Planaria EST Database

DrC_00454

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00454
         (1672 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q01406|SRC8_CHICK  Src substrate protein p85 (p80) (Corta...   458   e-128
sp|Q60598|SRC8_MOUSE  Src substrate cortactin                     451   e-126
sp|Q14247|SRC8_HUMAN  Src substrate cortactin (Amplaxin) (On...   449   e-125
sp|P14317|HCLS1_HUMAN  Hematopoietic lineage cell-specific p...   290   1e-77
sp|P49710|HCLS1_MOUSE  Hematopoietic lineage cell-specific p...   287   7e-77
sp|Q6XPR3|RPTN_HUMAN  Repetin                                      67   2e-10
sp|Q925Q9|SH3K1_RAT  SH3-domain kinase binding protein 1 (SH...    67   2e-10
sp|Q8R550|SH3K1_MOUSE  SH3-domain kinase binding protein 1 (...    66   3e-10
sp|Q14847|LASP1_HUMAN  LIM and SH3 domain protein 1 (LASP-1)...    66   3e-10
sp|Q99MZ8|LASP1_RAT  LIM and SH3 domain protein 1 (LASP-1)         65   4e-10

>sp|Q01406|SRC8_CHICK Src substrate protein p85 (p80) (Cortactin)
          Length = 563

 Score =  458 bits (1179), Expect = e-128
 Identities = 250/558 (44%), Positives = 337/558 (60%), Gaps = 59/558 (10%)
 Frame = +3

Query: 36   INMWKATAGSXXXXXXXXXXXXXXXXXXXXFQNDVTEKEQRWGSKTVSGSGRTDFIDLSA 215
            + MWKATAG                     F NDV+EKEQRWG+KTV GSG  + I++  
Sbjct: 9    LQMWKATAGHSIAVSQDDGADDWETDPD--FVNDVSEKEQRWGAKTVKGSGHQEHINIHQ 66

Query: 216  LKESVKKSDADNKKIAYDRSSKPSYGYGGSFGVQKDRMDKCAVGNDYVAAVDKHTSQKDY 395
            L+E+V +     K+   +   K S+GYGG FGV++DRMDK AVG++Y + + KH SQ D 
Sbjct: 67   LRENVFQEHQTIKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDS 126

Query: 396  SQGFGGKYGVQSDRKDKSAAGWEYQAEVQKHGSQQDYSKGFGGKYGVQKDRQDKAAVGWE 575
             +GFGGK+GVQ+DR D+SA G+EYQ + +KH SQ+DYS GFGGKYGVQ DR DK+AVG++
Sbjct: 127  VKGFGGKFGVQTDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFD 186

Query: 576  HKAELEKHSSQKDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGGKYG 755
            ++ + EKH SQKDYS+GFGGK+GV K++ DKSAVG+E++ +TEKH SQ+DY KGFGGK+G
Sbjct: 187  YQGKTEKHESQKDYSKGFGGKYGVDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFG 246

Query: 756  VQTDRQDKCAVGWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHG 935
            VQTDRQDKCA+GW+H+E++  H SQ+DY  GFGGKFGVQ ERQD SAVG+++KE+  KH 
Sbjct: 247  VQTDRQDKCALGWDHQEKVQLHESQKDYKSGFGGKFGVQTERQDPSAVGFDYKEKLAKHE 306

Query: 936  SQQDYSKGFGGKYGVQTDRQDKSAVGWE---------------------------HKEEV 1034
            SQQDYSKGFGGKYGVQ DR DK+A  +E                           + E +
Sbjct: 307  SQQDYSKGFGGKYGVQKDRMDKNAATFEDIEKPTSTYQKTKPVERVANKTSSIRANLENL 366

Query: 1035 GKHSSQTDQSKGFGGKF-GVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTA------TV 1193
             K   Q D+ K    +   +  ++Q++       E+ +K    Q  P  PT       T 
Sbjct: 367  AKEKEQEDRRKAEAERAQRMAREKQEQEEARRKLEEQAK-AKKQTPPPSPTTQPAEPKTP 425

