DrC_00619
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00619 (831 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 127 3e-29 sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 127 4e-29 sp|P47796|CTRA_GADMO Chymotrypsin A precursor 126 6e-29 sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 123 7e-28 sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 123 7e-28 sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 121 2e-27 sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 119 8e-27 sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 119 8e-27 sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 118 2e-26 sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 117 3e-26
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2) Length = 799 Score = 127 bits (320), Expect = 3e-29 Identities = 87/249 (34%), Positives = 128/249 (51%), Gaps = 6/249 (2%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246 +I+ GT + E+P SL+I G HICGG L+ V+TAAHC E KL Sbjct: 564 RIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLW----- 618 Query: 247 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 426 V LG+ + + E F+V+ + +H Y+ E+++ DVAL++ D + V Y Sbjct: 619 TVFLGKMRQNSRWPGEVSFKVSRLFLH-PYHEEDSH--DYDVALLQLD-----HPVVYSA 670 Query: 427 YNTLDTVAIS------KPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 588 T+ V + +PG C + GWG+ G + LQK V ++ + CS+ +R Sbjct: 671 --TVRPVCLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAYRY 727 Query: 589 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 768 R +CAG +C+GDSGGPL CR+ R G+VS+G+ CGRPN VYT Sbjct: 728 QVSPRM-LCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGL-GCGRPNFFGVYT 785 Query: 769 KVSEVARWI 795 +V+ V WI Sbjct: 786 RVTRVINWI 794
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Length = 638 Score = 127 bits (319), Expect = 4e-29 Identities = 94/248 (37%), Positives = 131/248 (52%), Gaps = 5/248 (2%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237 +I+ GT A + E+P VSL+++ H+CGG+++ VLTAAHC + Y D + + Sbjct: 390 RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPD--VWRI 447 Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGN-DVALMKFDGYISNYEV 414 Y G L + ++ E+I+H Y +GN D+AL+K + NY Sbjct: 448 YG-----GILSLSEITKETPSSRIKELIIHQEYKVS----EGNYDIALIKLQTPL-NY-T 496 Query: 415 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 591 E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+ Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDY 555 Query: 592 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 771 + ICAG T +C+GDSGGPL C+ S R VGI S+G CGR + P VYTK Sbjct: 556 VINKQMICAGYKEGGTDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCGRKDQPGVYTK 613 Query: 772 VSEVARWI 795 VSE WI Sbjct: 614 VSEYMDWI 621
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor Length = 263 Score = 126 bits (317), Expect = 6e-29 Identities = 88/250 (35%), Positives = 131/250 (52%), Gaps = 1/250 (0%) Frame = +1 Query: 49 IATSGWKIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRK 225 + T +I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R Sbjct: 27 VITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR- 83 Query: 226 LLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISN 405 VVLGE+D +V V ++ H YNG + ND+ L+K + Sbjct: 84 --------VVLGEHDRSSNSEGVQVMTVGQVFKHPRYNG---FTINNDILLVKL-ATPAT 131 Query: 406 YEVEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFR 585 + +T + + G +C GWG DT LQ+A + +++NE+C KKF Sbjct: 132 LNMRVSPVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFW 190 Query: 586 NMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVY 765 K ICAG+ SSC GDSGGPL C+ + + + VGIVS+G C P +P VY Sbjct: 191 GNKISDLMICAGAA--GASSCMGDSGGPLVCQKAGSWTL-VGIVSWGSGTC-TPTMPGVY 246 Query: 766 TKVSEVARWI 795 +V+E+ W+ Sbjct: 247 ARVTELRAWV 256
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] Length = 1019 Score = 123 bits (308), Expect = 7e-28 Identities = 80/248 (32%), Positives = 130/248 (52%), Gaps = 2/248 (0%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246 KI+ G+ A +P +V L G +CG +L++ + +++AAHCV+ L+ K Sbjct: 784 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN------LEPSKW 837 Query: 247 DVVLGEYDLHHMYGVEKVFQ-VTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYI 423 +LG + ++ + V + + EI+++ YN ND+A+M + + NY +YI Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK---DNDIAMMHLEFKV-NY-TDYI 892 Query: 424 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 600 + L + + PG C + GWG+++ G TA LQ+A V ++SNE C ++ Sbjct: 893 QPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNIT 951 Query: 601 RSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSE 780 + ICAG SC+GDSGGPL C+++ NR G+ S+G C PN P VY +VS Sbjct: 952 ENMICAGYEEGGIDSCQGDSGGPLMCQEN-NRWFLAGVTSFG-YKCALPNRPGVYARVSR 1009 Query: 781 VARWISIY 804 WI + Sbjct: 1010 FTEWIQSF 1017
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Length = 638 Score = 123 bits (308), Expect = 7e-28 Identities = 89/248 (35%), Positives = 128/248 (51%), Gaps = 5/248 (2%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237 +I+ GT + + E+P VSL+++ H+CGG+++ +LTAAHC + Y D + + Sbjct: 390 RIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPD--VWRI 447 Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYN-GENAYLDGNDVALMKFDGYISNYEV 414 Y G +L + + E+I+H Y E +Y D+AL+K + NY Sbjct: 448 YG-----GILNLSEITNKTPFSSIKELIIHQKYKMSEGSY----DIALIKLQTPL-NY-T 496 Query: 415 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 591 E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+ Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKERGE-TQNILQKATIPLVPNEECQKKYRDY 555 Query: 592 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 771 + ICAG +C+GDSGGPL C+ S R VGI S+G C R P VYTK Sbjct: 556 VITKQMICAGYKEGGIDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCARKEQPGVYTK 613 Query: 772 VSEVARWI 795 V+E WI Sbjct: 614 VAEYIDWI 621
