Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_J09
(819 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 94 4e-19
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 89 1e-17
sp|P49864|GRAK_RAT Granzyme K precursor (NK-tryptase-2) (NK... 89 1e-17
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 89 1e-17
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 89 2e-17
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 89 2e-17
sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I) 88 2e-17
sp|P18291|NKP1_RAT Natural killer cell protease 1 precursor... 87 7e-17
sp|Q03238|GRAM_RAT Granzyme M precursor (Met-ase) (Natural ... 86 9e-17
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 86 1e-16
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 94.0 bits (232), Expect = 4e-19
Identities = 69/205 (33%), Positives = 102/205 (49%), Gaps = 1/205 (0%)
Frame = +3
Query: 39 IATSGWKIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRK 215
+ T +I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R
Sbjct: 27 VITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR- 83
Query: 216 LLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISN 395
VVLGE+D +V V ++ H YNG + ND+ L+K +
Sbjct: 84 --------VVLGEHDRSSNSEGVQVMTVGQVFKHPRYNG---FTINNDILLVKL-ATPAT 131
Query: 396 YEVEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFR 575
+ +T + + G +C GWG DT LQ+A + +++NE+C KKF
Sbjct: 132 LNMRVSPVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFW 190
Query: 576 NMKYVRSNICAGSGNLSTSSCRGDS 650
K ICAG+ SSC GDS
Sbjct: 191 GNKISDLMICAGAA--GASSCMGDS 213
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 89.4 bits (220), Expect = 1e-17
Identities = 62/207 (29%), Positives = 99/207 (47%), Gaps = 9/207 (4%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 227
+I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444
Query: 228 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVE 407
Y G + + F V EII+H Y + G D+AL+K + + NY
Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493
Query: 408 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKK 569
++ + + GDR C V GWG + LQKA + +++NEEC K+
Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548
Query: 570 FRNMKYVRSNICAGSGNLSTSSCRGDS 650
+R K ICAG +C+GDS
Sbjct: 549 YRGHKITHKMICAGYREGGKDACKGDS 575
>sp|P49864|GRAK_RAT Granzyme K precursor (NK-tryptase-2) (NK-Tryp-2)
Length = 258
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/202 (31%), Positives = 97/202 (48%), Gaps = 4/202 (1%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 236
+II G + H P + S++ G+HICGG L++ VLTAAHC + +
Sbjct: 25 EIIGGREVQPHSRPFMASIQYRGKHICGGVLIHPQWVLTAAHC----------YSRGHSP 74
Query: 237 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS-NYEVEYI 413
VVLG + L +++ F++ E I + ND+ L+K N V+ +
Sbjct: 75 TVVLGAHSLSKNEPMKQTFEIKEFIPFSGFKSGT-----NDIMLIKLRTAAELNKHVQLL 129
Query: 414 KYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEEC-SKKFRNMKYV 590
+ + + + G +C+V GWGS P T+ LQ+ V IIS + C S+ + N K V
Sbjct: 130 HLRSKNYI---RDGTKCQVTGWGSTKPDVLTTSDTLQEVTVTIISRKRCNSQSYYNHKPV 186
Query: 591 --RSNICAGSGNLSTSSCRGDS 650
+ ICAG SC+GDS
Sbjct: 187 ITKDMICAGDRRGEKDSCKGDS 208
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 89.0 bits (219), Expect = 1e-17
Identities = 69/203 (33%), Positives = 103/203 (50%), Gaps = 5/203 (2%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 227
+I+ GT A + E+P VSL+++ H+CGG+++ VLTAAHC + Y D + +
Sbjct: 390 RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPD--VWRI 447
Query: 228 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGN-DVALMKFDGYISNYEV 404
Y G L + ++ E+I+H Y +GN D+AL+K + NY
Sbjct: 448 YG-----GILSLSEITKETPSSRIKELIIHQEYKVS----EGNYDIALIKLQTPL-NY-T 496
Query: 405 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 581
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 582 KYVRSNICAGSGNLSTSSCRGDS 650
+ ICAG T +C+GDS
Sbjct: 556 VINKQMICAGYKEGGTDACKGDS 578
Score = 30.8 bits (68), Expect = 4.7
Identities = 13/20 (65%), Positives = 14/20 (70%)
Frame = +1
Query: 724 CGRPNVPTVYTKVSEVARWI 783
CGR + P VYTKVSE WI
Sbjct: 602 CGRKDQPGVYTKVSEYMDWI 621
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 88.6 bits (218), Expect = 2e-17
Identities = 66/203 (32%), Positives = 102/203 (50%), Gaps = 5/203 (2%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 227
+I+ GT + + E+P VSL+++ H+CGG+++ +LTAAHC + Y D + +
Sbjct: 390 RIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPD--VWRI 447
Query: 228 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYN-GENAYLDGNDVALMKFDGYISNYEV 404
Y G +L + + E+I+H Y E +Y D+AL+K + NY
Sbjct: 448 YG-----GILNLSEITNKTPFSSIKELIIHQKYKMSEGSY----DIALIKLQTPL-NY-T 496
Query: 405 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 581
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKERGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 582 KYVRSNICAGSGNLSTSSCRGDS 650
