Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_D17
(708 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q01406|SRC8_CHICK Src substrate protein p85 (p80) (Corta... 112 1e-24
sp|Q14247|SRC8_HUMAN Src substrate cortactin (Amplaxin) (On... 111 2e-24
sp|Q60598|SRC8_MOUSE Src substrate cortactin 111 2e-24
sp|P14317|HCLS1_HUMAN Hematopoietic lineage cell-specific p... 102 1e-21
sp|P49710|HCLS1_MOUSE Hematopoietic lineage cell-specific p... 100 3e-21
sp|Q925Q9|SH3K1_RAT SH3-domain kinase binding protein 1 (SH... 67 5e-11
sp|Q8R550|SH3K1_MOUSE SH3-domain kinase binding protein 1 (... 66 8e-11
sp|P43603|YFJ4_YEAST Hypothetical 40.4 kDa protein in PES4-... 64 4e-10
sp|Q9UJU6|DBNL_HUMAN Drebrin-like protein (SH3 domain-conta... 64 5e-10
sp|P38479|ABP1_SACEX Actin-binding protein 63 7e-10
>sp|Q01406|SRC8_CHICK Src substrate protein p85 (p80) (Cortactin)
Length = 563
Score = 112 bits (279), Expect = 1e-24
Identities = 52/82 (63%), Positives = 67/82 (81%), Gaps = 1/82 (1%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DY KGFGGK+GVQTDRQDK A+GW+H+E+V H SQ D GFGGKFGVQ++R
Sbjct: 229 EKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKVQLHESQKDYKSGFGGKFGVQTER 288
Query: 182 QDKSALGWD-TEQVSKNVSHQN 244
QD SA+G+D E+++K+ S Q+
Sbjct: 289 QDPSAVGFDYKEKLAKHESQQD 310
Score = 110 bits (276), Expect = 3e-24
Identities = 53/84 (63%), Positives = 65/84 (77%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYSKGFGGKYGV D+ DKSAVG+E++ + KH SQ D KGFGGKFGVQ+DR
Sbjct: 192 EKHESQKDYSKGFGGKYGVDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDR 251
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
QDK ALGWD ++ K H+++ D
Sbjct: 252 QDKCALGWDHQE--KVQLHESQKD 273
Score = 107 bits (268), Expect = 2e-23
Identities = 81/261 (31%), Positives = 116/261 (44%), Gaps = 59/261 (22%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWE---------------------------HK 103
KH SQQDYSKGFGGKYGVQ DR DK+A +E +
Sbjct: 304 KHESQQDYSKGFGGKYGVQKDRMDKNAATFEDIEKPTSTYQKTKPVERVANKTSSIRANL 363
Query: 104 EEVGKHSSQTDQSKGFGGKF-GVQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTA----- 265
E + K Q D+ K + + ++Q++ E+ +K Q P PT
Sbjct: 364 ENLAKEKEQEDRRKAEAERAQRMAREKQEQEEARRKLEEQAK-AKKQTPPPSPTTQPAEP 422
Query: 266 -TVTKKIEQLSVKEDIRIEEQSSNDPV----EPVAGYG------EEHHSHDIEETEPQHN 412
T + + Q +V D ++S+ EP +GY +E S E EP+
Sbjct: 423 KTPSSPVYQDAVSYDAESAYKNSSTTYSAEHEPESGYKTTGSDYQEAVSQREAEYEPETV 482
Query: 413 LETNQSSDE---------------GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGW 547
E + D G+ A+AL+D+ +DE++F D IT+IE ID GW
Sbjct: 483 YEVAGAGDHYQAEENTYDEYENELGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGW 542
Query: 548 WVGVINGRKGMFPSNYVEINE 610
W GV GR G+FP+NYVE+ +
Sbjct: 543 WRGVCKGRYGLFPANYVELRQ 563
Score = 103 bits (257), Expect = 4e-22
Identities = 49/84 (58%), Positives = 62/84 (73%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYS GFGGKYGVQ DR DKSAVG++++ + KH SQ D SKGFGGK+GV D+
Sbjct: 155 EKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGVDKDK 214
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+ E K H+++ D
Sbjct: 215 VDKSAVGF--EYQGKTEKHESQKD 236
Score = 101 bits (252), Expect = 2e-21
Identities = 56/137 (40%), Positives = 77/137 (56%)
Frame = +2
Query: 8 HGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQD 187
H SQ+DY GFGGK+GVQT+RQD SAVG+++KE++ KH SQ D SKGFGGK+GVQ DR D
