Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_F19
(744 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 112 1e-24
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 109 9e-24
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 108 2e-23
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 108 2e-23
sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I) 107 4e-23
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 106 6e-23
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 106 7e-23
sp|P18291|NKP1_RAT Natural killer cell protease 1 precursor... 105 1e-22
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 105 1e-22
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 104 3e-22
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 112 bits (280), Expect = 1e-24
Identities = 81/231 (35%), Positives = 118/231 (51%), Gaps = 1/231 (0%)
Frame = +1
Query: 49 IATSGWKIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRK 225
+ T +I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R
Sbjct: 27 VITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR- 83
Query: 226 LLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISN 405
VVLGE+D +V V ++ H YNG + ND+ L+K +
Sbjct: 84 --------VVLGEHDRSSNSEGVQVMTVGQVFKHPRYNG---FTINNDILLVKL-ATPAT 131
Query: 406 YEVEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFR 585
+ +T + + G +C GWG DT LQ+A + +++NE+C KKF
Sbjct: 132 LNMRVSPVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFW 190
Query: 586 NMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYGIVPC 738
K ICAG+ SSC GDSGGPL C+ + + VGIVS+G C
Sbjct: 191 GNKISDLMICAGAA--GASSCMGDSGGPLVCQKAGSWTL-VGIVSWGSGTC 238
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 109 bits (272), Expect = 9e-24
Identities = 78/232 (33%), Positives = 117/232 (50%), Gaps = 6/232 (2%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246
+I+ GT + E+P SL+I G HICGG L+ V+TAAHC E KL
Sbjct: 564 RIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLW----- 618
Query: 247 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 426
V LG+ + + E F+V+ + +H Y+ E+++ DVAL++ D + V Y
Sbjct: 619 TVFLGKMRQNSRWPGEVSFKVSRLFLH-PYHEEDSH--DYDVALLQLD-----HPVVYSA 670
Query: 427 YNTLDTVAIS------KPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 588
T+ V + +PG C + GWG+ G + LQK V ++ + CS+ +R
Sbjct: 671 --TVRPVCLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAYRY 727
Query: 589 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYGIVPCGR 744
R +CAG +C+GDSGGPL CR+ R G+VS+G+ CGR
Sbjct: 728 QVSPRM-LCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGL-GCGR 777
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 108 bits (270), Expect = 2e-23
Identities = 84/231 (36%), Positives = 120/231 (51%), Gaps = 5/231 (2%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237
+I+ GT A + E+P VSL+++ H+CGG+++ VLTAAHC + Y D + +
Sbjct: 390 RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPD--VWRI 447
Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGN-DVALMKFDGYISNYEV 414
Y G L + ++ E+I+H Y +GN D+AL+K + NY
Sbjct: 448 YG-----GILSLSEITKETPSSRIKELIIHQEYKVS----EGNYDIALIKLQTPL-NY-T 496
Query: 415 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 591
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 592 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYGIVPCGR 744
+ ICAG T +C+GDSGGPL C+ S R VGI S+G CGR
Sbjct: 556 VINKQMICAGYKEGGTDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCGR 604
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 108 bits (270), Expect = 2e-23
Identities = 73/229 (31%), Positives = 114/229 (49%), Gaps = 9/229 (3%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237
+I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444
Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVE 417
Y G + + F V EII+H Y + G D+AL+K + + NY
Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493
Query: 418 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKK 579
++ + + GDR C V GWG + LQKA + +++NEEC K+
Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548
Query: 580 FRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYG 726
+R K ICAG +C+GDSGGPL C+ + H+ VGI S+G
Sbjct: 549 YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWG 596
>sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I)
Length = 248
Score = 107 bits (266), Expect = 4e-23
Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 5/242 (2%)
Frame = +1
Query: 16 LLTVSILYLCIIATSGWKIINGTKAIMHEYPQIVSLRIEGEH----ICGGTLLNGNTVLT 183
LLTVS+ T +II G +A H P + L+ + E ICGG L+ + VLT
Sbjct: 7 LLTVSLAP----TTEAAEIIGGHEADPHSRPYMAYLQYKNEDSRDTICGGFLIREDFVLT 62
Query: 184 AAHCVWEMKYWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDG 363
AAHC K++V LG +++ ++V V +II H YN +
Sbjct: 63 AAHC------------SGSKINVTLGAHNIKEQEKTQQVIPVVKIIPHPAYNAKTI---S 107
Query: 364 NDVALMKFDGYISNYEVEYIKYNTLDTVAIS-KPGDRCEVVGWGSMMPAGEDTARFLQKA 540
ND+ L+K +K +L KPGD C V GWG + P G+ + LQ+
Sbjct: 108 NDIMLLKLKSKAKRTRA--VKTLSLPRSNFKVKPGDVCYVAGWGKLGPMGKFPDK-LQEV 164
Query: 541 YVNIISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVS 720
+ + ++EC +N + ICAG + +S +GDSGGPL C + + GIVS
