Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_P13
(818 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 127 3e-29
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 127 4e-29
sp|P47796|CTRA_GADMO Chymotrypsin A precursor 126 6e-29
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 123 7e-28
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 123 7e-28
sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8) 121 2e-27
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 119 8e-27
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 119 8e-27
sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-l... 118 2e-26
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 117 3e-26
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 127 bits (320), Expect = 3e-29
Identities = 87/249 (34%), Positives = 128/249 (51%), Gaps = 6/249 (2%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 233
+I+ GT + E+P SL+I G HICGG L+ V+TAAHC E KL
Sbjct: 564 RIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLW----- 618
Query: 234 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 413
V LG+ + + E F+V+ + +H Y+ E+++ DVAL++ D + V Y
Sbjct: 619 TVFLGKMRQNSRWPGEVSFKVSRLFLH-PYHEEDSH--DYDVALLQLD-----HPVVYSA 670
Query: 414 YNTLDTVAIS------KPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 575
T+ V + +PG C + GWG+ G + LQK V ++ + CS+ +R
Sbjct: 671 --TVRPVCLPARSHFFEPGQHCWITGWGAQREGG-PVSNTLQKVDVQLVPQDLCSEAYRY 727
Query: 576 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 755
R +CAG +C+GDSGGPL CR+ R G+VS+G+ CGRPN VYT
Sbjct: 728 QVSPRM-LCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGL-GCGRPNFFGVYT 785
Query: 756 KVSEVARWI 782
+V+ V WI
Sbjct: 786 RVTRVINWI 794
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 127 bits (319), Expect = 4e-29
Identities = 94/248 (37%), Positives = 131/248 (52%), Gaps = 5/248 (2%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 224
+I+ GT A + E+P VSL+++ H+CGG+++ VLTAAHC + Y D + +
Sbjct: 390 RIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPD--VWRI 447
Query: 225 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGN-DVALMKFDGYISNYEV 401
Y G L + ++ E+I+H Y +GN D+AL+K + NY
Sbjct: 448 YG-----GILSLSEITKETPSSRIKELIIHQEYKVS----EGNYDIALIKLQTPL-NY-T 496
Query: 402 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 578
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 579 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 758
+ ICAG T +C+GDSGGPL C+ S R VGI S+G CGR + P VYTK
Sbjct: 556 VINKQMICAGYKEGGTDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCGRKDQPGVYTK 613
Query: 759 VSEVARWI 782
VSE WI
Sbjct: 614 VSEYMDWI 621
>sp|P47796|CTRA_GADMO Chymotrypsin A precursor
Length = 263
Score = 126 bits (317), Expect = 6e-29
Identities = 88/250 (35%), Positives = 131/250 (52%), Gaps = 1/250 (0%)
Frame = +3
Query: 36 IATSGWKIINGTKAIMHEYPQIVSLRIE-GEHICGGTLLNGNTVLTAAHCVWEMKYWDRK 212
+ T +I+NG +A+ H + VSL+ + G H CGG+L+N N V+TAAHC +K + R
Sbjct: 27 VITGYSRIVNGEEAVPHSWSWQVSLQDQTGFHFCGGSLINENWVVTAAHC--NVKNYHR- 83
Query: 213 LLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISN 392
VVLGE+D +V V ++ H YNG + ND+ L+K +
Sbjct: 84 --------VVLGEHDRSSNSEGVQVMTVGQVFKHPRYNG---FTINNDILLVKL-ATPAT 131
Query: 393 YEVEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFR 572
+ +T + + G +C GWG DT LQ+A + +++NE+C KKF
Sbjct: 132 LNMRVSPVCLAETDDVFEGGMKCVTSGWGLTRYNAADTPALLQQAALPLLTNEQC-KKFW 190
Query: 573 NMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVY 752
K ICAG+ SSC GDSGGPL C+ + + + VGIVS+G C P +P VY
Sbjct: 191 GNKISDLMICAGAA--GASSCMGDSGGPLVCQKAGSWTL-VGIVSWGSGTC-TPTMPGVY 246
Query: 753 TKVSEVARWI 782
+V+E+ W+
Sbjct: 247 ARVTELRAWV 256
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 123 bits (308), Expect = 7e-28
