Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_C07
(848 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (... 251 2e-66
sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (... 250 3e-66
sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (... 250 3e-66
sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p7... 250 3e-66
sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) ... 248 2e-65
sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S... 246 4e-65
sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (... 236 6e-62
sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (... 235 1e-61
sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha 3 (... 233 4e-61
sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (... 233 7e-61
>sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 251 bits (641), Expect = 2e-66
Identities = 131/251 (52%), Positives = 167/251 (66%), Gaps = 7/251 (2%)
Frame = +2
Query: 116 DEVEVNTNLNGSEQINSNDYESVSKSVDICEE------TVNPPGEKVTSHDFDXXXXXXX 277
DE+E LN E ++ E ++ CE+ +VN EK+ F+
Sbjct: 42 DELEEGGQLN--ESMDHGGVEPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGK 99
Query: 278 XXYGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKL 457
YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L
Sbjct: 100 GGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDL 158
Query: 458 YFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRD 637
+AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRD
Sbjct: 159 IYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD 218
Query: 638 LKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWS 814
LK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS
Sbjct: 219 LKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWS 278
Query: 815 MGILLYDMLIG 847
+G L+YDML G
Sbjct: 279 LGALMYDMLTG 289
>sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal
protein S6 kinase 1) (p70 S6 kinase alpha)
(p70(S6K)-alpha) (p70-S6K) (p70-alpha)
Length = 525
Score = 250 bits (639), Expect = 3e-66
Identities = 132/249 (53%), Positives = 166/249 (66%), Gaps = 5/249 (2%)
Frame = +2
Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283
DE+E LN S + YE + +I E +VN EK+ F+
Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101
Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463
YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L +
Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160
Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643
AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820
EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G
Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280
Query: 821 ILLYDMLIG 847
L+YDML G
Sbjct: 281 ALMYDMLTG 289
>sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 250 bits (639), Expect = 3e-66
Identities = 132/249 (53%), Positives = 166/249 (66%), Gaps = 5/249 (2%)
Frame = +2
Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283
DE+E LN S + YE + +I E +VN EK+ F+
Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101
Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463
YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L +
Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160
Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643
AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820
EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G
Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280
Query: 821 ILLYDMLIG 847
L+YDML G
Sbjct: 281 ALMYDMLTG 289
>sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 250 bits (639), Expect = 3e-66
Identities = 132/249 (53%), Positives = 166/249 (66%), Gaps = 5/249 (2%)
Frame = +2
Query: 116 DEVEVNTNLNGS-EQINSNDYE---SVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXX 283
DE+E LN S + YE + +I E +VN EK+ F+
Sbjct: 42 DELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101
Query: 284 YGQVYLAKKVNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYF 463
YG+V+ +KV GA G+ FAMKV+KKA +V N K DT + ERNILE V HPF+V L +
Sbjct: 102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK-DTAHTKAERNILEEVKHPFIVDLIY 160
Query: 464 AFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLK 643
AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G+IYRDLK
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLK 220
Query: 644 SENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMG 820
EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +VDWWS+G
Sbjct: 221 PENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLG 280
Query: 821 ILLYDMLIG 847
L+YDML G
Sbjct: 281 ALMYDMLTG 289
>sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein S6
kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70
S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6
kinase-related kinase) (SRK) (Serine/threonine-protein
kinase 14 beta)
Length = 482
Score = 248 bits (633), Expect = 2e-65
Identities = 121/221 (54%), Positives = 159/221 (71%), Gaps = 1/221 (0%)
