Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_I18
(776 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 128 2e-29
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 127 3e-29
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 125 1e-28
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 124 4e-28
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 122 8e-28
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 121 2e-27
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 120 4e-27
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 120 5e-27
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 119 7e-27
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 119 1e-26
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 128 bits (322), Expect = 2e-29
Identities = 87/249 (34%), Positives = 128/249 (51%), Gaps = 6/249 (2%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 190
+I+ GT + E+P SL+I G HICGG L+ V+TAAHC E KL
Sbjct: 564 RIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLW----- 618
Query: 191 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVEYIK 370
V LG+ + + E F+V+ + +H Y+ E+++ DVAL++ D + V Y
Sbjct: 619 TVFLGKMRQNSRWPGEVSFKVSRLFLH-PYHEEDSH--DYDVALLQLD-----HPVVYSA 670
Query: 371 YNTLDTVAIS------KPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 532
T+ V + +PG C + GWG+ G + LQK V ++ + CS+ +R
Sbjct: 671 --TVRPVCLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAYRY 727
Query: 533 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 712
R +CAG +C+GDSGGPL CR+ R G+VS+G+ CGRPN VYT
Sbjct: 728 QVSPRM-LCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGL-GCGRPNFFGVYT 785
Query: 713 KVSEVARWI 739
+V+ V WI
Sbjct: 786 RVTRVINWI 794
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 127 bits (319), Expect = 3e-29
Identities = 94/248 (37%), Positives = 131/248 (52%), Gaps = 5/248 (2%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 181
+I+ GT A + E+P VSL+++ H+CGG+++ VLTAAHC + Y D + +
Sbjct: 390 RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPD--VWRI 447
Query: 182 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGN-DVALMKFDGYISNYEV 358
Y G L + ++ E+I+H Y +GN D+AL+K + NY
Sbjct: 448 YG-----GILSLSEITKETPSSRIKELIIHQEYKVS----EGNYDIALIKLQTPL-NY-T 496
Query: 359 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 535
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 536 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 715
+ ICAG T +C+GDSGGPL C+ S R VGI S+G CGR + P VYTK
Sbjct: 556 VINKQMICAGYKEGGTDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCGRKDQPGVYTK 613
Query: 716 VSEVARWI 739
VSE WI
Sbjct: 614 VSEYMDWI 621
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 125 bits (315), Expect = 1e-28
Identities = 81/248 (32%), Positives = 131/248 (52%), Gaps = 2/248 (0%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 190
KI+ G+ A +P +V L G +CG +L++ + +++AAHCV+ L+ K
Sbjct: 784 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN------LEPSKW 837
Query: 191 DVVLGEYDLHHMYGVEKVFQ-VTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVEYI 367
+LG + ++ + V + + EI+++ YNR ND+A+M + + NY +YI
Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK---DNDIAMMHLEFKV-NY-TDYI 892
Query: 368 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 544
+ L + + PG C + GWG+++ G TA LQ+A V ++SNE C ++
Sbjct: 893 QPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNIT 951
Query: 545 RSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSE 724
+ ICAG SC+GDSGGPL C+++ NR G+ S+G C PN P VY +VS
Sbjct: 952 ENMICAGYEEGGIDSCQGDSGGPLMCQEN-NRWFLAGVTSFG-YKCALPNRPGVYARVSR 1009
Query: 725 VARWISIY 748
WI +
Sbjct: 1010 FTEWIQSF 1017
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 124 bits (310), Expect = 4e-28
Identities = 86/244 (35%), Positives = 128/244 (52%), Gaps = 1/244 (0%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYK 187
+I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R
Sbjct: 33 RIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR------- 83
Query: 188 VDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVEYI 367
VVLGE+D +V V ++ H Y N + ND+ L+K + +
Sbjct: 84 --VVLGEHDRSSNSEGVQVMTVGQVFKHPRY---NGFTINNDILLVKL-ATPATLNMRVS 137
Query: 368 KYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYVR 547
+T + + G +C GWG DT LQ+A + +++NE+C KKF K
Sbjct: 138 PVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFWGNKISD 196
Query: 548 SNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSEV 727
ICAG+ SSC GDSGGPL C+ + + + VGIVS+G C P +P VY +V+E+
Sbjct: 197 LMICAGAA--GASSCMGDSGGPLVCQKAGSWTL-VGIVSWGSGTC-TPTMPGVYARVTEL 252
Query: 728 ARWI 739
W+
Sbjct: 253 RAWV 256
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 122 bits (307), Expect = 8e-28
Identities = 89/248 (35%), Positives = 128/248 (51%), Gaps = 5/248 (2%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 181
+I+ GT + + E+P VSL+++ H+CGG+++ +LTAAHC + Y D + +
Sbjct: 390 RIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPD--VWRI 447
Query: 182 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNR-ENAYLDGNDVALMKFDGYISNYEV 358
Y G +L + + E+I+H Y E +Y D+AL+K + NY
Sbjct: 448 YG-----GILNLSEITNKTPFSSIKELIIHQKYKMSEGSY----DIALIKLQTPL-NY-T 496
Query: 359 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 535
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKERGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 536 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 715
