Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_019_C23
(806 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (... 271 1e-72
sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (... 271 1e-72
sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (... 271 1e-72
sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p7... 271 1e-72
sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S... 266 5e-71
sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) ... 261 2e-69
sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (... 256 4e-68
sp|Q9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase alpha 6 (... 256 5e-68
sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (... 256 7e-68
sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (... 255 1e-67
>sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal
protein S6 kinase 1) (p70 S6 kinase alpha)
(p70(S6K)-alpha) (p70-S6K) (p70-alpha)
Length = 525
Score = 271 bits (694), Expect = 1e-72
Identities = 135/265 (50%), Positives = 175/265 (66%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V L +AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G
Sbjct: 154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +
Sbjct: 214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA 273
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML G+ PF G NR + I K++ KL +P +L+
Sbjct: 274 VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
+RLG D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V
Sbjct: 334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVD 393
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP ST +S F F+YV+P V
Sbjct: 394 SPDDSTLSESANQVFLGFTYVAPSV 418
>sp|P67998|KS6B1_RABIT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 271 bits (694), Expect = 1e-72
Identities = 135/265 (50%), Positives = 175/265 (66%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V L +AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G
Sbjct: 154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +
Sbjct: 214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA 273
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML G+ PF G NR + I K++ KL +P +L+
Sbjct: 274 VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
+RLG D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V
Sbjct: 334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVD 393
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP ST +S F F+YV+P V
Sbjct: 394 SPDDSTLSESANQVFLGFTYVAPSV 418
>sp|Q8BSK8|KS6B1_MOUSE Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 271 bits (694), Expect = 1e-72
Identities = 135/265 (50%), Positives = 175/265 (66%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V L +AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G
Sbjct: 154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +
Sbjct: 214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA 273
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML G+ PF G NR + I K++ KL +P +L+
Sbjct: 274 VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
+RLG D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V
Sbjct: 334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVD 393
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP ST +S F F+YV+P V
Sbjct: 394 SPDDSTLSESANQVFLGFTYVAPSV 418
>sp|P67999|KS6B1_RAT Ribosomal protein S6 kinase I (S6K) (p70-S6K)
Length = 525
Score = 271 bits (694), Expect = 1e-72
Identities = 135/265 (50%), Positives = 175/265 (66%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V L +AFQT L+++LEYL+GGELFM LER+ E+ A FYLAE ++ALGHLH G
Sbjct: 154 FIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKG 213
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML+ GHVKLTDFGL KE +D +TH+FCGT+EYMAPEIL R GH +
Sbjct: 214 IIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA 273
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML G+ PF G NR + I K++ KL +P +L+
Sbjct: 274 VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA 333
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
+RLG D E++ H FFR INW++ AR+++PPF P L S +DVS FD + V
Sbjct: 334 SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVD 393
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP ST +S F F+YV+P V
Sbjct: 394 SPDDSTLSESANQVFLGFTYVAPSV 418
>sp|Q9Z1M4|KS6B2_MOUSE Ribosomal protein S6 kinase beta 2 (S6K-beta 2) (70 kDa ribosomal
protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase
beta) (p70 S6Kbeta) (S6K2)
Length = 485
Score = 266 bits (680), Expect = 5e-71
Identities = 134/265 (50%), Positives = 171/265 (64%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V+L +AFQT L+++LE L+GGELF HLER+ E+ A FYLAE TLALGHLHS G
Sbjct: 130 FIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSHG 189