Frame = +2
Query: 188 KSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMAGEYFAMKVVKKAR 367
+ V++ E +VN E++ H F+ YG+V+ +KV G G+ +AMKV++KA+
Sbjct: 46 EEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAK 105
Query: 368 LVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQH 547
+V N K DT + ERNILE+V HPF+V+L +AFQT L+++LE L+GGELF HLER+
Sbjct: 106 IVRNAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG 164
Query: 548 TLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDE 724
E+ A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++
Sbjct: 165 IFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGA 224
Query: 725 LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
+TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G
Sbjct: 225 VTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTG 265
>sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S6K-beta 2) (70 kDa ribosomal
protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase
beta) (p70 S6Kbeta) (S6K2)
Length = 485
Score = 246 bits (629), Expect = 4e-65
Identities = 120/221 (54%), Positives = 159/221 (71%), Gaps = 1/221 (0%)
Frame = +2
Query: 188 KSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMAGEYFAMKVVKKAR 367
+ V++ E +VN E++ H F+ YG+V+ +KV G G+ +AMKV++KA+
Sbjct: 46 EEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAK 105
Query: 368 LVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQH 547
+V + K DT + ERNILE+V HPF+V+L +AFQT L+++LE L+GGELF HLER+
Sbjct: 106 IVCSAK-DTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREG 164
Query: 548 TLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDE 724
E+ A FYLAE TLALGHLHS G+IYRDLK EN+ML GH+KLTDFGL KE ++
Sbjct: 165 IFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGA 224
Query: 725 LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
+TH+FCGT+EYMAPEIL R GH +VDWWS+G L+YDML G
Sbjct: 225 ITHTFCGTIEYMAPEILVRTGHNRAVDWWSLGALMYDMLTG 265
>sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal
protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3)
(RSK-3) (pp90RSK3)
Length = 733
Score = 236 bits (602), Expect = 6e-62
Identities = 117/234 (50%), Positives = 159/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 149 SEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMA 328
S ++ + E V K +DI V EK F+ YG+V+L +KV G+ A
Sbjct: 26 SSSLSRLEEEGVVKEIDISHH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDA 84
Query: 329 GEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYL 508
G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+++L++L
Sbjct: 85 GQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 141
Query: 509 AGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLT 688
GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+K+T
Sbjct: 142 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKIT 201
Query: 689 DFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
DFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML G
Sbjct: 202 DFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255
Score = 99.4 bits (246), Expect = 1e-20
Identities = 60/174 (34%), Positives = 98/174 (56%), Gaps = 17/174 (9%)
Frame = +2
Query: 377 NKKNDTKYAM-----TERNILEAVN-------HPFLVKLYFAFQTNHSLFMVLEYLAGGE 520
+K DT+YA+ ++R+ E + HP ++ L + +++V+E + GGE
Sbjct: 434 HKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGE 493
Query: 521 LFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVML-DRYG---HVKLT 688
L + RQ +E EA L T + +LHS GV++RDLK N++ D G +++
Sbjct: 494 LLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVC 553
Query: 689 DFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
DFG +K+ R + L + C T ++APE+L+R+G+ + D WS+GILLY ML G
Sbjct: 554 DFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAG 607
>sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal
protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3)
(RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP
kinase-activated protein kinase 1c) (MAPKAPK1C)
Length = 733
Score = 235 bits (600), Expect = 1e-61
Identities = 115/234 (49%), Positives = 158/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 149 SEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAMA 328
S ++ + E + K +DI V EK F+ YG+V+L +KV G+ A
Sbjct: 26 SSSLSRLEEEGIVKEIDISNH-VKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDA 84
Query: 329 GEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYL 508
G+ +AMKV+KKA L K D + ER+IL VNHPF+VKL++AFQT L+++L++L
Sbjct: 85 GQLYAMKVLKKATL---KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 141
Query: 509 AGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKLT 688
GG+LF L ++ TEE+ +FYLAE LAL HLH +G+IYRDLK EN++LD GH+K+T
Sbjct: 142 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKIT 201
Query: 689 DFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
DFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S DWWS G+L+++ML G
