Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_A10
(557 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (... 84 2e-16
sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (... 84 2e-16
sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (... 84 2e-16
sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p7... 84 2e-16
sp|Q16513|PKN2_HUMAN Protein kinase N2 (Protein kinase C-li... 82 9e-16
sp|P70268|PKN1_MOUSE Serine/threonine-protein kinase N1 (Pr... 81 2e-15
sp|Q63433|PKN1_RAT Protein kinase N1 (Protein kinase C-like... 80 3e-15
sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S... 80 3e-15
sp|Q16512|PKN1_HUMAN Protein kinase N1 (Protein kinase C-li... 80 4e-15
sp|Q8BWW9|PKN2_MOUSE Protein kinase N2 (Protein kinase C-li... 78 1e-14
>sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal
protein S6 kinase 1) (p70 S6 kinase alpha)
(p70(S6K)-alpha) (p70-S6K) (p70-alpha)
Length = 525
Score = 84.3 bits (207), Expect = 2e-16
Identities = 47/131 (35%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Frame = +2
Query: 2 RSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINW 181
R + I K++ KL +P +L+ +RLG D E++ H FFR INW
Sbjct: 298 RKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW 357
Query: 182 DKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQ 355
++ AR+++PPF P L S +DVS FD + V SP ST +S F F+YV+P
Sbjct: 358 EELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPS 417
Query: 356 VYLEFSEQGSF 388
V E+ SF
Sbjct: 418 VLESVKEKFSF 428
>sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 84.3 bits (207), Expect = 2e-16
Identities = 47/131 (35%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Frame = +2
Query: 2 RSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINW 181
R + I K++ KL +P +L+ +RLG D E++ H FFR INW
Sbjct: 298 RKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW 357
Query: 182 DKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQ 355
++ AR+++PPF P L S +DVS FD + V SP ST +S F F+YV+P
Sbjct: 358 EELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPS 417
Query: 356 VYLEFSEQGSF 388
V E+ SF
Sbjct: 418 VLESVKEKFSF 428
>sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 84.3 bits (207), Expect = 2e-16
Identities = 47/131 (35%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Frame = +2
Query: 2 RSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINW 181
R + I K++ KL +P +L+ +RLG D E++ H FFR INW
Sbjct: 298 RKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW 357
Query: 182 DKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQ 355
++ AR+++PPF P L S +DVS FD + V SP ST +S F F+YV+P
Sbjct: 358 EELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPS 417
Query: 356 VYLEFSEQGSF 388
V E+ SF
Sbjct: 418 VLESVKEKFSF 428
>sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 84.3 bits (207), Expect = 2e-16
Identities = 47/131 (35%), Positives = 67/131 (51%), Gaps = 2/131 (1%)
Frame = +2
Query: 2 RSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINW 181
R + I K++ KL +P +L+ +RLG D E++ H FFR INW
Sbjct: 298 RKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINW 357
Query: 182 DKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQ 355
++ AR+++PPF P L S +DVS FD + V SP ST +S F F+YV+P
Sbjct: 358 EELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPS 417
Query: 356 VYLEFSEQGSF 388
V E+ SF
Sbjct: 418 VLESVKEKFSF 428
>sp|Q16513|PKN2_HUMAN Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related
kinase 2)
Length = 984
Score = 82.0 bits (201), Expect = 9e-16
Identities = 40/118 (33%), Positives = 62/118 (52%), Gaps = 4/118 (3%)
Frame = +2
Query: 8 QVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDK 187
+V ++N +++ PRFLS RLG SEKD E++K+H FFR I+W
Sbjct: 864 EVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSA 923
Query: 188 AFARELKPPFIPELSSRDDVSLFDKNIVSEPCVIS----PSTADDSNCYWFENFSYVS 349
+++KPPFIP + R+DVS FD SE +++ P + F +F Y++