Query: 1194 TKKIEQLSVKEDIRIEEQSSNDPV----EPVAGYG------EEHHSHDIEETEPQHNLET 1343
            +  + Q +V  D     ++S+       EP +GY       +E  S    E EP+   E 
Sbjct: 426  SSPVYQDAVSYDAESAYKNSSTTYSAEHEPESGYKTTGSDYQEAVSQREAEYEPETVYEV 485

Query: 1344 NQSSDE---------------GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVG 1478
              + D                G+ A+AL+D+    +DE++F   D IT+IE ID GWW G
Sbjct: 486  AGAGDHYQAEENTYDEYENELGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRG 545

Query: 1479 VINGRKGMFPSNYVEINE 1532
            V  GR G+FP+NYVE+ +
Sbjct: 546  VCKGRYGLFPANYVELRQ 563

>sp|Q60598|SRC8_MOUSE Src substrate cortactin
          Length = 546

 Score =  451 bits (1159), Expect = e-126
 Identities = 237/547 (43%), Positives = 327/547 (59%), Gaps = 50/547 (9%)
 Frame = +3

Query: 42   MWKATAGSXXXXXXXXXXXXXXXXXXXXFQNDVTEKEQRWGSKTVSGSGRTDFIDLSALK 221
            MWKA+AG                     F NDV+EKEQRWG+KTV GSG  + I++  L+
Sbjct: 1    MWKASAGHAVSITQDDGGADDWETDPD-FVNDVSEKEQRWGAKTVQGSGHQEHINIHKLR 59

Query: 222  ESVKKSDADNKKIAYDRSSKPSYGYGGSFGVQKDRMDKCAVGNDYVAAVDKHTSQKDYSQ 401
            E+V +     K+   +   K S+GYGG FGV++DRMD+ AVG++Y + + KH SQ D  +
Sbjct: 60   ENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVR 119

Query: 402  GFGGKYGVQSDRKDKSAAGWEYQAEVQKHGSQQDYSKGFGGKYGVQKDRQDKAAVGWEHK 581
            GFGGK+GVQ DR D+SA G+EYQ + +KH SQ+DYS GFGGKYGVQ DR DK+AVG++++
Sbjct: 120  GFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQ 179

Query: 582  AELEKHSSQKDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGGKYGVQ 761
             + EKH SQKDYS+GFGGK+G+ K++ DKSAVG+E++ +TEKH SQ+DY KGFGGK+GVQ
Sbjct: 180  GKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQ 239

Query: 762  TDRQDKCAVGWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQ 941
            TDRQDKCA+GW+H+E+L  H SQ+DY  GFGGKFGVQ ERQD SAVG+++KE   KH  Q
Sbjct: 240  TDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHEPQ 299

Query: 942  QDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKF--------GVQS 1097
            QDY+KGFGGKYGVQ DR DK+A  +E   +V     +T   +    K          +  
Sbjct: 300  QDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAK 359

Query: 1098 DRQDKSALGWDTEQVSKNVSHQNEPD-----VPTATVTKKIEQLSVKEDIRIEEQSSNDP 1262
            +R+ +     + E+  +    + E +     +      KK    +      IE++  + P
Sbjct: 360  EREQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDRPPSSP 419

Query: 1263 VEPVAGYGEEHHSHDIEETEPQHNLET--------------------------------- 1343
            +   A   +   S+   E EP++++E                                  
Sbjct: 420  IYEDAAPFKAEPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGHYQAED 479

Query: 1344 ----NQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPS 1511
                   SD G+ A+AL+D+    +DE++F   D IT+IE ID GWW GV  GR G+FP+
Sbjct: 480  DTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPA 539

Query: 1512 NYVEINE 1532
            NYVE+ +
Sbjct: 540  NYVELRQ 546

>sp|Q14247|SRC8_HUMAN Src substrate cortactin (Amplaxin) (Oncogene EMS1)
          Length = 550