Sbjct: 165 ELTVQEDQECETYLKNAYDKANQICAGDPKIKCASFQGDSGGPLVC-----KKVAAGIVS 219
Query: 721 YG 726
YG
Sbjct: 220 YG 221
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 106 bits (265), Expect = 6e-23
Identities = 78/225 (34%), Positives = 116/225 (51%), Gaps = 5/225 (2%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237
+I+ GT + + E+P VSL+++ H+CGG+++ +LTAAHC + Y D + +
Sbjct: 390 RIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPD--VWRI 447
Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYN-GENAYLDGNDVALMKFDGYISNYEV 414
Y G +L + + E+I+H Y E +Y D+AL+K + NY
Sbjct: 448 YG-----GILNLSEITNKTPFSSIKELIIHQKYKMSEGSY----DIALIKLQTPL-NY-T 496
Query: 415 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 591
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKERGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 592 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYG 726
+ ICAG +C+GDSGGPL C+ S R VGI S+G
Sbjct: 556 VITKQMICAGYKEGGIDACKGDSGGPLVCKHS-GRWQLVGITSWG 599
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 106 bits (264), Expect = 7e-23
Identities = 72/226 (31%), Positives = 113/226 (50%), Gaps = 6/226 (2%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246
+++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y
Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446
Query: 247 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 426
V E + + F+ E+I+H Y + G D+AL+K + ++ + +
Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQR-- 496
Query: 427 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 588
+ + GDR C V GWG GE + LQKA V ++SNEEC ++R
Sbjct: 497 -----PICLPSKGDRNAVHTECWVTGWGYTALRGEVQST-LQKAKVPLVSNEECQTRYRR 550
Query: 589 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYG 726
K ICAG +C+GDSGGPL C+ + H+ VGI S+G
Sbjct: 551 HKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHL-VGITSWG 595
>sp|P18291|NKP1_RAT Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)
Length = 248
Score = 105 bits (262), Expect = 1e-22
Identities = 76/244 (31%), Positives = 115/244 (47%), Gaps = 7/244 (2%)
Frame = +1
Query: 16 LLTVSILYLCIIATSGWKIINGTKAIMHEYPQIVSLRIEGEHI----CGGTLLNGNTVLT 183
LL + + + T +II G +A H P + L+I E+ CGG L+ + VLT
Sbjct: 3 LLLLLLSFSLAPKTEAGEIIGGHEAKPHSRPYMAYLQIMDEYSGSKKCGGFLIREDFVLT 62
Query: 184 AAHCVWEMKYWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDG 363
AAHC K++V LG +++ ++++ V +II H YN +
Sbjct: 63 AAHC------------SGSKINVTLGAHNIKEQEKMQQIIPVVKIIPHPAYNSKTI---S 107
Query: 364 NDVALMKFDGYISNYEVEYIKYNTLDTVAIS-KPGDRCEVVGWGSMMPAGE--DTARFLQ 534
ND+ L+K +K L + KPGD C V GWG + P G+ DT LQ
Sbjct: 108 NDIMLLKLKSKAKRSSA--VKPLNLPRRNVKVKPGDVCYVAGWGKLGPMGKYSDT---LQ 162
Query: 535 KAYVNIISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGI 714
+ + + +++C +N + ICAG + +S RGDSGGPL C + + GI
Sbjct: 163 EVELTVQEDQKCESYLKNYFDKANEICAGDPKIKRASFRGDSGGPLVC-----KKVAAGI 217
Query: 715 VSYG 726
VSYG
Sbjct: 218 VSYG 221
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 105 bits (262), Expect = 1e-22
Identities = 77/230 (33%), Positives = 109/230 (47%), Gaps = 2/230 (0%)
Frame = +1
Query: 61 GWKIINGTKAIMHEYPQIVSLRIEGEH-ICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 237
G KI+ G + I H P +L +GE ICGG L+ VLTAAHC K
Sbjct: 30 GSKILEGRECIPHSQPWQAAL-FQGERLICGGVLVGDRWVLTAAHC------------KK 76
Query: 238 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS-NYEV 414
K V LG++ L E+ QV + I H YN N +D+ L++ + +V
Sbjct: 77 QKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKV 136
Query: 415 EYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMK 594
+ ++ L K G +C + GWG++ E+ L A V I S +C + + K
Sbjct: 137 KPVQLANL----CPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-K 191
Query: 595 YVRSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYGIVPCGR 744
+CAGS N +C+GDSGGPL C D +Q GI S+G PCG+
Sbjct: 192 ITEGMVCAGSSN-GADTCQGDSGGPLVC----DGMLQ-GITSWGSDPCGK 235
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 104 bits (259), Expect = 3e-22
Identities = 69/222 (31%), Positives = 118/222 (53%), Gaps = 2/222 (0%)
Frame = +1
Query: 67 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 246
KI+ G+ A +P +V L G +CG +L++ + +++AAHCV+ L+ K
Sbjct: 784 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN------LEPSKW 837
Query: 247 DVVLGEYDLHHMYGVEKVFQ-VTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYI 423
+LG + ++ + V + + EI+++ YN ND+A+M + + NY +YI
Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK---DNDIAMMHLEFKV-NY-TDYI 892
Query: 424 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 600
+ L + + PG C + GWG+++ G TA LQ+A V ++SNE C ++
Sbjct: 893 QPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNIT 951
Query: 601 RSNICAGSGNLSTSSCRGDSGGPLFCRDSHDRHIQVGIVSYG 726
+ ICAG SC+GDSGGPL C++ ++R G+ S+G
Sbjct: 952 ENMICAGYEEGGIDSCQGDSGGPLMCQE-NNRWFLAGVTSFG 992
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,400,940
Number of Sequences: 369166
Number of extensions: 2083438
Number of successful extensions: 6796
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5729
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6050
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6728100400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)