Sbjct: 202 DFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 255
Score = 100 bits (248), Expect = 7e-21
Identities = 60/184 (32%), Positives = 105/184 (57%), Gaps = 5/184 (2%)
Frame = +2
Query: 311 VNGAMAGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLF 490
V+ A EY A+K++ K++ +++ + +L HP ++ L + ++
Sbjct: 433 VHKATDAEY-AVKIIDKSKRDPSEEIEI--------LLRYGQHPNIITLKDVYDDGKYVY 483
Query: 491 MVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDR 667
+V+E + GGEL + RQ +E EA L + +LHS GV++RDLK N++ +D
Sbjct: 484 LVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDE 543
Query: 668 YGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYD 835
G+ +++ DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+GILLY
Sbjct: 544 SGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYT 603
Query: 836 MLIG 847
ML G
Sbjct: 604 MLAG 607
>sp|P18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal
protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)
(RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase
1b) (MAPKAPK1B)
Length = 740
Score = 233 bits (595), Expect = 4e-61
Identities = 118/235 (50%), Positives = 157/235 (66%), Gaps = 1/235 (0%)
Frame = +2
Query: 146 GSEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAM 325
G E+IN E K + I V EK F+ +G+V+L KK++G+
Sbjct: 34 GEEEINPQTEEGSIKEIAITHH-VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92
Query: 326 AGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEY 505
A + +AMKV+KKA L + TK ER+IL VNHPF+VKL++AFQT L+++L++
Sbjct: 93 ARQLYAMKVLKKATLKVRDRVRTKM---ERDILVEVNHPFIVKLHYAFQTEGKLYLILDF 149
Query: 506 LAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKL 685
L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+KL
Sbjct: 150 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKL 209
Query: 686 TDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
TDFGLSKE D E +SFCGTVEYMAPE++ RRGH S DWWS G+L+++ML G
Sbjct: 210 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 264
Score = 97.4 bits (241), Expect = 4e-20
Identities = 56/175 (32%), Positives = 100/175 (57%), Gaps = 5/175 (2%)
Frame = +2
Query: 338 FAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGG 517
FA+K++ K++ ++ + +L HP ++ L + +++V E + GG
Sbjct: 448 FAVKIIDKSKRDPTEEIEI--------LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG 499
Query: 518 ELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYGH---VKL 685
EL + RQ +E EA L T + +LH+ GV++RDLK N++ +D G+ +++
Sbjct: 500 ELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI 559
Query: 686 TDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G
Sbjct: 560 CDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTG 614
>sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal
protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)
(RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1)
(ISPK-1)
Length = 740
Score = 233 bits (593), Expect = 7e-61
Identities = 118/235 (50%), Positives = 157/235 (66%), Gaps = 1/235 (0%)
Frame = +2
Query: 146 GSEQINSNDYESVSKSVDICEETVNPPGEKVTSHDFDXXXXXXXXXYGQVYLAKKVNGAM 325
G E+IN E K + I V EK F+ +G+V+L KK++G+
Sbjct: 34 GEEEINPQTEEVSIKEIAITHH-VKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSD 92
Query: 326 AGEYFAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEY 505
A + +AMKV+KKA L + TK ER+IL VNHPF+VKL++AFQT L+++L++
Sbjct: 93 ARQLYAMKVLKKATLKVRDRVRTKM---ERDILVEVNHPFIVKLHYAFQTEGKLYLILDF 149
Query: 506 LAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVMLDRYGHVKL 685
L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G+IYRDLK EN++LD GH+KL
Sbjct: 150 LRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKL 209
Query: 686 TDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
TDFGLSKE D E +SFCGTVEYMAPE++ RRGH S DWWS G+L+++ML G
Sbjct: 210 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG 264
Score = 97.4 bits (241), Expect = 4e-20
Identities = 56/175 (32%), Positives = 100/175 (57%), Gaps = 5/175 (2%)
Frame = +2
Query: 338 FAMKVVKKARLVTNKKNDTKYAMTERNILEAVNHPFLVKLYFAFQTNHSLFMVLEYLAGG 517
FA+K++ K++ ++ + +L HP ++ L + +++V E + GG
Sbjct: 448 FAVKIIDKSKRDPTEEIEI--------LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGG 499
Query: 518 ELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGVIYRDLKSENVM-LDRYGH---VKL 685
EL + RQ +E EA L T + +LH+ GV++RDLK N++ +D G+ +++
Sbjct: 500 ELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI 559
Query: 686 TDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGHGPSVDWWSMGILLYDMLIG 847
DFG +K+ R ++ L + C T ++APE+L+R+G+ + D WS+G+LLY ML G
Sbjct: 560 CDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTG 614
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,842,386
Number of Sequences: 369166
Number of extensions: 1873004
Number of successful extensions: 8030
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5947
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6249
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)