 Score =  449 bits (1154), Expect = e-125
 Identities = 247/552 (44%), Positives = 331/552 (59%), Gaps = 55/552 (9%)
 Frame = +3

Query: 42   MWKATAGSXXXXXXXXXXXXXXXXXXXXFQNDVTEKEQRWGSKTVSGSGRTDFIDLSALK 221
            MWKA+AG                     F NDV+EKEQRWG+KTV GSG  + I++  L+
Sbjct: 1    MWKASAGHAVSIAQDDAGADDWETDPD-FVNDVSEKEQRWGAKTVQGSGHQEHINIHKLR 59

Query: 222  ESVKKSDADNKKIAYDRSSKPSYGYGGSFGVQKDRMDKCAVGNDYVAAVDKHTSQKDYSQ 401
            E+V +     K+   +   K S+GYGG FGV++DRMDK AVG++Y + + KH SQ D  +
Sbjct: 60   ENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVR 119

Query: 402  GFGGKYGVQSDRKDKSAAGWEYQAEVQKHGSQQDYSKGFGGKYGVQKDRQDKAAVGWEHK 581
            GFGGK+GVQ DR D+SA G+EYQ + +KH SQ+DYS GFGGKYGVQ DR DK+AVG++++
Sbjct: 120  GFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQ 179

Query: 582  AELEKHSSQKDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGGKYGVQ 761
             + EKH SQ+DYS+GFGGK+G+ K++ DKSAVG+E++ +TEKH SQ+DY KGFGGK+GVQ
Sbjct: 180  GKTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQ 239

Query: 762  TDRQDKCAVGWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQ 941
            TDRQDKCA+GW+H+E+L  H SQ+DY  GFGGKFGVQ ERQD +AVG+++KE+  KH SQ
Sbjct: 240  TDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ 299

Query: 942  QDYSKGFGGKYGVQTDRQDKSAVGWE---------------------------HKEEVGK 1040
            QDYSKGFGGKYGVQ DR DK+A  +E                           + E + K
Sbjct: 300  QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359

Query: 1041 HSSQTDQSKGFGGKF-GVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTATVTKK----- 1202
               Q D+ K    +   +  +RQ++       E+ ++    Q  P  P    T++     
Sbjct: 360  EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR-AKTQTPPVSPAPQPTEERLPSS 418

Query: 1203 ---IEQLSVKEDIRIEEQSSNDPVEPV-----AGYGEEHHSHDI--------EETE-PQH 1331
                +  S K ++      S    EPV     A Y E      +        E  E P H
Sbjct: 419  PVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGH 478

Query: 1332 NLETNQSSDE-----GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRK 1496
                + + DE     G  AVAL+D+    +DE++F   D IT+IE ID GWW GV  GR 
Sbjct: 479  YPAEDSTYDEYENDLGYTAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538

Query: 1497 GMFPSNYVEINE 1532
            G+FP+NYVE+ +
Sbjct: 539  GLFPANYVELRQ 550

>sp|P14317|HCLS1_HUMAN Hematopoietic lineage cell-specific protein (Hematopoietic
            cell-specific LYN substrate 1) (LckBP1) (p75)
          Length = 486

 Score =  290 bits (741), Expect = 1e-77
 Identities = 181/499 (36%), Positives = 266/499 (53%), Gaps = 30/499 (6%)
 Frame = +3

Query: 126  FQNDVTEKEQRWGSKTVSGSGRTDFIDLSALKESVKKSDADNKKIAYDRSSKPSYGYGGS 305
            F ND++EKEQRWG+KT+ GSGRT+ I++  L+  V +     +K   +   K S+GYGG 
Sbjct: 27   FVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGR 86

Query: 306  FGVQKDRMDKCAVGNDYVAAVDKHTSQKDYSQGFGGKYGVQSDRKDKSAAGWEYQAEVQK 485
            FGV++DRMDK AVG++YVA V+KH+SQ D ++GFGGKYGV+ DR DKSA G++Y+ EV+K
Sbjct: 87   FGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEK 146