+ ICAG +C+GDS
Sbjct: 556 VITKQMICAGYKEGGIDACKGDS 578
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 88.6 bits (218), Expect = 2e-17
Identities = 61/204 (29%), Positives = 98/204 (48%), Gaps = 6/204 (2%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 236
+++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y
Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446
Query: 237 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 416
V E + + F+ E+I+H Y + G D+AL+K + ++ + +
Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQR-- 496
Query: 417 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 578
+ + GDR C V GWG GE + LQKA V ++SNEEC ++R
Sbjct: 497 -----PICLPSKGDRNAVHTECWVTGWGYTALRGEVQST-LQKAKVPLVSNEECQTRYRR 550
Query: 579 MKYVRSNICAGSGNLSTSSCRGDS 650
K ICAG +C+GDS
Sbjct: 551 HKITNKMICAGYKEGGKDTCKGDS 574
>sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I)
Length = 248
Score = 88.2 bits (217), Expect = 2e-17
Identities = 67/220 (30%), Positives = 101/220 (45%), Gaps = 5/220 (2%)
Frame = +3
Query: 6 LLTVSILYLCIIATSGWKIINGTKAIMHEYPQIVSLRIEGEH----ICGGTLLNGNTVLT 173
LLTVS+ T +II G +A H P + L+ + E ICGG L+ + VLT
Sbjct: 7 LLTVSLAP----TTEAAEIIGGHEADPHSRPYMAYLQYKNEDSRDTICGGFLIREDFVLT 62
Query: 174 AAHCVWEMKYWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDG 353
AAHC K++V LG +++ ++V V +II H YN +
Sbjct: 63 AAHC------------SGSKINVTLGAHNIKEQEKTQQVIPVVKIIPHPAYNAKTI---S 107
Query: 354 NDVALMKFDGYISNYEVEYIKYNTLDTVAIS-KPGDRCEVVGWGSMMPAGEDTARFLQKA 530
ND+ L+K +K +L KPGD C V GWG + P G+ + LQ+
Sbjct: 108 NDIMLLKLKSKAKRTRA--VKTLSLPRSNFKVKPGDVCYVAGWGKLGPMGKFPDK-LQEV 164
Query: 531 YVNIISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDS 650
+ + ++EC +N + ICAG + +S +GDS
Sbjct: 165 ELTVQEDQECETYLKNAYDKANQICAGDPKIKCASFQGDS 204
>sp|P18291|NKP1_RAT Natural killer cell protease 1 precursor (RNKP-1) (Granzyme B)
Length = 248
Score = 86.7 bits (213), Expect = 7e-17
Identities = 65/222 (29%), Positives = 102/222 (45%), Gaps = 7/222 (3%)
Frame = +3
Query: 6 LLTVSILYLCIIATSGWKIINGTKAIMHEYPQIVSLRIEGEHI----CGGTLLNGNTVLT 173
LL + + + T +II G +A H P + L+I E+ CGG L+ + VLT
Sbjct: 3 LLLLLLSFSLAPKTEAGEIIGGHEAKPHSRPYMAYLQIMDEYSGSKKCGGFLIREDFVLT 62
Query: 174 AAHCVWEMKYWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDG 353
AAHC K++V LG +++ ++++ V +II H YN +
Sbjct: 63 AAHC------------SGSKINVTLGAHNIKEQEKMQQIIPVVKIIPHPAYNSKTI---S 107
Query: 354 NDVALMKFDGYISNYEVEYIKYNTLDTVAIS-KPGDRCEVVGWGSMMPAGE--DTARFLQ 524
ND+ L+K +K L + KPGD C V GWG + P G+ DT LQ
Sbjct: 108 NDIMLLKLKSKAKRSSA--VKPLNLPRRNVKVKPGDVCYVAGWGKLGPMGKYSDT---LQ 162
Query: 525 KAYVNIISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDS 650
+ + + +++C +N + ICAG + +S RGDS
Sbjct: 163 EVELTVQEDQKCESYLKNYFDKANEICAGDPKIKRASFRGDS 204
>sp|Q03238|GRAM_RAT Granzyme M precursor (Met-ase) (Natural killer cell granular
protease) (RNK-Met-1)
Length = 258
Score = 86.3 bits (212), Expect = 9e-17
Identities = 62/201 (30%), Positives = 95/201 (47%), Gaps = 3/201 (1%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 236
+II G +A+ H P +VSL+ H+CGG L++ VLTAAHC+ E ++
Sbjct: 20 QIIGGREAVPHSRPYMVSLQNTKSHMCGGVLVHQKWVLTAAHCLSE---------PLQQL 70
Query: 237 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 416
+V G + LH F + + I H YN + ND+AL+K DG + + +K
Sbjct: 71 KLVFGLHSLHDPQDPGLTFYIKQAIKHPGYNLKYE----NDLALLKLDGRVK--PSKNVK 124
Query: 417 YNTLDTVAISKP--GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEEC-SKKFRNMKY 587
L KP G RC GWG G+ A+ LQ+ + ++ C + +F N
Sbjct: 125 PLALPRKPRDKPAEGSRCSTAGWGITHQRGQ-LAKSLQELDLRLLDTRMCNNSRFWNGVL 183
Query: 588 VRSNICAGSGNLSTSSCRGDS 650
S +C +G + C+GDS
Sbjct: 184 TDSMLCLKAGAKGQAPCKGDS 204
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 85.9 bits (211), Expect = 1e-16
Identities = 60/200 (30%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Frame = +3
Query: 57 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 236
KI+ G+ A +P +V L G +CG +L++ + +++AAHCV+ L+ K
Sbjct: 784 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN------LEPSKW 837
Query: 237 DVVLGEYDLHHMYGVEKVFQ-VTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYI 413
+LG + ++ + V + + EI+++ YN ND+A+M + + NY +YI
Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK---DNDIAMMHLEFKV-NY-TDYI 892
Query: 414 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 590
+ L + + PG C + GWG+++ G TA LQ+A V ++SNE C ++
Sbjct: 893 QPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNIT 951
Query: 591 RSNICAGSGNLSTSSCRGDS 650
+ ICAG SC+GDS
Sbjct: 952 ENMICAGYEEGGIDSCQGDS 971
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,846,680
Number of Sequences: 369166
Number of extensions: 2304914
Number of successful extensions: 6991
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5881
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6528
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)