DrC_00703
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00703 (1202 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O95197|RTN3_HUMAN Reticulon-3 (Neuroendocrine-specific p... 80 2e-14 sp|Q9ES97|RTN3_MOUSE Reticulon-3 80 2e-14 sp|Q16799|RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific p... 77 1e-13 sp|Q5IS59|RTN1_PANTR Reticulon-1 77 1e-13 sp|Q64548|RTN1_RAT Reticulon-1 (Neuroendocrine-specific pro... 75 3e-13 sp|Q8K0T0|RTN1_MOUSE Reticulon-1 (Neuroendocrine-specific p... 75 3e-13 sp|Q9NQC3|RTN4_HUMAN Reticulon-4 (Neurite outgrowth inhibit... 74 8e-13 sp|Q9JK11|RTN4_RAT Reticulon-4 (Neurite outgrowth inhibitor... 74 8e-13 sp|Q99P72|RTN4_MOUSE Reticulon-4 (Neurite outgrowth inhibit... 73 1e-12 sp|O75298|RTN2_HUMAN Reticulon-2 (Neuroendocrine-specific p... 65 3e-10
>sp|O95197|RTN3_HUMAN Reticulon-3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII) Length = 236 Score = 79.7 bits (195), Expect = 2e-14 Identities = 57/185 (30%), Positives = 90/185 (48%), Gaps = 4/185 (2%) Frame = +2 Query: 167 SIKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN- 343 ++ +I W+ TG + T +I + + S ISV++Y+ L L+ ++ FR Y + I Sbjct: 47 AVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQA 106 Query: 344 ---NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVG 514 +E +PF+ LD D+ L ++++ + K II+ +FL+E D Sbjct: 107 VQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIR----LFLVEDLVDSL 162 Query: 515 KFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAI 694 K V M YVG FN I L+ LA L + + P VY Y+ QID V AR+ V Sbjct: 163 KLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEK 222 Query: 695 AKEKL 709 + KL Sbjct: 223 IQAKL 227
>sp|Q9ES97|RTN3_MOUSE Reticulon-3 Length = 237 Score = 79.7 bits (195), Expect = 2e-14 Identities = 57/185 (30%), Positives = 90/185 (48%), Gaps = 4/185 (2%) Frame = +2 Query: 167 SIKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN- 343 ++ +I W+ TG + T +I + + S ISV++Y+ L L+ ++ FR Y + I Sbjct: 48 AVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQA 107 Query: 344 ---NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVG 514 +E +PF+ LD D+ L ++++ + K II+ +FL+E D Sbjct: 108 VQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHVNKALKLIIR----LFLVEDLVDSL 163 Query: 515 KFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAI 694 K V M YVG FN I L+ LA L + + P VY Y+ QID V AR+ V Sbjct: 164 KLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEK 223 Query: 695 AKEKL 709 + KL Sbjct: 224 IQAKL 228
>sp|Q16799|RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific protein) Length = 776 Score = 77.0 bits (188), Expect = 1e-13 Identities = 49/184 (26%), Positives = 93/184 (50%), Gaps = 7/184 (3%) Frame = +2 Query: 179 VISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN----N 346 ++ W+ TG + ++++ + S +SV+AY+ L + +++ FR Y + + Sbjct: 592 LLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKT 651 Query: 347 EASNPFQECLDKDVNL---YLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGK 517 + +PF+ L+ ++ L + K +D + F + S +K L +FL++ D K Sbjct: 652 DEGHPFKAYLELEITLSQEQIQKYTDCLQFYVN-------STLKELRRLFLVQDLVDSLK 704 Query: 518 FLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAIA 697 F V + YVG FN + L+ +AV+S+ T P VY ++ QID + R H+ VA Sbjct: 705 FAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKI 764 Query: 698 KEKL 709 + K+ Sbjct: 765 QAKI 768
>sp|Q5IS59|RTN1_PANTR Reticulon-1 Length = 776 Score = 77.0 bits (188), Expect = 1e-13 Identities = 49/184 (26%), Positives = 93/184 (50%), Gaps = 7/184 (3%) Frame = +2 Query: 179 VISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN----N 346 ++ W+ TG + ++++ + S +SV+AY+ L + +++ FR Y + + Sbjct: 592 LLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKT 651 Query: 347 EASNPFQECLDKDVNL---YLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGK 517 + +PF+ L+ ++ L + K +D + F + S +K L +FL++ D K Sbjct: 652 DEGHPFKAYLELEITLSQEQIQKYTDCLQFYVN-------STLKELRRLFLVQDLVDSLK 704 Query: 518 FLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAIA 697 F V + YVG FN + L+ +AV+S+ T P VY ++ QID + R H+ VA Sbjct: 705 FAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKI 764 Query: 698 KEKL 709 + K+ Sbjct: 765 QAKI 768
>sp|Q64548|RTN1_RAT Reticulon-1 (Neuroendocrine-specific protein) (S-rex) Length = 777 Score = 75.5 bits (184), Expect = 3e-13 Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 4/181 (2%) Frame = +2 Query: 179 VISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN----N 346 ++ W+ TG + ++++ + S +SV+AY+ L + +++ FR Y + + Sbjct: 593 LLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKT 652 Query: 347 EASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGKFLV 526 + +PF+ L+ ++ L +I + T S +K L +FL++ D KF V Sbjct: 653 DEGHPFKAYLELEITLSQEQIQKY----TDCLQLYVNSTLKELRRLFLVQDLVDSLKFAV 708 Query: 527 GNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAIAKEK 706 + YVG FN + L+ +AV+S+ T P VY ++ Q+D + R H+ VA + K Sbjct: 709 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAK 768 Query: 707 L 709 + Sbjct: 769 I 769