Query: 486  HGSQQDYSKGFGGKYGVQKDRQDKAAVGWEHKAELEKHSSQKDYSQGFGGKFGVQKERQD 665
            H SQ+DYS+GFGG+YGV+KD+ DKAA+G+++K E EKH SQ+DY++GFGG++G+QK+R D
Sbjct: 147  HTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVD 206

Query: 666  KSAVGWEHKE-ETEKHGSQQDYSKGFGGKYGVQTDRQDKCAVGWEHKEELGKHASQQDYS 842
            KSAVG+   E  T  +           G  G++   +          EE  K   ++   
Sbjct: 207  KSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMA-------EEKRKREEEEKAQ 259

Query: 843  QGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGGKYGVQTDRQDK-SAVGWE 1019
            Q       V + +Q++ AV     E  +   + ++ +        V      K S+  W 
Sbjct: 260  Q-------VARRQQERKAVTKRSPEAPQPVIAMEEPA--------VPAPLPKKISSEAW- 303

Query: 1020 HKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTATVTK 1199
                VG   S   +         V++ R+    L      + + +   NE   P A   +
Sbjct: 304  --PPVGTPPSSESEP--------VRTSREHPVPL----LPIRQTLPEDNEE--PPALPPR 347

Query: 1200 KIEQLSVKEDIRIEEQSSNDP---VEPVAGYG-----EEHHSHDIEETEPQHNLETNQSS 1355
             +E L V+E+   E +   +P    EP   Y      + H   D  E + +  LE   SS
Sbjct: 348  TLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSS 407

Query: 1356 DE--------------------GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWV 1475
                                  G+ AVAL+D+ GE  DE++F   D IT IE +D GWW 
Sbjct: 408  FSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWR 467

Query: 1476 GVINGRKGMFPSNYVEINE 1532
            G  +G  G+FP+NYV++ E
Sbjct: 468  GRCHGHFGLFPANYVKLLE 486

>sp|P49710|HCLS1_MOUSE Hematopoietic lineage cell-specific protein (Hematopoietic
            cell-specific LYN substrate 1) (LckBP1)
          Length = 486

 Score =  287 bits (734), Expect = 7e-77
 Identities = 178/494 (36%), Positives = 263/494 (53%), Gaps = 27/494 (5%)
 Frame = +3

Query: 126  FQNDVTEKEQRWGSKTVSGSGRTDFIDLSALKESVKKSDADNKKIAYDRSSKPSYGYGGS 305
            F ND++EKEQRWG+KT+ GSGRT+ I++  L+  V +     KK   +   K S+GYGG 
Sbjct: 27   FVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDILKKKELESGPKASHGYGGQ 86

Query: 306  FGVQKDRMDKCAVGNDYVAAVDKHTSQKDYSQGFGGKYGVQSDRKDKSAAGWEYQAEVQK 485
            FGV++DRMDK AVG++YVA V+KH+SQ D ++GFGGKYGV+ DR DKSA G++Y+ EV+K
Sbjct: 87   FGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVERDRADKSAVGFDYKGEVEK 146

Query: 486  HGSQQDYSKGFGGKYGVQKDRQDKAAVGWEHKAELEKHSSQKDYSQGFGGKFGVQKERQD 665
            H SQ+DYS GFGG+YGV+KD++DKAA+G+++K E EKH SQ+DY++GFGG++G+QK+R D
Sbjct: 147  HASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVD 206

Query: 666  KSAVGWEHKE-ETEKHGSQQDYSKGFGGKYGVQTDRQDKCAVGWEHKEELGKHASQQDYS 842
            KSAVG+   E  T  +           G  G++   +          EE  K   ++   
Sbjct: 207  KSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESLA-------EEKRKREEEEKAQ 259

