DrC_00413
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00413 (1427 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (... 339 1e-92 sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (... 338 2e-92 sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (... 338 2e-92 sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p7... 338 2e-92 sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S... 330 8e-90 sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) ... 327 7e-89 sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (... 312 2e-84 sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (... 311 2e-84 sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha 3 (... 306 1e-82 sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (... 305 2e-82
>sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (p70-S6K) Length = 525 Score = 339 bits (870), Expect = 1e-92 Identities = 182/390 (46%), Positives = 239/390 (61%), Gaps = 9/390 (2%) Frame = +2 Query: 116 DEVEVNTNLNGSEQINSNDYESVSKSVDICEE------TVNPPGEKVTSHDFDXXXXXXX 277 DE+E LN E ++ E ++ CE+ +VN EK+ F+ Sbjct: 42 DELEEGGQLN--ESMDHGGVEPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGK 99 Query: 278 XXYGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKL 457 YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L Sbjct: 100 GGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDL 158 Query: 458 YFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRD 637 +AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRD Sbjct: 159 IYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD 218 Query: 638 LKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWS 814 LK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS Sbjct: 219 LKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWS 278 Query: 815 MGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGG 994 +G L+YDML G+ PF G NR + I K++ KL +P +L+ +RLG Sbjct: 279 LGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGA 338 Query: 995 SEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--S 1168 D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V SP S Sbjct: 339 GPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS 398 Query: 1169 TADDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 T +S F F+YV+P V E+ SF Sbjct: 399 TLSESANQVFLGFTYVAPSVLESVKEKFSF 428
>sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 338 bits (868), Expect = 2e-92 Identities = 183/388 (47%), Positives = 238/388 (61%), Gaps = 7/388 (1%) Frame = +2 Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283 DE+E LN S + YE + +I E +VN EK+ F+ Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101 Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463 YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L + Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160 Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643 AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220 Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820 EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280 Query: 821 ILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSE 1000 L+YDML G+ PF G NR + I K++ KL +P +L+ +RLG Sbjct: 281 ALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 340 Query: 1001 KDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STA 1174 D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V SP ST Sbjct: 341 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 400 Query: 1175 DDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 +S F F+YV+P V E+ SF Sbjct: 401 SESANQVFLGFTYVAPSVLESVKEKFSF 428
>sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (p70-S6K) Length = 525 Score = 338 bits (868), Expect = 2e-92 Identities = 183/388 (47%), Positives = 238/388 (61%), Gaps = 7/388 (1%) Frame = +2 Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283 DE+E LN S + YE + +I E +VN EK+ F+ Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101 Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463 YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L + Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160 Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643 AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220 Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820 EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280 Query: 821 ILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSE 1000 L+YDML G+ PF G NR + I K++ KL +P +L+ +RLG Sbjct: 281 ALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 340 Query: 1001 KDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STA 1174 D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V SP ST Sbjct: 341 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 400 Query: 1175 DDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 +S F F+YV+P V E+ SF Sbjct: 401 SESANQVFLGFTYVAPSVLESVKEKFSF 428
>sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p70-S6K) Length = 525 Score = 338 bits (868), Expect = 2e-92 Identities = 183/388 (47%), Positives = 238/388 (61%), Gaps = 7/388 (1%) Frame = +2 Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283 DE+E LN S + YE + +I E +VN EK+ F+ Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101 Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463 YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L + Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160 Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643 AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220 Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820 EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280 Query: 821 ILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSE 1000 L+YDML G+ PF G NR + I K++ KL +P +L+ +RLG Sbjct: 281 ALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 340 Query: 1001 KDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STA 1174 D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V SP ST Sbjct: 341 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTL 400 Query: 1175 DDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 +S F F+YV+P V E+ SF Sbjct: 401 SESANQVFLGFTYVAPSVLESVKEKFSF 428
>sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2) Length = 485 Score = 330 bits (845), Expect = 8e-90 Identities = 170/360 (47%), Positives = 226/360 (62%), Gaps = 3/360 (0%) Frame = +2 Query: 188 KSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMAGEYFAMKVVKKAR 367 + V++ E +VN E++ H F+ YG+V+ +KV G G+ +AMKV++KA+ Sbjct: 46 EEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAK 105 Query: 368 LVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQH 547 +V + K DT + ERNILE+V HPF+V+L +AFQT L+++LE L+GGELF HLER+ Sbjct: 106 IVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG 164 Query: 548 TLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDE 724 E+ A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ Sbjct: 165 IFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGA 224 Query: 725 LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINA 904 +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML GS PF NR + + K+I Sbjct: 225 ITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKG 284 Query: 905 KLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPP 1084 KL +P +L+ R+GG D +++RH FFR INWD AR + PP Sbjct: 285 KLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPP 344 Query: 1085 FIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 F P L S +DVS FD + V SP + +S F F+YV+P V E SF Sbjct: 345 FRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSF 404
>sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta) Length = 482 Score = 327 bits (837), Expect = 7e-89 Identities = 169/360 (46%), Positives = 225/360 (62%), Gaps = 3/360 (0%) Frame = +2 Query: 188 KSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMAGEYFAMKVVKKAR 367 + V++ E +VN E++ H F+ YG+V+ +KV G G+ +AMKV++KA+ Sbjct: 46 EEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAK 105 Query: 368 LVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQH 547 +V N K DT + ERNILE+V HPF+V+L +AFQT L+++LE L+GGELF HLER+ Sbjct: 106 IVRNAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG 164 Query: 548 TLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDE 724 E+ A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++ Sbjct: 165 IFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGA 224 Query: 725 LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINA 904 +TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML GS PF NR + + K+I Sbjct: 225 VTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG 284 Query: 905 KLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPP 1084 KL +P +L+ R+GG D +++RH FFR +NWD A + PP Sbjct: 285 KLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPP 344 Query: 1085 FIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQVYLEFSEQGSF 1258 F P L S +DVS FD + V SP + +S F F+YV+P V E SF Sbjct: 345 FRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSF 404
>sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 312 bits (799), Expect = 2e-84 Identities = 161/369 (43%), Positives = 226/369 (61%), Gaps = 2/369 (0%) Frame = +2 Query: 149 SEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMA 328 S ++ + E + K +DI V EK F+ YG+V+L +KV G+ A Sbjct: 26 SSSLSRLEEEGIVKEIDISNH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDA 84 Query: 329 GEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYL 508 G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+++L++L Sbjct: 85 GQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 141 Query: 509 AGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLT 688 GG+LF L ++ TEE+ +FYLAE LAL HLH +G+IYRDLK EN++LD GH+K+T Sbjct: 142 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKIT 201 Query: 689 DFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFIG 865 DFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML GS PF G Sbjct: 202 DFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQG 261 Query: 866 GNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSI 1045 +R + + ++ AKL +P+FLS RLG VEEIKRH FF +I Sbjct: 262 KDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTI 321 Query: 1046 NWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISPSTADDSNC-YWFENFSYVSP 1222 +W+K + +E+KPPF P + +D FD + SP +N + F FS+V+ Sbjct: 322 DWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381 Query: 1223 QVYLEFSEQ 1249 + E S+Q Sbjct: 382 SLVQEPSQQ 390
Score = 106 bits (265), Expect = 1e-22
Identities = 63/191 (32%), Positives = 109/191 (57%), Gaps = 5/191 (2%)
Frame = +2
Query: 311 VNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLF 490
V+ A EY A+K++ K++ +++ + +L HP ++ L + ++
Sbjct: 433 VHKATDAEY-AVKIIDKSKRDPSEEIEI--------LLRYGQHPNIITLKDVYDDGKYVY 483
Query: 491 MVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDR 667
+V+E + GGEL + RQ +E EA L + +LHS GV++RDLK N++ +D
Sbjct: 484 LVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDE 543
Query: 668 YGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYD 835
G+ +++ DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+GILLY
Sbjct: 544 SGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYT 603
Query: 836 MLIGSSPFIGG 868
ML G +PF G
Sbjct: 604 MLAGFTPFANG 614
>sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Length = 733 Score = 311 bits (798), Expect = 2e-84 Identities = 163/369 (44%), Positives = 226/369 (61%), Gaps = 2/369 (0%) Frame = +2 Query: 149 SEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMA 328 S ++ + E V K +DI V EK F+ YG+V+L +KV G+ A Sbjct: 26 SSSLSRLEEEGVVKEIDISHH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDA 84 Query: 329 GEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYL 508 G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+++L++L Sbjct: 85 GQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 141 Query: 509 AGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLT 688 GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+K+T Sbjct: 142 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKIT 201 Query: 689 DFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFIG 865 DFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML GS PF G Sbjct: 202 DFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQG 261 Query: 866 GNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSI 1045 +R + + ++ AKL +P+FLS RLG VEEIKRH FF +I Sbjct: 262 KDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 321 Query: 1046 NWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISPSTADDSNC-YWFENFSYVSP 1222 +W+ + +E+KPPF P L +D FD + SP +N + F FS+V+ Sbjct: 322 DWNTLYRKEIKPPFKPALGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 381 Query: 1223 QVYLEFSEQ 1249 + E S+Q Sbjct: 382 SLIQEPSQQ 390