Sbjct: 924 LMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPprePRILSEEEQEMFRDFDYIA 981
>sp|P70268|PKN1_MOUSE Serine/threonine-protein kinase N1 (Protein kinase C-like 1)
(Protein-kinase C-related kinase 1) (Protein kinase
C-like PKN) (Serine-threonine protein kinase N)
Length = 946
Score = 80.9 bits (198), Expect = 2e-15
Identities = 38/96 (39%), Positives = 53/96 (55%)
Frame = +2
Query: 8 QVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDK 187
+V ++N +++ PRFLS RLG +E+D E++K+ FFRS+ WD
Sbjct: 826 EVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRSLGWDV 885
Query: 188 AFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP 295
AR L PPF+P LS R DVS FD+ E +SP
Sbjct: 886 LLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 921
>sp|Q63433|PKN1_RAT Protein kinase N1 (Protein kinase C-like 1) (Protein-kinase C-related
kinase 1) (Protein kinase C-like PKN) (Serine-threonine
protein kinase N) (Protease-activated kinase 1) (PAK-1)
Length = 946
Score = 80.5 bits (197), Expect = 3e-15
Identities = 37/96 (38%), Positives = 54/96 (56%)
Frame = +2
Query: 8 QVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDK 187
+V ++N +++ PRFLS RLG +E+D E++K+ FFR+++WD
Sbjct: 826 EVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDA 885
Query: 188 AFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP 295
AR L PPF+P LS R DVS FD+ E +SP
Sbjct: 886 LLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 921
>sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S6K-beta 2) (70 kDa ribosomal
protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase
beta) (p70 S6Kbeta) (S6K2)
Length = 485
Score = 80.5 bits (197), Expect = 3e-15
Identities = 46/131 (35%), Positives = 63/131 (48%), Gaps = 2/131 (1%)
Frame = +2
Query: 2 RSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINW 181
R + + K+I KL +P +L+ R+GG D +++RH FFR INW
Sbjct: 274 RKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHINW 333
Query: 182 DKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP--STADDSNCYWFENFSYVSPQ 355
D AR + PPF P L S +DVS FD + V SP + +S F F+YV+P
Sbjct: 334 DDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDTALSESANQAFLGFTYVAPS 393
Query: 356 VYLEFSEQGSF 388
V E SF
Sbjct: 394 VLDSIKEGFSF 404
>sp|Q16512|PKN1_HUMAN Protein kinase N1 (Protein kinase C-like 1) (Protein-kinase C-related
kinase 1) (Protein kinase C-like PKN) (Serine-threonine
protein kinase N) (Protein kinase PKN-alpha)
Length = 942
Score = 79.7 bits (195), Expect = 4e-15
Identities = 37/96 (38%), Positives = 53/96 (55%)
Frame = +2
Query: 8 QVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDK 187
+V ++N +++ PRFLS RLG SE+D E++K+ FFR++ W+
Sbjct: 822 EVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEA 881
Query: 188 AFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISP 295
AR L PPF+P LS R DVS FD+ E +SP
Sbjct: 882 LLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 917
>sp|Q8BWW9|PKN2_MOUSE Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related
kinase 2)
Length = 983
Score = 78.2 bits (191), Expect = 1e-14
Identities = 38/118 (32%), Positives = 60/118 (50%), Gaps = 4/118 (3%)
Frame = +2
Query: 8 QVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXXARLGGSEKDVEEIKRHFFFRSINWDK 187
+V ++N +++ PRFLS RLG EKD E++K+H FFR +W
Sbjct: 863 EVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSA 922
Query: 188 AFARELKPPFIPELSSRDDVSLFDKNIVSEPCVISPSTAD----DSNCYWFENFSYVS 349
+++KPPF+P + R+DVS FD SE +++P + F +F YV+
Sbjct: 923 LMDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPprePRILLEEEQEMFHDFDYVA 980
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,107,663
Number of Sequences: 369166
Number of extensions: 1081877
Number of successful extensions: 3299
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3169
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3241
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)