Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_H09
(600 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q03238|GRAM_RAT Granzyme M precursor (Met-ase) (Natural ... 78 1e-14
sp|P49864|GRAK_RAT Granzyme K precursor (NK-tryptase-2) (NK... 78 1e-14
sp|Q5R1M5|ELA1_FELCA Elastase-1 precursor 78 1e-14
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 78 2e-14
sp|P00772|ELA1_PIG Elastase-1 precursor 77 4e-14
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 76 6e-14
sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor 76 7e-14
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 75 1e-13
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 74 2e-13
sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I) 74 2e-13
>sp|Q03238|GRAM_RAT Granzyme M precursor (Met-ase) (Natural killer cell granular
protease) (RNK-Met-1)
Length = 258
Score = 78.2 bits (191), Expect = 1e-14
Identities = 58/186 (31%), Positives = 88/186 (47%), Gaps = 3/186 (1%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 229
+II G +A+ H P +VSL+ H+CGG L++ VLTAAHC+ E ++
Sbjct: 20 QIIGGREAVPHSRPYMVSLQNTKSHMCGGVLVHQKWVLTAAHCLSE---------PLQQL 70
Query: 230 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 409
+V G + LH F + + I H YN + ND+AL+K DG + + +K
Sbjct: 71 KLVFGLHSLHDPQDPGLTFYIKQAIKHPGYNLKYE----NDLALLKLDGRVK--PSKNVK 124
Query: 410 YNTLDTVAISKP--GDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAEC-SQKFRNMKY 580
L KP G RC GWG G+ A+SLQ+ + ++ C + +F N
Sbjct: 125 PLALPRKPRDKPAEGSRCSTAGWGITHQRGQ-LAKSLQELDLRLLDTRMCNNSRFWNGVL 183
Query: 581 VRSNIC 598
S +C
Sbjct: 184 TDSMLC 189
>sp|P49864|GRAK_RAT Granzyme K precursor (NK-tryptase-2) (NK-Tryp-2)
Length = 258
Score = 78.2 bits (191), Expect = 1e-14
Identities = 55/180 (30%), Positives = 86/180 (47%), Gaps = 2/180 (1%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 229
+II G + H P + S++ G+HICGG L++ VLTAAHC + +
Sbjct: 25 EIIGGREVQPHSRPFMASIQYRGKHICGGVLIHPQWVLTAAHC----------YSRGHSP 74
Query: 230 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS-NYEVEYI 406
VVLG + L +++ F++ E I + ND+ L+K N V+ +
Sbjct: 75 TVVLGAHSLSKNEPMKQTFEIKEFIPFSGFKSGT-----NDIMLIKLRTAAELNKHVQLL 129
Query: 407 KYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAEC-SQKFRNMKYV 583
+ + + + G +C+V GWGS P T+ +LQ+ V IIS C SQ + N K V
Sbjct: 130 HLRSKNYI---RDGTKCQVTGWGSTKPDVLTTSDTLQEVTVTIISRKRCNSQSYYNHKPV 186
>sp|Q5R1M5|ELA1_FELCA Elastase-1 precursor
Length = 266
Score = 78.2 bits (191), Expect = 1e-14
Identities = 55/174 (31%), Positives = 89/174 (51%), Gaps = 5/174 (2%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRI----EGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLK 217
+++ GT+A + +P +SL+ + H CGGTL+ N V+TAAHCV DRK+
Sbjct: 26 RVVGGTEARKNPWPSQISLQYLSGGKWYHTCGGTLIRQNWVMTAAHCV------DRKM-- 77
Query: 218 AYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEV 397
VV GE++L G E+ V +I++H +N N G D+AL++ ++
Sbjct: 78 --TFRVVAGEHNLSQNDGTEQRVSVQKIVVHPYWNSNNV-AAGYDIALLRLAQRVTLN-- 132
Query: 398 EYIKYNTLDTV-AISKPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECS 556
Y++ L I + C + GWG G+ A++LQ+AY+ + A CS
Sbjct: 133 NYVQLGVLPAAGTILANNNPCYITGWGMTKTNGQ-LAQALQQAYLPSVDYATCS 185
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/190 (31%), Positives = 92/190 (48%), Gaps = 1/190 (0%)
Frame = +2
Query: 32 IATSGWKIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRK 208
+ T +I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R
Sbjct: 27 VITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR- 83
Query: 209 LLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISN 388
VVLGE+D +V V ++ H YNG + ND+ L+K +
Sbjct: 84 --------VVLGEHDRSSNSEGVQVMTVGQVFKHPRYNG---FTINNDILLVKL-ATPAT 131
Query: 389 YEVEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECSQKFR 568
+ +T + + G +C GWG DT LQ+A + +++N +C +KF
Sbjct: 132 LNMRVSPVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFW 190
Query: 569 NMKYVRSNIC 598
K IC
Sbjct: 191 GNKISDLMIC 200
>sp|P00772|ELA1_PIG Elastase-1 precursor
Length = 266
Score = 76.6 bits (187), Expect = 4e-14
Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 5/174 (2%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEG----EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLK 217
+++ GT+A + +P +SL+ H CGGTL+ N V+TAAHCV DR+L
Sbjct: 26 RVVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCV------DREL-- 77
Query: 218 AYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEV 397