Score = 105 bits (263), Expect = 2e-22
Identities = 63/181 (34%), Positives = 102/181 (56%), Gaps = 17/181 (9%)
Frame = +2
Query: 377 NKKNDTKYAM-----TERNILEAVN-------HPFLVKLYFAFQTNHSLFMVLEYLAGGE 520
+K DT+YA+ ++R+ E + HP ++ L + +++V+E + GGE
Sbjct: 434 HKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGE 493
Query: 521 LFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVML-DRYG---HVKLT 688
L + RQ +E EA L T + +LHS GV++RDLK N++ D G +++
Sbjct: 494 LLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVC 553
Query: 689 DFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFIG 865
DFG +K+ R + L + C T ++APE+L+R+G+ + D WS+GILLY ML G +PF
Sbjct: 554 DFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFAN 613
Query: 866 G 868
G
Sbjct: 614 G 614
>sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 306 bits (784), Expect = 1e-82 Identities = 160/360 (44%), Positives = 219/360 (60%), Gaps = 2/360 (0%) Frame = +2 Query: 146 GSEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAM 325 G E+IN E K + I V EK F+ +G+V+L KK++G+ Sbjct: 34 GEEEINPQTEEGSIKEIAITHH-VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92 Query: 326 AGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEY 505 A + +AMKV+KKA L + TK ER+IL VNHPF+VKL++AFQT L+++L++ Sbjct: 93 ARQLYAMKVLKKATLKVRDRVRTKM---ERDILVEVNHPFIVKLHYAFQTEGKLYLILDF 149 Query: 506 LAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKL 685 L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+KL Sbjct: 150 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKL 209 Query: 686 TDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFI 862 TDFGLSKE D E +SFCGTVEYMAPE++ RRGH S DWWS G+L+++ML G+ PF Sbjct: 210 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQ 269 Query: 863 GGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRS 1042 G +R + + ++ AKL +P+FLS RLG VEEIKRH FF + Sbjct: 270 GKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFST 329 Query: 1043 INWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISPSTADDSNCY-WFENFSYVS 1219 I+W+K + RE+ PPF P +D FD ++ SP +N + F FS+V+ Sbjct: 330 IDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA 389
Score = 103 bits (258), Expect = 9e-22
Identities = 59/182 (32%), Positives = 104/182 (57%), Gaps = 5/182 (2%)
Frame = +2
Query: 338 FAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGG 517
FA+K++ K++ ++ + +L HP ++ L + +++V E + GG
Sbjct: 448 FAVKIIDKSKRDPTEEIEI--------LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG 499
Query: 518 ELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYGH---VKL 685
EL + RQ +E EA L T + +LH+ GV++RDLK N++ +D G+ +++
Sbjct: 500 ELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI 559
Query: 686 TDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFI 862
DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G +PF
Sbjct: 560 CDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA 619
Query: 863 GG 868
G
Sbjct: 620 NG 621
>sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) Length = 740 Score = 305 bits (782), Expect = 2e-82 Identities = 160/360 (44%), Positives = 219/360 (60%), Gaps = 2/360 (0%) Frame = +2 Query: 146 GSEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAM 325 G E+IN E K + I V EK F+ +G+V+L KK++G+ Sbjct: 34 GEEEINPQTEEVSIKEIAITHH-VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92 Query: 326 AGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEY 505 A + +AMKV+KKA L + TK ER+IL VNHPF+VKL++AFQT L+++L++ Sbjct: 93 ARQLYAMKVLKKATLKVRDRVRTKM---ERDILVEVNHPFIVKLHYAFQTEGKLYLILDF 149 Query: 506 LAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKL 685 L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+KL Sbjct: 150 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKL 209 Query: 686 TDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFI 862 TDFGLSKE D E +SFCGTVEYMAPE++ RRGH S DWWS G+L+++ML G+ PF Sbjct: 210 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQ 269 Query: 863 GGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRS 1042 G +R + + ++ AKL +P+FLS RLG VEEIKRH FF + Sbjct: 270 GKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFST 329 Query: 1043 INWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISPSTADDSNCY-WFENFSYVS 1219 I+W+K + RE+ PPF P +D FD ++ SP +N + F FS+V+ Sbjct: 330 IDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA 389
Score = 103 bits (258), Expect = 9e-22
Identities = 59/182 (32%), Positives = 104/182 (57%), Gaps = 5/182 (2%)
Frame = +2
Query: 338 FAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGG 517
FA+K++ K++ ++ + +L HP ++ L + +++V E + GG
Sbjct: 448 FAVKIIDKSKRDPTEEIEI--------LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG 499
Query: 518 ELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYGH---VKL 685
EL + RQ +E EA L T + +LH+ GV++RDLK N++ +D G+ +++
Sbjct: 500 ELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI 559
Query: 686 TDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIGSSPFI 862
DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G +PF
Sbjct: 560 CDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA 619
Query: 863 GG 868
G
Sbjct: 620 NG 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 158,633,831
Number of Sequences: 369166
Number of extensions: 3260140
Number of successful extensions: 12033
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 9289
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9916
length of database: 68,354,980
effective HSP length: 114
effective length of database: 47,295,190
effective search space used: 17073563590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