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) Length = 260 Score = 121 bits (304), Expect = 2e-27 Identities = 83/247 (33%), Positives = 116/247 (46%), Gaps = 2/247 (0%) Frame = +1 Query: 61 GWKIINGTKAIMHEYPQIVSLRIEGEH-ICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237 G KI+ G + I H P +L +GE ICGG L+ VLTAAHC K Sbjct: 30 GSKILEGRECIPHSQPWQAAL-FQGERLICGGVLVGDRWVLTAAHC------------KK 76 Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS-NYEV 414 K V LG++ L E+ QV + I H YN N +D+ L++ + +V Sbjct: 77 QKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKV 136 Query: 415 EYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMK 594 + ++ L K G +C + GWG++ E+ L A V I S +C + + K Sbjct: 137 KPVQLANL----CPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-K 191 Query: 595 YVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKV 774 +CAGS N +C+GDSGGPL C + GI S+G PCG+P P VYTK+ Sbjct: 192 ITEGMVCAGSSN-GADTCQGDSGGPLVCDG-----MLQGITSWGSDPCGKPEKPGVYTKI 245 Query: 775 SEVARWI 795 WI Sbjct: 246 CRYTTWI 252
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] Length = 625 Score = 119 bits (299), Expect = 8e-27 Identities = 82/252 (32%), Positives = 124/252 (49%), Gaps = 9/252 (3%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237 +I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+ Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444 Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVE 417 Y G + + F V EII+H Y + G D+AL+K + + NY Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493 Query: 418 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKK 579 ++ + + GDR C V GWG + LQKA + +++NEEC K+ Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548 Query: 580 FRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPT 759 +R K ICAG +C+GDSGGPL C+ + H+ VGI S+G C + P Sbjct: 549 YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWG-EGCAQRERPG 606 Query: 760 VYTKVSEVARWI 795 VYT V E WI Sbjct: 607 VYTNVVEYVDWI 618
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] Length = 624 Score = 119 bits (299), Expect = 8e-27 Identities = 81/249 (32%), Positives = 125/249 (50%), Gaps = 6/249 (2%) Frame = +1 Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246 +++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446 Query: 247 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 426 V E + + F+ E+I+H Y + G D+AL+K + ++ + + Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQR-- 496 Query: 427 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 588 + + GDR C V GWG GE + LQKA V ++SNEEC ++R Sbjct: 497 -----PICLPSKGDRNAVHTECWVTGWGYTALRGEVQST-LQKAKVPLVSNEECQTRYRR 550 Query: 589 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 768 K ICAG +C+GDSGGPL C+ + H+ VGI S+G CG+ P VYT Sbjct: 551 HKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHL-VGITSWG-EGCGQKERPGVYT 608 Query: 769 KVSEVARWI 795 V++ WI Sbjct: 609 NVAKYVDWI 617
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4) Length = 277 Score = 118 bits (295), Expect = 2e-26 Identities = 85/248 (34%), Positives = 123/248 (49%), Gaps = 1/248 (0%) Frame = +1 Query: 55 TSGWKIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLK 234 TSG+ + G H P +L ++G +CGG L++ VLTAAHC+ E LK Sbjct: 32 TSGF-LPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEG-------LK 83 Query: 235 AYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLD-GNDVALMKFDGYISNYE 411 Y LG++ L + E+V +V I H Y +L+ +D+ L++ + Sbjct: 84 VY-----LGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQL-- 136 Query: 412 VEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 591 YI+ L PG C V GWG+ + + LQ A + + S+EEC + + Sbjct: 137 TGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG- 195 Query: 592 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 771 K + +CAG+ SC GDSGGPL C NR + GIVS+G PCG+P+ P VYT+ Sbjct: 196 KITDNMLCAGTKEGGKDSCEGDSGGPLVC----NRTLY-GIVSWGDFPCGQPDRPGVYTR 250 Query: 772 VSEVARWI 795 VS WI Sbjct: 251 VSRYVLWI 258
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain] Length = 638 Score = 117 bits (294), Expect = 3e-26 Identities = 84/261 (32%), Positives = 127/261 (48%), Gaps = 9/261 (3%) Frame = +1 Query: 40 LCIIATSGWKIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMK 210 +C TS +I+ GT + E+P VSL+++ H+CGG+L+ VLTAAHC + Sbjct: 382 VCTTKTST-RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP 440 Query: 211 YWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFD 390 D + + Y G +L + Q+ EII+H Y +D+AL+K Sbjct: 441 LQD--VWRIYS-----GILNLSDITKDTPFSQIKEIIIHQNYKVSEG---NHDIALIKLQ 490 Query: 391 GYISNYEVEYIKYNTLDTVAISKPGD------RCEVVGWGSMMPAGEDTARFLQKAYVNI 552 ++ E + + + GD C V GWG GE LQK + + Sbjct: 491 APLNYTEFQ-------KPICLPSKGDTSTIYTNCWVTGWGFSKEKGE-IQNILQKVNIPL 542 Query: 553 ISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIV 732 ++NEEC K++++ K + +CAG +C+GDSGGPL C+ + + VGI S+G Sbjct: 543 VTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRL-VGITSWG-E 600 Query: 733 PCGRPNVPTVYTKVSEVARWI 795 C R P VYTKV+E WI Sbjct: 601 GCARREQPGVYTKVAEYMDWI 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,414,710
Number of Sequences: 369166
Number of extensions: 2359063
Number of successful extensions: 7891
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6459
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6852
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