+ ICAG +C+GDSGGPL C+ S R VGI S+G C R P VYTK
Sbjct: 556 VITKQMICAGYKEGGIDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCARKEQPGVYTK 613
Query: 716 VSEVARWI 739
V+E WI
Sbjct: 614 VAEYIDWI 621
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 121 bits (304), Expect = 2e-27
Identities = 83/247 (33%), Positives = 116/247 (46%), Gaps = 2/247 (0%)
Frame = +2
Query: 5 GWKIINGTKAIMHEYPQIVSLRIEGEH-ICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 181
G KI+ G + I H P +L +GE ICGG L+ VLTAAHC K
Sbjct: 30 GSKILEGRECIPHSQPWQAAL-FQGERLICGGVLVGDRWVLTAAHC------------KK 76
Query: 182 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYIS-NYEV 358
K V LG++ L E+ QV + I H YN N +D+ L++ + +V
Sbjct: 77 QKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKV 136
Query: 359 EYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMK 538
+ ++ L K G +C + GWG++ E+ L A V I S +C + + K
Sbjct: 137 KPVQLANL----CPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-K 191
Query: 539 YVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKV 718
+CAGS N +C+GDSGGPL C + GI S+G PCG+P P VYTK+
Sbjct: 192 ITEGMVCAGSSN-GADTCQGDSGGPLVCDG-----MLQGITSWGSDPCGKPEKPGVYTKI 245
Query: 719 SEVARWI 739
WI
Sbjct: 246 CRYTTWI 252
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 120 bits (301), Expect = 4e-27
Identities = 82/252 (32%), Positives = 124/252 (49%), Gaps = 9/252 (3%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 181
+I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444
Query: 182 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVE 361
Y G + + F V EII+H Y + G D+AL+K + + NY
Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493
Query: 362 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKK 523
++ + + GDR C V GWG + LQKA + +++NEEC K+
Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548
Query: 524 FRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPT 703
+R K ICAG +C+GDSGGPL C+ + H+ VGI S+G C + P
Sbjct: 549 YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWG-EGCAQRERPG 606
Query: 704 VYTKVSEVARWI 739
VYT V E WI
Sbjct: 607 VYTNVVEYVDWI 618
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 120 bits (300), Expect = 5e-27
Identities = 81/249 (32%), Positives = 125/249 (50%), Gaps = 6/249 (2%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 190
+++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y
Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446
Query: 191 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVEYIK 370
V E + + F+ E+I+H Y + G D+AL+K + ++ + +
Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQR-- 496
Query: 371 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 532
+ + GDR C V GWG GE + LQKA V ++SNEEC ++R
Sbjct: 497 -----PICLPSKGDRNAVHTECWVTGWGYTALRGEVQST-LQKAKVPLVSNEECQTRYRR 550
Query: 533 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 712
K ICAG +C+GDSGGPL C+ + H+ VGI S+G CG+ P VYT
Sbjct: 551 HKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHL-VGITSWG-EGCGQKERPGVYT 608
Query: 713 KVSEVARWI 739
V++ WI
Sbjct: 609 NVAKYVDWI 617
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 119 bits (299), Expect = 7e-27
Identities = 83/240 (34%), Positives = 119/240 (49%), Gaps = 1/240 (0%)
Frame = +2
Query: 23 GTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKVDVVL 202
G H P +L ++G +CGG L++ VLTAAHC+ E LK Y L
Sbjct: 39 GYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEG-------LKVY-----L 86
Query: 203 GEYDLHHMYGVEKVFQVTEIIMHYMYNRENAYLD-GNDVALMKFDGYISNYEVEYIKYNT 379
G++ L + E+V +V I H Y R +L+ +D+ L++ + YI+
Sbjct: 87 GKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQL--TGYIQTLP 144
Query: 380 LDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYVRSNIC 559
L PG C V GWG+ + + LQ A + + S+EEC + + K + +C
Sbjct: 145 LSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG-KITDNMLC 203
Query: 560 AGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSEVARWI 739
AG+ SC GDSGGPL C NR + GIVS+G PCG+P+ P VYT+VS WI
Sbjct: 204 AGTKEGGKDSCEGDSGGPLVC----NRTLY-GIVSWGDFPCGQPDRPGVYTRVSRYVLWI 258
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 119 bits (297), Expect = 1e-26
Identities = 74/248 (29%), Positives = 133/248 (53%), Gaps = 2/248 (0%)
Frame = +2
Query: 11 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 190
KI+ G+ + +P +V+L + + +CG +L++ + +++AAHCV+ ++ K
Sbjct: 800 KIVGGSDSREGAWPWVVALYFDDQQVCGASLVSRDWLVSAAHCVYGRN------MEPSKW 853
Query: 191 DVVLGEYDLHHMYGVE-KVFQVTEIIMHYMYNRENAYLDGNDVALMKFDGYISNYEVEYI 367
VLG + ++ + + + +I+++ YN+ ND+A+M + + NY +YI
Sbjct: 854 KAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRK---NNDIAMMHLEMKV-NY-TDYI 908
Query: 368 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 544
+ L + + PG C + GWG+++ G TA LQ+A V ++SNE+C ++
Sbjct: 909 QPICLPEENQVFPPGRICSIAGWGALIYQGS-TADVLQEADVPLLSNEKCQQQMPEYNIT 967
Query: 545 RSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSE 724
+ +CAG SC+GDSGGPL C+++ NR + G+ S+G C PN P VY +V
Sbjct: 968 ENMVCAGYEAGGVDSCQGDSGGPLMCQEN-NRWLLAGVTSFG-YQCALPNRPGVYARVPR 1025
Query: 725 VARWISIY 748
WI +
Sbjct: 1026 FTEWIQSF 1033
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,680,435
Number of Sequences: 369166
Number of extensions: 2186420
Number of successful extensions: 7435
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6037
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6381
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7260540000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)