = 75/131 (57%) Frame = +3 Query: 24 RLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKLLG 203 R++IG L E+D+++FF+ YGRIR +DLK G+GFVE +D RDA+DA+++LDG +L Sbjct: 5 RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCS 64 Query: 204 ERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHRII 383 ERVT+E AR+ + P+R+E+R+I Sbjct: 65 ERVTIEHARARS-------------RGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLI 111 Query: 384 VDGLSSRVSWQ 416 V+ LSSRVSWQ Sbjct: 112 VENLSSRVSWQ 122
Score = 66.2 bits (160), Expect = 2e-10 Identities = 31/56 (55%), Positives = 42/56 (75%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDKYDGYELYGYNLKVHE 830 DLKD MR+ GEVTFADAH+ + N+GVVEF++ D+K AI+K G E+ G +K+ E Sbjct: 123 DLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIE 178
>sp|Q23121|RSP1_CAEEL Probable splicing factor, arginine/serine-rich 1 (RNA-binding protein srp-5) (CeSRp75) Length = 312 Score = 99.0 bits (245), Expect = 3e-20 Identities = 54/140 (38%), Positives = 73/140 (52%), Gaps = 9/140 (6%) Frame = +3 Query: 24 RLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKLLG 203 R+YIG L R+ E+DI+ FFR YG+IR V LKNG+GFVE DD+RDAEDA+HDL+G +L G Sbjct: 4 RIYIGRLTSRVSEKDIEHFFRGYGQIRDVLLKNGFGFVEFDDKRDAEDAVHDLNGKELGG 63 Query: 204 ERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIR------ 365 ERV ++ ++ P R Sbjct: 64 ERVILDYSKPRGGGGDRGGFGGGGRGGARVSSYSGGGGGGRDRFDRYDRGPPRRESRYGR 123 Query: 366 ---SEHRIIVDGLSSRVSWQ 416 + HR++V+ LSSR+SWQ Sbjct: 124 PYSTRHRVVVENLSSRISWQ 143
>sp|Q23120|RSP2_CAEEL Probable splicing factor, arginine/serine-rich 2 (RNA-binding protein srp-4) (CeSRp40) Length = 281 Score = 94.0 bits (232), Expect = 1e-18 Identities = 48/133 (36%), Positives = 69/133 (51%) Frame = +3 Query: 18 MPRLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKL 197 M R+YIG LP R +RD++ FFR YG++ V +KNG+GFV+ D+RDA+DA+HDL+G +L Sbjct: 1 MVRVYIGRLPNRASDRDVEHFFRGYGKLSDVIMKNGFGFVDFQDQRDADDAVHDLNGKEL 60 Query: 198 LGERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHR 377 GERV +E R +P + R Sbjct: 61 CGERVILEFPRRKV-------GYNEERSGSGFRGREPTFRKGGERQFSNRYSRPCSTRFR 113 Query: 378 IIVDGLSSRVSWQ 416 +++D LS+R SWQ Sbjct: 114 LVIDNLSTRYSWQ 126
>sp|O35326|SFRS5_MOUSE Splicing factor, arginine/serine-rich 5 (Pre-mRNA splicing factor SRP40) (Delayed-early protein HRS) Length = 270 Score = 92.8 bits (229), Expect = 2e-18 Identities = 49/131 (37%), Positives = 72/131 (54%) Frame = +3 Query: 24 RLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKLLG 203 R++IG L E+D+++FF+ YGRIR +DLK G+GFVE +D RDA+DA+++LDG +L Sbjct: 5 RVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCS 64 Query: 204 ERVTVEMARSNAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPIRSEHRII 383 ERVT+E AR+ + ++ +R+I Sbjct: 65 ERVTIEHARARS-------------RGGRGRGRYSDRLAVADLGNDRRKCSTCKNRNRLI 111 Query: 384 VDGLSSRVSWQ 416 V+ LSSRVSWQ Sbjct: 112 VENLSSRVSWQ 122
Score = 57.8 bits (138), Expect = 8e-08 Identities = 26/41 (63%), Positives = 34/41 (82%) Frame = +3 Query: 663 DLKDLMRKVGEVTFADAHKLRQNQGVVEFSNSSDMKAAIDK 785 DLKD MR+ GEVTFADAH+ + N+GVVEF++ D+K AI+K Sbjct: 123 DLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEK 163
>sp|Q10021|RSP5_CAEEL Probable splicing factor, arginine/serine-rich 5 (RNA-binding protein srp-3) (CeSC35-2) Length = 208 Score = 83.2 bits (204), Expect = 2e-15 Identities = 37/73 (50%), Positives = 52/73 (71%), Gaps = 2/73 (2%) Frame = +3 Query: 18 MPRLYIGNLPRRIEERDIKKFFREYGRIRSVDLKNGYGFVEIDDRRDAEDAIHDLDGTKL 197 MPRLY+G +P ERD+++F + YG+I ++ +K G+ FV+ +D RDAEDA HDLDG + Sbjct: 1 MPRLYLGKIPYNARERDVERFLKGYGKINNISMKYGFAFVDFEDSRDAEDACHDLDGKTM 60 Query: 198 LGE--RVTVEMAR 230 G R+ VEMAR Sbjct: 61 EGSSMRLVVEMAR 73
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 127,994,618 Number of Sequences: 369166 Number of extensions: 2299847 Number of successful extensions: 5793 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 5286 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5710 length of database: 68,354,980 effective HSP length: 114 effective length of database: 47,295,190 effective search space used: 17262744350 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)