Query: 843  QGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEH 1022
            Q       + +++Q++ AV    +E  +     ++ +         Q  ++  S V W  
Sbjct: 260  Q-------MARQQQERKAVVKMSREVQQPSMPVEEPAA------PAQLPKKISSEV-WPP 305

Query: 1023 KEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTATVTKK 1202
             E      SQ  +S            R++       T Q S   +H  + + P A   + 
Sbjct: 306  AESHLPPESQPVRS------------RREYPVPSLPTRQ-SPLQNHLEDNEEPPALPPRT 352

Query: 1203 IEQLSVKEDIRIEEQSSNDPVEPVAGYGEEHHS---------------------HDIEET 1319
             E L V E+   E     +P EP   Y  E  +                      D+ E 
Sbjct: 353  PEGLQVVEEPVYEAAPELEP-EPEPDYEPEPETEPDYEDVGELDRQDEDAEGDYEDVLEP 411

Query: 1320 EPQHNLE-----TNQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVI 1484
            E   +L      +  +   G+ A+AL+D+ GE  DE++F   D IT IE +D GWW G  
Sbjct: 412  EDTPSLSYQAGPSAGAGGAGISAIALYDYQGEGSDELSFDPDDIITDIEMVDEGWWRGQC 471

Query: 1485 NGRKGMFPSNYVEI 1526
             G  G+FP+NYV++
Sbjct: 472  RGHFGLFPANYVKL 485


 Score =  193 bits (491), Expect = 1e-48
 Identities = 109/288 (37%), Positives = 167/288 (57%), Gaps = 29/288 (10%)
 Frame = +3

Query: 444  KSAAGWEYQAEVQKHGSQQDYSKGFGGKYGVQKDR------------------QDKAAVG 569
            KS  G +    V+  G   D    F      ++ R                  Q +  V 
Sbjct: 3    KSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVS 62

Query: 570  WEH----KAELEKHSSQKDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKG 737
             EH    K ELE   S    S G+GG+FGV+++R DKSAVG E+  + EKH SQ D ++G
Sbjct: 63   EEHDILKKKELE---SGPKASHGYGGQFGVERDRMDKSAVGHEYVADVEKHSSQTDAARG 119

Query: 738  FGGKYGVQTDRQDKCAVGWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKE 917
            FGGKYGV+ DR DK AVG+++K E+ KHASQ+DYS GFGG++GV+K+++DK+A+G+++K 
Sbjct: 120  FGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKG 179

Query: 918  ETEKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKE-------EVGKHSSQTDQSKGFG 1076
            ETEKH SQ+DY+KGFGG+YG+Q DR DKSAVG+   E       +     + +  ++G  
Sbjct: 180  ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK 239

Query: 1077 GKFGVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTATVTKKIEQLSV 1220
             KF   ++ + K     + E+ ++ ++ Q +       ++++++Q S+
Sbjct: 240  AKFESLAEEKRKR----EEEEKAQQMARQQQERKAVVKMSREVQQPSM 283

>sp|Q6XPR3|RPTN_HUMAN Repetin
          Length = 784

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 89/337 (26%), Positives = 147/337 (43%), Gaps = 23/337 (6%)
 Frame = +3

Query: 234  KSDADNKKIAYDRSSKPSYGYGGSFGVQKDRMDKCAVGNDYVAAVDKHTSQ-KDYSQGFG 410
            +S+  +K  ++D+S + S        V        A    ++ A+++     +D   G  
Sbjct: 184  QSERQDKDFSFDQSERQSQDSSSGKKVSHKSTSGQAKWQGHIFALNRCEKPIQDSHYGQS 243

Query: 411  GKYGVQSDRKDKSAAGWEYQAEVQKHGSQQDYSKGFGGKYGV-QKDRQDKAAVGWEHKAE 587
             ++  QS+   +  A    Q   QK GS    S+  G + G  Q DRQ +++    H  +
Sbjct: 244  ERHTQQSETLGQ--ASHFNQTNQQKSGSYCGQSERLGQELGCGQTDRQGQSS----HYGQ 297