Sbjct: 268 HESQKDYKSGFGGKFGVQTERQDPSAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMD 327
Query: 188 KSALGWDTEQVSKNVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEPVAGYGE 367
K+A + E + K S + P V K + + +E+ D + A +
Sbjct: 328 KNAATF--EDIEKPTSTYQKTK-PVERVANKTSSIRANLENLAKEKEQEDRRKAEAERAQ 384
Query: 368 EHHSHDIEETEPQHNLE 418
E+ E + LE
Sbjct: 385 RMAREKQEQEEARRKLE 401
Score = 99.0 bits (245), Expect = 1e-20
Identities = 48/83 (57%), Positives = 63/83 (75%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQ 184
KH SQ D KGFGGK+GVQTDR D+SAVG+E++ + KH+SQ D S GFGGK+GVQ+DR
Sbjct: 119 KHCSQVDSVKGFGGKFGVQTDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRV 178
Query: 185 DKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+D + K H+++ D
Sbjct: 179 DKSAVGFDYQ--GKTEKHESQKD 199
Score = 85.9 bits (211), Expect = 1e-16
Identities = 41/75 (54%), Positives = 54/75 (72%)
Frame = +2
Query: 29 SKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWD 208
S G+GGK+GV+ DR DKSAVG E++ ++ KH SQ D KGFGGKFGVQ+DR D+SA+G+
Sbjct: 90 SHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVKGFGGKFGVQTDRVDQSAVGF- 148
Query: 209 TEQVSKNVSHQNEPD 253
E K H ++ D
Sbjct: 149 -EYQGKTEKHASQKD 162
>sp|Q14247|SRC8_HUMAN Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Length = 550
Score = 111 bits (278), Expect = 2e-24
Identities = 53/87 (60%), Positives = 66/87 (75%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYSKGFGGKYG+ D+ DKSAVG+E++ + KH SQ D KGFGGKFGVQ+DR
Sbjct: 183 EKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDR 242
Query: 182 QDKSALGWDTEQVSKNVSHQNEPDVPT 262
QDK ALGWD ++ K H+++ D T
Sbjct: 243 QDKCALGWDHQE--KLQLHESQKDYKT 267
Score = 110 bits (276), Expect = 3e-24
Identities = 51/82 (62%), Positives = 67/82 (81%), Gaps = 1/82 (1%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DY KGFGGK+GVQTDRQDK A+GW+H+E++ H SQ D GFGGKFGVQS+R
Sbjct: 220 EKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSER 279
Query: 182 QDKSALGWD-TEQVSKNVSHQN 244
QD +A+G+D E+++K+ S Q+
Sbjct: 280 QDSAAVGFDYKEKLAKHESQQD 301
Score = 104 bits (259), Expect = 3e-22
Identities = 56/137 (40%), Positives = 78/137 (56%)
Frame = +2
Query: 8 HGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQD 187
H SQ+DY GFGGK+GVQ++RQD +AVG+++KE++ KH SQ D SKGFGGK+GVQ DR D
Sbjct: 259 HESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMD 318
Query: 188 KSALGWDTEQVSKNVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEPVAGYGE 367
K+A T + VS + VP VT K + + +E+ D + A +
Sbjct: 319 KNA---STFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQ 375
Query: 368 EHHSHDIEETEPQHNLE 418
E+ E + LE
Sbjct: 376 RMAKERQEQEEARRKLE 392
Score = 103 bits (256), Expect = 6e-22
Identities = 48/84 (57%), Positives = 62/84 (73%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYS GFGGKYGVQ DR DKSAVG++++ + KH SQ D SKGFGGK+G+ D+
Sbjct: 146 EKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDKDK 205
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+ E K H+++ D
Sbjct: 206 VDKSAVGF--EYQGKTEKHESQKD 227
Score = 102 bits (254), Expect = 1e-21
Identities = 81/257 (31%), Positives = 112/257 (43%), Gaps = 55/257 (21%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWE---------------------------HK 103
KH SQQDYSKGFGGKYGVQ DR DK+A +E +
Sbjct: 295 KHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANF 354
Query: 104 EEVGKHSSQTDQSKGFGGKFG-VQSDRQDKSALGWDTEQVSKNVSHQNEPDVPTATVTKK 280
E + K Q D+ K + + +RQ++ E+ ++ Q P P T++