Identities = 80/248 (32%), Positives = 130/248 (52%), Gaps = 2/248 (0%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 233
KI+ G+ A +P +V L G +CG +L++ + +++AAHCV+ L+ K
Sbjct: 784 KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN------LEPSKW 837
Query: 234 DVVLGEYDLHHMYGVEKVFQ-VTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYI 410
+LG + ++ + V + + EI+++ YN ND+A+M + + NY +YI
Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK---DNDIAMMHLEFKV-NY-TDYI 892
Query: 411 KYNTL-DTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMKYV 587
+ L + + PG C + GWG+++ G TA LQ+A V ++SNE C ++
Sbjct: 893 QPICLPEENQVFPPGRNCSIAGWGTVVYQGT-TANILQEADVPLLSNERCQQQMPEYNIT 951
Query: 588 RSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKVSE 767
+ ICAG SC+GDSGGPL C+++ NR G+ S+G C PN P VY +VS
Sbjct: 952 ENMICAGYEEGGIDSCQGDSGGPLMCQEN-NRWFLAGVTSFG-YKCALPNRPGVYARVSR 1009
Query: 768 VARWISIY 791
WI +
Sbjct: 1010 FTEWIQSF 1017
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 123 bits (308), Expect = 7e-28
Identities = 89/248 (35%), Positives = 128/248 (51%), Gaps = 5/248 (2%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 224
+I+ GT + + E+P VSL+++ H+CGG+++ +LTAAHC + Y D + +
Sbjct: 390 RIVGGTNSSLGEWPWQVSLQVKLVSQNHMCGGSIIGRQWILTAAHCFDGIPYPD--VWRI 447
Query: 225 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYN-GENAYLDGNDVALMKFDGYISNYEV 401
Y G +L + + E+I+H Y E +Y D+AL+K + NY
Sbjct: 448 YG-----GILNLSEITNKTPFSSIKELIIHQKYKMSEGSY----DIALIKLQTPL-NY-T 496
Query: 402 EYIKYNTLDTVAISKP-GDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 578
E+ K L + A + C V GWG GE T LQKA + ++ NEEC KK+R+
Sbjct: 497 EFQKPICLPSKADTNTIYTNCWVTGWGYTKERGE-TQNILQKATIPLVPNEECQKKYRDY 555
Query: 579 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 758
+ ICAG +C+GDSGGPL C+ S R VGI S+G C R P VYTK
Sbjct: 556 VITKQMICAGYKEGGIDACKGDSGGPLVCKHS-GRWQLVGITSWG-EGCARKEQPGVYTK 613
Query: 759 VSEVARWI 782
V+E WI
Sbjct: 614 VAEYIDWI 621
>sp|Q61955|NRPN_MOUSE Neuropsin precursor (NP) (Kallikrein 8)
Length = 260
Score = 121 bits (304), Expect = 2e-27
Identities = 83/247 (33%), Positives = 116/247 (46%), Gaps = 2/247 (0%)
Frame = +3
Query: 48 GWKIINGTKAIMHEYPQIVSLRIEGEH-ICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 224
G KI+ G + I H P +L +GE ICGG L+ VLTAAHC K
Sbjct: 30 GSKILEGRECIPHSQPWQAAL-FQGERLICGGVLVGDRWVLTAAHC------------KK 76
Query: 225 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYIS-NYEV 401
K V LG++ L E+ QV + I H YN N +D+ L++ + +V
Sbjct: 77 QKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKV 136
Query: 402 EYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNMK 581
+ ++ L K G +C + GWG++ E+ L A V I S +C + + K
Sbjct: 137 KPVQLANL----CPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPG-K 191
Query: 582 YVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTKV 761
+CAGS N +C+GDSGGPL C + GI S+G PCG+P P VYTK+
Sbjct: 192 ITEGMVCAGSSN-GADTCQGDSGGPLVCDG-----MLQGITSWGSDPCGKPEKPGVYTKI 245
Query: 762 SEVARWI 782
WI
Sbjct: 246 CRYTTWI 252
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 119 bits (299), Expect = 8e-27
Identities = 82/252 (32%), Positives = 124/252 (49%), Gaps = 9/252 (3%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIEG---EHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKA 224
+I+ GT ++ E+P V+L H+CGG+++ +LTAAHC + ++ K+L+
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE--SPKILRV 444
Query: 225 YKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVE 404
Y G + + F V EII+H Y + G D+AL+K + + NY
Sbjct: 445 YS-----GILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTV-NYT-- 493
Query: 405 YIKYNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKK 566
++ + + GDR C V GWG + LQKA + +++NEEC K+
Sbjct: 494 ----DSQRPICLPSKGDRNVIYTDCWVTGWG-YRKLRDKIQNTLQKAKIPLVTNEECQKR 548