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +
Sbjct: 190 IIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRTGHNRA 249
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML GS PF NR + + K+I KL +P +L+
Sbjct: 250 VDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPT 309
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
R+GG D +++RH FFR INWD AR + PPF P L S +DVS FD + V
Sbjct: 310 QRIGGGLGDAADVQRHPFFRHINWDDLLARRVDPPFRPSLQSEEDVSQFDARFTRQTPVD 369
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP + +S F F+YV+P V
Sbjct: 370 SPDDTALSESANQAFLGFTYVAPSV 394
>sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein S6
kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70
S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6
kinase-related kinase) (SRK) (Serine/threonine-protein
kinase 14 beta)
Length = 482
Score = 261 bits (667), Expect = 2e-69
Identities = 132/265 (49%), Positives = 170/265 (64%), Gaps = 3/265 (1%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+V+L +AFQT L+++LE L+GGELF HLER+ E+ A FYLAE TLALGHLHS G
Sbjct: 130 FIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQG 189
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKER-NDDELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN+ML GH+KLTDFGL KE ++ +TH+FCGT+EYMAPEIL R GH +
Sbjct: 190 IIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRA 249
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
VDWWS+G L+YDML GS PF NR + + K+I KL +P +L+
Sbjct: 250 VDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPS 309
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
R+GG D +++RH FFR +NWD A + PPF P L S +DVS FD + V
Sbjct: 310 QRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVD 369
Query: 720 SP--STADDSNCYWFENFSYVSPQV 788
SP + +S F F+YV+P V
Sbjct: 370 SPDDTALSESANQAFLGFTYVAPSV 394
>sp|Q9WUT3|KS6A2_MOUSE Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal
protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3)
(RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP
kinase-activated protein kinase 1c) (MAPKAPK1C)
Length = 733
Score = 256 bits (655), Expect = 4e-68
Identities = 124/270 (45%), Positives = 174/270 (64%), Gaps = 2/270 (0%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+VKL++AFQT L+++L++L GG+LF L ++ TEE+ +FYLAE LAL HLH +G
Sbjct: 120 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLG 179
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN++LD GH+K+TDFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S
Sbjct: 180 IIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQS 239
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
DWWS G+L+++ML GS PF G +R + + ++ AKL +P+FLS
Sbjct: 240 ADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPC 299
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
RLG VEEIKRH FF +I+W+K + +E+KPPF P + +D FD +
Sbjct: 300 NRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTD 359
Query: 720 SPSTADDSNC-YWFENFSYVSPQVYLEFSE 806
SP +N + F FS+V+ + E S+
Sbjct: 360 SPGVPPSANAHHLFRGFSFVASSLVQEPSQ 389
Score = 100 bits (249), Expect = 5e-21
Identities = 53/146 (36%), Positives = 88/146 (60%), Gaps = 5/146 (3%)
Frame = +3
Query: 6 LVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGV 185
++ L + +++V+E + GGEL + RQ +E EA L + +LHS GV
Sbjct: 469 IITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGV 528
Query: 186 IYRDLKSENVM-LDRYGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGH 350
++RDLK N++ +D G+ +++ DFG +K+ R ++ L + C T ++APE+L+R+G+
Sbjct: 529 VHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 588
Query: 351 GPSVDWWSMGILLYDMLIGSSPFIGG 428
+ D WS+GILLY ML G +PF G
Sbjct: 589 DAACDVWSLGILLYTMLAGFTPFANG 614
>sp|Q9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase alpha 6 (S6K-alpha 6) (90 kDa ribosomal
protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4)
(RSK-4) (pp90RSK4)
Length = 745
Score = 256 bits (654), Expect = 5e-68
Identities = 124/268 (46%), Positives = 175/268 (65%), Gaps = 2/268 (0%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+VKL++AFQT L+++L++L GG++F L ++ TEE+ +FYLAE LAL HLH +G
Sbjct: 134 FIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLG 193
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPS 359
++YRDLK EN++LD GH+KLTDFGLSKE D E +SFCGTVEYMAPE++ RRGH S
Sbjct: 194 IVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQS 253
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
DWWS G+L+++ML G+ PF G +R++ + ++ AKL +P+FLS
Sbjct: 254 ADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPA 313
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
RLG + VEEIKRH FF +I+WDK + RE++PPF P DD FD ++
Sbjct: 314 NRLG--SEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKD 371
Query: 720 SPSTADDSNCY-WFENFSYVSPQVYLEF 800