Sbjct: 355 ENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR-AKTQTPPVSPAPQPTEE 413
Query: 281 I--------EQLSVKEDIRIEEQSSNDPVEPV-----AGYGEEHHSHDI--------EET 397
+ S K ++ S EPV A Y E + E
Sbjct: 414 RLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESA 473
Query: 398 E-PQHNLETNQSSDE-----GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGV 559
E P H + + DE G AVAL+D+ +DE++F D IT+IE ID GWW GV
Sbjct: 474 EAPGHYPAEDSTYDEYENDLGYTAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV 533
Query: 560 INGRKGMFPSNYVEINE 610
GR G+FP+NYVE+ +
Sbjct: 534 CKGRYGLFPANYVELRQ 550
Score = 95.1 bits (235), Expect = 2e-19
Identities = 46/83 (55%), Positives = 62/83 (74%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQ 184
KH SQ D +GFGGK+GVQ DR D+SAVG+E++ + KH+SQ D S GFGGK+GVQ+DR
Sbjct: 110 KHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRV 169
Query: 185 DKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+D + K H+++ D
Sbjct: 170 DKSAVGFDYQ--GKTEKHESQRD 190
Score = 84.0 bits (206), Expect = 4e-16
Identities = 40/75 (53%), Positives = 53/75 (70%)
Frame = +2
Query: 29 SKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWD 208
S G+GGK+GV+ DR DKSAVG E++ ++ KH SQ D +GFGGKFGVQ DR D+SA+G+
Sbjct: 81 SHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGF- 139
Query: 209 TEQVSKNVSHQNEPD 253
E K H ++ D
Sbjct: 140 -EYQGKTEKHASQKD 153
>sp|Q60598|SRC8_MOUSE Src substrate cortactin
Length = 546
Score = 111 bits (278), Expect = 2e-24
Identities = 53/87 (60%), Positives = 66/87 (75%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYSKGFGGKYG+ D+ DKSAVG+E++ + KH SQ D KGFGGKFGVQ+DR
Sbjct: 183 EKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDR 242
Query: 182 QDKSALGWDTEQVSKNVSHQNEPDVPT 262
QDK ALGWD ++ K H+++ D T
Sbjct: 243 QDKCALGWDHQE--KLQLHESQKDYKT 267
Score = 110 bits (274), Expect = 5e-24
Identities = 51/82 (62%), Positives = 66/82 (80%), Gaps = 1/82 (1%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DY KGFGGK+GVQTDRQDK A+GW+H+E++ H SQ D GFGGKFGVQS+R
Sbjct: 220 EKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSER 279
Query: 182 QDKSALGWD-TEQVSKNVSHQN 244
QD SA+G+D E+++K+ Q+
Sbjct: 280 QDSSAVGFDYKERLAKHEPQQD 301
Score = 103 bits (257), Expect = 4e-22
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 50/252 (19%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKF------- 163
KH QQDY+KGFGGKYGVQ DR DK+A +E +V +T + K
Sbjct: 295 KHEPQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANF 354
Query: 164 -GVQSDRQDKSALGWDTEQVSKNVSHQNEPD-----VPTATVTKKIEQLSVKEDIRIEEQ 325
+ +R+ + + E+ + + E + + KK + IE++
Sbjct: 355 ENLAKEREQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDR 414
Query: 326 SSNDPVEPVAGYGEEHHSHDIEETEPQHNLET---------------------------- 421
+ P+ A + S+ E EP++++E
Sbjct: 415 PPSSPIYEDAAPFKAEPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGH 474
Query: 422 ---------NQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRK 574
SD G+ A+AL+D+ +DE++F D IT+IE ID GWW GV GR
Sbjct: 475 YQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 534
Query: 575 GMFPSNYVEINE 610
G+FP+NYVE+ +
Sbjct: 535 GLFPANYVELRQ 546
Score = 103 bits (256), Expect = 6e-22
Identities = 48/84 (57%), Positives = 62/84 (73%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYS GFGGKYGVQ DR DKSAVG++++ + KH SQ D SKGFGGK+G+ D+
Sbjct: 146 EKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDK 205
