Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_C17
(396 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q16799|RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific p... 57 1e-08
sp|Q5IS59|RTN1_PANTR Reticulon-1 57 1e-08
sp|O95197|RTN3_HUMAN Reticulon-3 (Neuroendocrine-specific p... 57 2e-08
sp|Q9ES97|RTN3_MOUSE Reticulon-3 57 2e-08
sp|Q64548|RTN1_RAT Reticulon-1 (Neuroendocrine-specific pro... 56 3e-08
sp|Q8K0T0|RTN1_MOUSE Reticulon-1 (Neuroendocrine-specific p... 56 3e-08
sp|Q99P72|RTN4_MOUSE Reticulon-4 (Neurite outgrowth inhibit... 54 1e-07
sp|Q9NQC3|RTN4_HUMAN Reticulon-4 (Neurite outgrowth inhibit... 53 2e-07
sp|Q9JK11|RTN4_RAT Reticulon-4 (Neurite outgrowth inhibitor... 53 2e-07
sp|O75298|RTN2_HUMAN Reticulon-2 (Neuroendocrine-specific p... 49 4e-06
>sp|Q16799|RTN1_HUMAN Reticulon-1 (Neuroendocrine-specific protein)
Length = 776
Score = 57.4 bits (137), Expect = 1e-08
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 7/132 (5%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNL---YLSKISDFVHFQTSEESSQFKSIIKYL 169
FR Y + + + +PF+ L+ ++ L + K +D + F + S +K L
Sbjct: 638 FRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVN-------STLKEL 690
Query: 170 NSIFLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAV 349
+FL++ D KF V + YVG FN + L+ +AV+S+ T P VY ++ QID +
Sbjct: 691 RRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYL 750
Query: 350 MKAREHVGKAVA 385
R H+ VA
Sbjct: 751 GLVRTHINAVVA 762
>sp|Q5IS59|RTN1_PANTR Reticulon-1
Length = 776
Score = 57.4 bits (137), Expect = 1e-08
Identities = 39/132 (29%), Positives = 65/132 (49%), Gaps = 7/132 (5%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNL---YLSKISDFVHFQTSEESSQFKSIIKYL 169
FR Y + + + +PF+ L+ ++ L + K +D + F + S +K L
Sbjct: 638 FRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVN-------STLKEL 690
Query: 170 NSIFLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAV 349
+FL++ D KF V + YVG FN + L+ +AV+S+ T P VY ++ QID +
Sbjct: 691 RRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYL 750
Query: 350 MKAREHVGKAVA 385
R H+ VA
Sbjct: 751 GLVRTHINAVVA 762
>sp|O95197|RTN3_HUMAN Reticulon-3 (Neuroendocrine-specific protein-like 2) (NSP-like
protein II) (NSPLII)
Length = 236
Score = 56.6 bits (135), Expect = 2e-08
Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 4/128 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y + I +E +PF+ LD D+ L ++++ + K II+ +
Sbjct: 97 FRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIR----L 152
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL+E D K V M YVG FN I L+ LA L + + P VY Y+ QID V A
Sbjct: 153 FLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIA 212
Query: 359 REHVGKAV 382
R+ V
Sbjct: 213 RDQTKSIV 220
>sp|Q9ES97|RTN3_MOUSE Reticulon-3
Length = 237
Score = 56.6 bits (135), Expect = 2e-08
Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 4/128 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y + I +E +PF+ LD D+ L ++++ + K II+ +
Sbjct: 98 FRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHVNKALKLIIR----L 153
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL+E D K V M YVG FN I L+ LA L + + P VY Y+ QID V A
Sbjct: 154 FLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIA 213
Query: 359 REHVGKAV 382
R+ V
Sbjct: 214 RDQTKSIV 221
>sp|Q64548|RTN1_RAT Reticulon-1 (Neuroendocrine-specific protein) (S-rex)
Length = 777
Score = 55.8 bits (133), Expect = 3e-08
Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 4/129 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y + + + +PF+ L+ ++ L +I + T S +K L +
Sbjct: 639 FRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKY----TDCLQLYVNSTLKELRRL 694
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL++ D KF V + YVG FN + L+ +AV+S+ T P VY ++ Q+D +
Sbjct: 695 FLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLV 754