>sp|Q8K0T0|RTN1_MOUSE Reticulon-1 (Neuroendocrine-specific protein) Length = 780 Score = 75.5 bits (184), Expect = 3e-13 Identities = 47/181 (25%), Positives = 90/181 (49%), Gaps = 4/181 (2%) Frame = +2 Query: 179 VISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN----N 346 ++ W+ TG + ++++ + S +SV+AY+ L + +++ FR Y + + Sbjct: 596 LLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKT 655 Query: 347 EASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGKFLV 526 + +PF+ L+ ++ L +I + T S +K L +FL++ D KF V Sbjct: 656 DEGHPFKAYLELEITLSQEQIQKY----TDCLQLYVNSTLKELRRLFLVQDLVDSLKFAV 711 Query: 527 GNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAIAKEK 706 + YVG FN + L+ +AV+S+ T P VY ++ Q+D + R H+ VA + K Sbjct: 712 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLVRTHINTVVAKIQAK 771 Query: 707 L 709 + Sbjct: 772 I 772
>sp|Q9NQC3|RTN4_HUMAN Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) Length = 1192 Score = 73.9 bits (180), Expect = 8e-13 Identities = 51/188 (27%), Positives = 90/188 (47%), Gaps = 4/188 (2%) Frame = +2 Query: 167 SIKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN- 343 S+ ++ W+ TG + + + + S +SV AYI L L+ ++ FR Y I Sbjct: 1004 SVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQA 1063 Query: 344 ---NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVG 514 ++ +PF+ L+ +V + + V ++ IK L +FL++ D Sbjct: 1064 IQKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 1119 Query: 515 KFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAI 694 KF V YVG FN + L+ LA++SL + P +Y ++ QID + A ++V A+A Sbjct: 1120 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAK 1179 Query: 695 AKEKLATL 718 + K+ L Sbjct: 1180 IQAKIPGL 1187
>sp|Q9JK11|RTN4_RAT Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Glut4 vesicle 20 kDa protein) Length = 1163 Score = 73.9 bits (180), Expect = 8e-13 Identities = 52/188 (27%), Positives = 90/188 (47%), Gaps = 4/188 (2%) Frame = +2 Query: 167 SIKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN- 343 S+ ++ W+ TG + + + + S +SV AYI L L+ ++ FR Y I Sbjct: 975 SVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQA 1034 Query: 344 ---NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVG 514 ++ +PF+ L+ +V + + V ++ S IK L +FL++ D Sbjct: 1035 IQKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSL 1090 Query: 515 KFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAI 694 KF V YVG FN + L+ LA++SL + P +Y ++ QID + A + V A+A Sbjct: 1091 KFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQVQIDHYLGLANKSVKDAMAK 1150 Query: 695 AKEKLATL 718 + K+ L Sbjct: 1151 IQAKIPGL 1158
>sp|Q99P72|RTN4_MOUSE Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) Length = 199 Score = 73.2 bits (178), Expect = 1e-12 Identities = 51/187 (27%), Positives = 89/187 (47%), Gaps = 4/187 (2%) Frame = +2 Query: 170 IKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN-- 343 + ++ W+ TG + + + + S +SV AYI L L+ ++ FR Y I Sbjct: 12 VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAI 71 Query: 344 --NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGK 517 ++ +PF+ L+ +V + + V ++ S IK L +FL++ D K Sbjct: 72 QKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLK 127 Query: 518 FLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKAREHVGKAVAIA 697 F V YVG FN + L+ LA++SL + P +Y ++ QID + A + V A+A Sbjct: 128 FAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLANKSVKDAMAKI 187 Query: 698 KEKLATL 718 + K+ L Sbjct: 188 QAKIPGL 194
>sp|O75298|RTN2_HUMAN Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI) Length = 545 Score = 65.5 bits (158), Expect = 3e-10 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 4/166 (2%) Frame = +2 Query: 170 IKSVISWKCPVVTGSILVTWVIFAVMVKTMSFISVIAYIGLILIMSSMLFRFYSNFIN-- 343 + ++ WK +G + ++ + + S +SV A++ L+L+ ++ R Y + Sbjct: 345 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 404 Query: 344 --NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGK 517 + +NPFQ LD D+ L + H + +S+ S L FL+E D K Sbjct: 405 HRGDGANPFQAYLDVDLTLTREQTERLSH----QITSRVVSAATQLRHFFLVEDLVDSLK 460 Query: 518 FLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAV 655 + + +VG FN + L+ L V+ L T P +Y ++ QID V Sbjct: 461 LALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYV 506
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,313,648
Number of Sequences: 369166
Number of extensions: 2273891
Number of successful extensions: 6322
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6035
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6310
length of database: 68,354,980
effective HSP length: 113
effective length of database: 47,479,925
effective search space used: 13626738475
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