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+ E K H+++ D
Sbjct: 206 VDKSAVGF--EYQGKTEKHESQKD 227
Score = 99.8 bits (247), Expect = 6e-21
Identities = 54/137 (39%), Positives = 75/137 (54%)
Frame = +2
Query: 8 HGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQD 187
H SQ+DY GFGGK+GVQ++RQD SAVG+++KE + KH Q D +KGFGGK+GVQ DR D
Sbjct: 259 HESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHEPQQDYAKGFGGKYGVQKDRMD 318
Query: 188 KSALGWDTEQVSKNVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEPVAGYGE 367
K+A T + V + VP VT K + + +E+ D + A +
Sbjct: 319 KNA---STFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQ 375
Query: 368 EHHSHDIEETEPQHNLE 418
E+ E + LE
Sbjct: 376 RMAKERQEQEEARRKLE 392
Score = 95.5 bits (236), Expect = 1e-19
Identities = 46/83 (55%), Positives = 62/83 (74%)
Frame = +2
Query: 5 KHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQ 184
KH SQ D +GFGGK+GVQ DR D+SAVG+E++ + KH+SQ D S GFGGK+GVQ+DR
Sbjct: 110 KHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRV 169
Query: 185 DKSALGWDTEQVSKNVSHQNEPD 253
DKSA+G+D + K H+++ D
Sbjct: 170 DKSAVGFDYQ--GKTEKHESQKD 190
Score = 82.8 bits (203), Expect = 8e-16
Identities = 39/75 (52%), Positives = 53/75 (70%)
Frame = +2
Query: 29 SKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWD 208
S G+GGK+GV+ DR D+SAVG E++ ++ KH SQ D +GFGGKFGVQ DR D+SA+G+
Sbjct: 81 SHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGF- 139
Query: 209 TEQVSKNVSHQNEPD 253
E K H ++ D
Sbjct: 140 -EYQGKTEKHASQKD 153
>sp|P14317|HCLS1_HUMAN Hematopoietic lineage cell-specific protein (Hematopoietic
cell-specific LYN substrate 1) (LckBP1) (p75)
Length = 486
Score = 102 bits (253), Expect = 1e-21
Identities = 47/84 (55%), Positives = 65/84 (77%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ D +KGFGGKYGV+ DR DKSAVG+++K EV KH+SQ D S+GFGG++GV+ D+
Sbjct: 108 EKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDK 167
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
DK+ALG+D + + H+++ D
Sbjct: 168 WDKAALGYDYK--GETEKHESQRD 189
Score = 99.4 bits (246), Expect = 8e-21
Identities = 48/115 (41%), Positives = 78/115 (67%), Gaps = 5/115 (4%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYS+GFGG+YGV+ D+ DK+A+G+++K E KH SQ D +KGFGG++G+Q DR
Sbjct: 145 EKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDR 204
Query: 182 QDKSALGWDTEQVSKNVSHQNEPDVPTAT-----VTKKIEQLSVKEDIRIEEQSS 331
DKSA+G++ E + +++ + A+ + K E ++ ++ R EE+ +
Sbjct: 205 VDKSAVGFN-EMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKRKREEEEKA 258
Score = 90.1 bits (222), Expect = 5e-18
Identities = 43/73 (58%), Positives = 58/73 (79%), Gaps = 1/73 (1%)
Frame = +2
Query: 29 SKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWD 208
S G+GG++GV+ DR DKSAVG E+ EV KHSSQTD +KGFGGK+GV+ DR DKSA+G+D
Sbjct: 80 SHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFD 139
Query: 209 TE-QVSKNVSHQN 244
+ +V K+ S ++
Sbjct: 140 YKGEVEKHTSQKD 152
Score = 70.9 bits (172), Expect = 3e-12
Identities = 47/146 (32%), Positives = 67/146 (45%), Gaps = 28/146 (19%)
Frame = +2
Query: 257 PTATVTKKIEQLSVKEDIRIEEQSSNDPV---EPVAGYGE-----EHHSHDIEETEPQHN 412
P A + +E L V+E+ E + +P EP Y + H D E + +
Sbjct: 341 PPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEV 400
Query: 413 LETNQSSDE--------------------GLIAVALFDFDGEEEDEVNFAAGDTITHIEK 532
LE SS G+ AVAL+D+ GE DE++F D IT IE
Sbjct: 401 LEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEM 460