Query: 359 REHVGKAVA 385
R H+ VA
Sbjct: 755 RTHINTVVA 763
>sp|Q8K0T0|RTN1_MOUSE Reticulon-1 (Neuroendocrine-specific protein)
Length = 780
Score = 55.8 bits (133), Expect = 3e-08
Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 4/129 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y + + + +PF+ L+ ++ L +I + T S +K L +
Sbjct: 642 FRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKY----TDCLQLYVNSTLKELRRL 697
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL++ D KF V + YVG FN + L+ +AV+S+ T P VY ++ Q+D +
Sbjct: 698 FLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQVDQYLGLV 757
Query: 359 REHVGKAVA 385
R H+ VA
Sbjct: 758 RTHINTVVA 766
>sp|Q99P72|RTN4_MOUSE Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)
Length = 199
Score = 53.9 bits (128), Expect = 1e-07
Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 4/129 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y I ++ +PF+ L+ +V + + V ++ S IK L +
Sbjct: 61 FRIYKGVIQAIQKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNSTIKELRRL 116
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL++ D KF V YVG FN + L+ LA++SL + P +Y ++ QID + A
Sbjct: 117 FLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLA 176
Query: 359 REHVGKAVA 385
+ V A+A
Sbjct: 177 NKSVKDAMA 185
>sp|Q9NQC3|RTN4_HUMAN Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen)
(Neuroendocrine-specific protein) (NSP)
(Neuroendocrine-specific protein C homolog) (RTN-x)
(Reticulon-5)
Length = 1192
Score = 53.1 bits (126), Expect = 2e-07
Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 4/129 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y I ++ +PF+ L+ +V + + V ++ IK L +
Sbjct: 1054 FRIYKGVIQAIQKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNCTIKELRRL 1109
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL++ D KF V YVG FN + L+ LA++SL + P +Y ++ QID + A
Sbjct: 1110 FLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLA 1169
Query: 359 REHVGKAVA 385
++V A+A
Sbjct: 1170 NKNVKDAMA 1178
>sp|Q9JK11|RTN4_RAT Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen)
(Glut4 vesicle 20 kDa protein)
Length = 1163
Score = 53.1 bits (126), Expect = 2e-07
Identities = 38/129 (29%), Positives = 62/129 (48%), Gaps = 4/129 (3%)
Frame = +2
Query: 11 FRFYSNFIN----NEASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSI 178
FR Y I ++ +PF+ L+ +V + + V ++ S IK L +
Sbjct: 1025 FRIYKGVIQAIQKSDEGHPFRAYLESEVAIS----EELVQKYSNSALGHVNSTIKELRRL 1080
Query: 179 FLLESYADVGKFLVGNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAVMKA 358
FL++ D KF V YVG FN + L+ LA++SL + P +Y ++ QID + A
Sbjct: 1081 FLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQVQIDHYLGLA 1140
Query: 359 REHVGKAVA 385
+ V A+A
Sbjct: 1141 NKSVKDAMA 1149
>sp|O75298|RTN2_HUMAN Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like
protein 1) (NSPLI)
Length = 545
Score = 48.9 bits (115), Expect = 4e-06
Identities = 32/103 (31%), Positives = 49/103 (47%)
Frame = +2
Query: 41 EASNPFQECLDKDVNLYLSKISDFVHFQTSEESSQFKSIIKYLNSIFLLESYADVGKFLV 220
+ +NPFQ LD D+ L + H + +S+ S L FL+E D K +
Sbjct: 408 DGANPFQAYLDVDLTLTREQTERLSH----QITSRVVSAATQLRHFFLVEDLVDSLKLAL 463
Query: 221 GNVAMVYVGMYFNLIDLVTLAVLSLLTGPKVYNLYRRQIDDAV 349
+ +VG FN + L+ L V+ L T P +Y ++ QID V
Sbjct: 464 LFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYV 506
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,909,443
Number of Sequences: 369166
Number of extensions: 881167
Number of successful extensions: 2858
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2793
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2857
length of database: 68,354,980
effective HSP length: 97
effective length of database: 50,435,685
effective search space used: 1714813290
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)