Query: 588  LEKHSSQKDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSK----GFGGKYG 755
             ++    +D S  +G     Q +RQ +S+    H  +T++ G    YS+    G    YG
Sbjct: 298  TDR----QDQSYHYG-----QTDRQGQSS----HYSQTDRQGQSSHYSQPDRQGQSSHYG 344

Query: 756  VQTDRQDKCA-VGWEHKEELGKHASQQDYSQGFGGKFGV-----------QKERQDKSAV 899
             Q DR+ +C      +++  G H SQ +  QG    +G            Q +RQD+S+ 
Sbjct: 345  -QMDRKGQCYHYDQTNRQGQGSHYSQPN-RQGQSSHYGQPDTQDQSSHYGQTDRQDQSS- 401

Query: 900  GWEHKEETEKHGSQQDYS----KGFGGKYGVQTDRQDKSA-VGWEHKEEVGKHSSQTDQS 1064
               H  +TE+ G    YS    +G G  YG QTDRQ +S+  G   ++    H  QTD+ 
Sbjct: 402  ---HYGQTERQGQSSHYSQMDRQGQGSHYG-QTDRQGQSSHYGQPDRQGQNSHYGQTDR- 456

Query: 1065 KGFGGKFGVQSDRQDKSALGWDTEQVSKNVSHQNEPD 1175
            +G    +G Q+DRQ +S             SH ++PD
Sbjct: 457  QGQSSHYG-QTDRQGQS-------------SHYSQPD 479

>sp|Q925Q9|SH3K1_RAT SH3-domain kinase binding protein 1 (SH3 containing, expressed in
            tumorigenic astrocytes) (Regulator of ubiquitous kinase)
            (Ruk)
          Length = 709

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 31/67 (46%), Positives = 45/67 (67%), Gaps = 1/67 (1%)
 Frame = +3

Query: 1371 AVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYV-EINE*KNIY 1547
            A+  FD+  + +DE+  + G+ IT+I K D GWW G INGR+G+FP N+V EI   K++ 
Sbjct: 4    AIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIK--KDVK 61

Query: 1548 KHLLINR 1568
            K LL N+
Sbjct: 62   KDLLSNK 68


 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 22/51 (43%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
 Frame = +3

Query: 1380 LFDFDGEEEDEVNFAAGDTITHIEK--IDSGWWVGVINGRKGMFPSNYVEI 1526
            +F ++ + +DE+    GD +T I K  ID GWW G +NGR+G+FP N+V++
Sbjct: 319  IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 369


 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
 Frame = +3

Query: 1218 VKEDIRIEEQSSNDPVEPVAGYGEEHHSHDIEE----TEPQHNLETNQSSDEGLIAVAL- 1382
            +K+D++ +  S+  P +P+         HD+         +  L TN+  +       + 
Sbjct: 56   IKKDVKKDLLSNKAPEKPM---------HDVSSGNSLLSSETILRTNKRGERRRRRCQVA 106

Query: 1383 FDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYVE 1523
            F +  + +DE+    GD I  + +++ GWW GV+NG+ GMFPSN+++
Sbjct: 107  FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153

>sp|Q8R550|SH3K1_MOUSE SH3-domain kinase binding protein 1 (SH3 containing, expressed in
            tumorigenic astrocytes) (Regulator of ubiquitous kinase)
            (Ruk)
          Length = 709

 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 31/67 (46%), Positives = 45/67 (67%), Gaps = 1/67 (1%)
 Frame = +3

Query: 1371 AVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYV-EINE*KNIY 1547
            A+  FD+  + +DE+  + G+ IT+I K D GWW G INGR+G+FP N+V EI   K++ 
Sbjct: 4    AIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIK--KDMK 61

Query: 1548 KHLLINR 1568
            K LL N+
Sbjct: 62   KDLLSNK 68


 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 22/51 (43%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
 Frame = +3