Query: 533 IDSGWWVGVINGRKGMFPSNYVEINE 610
+D GWW G +G G+FP+NYV++ E
Sbjct: 461 VDEGWWRGRCHGHFGLFPANYVKLLE 486
>sp|P49710|HCLS1_MOUSE Hematopoietic lineage cell-specific protein (Hematopoietic
cell-specific LYN substrate 1) (LckBP1)
Length = 486
Score = 100 bits (250), Expect = 3e-21
Identities = 46/84 (54%), Positives = 65/84 (77%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ D ++GFGGKYGV+ DR DKSAVG+++K EV KH+SQ D S GFGG++GV+ D+
Sbjct: 108 EKHSSQTDAARGFGGKYGVERDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDK 167
Query: 182 QDKSALGWDTEQVSKNVSHQNEPD 253
+DK+ALG+D + + H+++ D
Sbjct: 168 RDKAALGYDYK--GETEKHESQRD 189
Score = 100 bits (250), Expect = 3e-21
Identities = 49/115 (42%), Positives = 78/115 (67%), Gaps = 5/115 (4%)
Frame = +2
Query: 2 EKHGSQQDYSKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDR 181
EKH SQ+DYS GFGG+YGV+ D++DK+A+G+++K E KH SQ D +KGFGG++G+Q DR
Sbjct: 145 EKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDR 204
Query: 182 QDKSALGWDTEQVSKNVSHQNEPDVPTAT-----VTKKIEQLSVKEDIRIEEQSS 331
DKSA+G++ E + +++ + A+ + K E L+ ++ R EE+ +
Sbjct: 205 VDKSAVGFN-EMEAPTTAYKKTTPIEAASSGARGLKAKFESLAEEKRKREEEEKA 258
Score = 87.4 bits (215), Expect = 3e-17
Identities = 41/73 (56%), Positives = 58/73 (79%), Gaps = 1/73 (1%)
Frame = +2
Query: 29 SKGFGGKYGVQTDRQDKSAVGWEHKEEVGKHSSQTDQSKGFGGKFGVQSDRQDKSALGWD 208
S G+GG++GV+ DR DKSAVG E+ +V KHSSQTD ++GFGGK+GV+ DR DKSA+G+D
Sbjct: 80 SHGYGGQFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVERDRADKSAVGFD 139
Query: 209 TE-QVSKNVSHQN 244
+ +V K+ S ++
Sbjct: 140 YKGEVEKHASQKD 152
Score = 66.2 bits (160), Expect = 8e-11
Identities = 27/55 (49%), Positives = 38/55 (69%)
Frame = +2
Query: 440 GLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYVEI 604
G+ A+AL+D+ GE DE++F D IT IE +D GWW G G G+FP+NYV++
Sbjct: 431 GISAIALYDYQGEGSDELSFDPDDIITDIEMVDEGWWRGQCRGHFGLFPANYVKL 485
>sp|Q925Q9|SH3K1_RAT SH3-domain kinase binding protein 1 (SH3 containing, expressed in
tumorigenic astrocytes) (Regulator of ubiquitous kinase)
(Ruk)
Length = 709
Score = 67.0 bits (162), Expect = 5e-11
Identities = 31/67 (46%), Positives = 45/67 (67%), Gaps = 1/67 (1%)
Frame = +2
Query: 449 AVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYV-EINE*KNIY 625
A+ FD+ + +DE+ + G+ IT+I K D GWW G INGR+G+FP N+V EI K++
Sbjct: 4 AIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIK--KDVK 61
Query: 626 KHLLINR 646
K LL N+
Sbjct: 62 KDLLSNK 68
Score = 55.8 bits (133), Expect = 1e-07
Identities = 22/51 (43%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +2
Query: 458 LFDFDGEEEDEVNFAAGDTITHIEK--IDSGWWVGVINGRKGMFPSNYVEI 604
+F ++ + +DE+ GD +T I K ID GWW G +NGR+G+FP N+V++
Sbjct: 319 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 369
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
Frame = +2
Query: 296 VKEDIRIEEQSSNDPVEPVAGYGEEHHSHDIEE----TEPQHNLETNQSSDEGLIAVAL- 460
+K+D++ + S+ P +P+ HD+ + L TN+ + +
Sbjct: 56 IKKDVKKDLLSNKAPEKPM---------HDVSSGNSLLSSETILRTNKRGERRRRRCQVA 106
Query: 461 FDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYVE 601
F + + +DE+ GD I + +++ GWW GV+NG+ GMFPSN+++
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
>sp|Q8R550|SH3K1_MOUSE SH3-domain kinase binding protein 1 (SH3 containing, expressed in
tumorigenic astrocytes) (Regulator of ubiquitous kinase)
(Ruk)
Length = 709
Score = 66.2 bits (160), Expect = 8e-11