VV+GE++L+ G E+ V +I++H +N ++ G D+AL++ ++
Sbjct: 78 --TFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDV-AAGYDIALLRLAQSVTLN-- 132
Query: 398 EYIKYNTLDTV-AISKPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECS 556
Y++ L I C + GWG G+ A++LQ+AY+ + A CS
Sbjct: 133 SYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQ-LAQTLQQAYLPTVDYAICS 185
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 76.3 bits (186), Expect = 6e-14
Identities = 54/189 (28%), Positives = 89/189 (47%), Gaps = 6/189 (3%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 229
+++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y
Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446
Query: 230 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 409
V E + + F+ E+I+H Y + G D+AL+K + ++ + +
Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQ--- 495
Query: 410 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARSLQKAYVNIISNAECSQKFRN 571
+ + GDR C V GWG GE +LQKA V ++SN EC ++R
Sbjct: 496 ----RPICLPSKGDRNAVHTECWVTGWGYTALRGE-VQSTLQKAKVPLVSNEECQTRYRR 550
Query: 572 MKYVRSNIC 598
K IC
Sbjct: 551 HKITNKMIC 559
>sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor
Length = 258
Score = 75.9 bits (185), Expect = 7e-14
Identities = 53/174 (30%), Positives = 87/174 (50%), Gaps = 5/174 (2%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEGE----HICGGTLLNGNTVLTAAHCVWEMKYWDRKLLK 217
+++ GT+A + +P +SL+ H CGGTL+ N V+TAAHCV K +
Sbjct: 18 RVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKTF------ 71
Query: 218 AYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEV 397
VV G+++L G E+ V +I++H +N +N G D+AL++ ++
Sbjct: 72 ----RVVAGDHNLSQNDGTEQYVSVQKIVVHPYWNSDNV-AAGYDIALLRLAQSVTLN-- 124
Query: 398 EYIKYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECS 556
Y++ L AI C + GWG G+ A++LQ+AY+ + A CS
Sbjct: 125 SYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQ-LAQTLQQAYLPSVDYAICS 177
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 9/192 (4%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 220
+I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444
Query: 221 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVE 400
Y G + + F V EII+H Y + G D+AL+K + + NY
Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493
Query: 401 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARSLQKAYVNIISNAECSQK 562
++ + + GDR C V GWG + +LQKA + +++N EC ++
Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548
Query: 563 FRNMKYVRSNIC 598
+R K IC
Sbjct: 549 YRGHKITHKMIC 560
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/179 (31%), Positives = 88/179 (49%), Gaps = 6/179 (3%)
Frame = +2
Query: 50 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 229
+I+ GT + E+P SL+I G HICGG L+ V+TAAHC E KL
Sbjct: 564 RIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLW----- 618
Query: 230 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 409
V LG+ + + E F+V+ + +H Y+ E+++ DVAL++ D + V Y
Sbjct: 619 TVFLGKMRQNSRWPGEVSFKVSRLFLH-PYHEEDSH--DYDVALLQLD-----HPVVYSA 670
Query: 410 YNTLDTVAIS------KPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECSQKFR 568
T+ V + +PG C + GWG+ G + +LQK V ++ CS+ +R
Sbjct: 671 --TVRPVCLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAYR 726
>sp|Q06605|GRZ1_RAT Granzyme-like protein I precursor (GLP I)
Length = 248
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/192 (29%), Positives = 85/192 (44%), Gaps = 5/192 (2%)
Frame = +2
Query: 38 TSGWKIINGTKAIMHEYPQIVSLRIEGEH----ICGGTLLNGNTVLTAAHCVWEMKYWDR 205
T +II G +A H P + L+ + E ICGG L+ + VLTAAHC
Sbjct: 16 TEAAEIIGGHEADPHSRPYMAYLQYKNEDSRDTICGGFLIREDFVLTAAHC--------- 66
Query: 206 KLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS 385
K++V LG +++ ++V V +II H YN + ND+ L+K
Sbjct: 67 ---SGSKINVTLGAHNIKEQEKTQQVIPVVKIIPHPAYNAKTI---SNDIMLLKLKSKAK 120
Query: 386 NYEVEYIKYNTLDTVAIS-KPGDRCEVVGWGSMMPAGEDTARSLQKAYVNIISNAECSQK 562
+K +L KPGD C V GWG + P G+ + LQ+ + + + EC
Sbjct: 121 RTRA--VKTLSLPRSNFKVKPGDVCYVAGWGKLGPMGKFPDK-LQEVELTVQEDQECETY 177
Query: 563 FRNMKYVRSNIC 598
+N + IC
Sbjct: 178 LKNAYDKANQIC 189
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,510,013
Number of Sequences: 369166
Number of extensions: 1586046
Number of successful extensions: 4850
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4370
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4561
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)