SP +N + F+ FS+V+ + E+
Sbjct: 372 SPGLPASANAHQLFKGFSFVATSIAEEY 399
Score = 90.5 bits (223), Expect = 5e-18
Identities = 49/165 (29%), Positives = 91/165 (55%), Gaps = 8/165 (4%)
Frame = +3
Query: 6 LVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGV 185
++ L F +++V + + GGEL + +Q +E EA L + + +LH GV
Sbjct: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 539
Query: 186 IYRDLKSENVM-LDRYGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGH 350
++RDLK N++ +D +++ DFG +K+ R ++ L + C T ++APE+L ++G+
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGY 599
Query: 351 GPSVDWWSMGILLYDMLIGSSPFIGG---NRSQVIQKVINAKLKI 476
+ D WS+G+L Y ML G +PF G +++ ++ N K +
Sbjct: 600 DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
>sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal
protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3)
(RSK-3) (pp90RSK3)
Length = 733
Score = 256 bits (653), Expect = 7e-68
Identities = 125/270 (46%), Positives = 174/270 (64%), Gaps = 2/270 (0%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+VKL++AFQT L+++L++L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G
Sbjct: 120 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 179
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKERND-DELTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN++LD GH+K+TDFGLSKE D D+ +SFCGT+EYMAPE++ RRGH S
Sbjct: 180 IIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQS 239
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
DWWS G+L+++ML GS PF G +R + + ++ AKL +P+FLS
Sbjct: 240 ADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPC 299
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
RLG VEEIKRH FF +I+W+ + +E+KPPF P L +D FD +
Sbjct: 300 NRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPALGRPEDTFHFDPEFTARTPTD 359
Query: 720 SPSTADDSNC-YWFENFSYVSPQVYLEFSE 806
SP +N + F FS+V+ + E S+
Sbjct: 360 SPGVPPSANAHHLFRGFSFVASSLIQEPSQ 389
Score = 99.4 bits (246), Expect = 1e-20
Identities = 54/146 (36%), Positives = 86/146 (58%), Gaps = 5/146 (3%)
Frame = +3
Query: 6 LVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGV 185
++ L + +++V+E + GGEL + RQ +E EA L T + +LHS GV
Sbjct: 469 IITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGV 528
Query: 186 IYRDLKSENVML-DRYGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGH 350
++RDLK N++ D G +++ DFG +K+ R + L + C T ++APE+L+R+G+
Sbjct: 529 VHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGY 588
Query: 351 GPSVDWWSMGILLYDMLIGSSPFIGG 428
+ D WS+GILLY ML G +PF G
Sbjct: 589 DAACDIWSLGILLYTMLAGFTPFANG 614
>sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal
protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)
(RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1)
(ISPK-1)
Length = 740
Score = 255 bits (651), Expect = 1e-67
Identities = 124/261 (47%), Positives = 169/261 (64%), Gaps = 2/261 (0%)
Frame = +3
Query: 3 FLVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIG 182
F+VKL++AFQT L+++L++L GG+LF L ++ TEE+ +FYLAE LAL HLHS+G
Sbjct: 129 FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLG 188
Query: 183 VIYRDLKSENVMLDRYGHVKLTDFGLSKERNDDE-LTHSFCGTVEYMAPEILQRRGHGPS 359
+IYRDLK EN++LD GH+KLTDFGLSKE D E +SFCGTVEYMAPE++ RRGH S
Sbjct: 189 IIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQS 248
Query: 360 VDWWSMGILLYDMLIGSSPFIGGNRSQVIQKVINAKLKIPRFLSDSXXXXXXXXXXXXXX 539
DWWS G+L+++ML G+ PF G +R + + ++ AKL +P+FLS
Sbjct: 249 ADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPA 308
Query: 540 ARLGGSEKDVEEIKRHFFFRSINWDKAFARELKPPFIPELSSRDDVSLFDKNIVSEPCVI 719
RLG VEEIKRH FF +I+W+K + RE+ PPF P +D FD ++
Sbjct: 309 NRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKD 368
Query: 720 SPSTADDSNCY-WFENFSYVS 779
SP +N + F FS+V+
Sbjct: 369 SPGIPPSANAHQLFRGFSFVA 389
Score = 97.4 bits (241), Expect = 4e-20
Identities = 52/146 (35%), Positives = 88/146 (60%), Gaps = 5/146 (3%)
Frame = +3
Query: 6 LVKLYFAFQTNHSLFMVLEYLAGGELFMHLERQHTLTEEEARFYLAETTLALGHLHSIGV 185
++ L + +++V E + GGEL + RQ +E EA L T + +LH+ GV
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 535
Query: 186 IYRDLKSENVM-LDRYGH---VKLTDFGLSKE-RNDDELTHSFCGTVEYMAPEILQRRGH 350
++RDLK N++ +D G+ +++ DFG +K+ R ++ L + C T ++APE+L+R+G+
Sbjct: 536 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 595
Query: 351 GPSVDWWSMGILLYDMLIGSSPFIGG 428
+ D WS+G+LLY ML G +PF G
Sbjct: 596 DAACDIWSLGVLLYTMLTGYTPFANG 621
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,249,311
Number of Sequences: 369166
Number of extensions: 1919418
Number of successful extensions: 8583
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6499
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6806
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)