Identities = 31/67 (46%), Positives = 45/67 (67%), Gaps = 1/67 (1%)
Frame = +2
Query: 449 AVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYV-EINE*KNIY 625
A+ FD+ + +DE+ + G+ IT+I K D GWW G INGR+G+FP N+V EI K++
Sbjct: 4 AIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIK--KDMK 61
Query: 626 KHLLINR 646
K LL N+
Sbjct: 62 KDLLSNK 68
Score = 55.8 bits (133), Expect = 1e-07
Identities = 22/51 (43%), Positives = 35/51 (68%), Gaps = 2/51 (3%)
Frame = +2
Query: 458 LFDFDGEEEDEVNFAAGDTITHIEK--IDSGWWVGVINGRKGMFPSNYVEI 604
+F ++ + +DE+ GD +T I K ID GWW G +NGR+G+FP N+V++
Sbjct: 319 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 369
Score = 54.7 bits (130), Expect = 2e-07
Identities = 29/107 (27%), Positives = 55/107 (51%), Gaps = 5/107 (4%)
Frame = +2
Query: 296 VKEDIRIEEQSSNDPVEPVAGYGEEHHSHDIEE----TEPQHNLETNQSSDEGLIAVAL- 460
+K+D++ + S+ P +P+ HD+ + L TN+ + +
Sbjct: 56 IKKDMKKDLLSNKAPEKPM---------HDVSSGNALLSSETILRTNKRGERRRRRCQVA 106
Query: 461 FDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVINGRKGMFPSNYVE 601
F + + +DE+ GD I + +++ GWW GV+NG+ GMFPSN+++
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
>sp|P43603|YFJ4_YEAST Hypothetical 40.4 kDa protein in PES4-HIS2 intergenic region
Length = 373
Score = 63.9 bits (154), Expect = 4e-10
Identities = 29/54 (53%), Positives = 39/54 (72%), Gaps = 2/54 (3%)
Frame = +2
Query: 449 AVALFDFDGEEEDEVNFAAGDTITHIEKIDS--GWWVGVINGRKGMFPSNYVEI 604
AVAL+ F GEE ++ F GD IT ++K DS WW G +NGR+G+FP+NYVE+
Sbjct: 319 AVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVEL 372
>sp|Q9UJU6|DBNL_HUMAN Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F)
(Cervical SH3P7) (HPK1-interacting protein of 55 kDa)
(HIP-55) (Cervical mucin-associated protein)
Length = 430
Score = 63.5 bits (153), Expect = 5e-10
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 1/122 (0%)
Frame = +2
Query: 248 PDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEPVAGYGEEHHSHDIEETEPQHNLETNQ 427
P P V + E+ +E E P+ G G EH H I+
Sbjct: 319 PSTPPCLVQAE-EEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQG---------QG 368
Query: 428 SSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGV-INGRKGMFPSNYVEI 604
S +GL A AL+D+ ++ E++F + IT IE ID GWW G +G GMFP+NYVE+
Sbjct: 369 LSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVEL 428
Query: 605 NE 610
E
Sbjct: 429 IE 430
>sp|P38479|ABP1_SACEX Actin-binding protein
Length = 617
Score = 63.2 bits (152), Expect = 7e-10
Identities = 38/133 (28%), Positives = 64/133 (48%), Gaps = 2/133 (1%)
Frame = +2
Query: 206 DTEQVSKNVSHQNEPDVPTATVTKKIEQLSVKEDIRIEEQSSNDPVEPVAGYGEEHHSHD 385
+ E+ + P +P+ + E +E+ EE+ + P P G
Sbjct: 491 EEEEEEEEEEEAPAPSLPSRNAAPEPEPEQPQEEE--EEEEAPAPSLPSRG--------S 540
Query: 386 IEETEPQHNLETNQSSDEGLIAVALFDFDGEEEDEVNFAAGDTITHIEKIDSGWWVGVI- 562
+ PQ +E + + E A A +D++ E++E+ FA D I +IE +D WW+G +
Sbjct: 541 VPPPPPQRAVEPEEPAAEAPWATAEYDYEAGEDNELTFAENDKIINIEFVDDDWWLGELE 600
Query: 563 -NGRKGMFPSNYV 598
G+KG+FPSNYV
Sbjct: 601 TTGQKGLFPSNYV 613
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,382,585
Number of Sequences: 369166
Number of extensions: 1719312
Number of successful extensions: 6406
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5876
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6303
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6219306880
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)