Query: 1380 LFDFDGEEEDEVNFAAGDTITHIEK--IDSGWWVGVINGRKGMFPSNYVEI 1526
            +F ++ + +DE+    GD +T I K  ID GWW G +NGR+G+FP N+V++
Sbjct: 319  IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 369


 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
 Frame = +3

Query: 1218 VKEDIRIEEQSSNDPVEPVAGYGEEHHSHDIEE----TEPQHNLETNQSSDEGLIAVAL- 1382
            +K+D++ +  S+  P +P+         HD+         +  L TN+  +       + 
Sbjct: 56   IKKDMKKDLLSNKAPEKPM---------HDVSSGNALLSSETILRTNKRGERRRRRCQVA 106

Query: 1383 FDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYVE 1523
            F +  + +DE+    GD I  + +++ GWW GV+NG+ GMFPSN+++
Sbjct: 107  FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153

>sp|Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1) (MLN 50)
          Length = 261

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 58/248 (23%), Positives = 96/248 (38%), Gaps = 3/248 (1%)
 Frame = +3

Query: 789  GWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGG 968
            G+E K     H  +Q ++        ++ ++Q +      +KEE EK+       KG G 
Sbjct: 46   GYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKN-------KGKGF 98

Query: 969  KYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWDTEQVSK 1148
                 T    +     +    +  H        G  G  G++ +R+D      D     +
Sbjct: 99   SVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQ----DGSSYRR 154

Query: 1149 NVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPV-EPVAGYGEEHHSHDIEETEP 1325
             +  Q    +PT+                + +Q    PV +   GY E      I+ + P
Sbjct: 155  PLEQQQPHHIPTSAP--------------VYQQPQQQPVAQSYGGYKEPAAPVSIQRSAP 200

Query: 1326 QHNLETNQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVI--NGRKG 1499
                        G    A++D+   +EDEV+F  GDTI ++++ID GW  G +   G  G
Sbjct: 201  ---------GGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTG 251

Query: 1500 MFPSNYVE 1523
            M P+NYVE
Sbjct: 252  MLPANYVE 259

>sp|Q99MZ8|LASP1_RAT LIM and SH3 domain protein 1 (LASP-1)
          Length = 263

 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 62/251 (24%), Positives = 97/251 (38%), Gaps = 6/251 (2%)
 Frame = +3

Query: 789  GWEHKEELGKHASQQDYSQGFGGKFGVQKERQDKSAVGWEHKEETEKHGSQQDYSKGFGG 968
            G+E K     H  +Q ++        ++ ++Q +      +KEE EK+       KG G 
Sbjct: 46   GYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKN-------KGKGF 98

Query: 969  KYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR---QDKSALGWDTEQ 1139
                 T    +     +    +  H        G  G  G++ +R   QD S+    TEQ
Sbjct: 99   SVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGIEPERREAQDSSSYRRPTEQ 158

Query: 1140 VSKNVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEP-VAGYGEEHHSHDIEE 1316
                  H     +PT+                + +Q     V P   GY E      I+ 
Sbjct: 159  QQPQPHH-----IPTSAP--------------VYQQPQQQQVTPSYGGYKEPAAPVSIQR 199

Query: 1317 TEPQHNLETNQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVI--NG 1490
            + P            G    A++D+   +EDEV+F  GDTI ++++ID GW  G +   G
Sbjct: 200  SAP---------GGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTG 250

Query: 1491 RKGMFPSNYVE 1523
              GM P+NYVE
Sbjct: 251  DTGMLPANYVE 261

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 188,547,084
Number of Sequences: 369166
Number of extensions: 4189409
Number of successful extensions: 13937
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 11108
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 13647
length of database: 68,354,980
effective HSP length: 116
effective length of database: 46,925,720
effective search space used: 20647316800
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

DrC_00454

  1. Dr_sW_011_O14
  2. Dr_sW_022_H18
  3. Dr_sW_026_K10
  4. Dr_sW_028_D17
  5. Dr_sW_007_J12