Query: 567 FRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPT 746
+R K ICAG +C+GDSGGPL C+ + H+ VGI S+G C + P
Sbjct: 549 YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWG-EGCAQRERPG 606
Query: 747 VYTKVSEVARWI 782
VYT V E WI
Sbjct: 607 VYTNVVEYVDWI 618
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 119 bits (299), Expect = 8e-27
Identities = 81/249 (32%), Positives = 125/249 (50%), Gaps = 6/249 (2%)
Frame = +3
Query: 54 KIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLKAYKV 233
+++ G ++ E+P V+L I H+CGG+++ +LTAAHC ++ K L+ Y
Sbjct: 389 RVVGGAASVHGEWPWQVTLHISQGHLCGGSIIGNQWILTAAHCFSGIE--TPKKLRVYGG 446
Query: 234 DVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFDGYISNYEVEYIK 413
V E + + F+ E+I+H Y + G D+AL+K + ++ + +
Sbjct: 447 IVNQSEINEGTAF-----FREQEMIIHDQYTTAES---GYDIALLKLESAMNYTDFQR-- 496
Query: 414 YNTLDTVAISKPGDR------CEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRN 575
+ + GDR C V GWG GE + LQKA V ++SNEEC ++R
Sbjct: 497 -----PICLPSKGDRNAVHTECWVTGWGYTALRGEVQST-LQKAKVPLVSNEECQTRYRR 550
Query: 576 MKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYT 755
K ICAG +C+GDSGGPL C+ + H+ VGI S+G CG+ P VYT
Sbjct: 551 HKITNKMICAGYKEGGKDTCKGDSGGPLSCKYNGVWHL-VGITSWG-EGCGQKERPGVYT 608
Query: 756 KVSEVARWI 782
V++ WI
Sbjct: 609 NVAKYVDWI 617
>sp|Q9UKR3|KLK13_HUMAN Kallikrein 13 precursor (Kallikrein-like protein 4) (KLK-L4)
Length = 277
Score = 118 bits (295), Expect = 2e-26
Identities = 85/248 (34%), Positives = 123/248 (49%), Gaps = 1/248 (0%)
Frame = +3
Query: 42 TSGWKIINGTKAIMHEYPQIVSLRIEGEHICGGTLLNGNTVLTAAHCVWEMKYWDRKLLK 221
TSG+ + G H P +L ++G +CGG L++ VLTAAHC+ E LK
Sbjct: 32 TSGF-LPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEG-------LK 83
Query: 222 AYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLD-GNDVALMKFDGYISNYE 398
Y LG++ L + E+V +V I H Y +L+ +D+ L++ +
Sbjct: 84 VY-----LGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQL-- 136
Query: 399 VEYIKYNTLDTVAISKPGDRCEVVGWGSMMPAGEDTARFLQKAYVNIISNEECSKKFRNM 578
YI+ L PG C V GWG+ + + LQ A + + S+EEC + +
Sbjct: 137 TGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPG- 195
Query: 579 KYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIVPCGRPNVPTVYTK 758
K + +CAG+ SC GDSGGPL C NR + GIVS+G PCG+P+ P VYT+
Sbjct: 196 KITDNMLCAGTKEGGKDSCEGDSGGPLVC----NRTLY-GIVSWGDFPCGQPDRPGVYTR 250
Query: 759 VSEVARWI 782
VS WI
Sbjct: 251 VSRYVLWI 258
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 117 bits (294), Expect = 3e-26
Identities = 84/261 (32%), Positives = 127/261 (48%), Gaps = 9/261 (3%)
Frame = +3
Query: 27 LCIIATSGWKIINGTKAIMHEYPQIVSLRIE---GEHICGGTLLNGNTVLTAAHCVWEMK 197
+C TS +I+ GT + E+P VSL+++ H+CGG+L+ VLTAAHC +
Sbjct: 382 VCTTKTST-RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP 440
Query: 198 YWDRKLLKAYKVDVVLGEYDLHHMYGVEKVFQVTEIIMHYMYNGENAYLDGNDVALMKFD 377
D + + Y G +L + Q+ EII+H Y +D+AL+K
Sbjct: 441 LQD--VWRIYS-----GILNLSDITKDTPFSQIKEIIIHQNYKVSEG---NHDIALIKLQ 490
Query: 378 GYISNYEVEYIKYNTLDTVAISKPGD------RCEVVGWGSMMPAGEDTARFLQKAYVNI 539
++ E + + + GD C V GWG GE LQK + +
Sbjct: 491 APLNYTEFQ-------KPICLPSKGDTSTIYTNCWVTGWGFSKEKGE-IQNILQKVNIPL 542
Query: 540 ISNEECSKKFRNMKYVRSNICAGSGNLSTSSCRGDSGGPLFCRDSRNRHIQVGIVSYGIV 719
++NEEC K++++ K + +CAG +C+GDSGGPL C+ + + VGI S+G
Sbjct: 543 VTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRL-VGITSWG-E 600
Query: 720 PCGRPNVPTVYTKVSEVARWI 782
C R P VYTKV+E WI
Sbjct: 601 GCARREQPGVYTKVAEYMDWI 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,986,698
Number of Sequences: 369166
Number of extensions: 2326049
Number of successful extensions: 7791
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6366
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6752
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)